Peering inside lipid rafts and caveolae

Trends in Biochemical Sciences

Volumn 27, Issue 9, 2002, Pages 435-438

  Kenworthy, Anne ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; MEMBRANE PROTEIN; PHOSPHOTRANSFERASE; PROTEIN; RAS PROTEIN;

ARTICLE; CAVEOLA; CELL COMPARTMENTALIZATION; CELL FUNCTION; CELL MEMBRANE; CELL SURFACE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CYTOSOL; LABORATORY TEST; MYRISTYLATION; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN TARGETING; REGULATORY MECHANISM;

EID: 0036710588     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(02)02178-3     Document Type: Review

References (21)

1. Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572.
2. Anderson R.G.W. The caveolae membrane system. Annu. Rev. Biochem. 67:1998;199-225.
3. Casey P.J. Protein lipidation in cell signaling. Science. 268:1995;221-225.
4. Simons K., Toomre D. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1:2000;31-41.
5. Smart E.J., et al. Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell Biol. 19:1999;7289-7304.
6. Melkonian K.A., et al. Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. J. Biol. Chem. 274:1999;3910-3917.
7. Brown D.A., London E. Structure and origin of ordered lipid domains in biological membranes. J. Membr. Biol. 164:1998;103-114.
8. Zacharias D.A., et al. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science. 296:2002;913-916.
9. Anderson R.G.W., Jacobson K. A role for lipid shells in targeting proteins to caveolae, rafts and other lipid domains. Science. 296:2002;1821-1825.
10. Jacobson K., Dietrich C. Looking at lipid rafts? Trends Cell Biol. 9:1999;87-91.
11. Miyawaki A., Tsien R.Y. Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods Enzymol. 327:2000;472-500.
12. Phillips G.N. Jr. The three-dimensional structure of green fluorescent protein and its implications for function and design. Chalfie M., Kain S., Green Fluorescent Protein: Properties, Applications, and Protocols. 1998;77-96 Wiley-Liss.
13. Wang T.-Y., et al. Fluorescence-based evaluation of the partitioning of lipids and lipidated peptides into liquid-ordered lipid domains: a model for molecular partitioning into 'lipid rafts'. Biophys. J. 79:2000;919-933.
14. Choy E., et al. Endomembrane trafficking of Ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 98:1999;69-80.
15. Michaelson, D. et al. Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi. Mol. Biol. Cell (in press)
16. Prior I.A., et al. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat. Cell Biol. 3:2001;368-375.
17. McCabe J.B., Berthiaume L.G. N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae. Mol. Biol. Cell. 12:2001;3601-3617.
18. Oh P., Schnitzer J.E. Segregation of heterotrimeric G proteins in cell surface microdomains. Gq binds caveolin to concentrate in caveolae, whereas Gi and Gs target to lipid rafts by default. Mol. Biol. Cell. 12:2001;685-698.
19. Schnitzer J.E., et al. Separation of caveolae from associated microdomains of GPI-anchored proteins. Science. 269:1995;1435-1439.
20. Hao M., et al. Cholesterol depletion induces large scale domain segregation in living cell membranes. Proc. Natl. Acad. Sci. U. S. A. 98:2001;13072-13077.
21. Lippincott-Schwartz J., et al. Studying protein dynamics in living cells. Nat. Rev. Mol. Cell Biol. 2:2001;444-456.