메뉴 건너뛰기




Volumn 388, Issue 3, 2005, Pages 803-811

Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue

Author keywords

cAMP phosphodiesterase; FRTL5 thyroid cell; Phosphodiesterase 4 splice form (PDE4 splice form); Protein kinase A activation; SDS PAGE migration; Thyroid stimulating hormone (TSH)

Indexed keywords

ANTIBODIES; BIOCHEMISTRY; CLONING; DRUG PRODUCTS; ELECTROPHORESIS; ENZYME INHIBITION; GENES; IMMUNOLOGY; PRECIPITATION (CHEMICAL); PULMONARY DISEASES; RNA; TISSUE;

EID: 21744442922     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050030     Document Type: Article
Times cited : (133)

References (39)
  • 2
    • 0035818473 scopus 로고    scopus 로고
    • A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell
    • Rich, T. C., Fagan, K. A., Tse, T. E., Schaack, J., Cooper, D. M. and Karpen, J. W. (2001) A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc. Natl. Acad. Sci. U.S.A. 98, 13049-13054
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 13049-13054
    • Rich, T.C.1    Fagan, K.A.2    Tse, T.E.3    Schaack, J.4    Cooper, D.M.5    Karpen, J.W.6
  • 4
    • 0035029169 scopus 로고    scopus 로고
    • Compartmentation of G protein-coupled signaling pathways in cardiac myocytes
    • Steinberg, S. F. and Brunton, L. L. (2001) Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu. Rev. Pharmacol. Toxicol. 41, 751-773
    • (2001) Annu. Rev. Pharmacol. Toxicol. , vol.41 , pp. 751-773
    • Steinberg, S.F.1    Brunton, L.L.2
  • 6
    • 0344513958 scopus 로고    scopus 로고
    • Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease
    • Spina, D. (2003) Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease. Drugs 63, 2575-2594
    • (2003) Drugs , vol.63 , pp. 2575-2594
    • Spina, D.1
  • 7
    • 1342264246 scopus 로고    scopus 로고
    • Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
    • O'Donnell, J. M. and Zhang, H. T. (2004) Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4). Trends Pharmacol. Sci. 25, 158-163
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 158-163
    • O'Donnell, J.M.1    Zhang, H.T.2
  • 8
    • 0036755003 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction
    • Corbin, J. D., Francis, S. H. and Webb, D. J. (2002) Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction. Urology 60, 4-11
    • (2002) Urology , vol.60 , pp. 4-11
    • Corbin, J.D.1    Francis, S.H.2    Webb, D.J.3
  • 9
    • 0037458648 scopus 로고    scopus 로고
    • Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling
    • Conti, M., Richter, W., Mehats, C., Livera, G., Park, J. Y. and Jin, C. (2003) Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling. J. Biol. Chem. 278, 5493-5496
    • (2003) J. Biol. Chem. , vol.278 , pp. 5493-5496
    • Conti, M.1    Richter, W.2    Mehats, C.3    Livera, G.4    Park, J.Y.5    Jin, C.6
  • 10
    • 0037443097 scopus 로고    scopus 로고
    • PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signaling cross-talk, desensitization and compartmentalization
    • Houslay, M. D. and Adams, D. R. (2003) PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signaling cross-talk, desensitization and compartmentalization. Biochem. J. 370, 1-18
    • (2003) Biochem. J. , vol.370 , pp. 1-18
    • Houslay, M.D.1    Adams, D.R.2
  • 11
    • 0032692936 scopus 로고    scopus 로고
    • Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice
    • Jin, S. L., Richard, F. J., Kuo, W. P., D'Ercole, A. J. and Conti, M. (1999) Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 96, 11998-12003
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 11998-12003
    • Jin, S.L.1    Richard, F.J.2    Kuo, W.P.3    D'Ercole, A.J.4    Conti, M.5
  • 12
    • 0037188511 scopus 로고    scopus 로고
    • Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
    • Jin, S. L. and Conti, M. (2002) Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses. Proc. Natl. Acad. Sci. U.S.A. 99, 7628-7633
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 7628-7633
    • Jin, S.L.1    Conti, M.2
  • 14
    • 0024405251 scopus 로고
    • Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: Evidence for a family of genes
    • Swinnen, J. V., Joseph, D. R. and Conti, M. (1989) Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Proc. Natl. Acad. Sci. U.S.A. 86, 5325-5329
