Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ

Toxicology and Applied Pharmacology

Volumn 259, Issue 3, 2012, Pages 338-345

  Kojima, Hiroyuki ^a   Muromoto, Ryuta ^b   Takahashi, Miki ^b   Takeuchi, Shinji ^a   Takeda, Yukimasa ^c   Jetten, Anton M ^c   Matsuda, Tadashi ^b  

^a HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Fungicide; Interleukin 17; Mouse; Reporter gene assay; Retinoic acid receptor related orphan receptor

Indexed keywords

ENILCONAZOLE; FUNGICIDE; HEXACONAZOLE; IMIBENCONAZOLE; INTERLEUKIN 17; IONOMYCIN; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PYRROLE DERIVATIVE; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TETRACONAZOLE; TRIFLUMIZOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOCOMPETENT CELL; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T CELL LYMPHOMA; TH17 CELL;

ANIMALS; ANTIFUNGAL AGENTS; AZOLES; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENES, REPORTER; INTERLEUKIN-17; LYMPHOMA, T-CELL; MICE; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TH17 CELLS;

EID: 84858075855     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.01.011     Document Type: Article

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