Na/K pump current and [Na]i in rabbit ventricular myocytes: Local [Na]i depletion and Na buffering

Biophysical Journal

Volumn 84, Issue 6, 2003, Pages 4157-4166

  Despa, Sanda ^a   Bers, Donald M ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); SODIUM;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOPLASM; DIFFUSION; HEART MUSCLE CELL; MEMBRANE CURRENT; MEMBRANE TRANSPORT; NONHUMAN; POTASSIUM CURRENT; RABBIT; SARCOLEMMA; SODIUM CELL LEVEL; SODIUM CURRENT; VOLTAGE CLAMP;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0038440545     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(03)75140-6     Document Type: Article

References (29)

1. Bassani, J. W. M., R. A. Bassani, and D. M. Bers. 1994. Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms. J. Physiol. 476:279-293.
2. Bers, D. M. 2001. Excitation-Contraction Coupling and Cardiac Contractile Force. Kluwer Academic Publishing, Dordrecht, The Netherlands.
3. + concentration in internally perfused cardiac cells. Biochim. Biophys. Acta. 1065:269-271.
4. + pump current on external monovalent cations and membrane potential in rabbit cardiac Purkinje cells. J. Physiol. 442:169-189.
5. + in cardiac cells. Cardiovasc. Res. 26:433-442.
6. +-pump rate in rat and rabbit ventricular myocytes. J. Physiol. 539:133-143.
7. + concentration is elevated in heart failure, but Na/K-pump function is unchanged. Circulation. 105:2543-2548.
8. +-ATPase pump currents in giant excised patches activated by an ATP concentration jump. Biophys. J. 71:2486-2500.
9. i in a restricted space of guinea-pig ventricular cells. J. Physiol. 509:457-470.
10. Glitsch, H. G. 2001. Electrophysiology of the sodium-potassium-ATPase in cardiac cells. Physiol. Rev. 81:1791-1826.
11. th Ed. Molecular Probes Inc., Eugene, OR.
12. Hilgemann, D. W., G. A. Nagel, and D. C. Gadsby. 1991. Na/K pump current in giant membrane patches excised from ventricular myocytes. In The Sodium Pump: Recent Developments. J. H. Kaplan and P. De Weer, editors. Rockefeller University Press, New York.
13. Hilgemann, D. W., S. Matsuoka, G. A. Nagel, and A. Collins. 1992. Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation. J. Gen. Physiol. 100:905-932.
14. + in isolated heart mitochondria estimated using a fluorescent probe. Am. J. Physiol. 262:C1047-C1055.
15. Kushmerick, M. J., and R. J. Podolsky. 1969. Ionic mobility in muscle cells. Science. 166:1297-1298.
16. Lee, C. O., and M. Dagostino. 1982. Effect of strophanthidin on intracellular Na ion activity and twitch tension on constantly driven canine cardiac Purkinje fibers. Biophys. J. 40:185-198.
17. Lipp, P., and E. Niggli. 1994. Sodium current-induced calcium signals in guinea-pig ventricular myocytes. J. Physiol. 474:439-446.
18. Mathias, R. T., I. S. Cohen, and C. Oliva. 1990. Limitations of the wholecell patch-clamp technique in the control of intracellular concentrations. Biophys. J. 58:759-770.
19. McDonough, A. A., Y. Zhang, V. Shin, and J. S. Frank. 1996. Subcellular distribution of Na pump isoform subunits in mammalian cardiac myocytes. Am. J. Physiol. 270:C1221-C1227.
20. Nakao, M., and D. C. Gadsby. 1989. [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes. J. Gen. Physiol. 94:539-565.
21. Philipson, K. D., D. M. Bers, A. Y. Nishimoto, and G. A. Langer. 1980. The binding of calcium and sodium to sarcolemmal membranes: relation to the control of myocardial contractility. Am. J. Physiol. 238: H373-H378.
22. Satoh, H., L. M. Delbridge, L. A. Blatter, and D. M. Bers. 1996. Surface: volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects. Biophys. J. 70:1494-1504.
23. + pump rate in heart and skeletal muscle. Acta Physiol. Scand. 156:213-224.
24. Na in ventricular myocardium? Cardiovasc. Res. 57:1025-1034.
25. 2+ exchange currents in mouse ventricular myocytes. Am. J. Physiol. 275:H1808-H1817.
26. i transients in mouse ventricular myocytes. Biophys. J. 80:1230-1237.
27. 2+ exchanger-mediated relaxation in rabbit ventricular myocytes. J. Physiol. 533:165-173.
28. Trafford, A. W., M. E. Diaz, S. C. O'Neil, and D. A. Eisner. 1995. Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes. J. Physiol. 488:577-586.
29. Wendt-Gallitelli, M. F., T. Voigt, and G. Isenberg. 1993. Microheterogeneity of subsarcolemmal sodium gradients. Electron probe microanalysis in guinea-pig ventricular myocytes. J. Physiol. 472:33-44.