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 5325-5329
    • Swinnen, J.V.1    Joseph, D.R.2    Conti, M.3
  • 15
    • 0027454556 scopus 로고
    • A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
    • Bolger, G., Michaeli, T., Martins, T., St John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M. and Ferguson, K. (1993) A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol. Cell Biol. 13, 6558-6571
    • (1993) Mol. Cell Biol. , vol.13 , pp. 6558-6571
    • Bolger, G.1    Michaeli, T.2    Martins, T.3    St. John, T.4    Steiner, B.5    Rodgers, L.6    Riggs, M.7    Wigler, M.8    Ferguson, K.9
  • 16
    • 0029009878 scopus 로고
    • Recent progress in understanding the hormonal regulation of phosphodiesterases
    • Conti, M., Nemoz, G., Sette, C. and Vicini, E. (1995) Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocrinol. Rev. 16, 370-389
    • (1995) Endocrinol. Rev. , vol.16 , pp. 370-389
    • Conti, M.1    Nemoz, G.2    Sette, C.3    Vicini, E.4
  • 17
    • 0030006920 scopus 로고    scopus 로고
    • Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMF-dependent protein kinase. Involvement of serine 54 in the enzyme activation
    • Sette, C. and Conti, M. (1996) Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMF-dependent protein kinase. Involvement of serine 54 in the enzyme activation. J. Biol. Chem. 271, 16526-16534
    • (1996) J. Biol. Chem. , vol.271 , pp. 16526-16534
    • Sette, C.1    Conti, M.2
  • 19
    • 0346158373 scopus 로고    scopus 로고
    • The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways
    • Houslay, M. D. and Baillie, G. S. (2003) The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. Biochem. Soc. Trans. 31, 1186-1190
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 1186-1190
    • Houslay, M.D.1    Baillie, G.S.2
  • 20
    • 0034721870 scopus 로고    scopus 로고
    • The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding. Consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site
    • Grange, M., Sette, C., Cuomo, M., Conti, M., Lagarde, M., Prigent, A. F. and Nemoz, G, (2000) The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding. Consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site. J. Biol. Chem. 275, 33379-33387
    • (2000) J. Biol. Chem. , vol.275 , pp. 33379-33387
    • Grange, M.1    Sette, C.2    Cuomo, M.3    Conti, M.4    Lagarde, M.5    Prigent, A.F.6    Nemoz, G.7
  • 21
    • 0037174825 scopus 로고    scopus 로고
    • Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs)
    • Richter, W. and Conti, M. (2002) Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs). J. Biol. Chem. 277, 40212-40221
    • (2002) J. Biol. Chem. , vol.277 , pp. 40212-40221
    • Richter, W.1    Conti, M.2
  • 22
    • 3142776354 scopus 로고    scopus 로고
    • The oligomerization state determines regulatory properties and inhibitor sensitiviiy of type 4 cAMP-specific phosphodiesterases
    • Richter, W. and Conti, M. (2004) The oligomerization state determines regulatory properties and inhibitor sensitiviiy of type 4 cAMP-specific phosphodiesterases. J. Biol. Chem. 279, 30338-30348
    • (2004) J. Biol. Chem. , vol.279 , pp. 30338-30348
    • Richter, W.1    Conti, M.2
  • 25
    • 0031939478 scopus 로고    scopus 로고
    • Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: Identification and differential expression of immunologically distinct forms in the rat brain
    • Iona, S., Cuomo, M., Bushnik, T., Naro, F., Sette, C., Hess, M., Shelton, E. R. and Conti, M. (1998) Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain. Mol. Pharmacol. 53, 23-32
    • (1998) Mol. Pharmacol. , vol.53 , pp. 23-32
    • Iona, S.1    Cuomo, M.2    Bushnik, T.3    Naro, F.4    Sette, C.5    Hess, M.6    Shelton, E.R.7    Conti, M.8
  • 26
    • 1542572127 scopus 로고    scopus 로고
    • The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with β-arrestins
    • Bolger, G. B., McCahill, A., Huston, E., Cheung, Y. F., McSorley, T., Baillie, G. S. and Houslay, M. D. (2003) The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with β-arrestins. J. Biol. Chem. 278, 49230-49233
    • (2003) J. Biol. Chem. , vol.278 , pp. 49230-49233
    • Bolger, G.B.1    McCahill, A.2    Huston, E.3    Cheung, Y.F.4    McSorley, T.5    Baillie, G.S.6    Houslay, M.D.7
  • 27
    • 0034714376 scopus 로고    scopus 로고
    • Expression of phosphodiesterase 4D (PDE4D) is regulated by both the cyclic AMP-dependent protein kinase and mitogen-activated protein kinase signaling pathways. A potential mechanism allowing for the coordinated regulation of PDE4D activity and expression in cells
    • Liu, H., Palmer, D., Jimmo, S. L., Tilley, D. G., Dunkerley, H. A., Pang, S. C. and Maurice, D. H. (2000) Expression of phosphodiesterase 4D (PDE4D) is regulated by both the cyclic AMP-dependent protein kinase and mitogen-activated protein kinase signaling pathways. A potential mechanism allowing for the coordinated regulation of PDE4D activity and expression in cells. J. Biol. Chem. 275, 26615-26624
    • (2000) J. Biol. Chem. , vol.275 , pp. 26615-26624
    • Liu, H.1    Palmer, D.2    Jimmo, S.L.3    Tilley, D.G.4    Dunkerley, H.A.5    Pang, S.C.6    Maurice, D.H.7
  • 29
    • 0028360098 scopus 로고
    • The rat PDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase
    • Sette, C., Vicini, E. and Conti, M. (1994) The rat PDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase. J. Biol. Chem. 269, 18271-18274
    • (1994) J. Biol. Chem. , vol.269 , pp. 18271-18274
    • Sette, C.1    Vicini, E.2    Conti, M.3
  • 30
    • 0344531201 scopus 로고
    • The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP
    • Swinnen, J. V., Joseph, D. R. and Conti, M. (1989) The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP. Proc. Natl. Acad. Sci. U.S.A. 86, 8197-8201
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 8197-8201
    • Swinnen, J.V.1    Joseph, D.R.2    Conti, M.3
  • 31
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227, 680-685
    • (1970) Nature (London) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 32
    • 0015231739 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterase activities from rat brain
    • Thompson, W. J. and Appleman, M. M. (1971) Multiple cyclic nucleotide phosphodiesterase activities from rat brain. Biochemistry 10, 311-316
    • (1971) Biochemistry , vol.10 , pp. 311-316
    • Thompson, W.J.1    Appleman, M.M.2
  • 33
    • 0032584673 scopus 로고    scopus 로고
    • Subcellular localization of rolipram-sensitive, cAMP-specific phosphodiesterases. Differential targeting and activation of the splicing variants derived from the PDE4D gene
    • Jin, S. L., Bushnik, T., Lan, L. and Conti, M. (1998) Subcellular localization of rolipram-sensitive, cAMP-specific phosphodiesterases. Differential targeting and activation of the splicing variants derived from the PDE4D gene. J. Biol. Chem. 273, 19672-19678
    • (1998) J. Biol. Chem. , vol.273 , pp. 19672-19678
    • Jin, S.L.1    Bushnik, T.2    Lan, L.3    Conti, M.4
  • 34
    • 0034646689 scopus 로고    scopus 로고
    • Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation
    • Oki, N., Takahashi, S. I., Hidaka, H. and Conti, M. (2000) Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation. J. Biol. Chem. 275, 10831-10837
    • (2000) J. Biol. Chem. , vol.275 , pp. 10831-10837
    • Oki, N.1    Takahashi, S.I.2    Hidaka, H.3    Conti, M.4
  • 36
    • 0032605044 scopus 로고    scopus 로고
    • The molecular biology of cyclic nucleotide phosphodiesterases
    • Conti, M. and Jin, S. L. (1999) The molecular biology of cyclic nucleotide phosphodiesterases. Prog. Nucleic Acid Res. Mol. Biol. 63, 1-38
    • (1999) Prog. Nucleic Acid Res. Mol. Biol. , vol.63 , pp. 1-38
    • Conti, M.1    Jin, S.L.2
  • 39
    • 0036016114 scopus 로고    scopus 로고
    • Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in upstream conserved region 1 (UCR1)
    • MacKenzie, S. J., Baillie, G. S., McPhee, I., MacKenzie, C., Seamons, R., McSorley, T., Millen, J., Beard, M. B., van Heeke, G. and Houslay, M. D. (2002) Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in upstream conserved region 1 (UCR1). Br. J. Pharmacol. 136, 421-433
    • (2002) Br. J. Pharmacol. , vol.136 , pp. 421-433
    • MacKenzie, S.J.1    Baillie, G.S.2    McPhee, I.3    MacKenzie, C.4    Seamons, R.5    McSorley, T.6    Millen, J.7    Beard, M.B.8    Van Heeke, G.9    Houslay, M.D.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.