-
1
-
-
77955296167
-
Recent advances in retrometabolic drug design (RMDD) and development
-
Bodor N, Buchwald P: Recent advances in retrometabolic drug design (RMDD) and development. Pharmazie 2010, 65:395-403.
-
(2010)
Pharmazie
, vol.65
, pp. 395-403
-
-
Bodor, N.1
Buchwald, P.2
-
2
-
-
3042687583
-
Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites
-
Bodor N, Buchwald P: Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites. Mol.Biotechnol. 2004, 26:123-32.
-
(2004)
Mol.Biotechnol
, vol.26
, pp. 123-132
-
-
Bodor, N.1
Buchwald, P.2
-
3
-
-
0034787366
-
Retrometabolic drug design--novel aspects, future directions
-
Bodor N: Retrometabolic drug design--novel aspects, future directions. Pharmazie 2001, 56 Suppl 1:S67-74.
-
(2001)
Pharmazie
, vol.56
, Issue.SUPPL. 1
-
-
Bodor, N.1
-
4
-
-
0033966357
-
Soft drug design: General principles and recent applications
-
Bodor N, Buchwald P: Soft drug design: general principles and recent applications. Med.Res.Rev. 2000, 20:58-101.
-
(2000)
Med.Res.Rev
, vol.20
, pp. 58-101
-
-
Bodor, N.1
Buchwald, P.2
-
5
-
-
35649009910
-
Intestinal permeability and its relevance for absorption and elimination
-
Lennernas H: Intestinal permeability and its relevance for absorption and elimination. Xenobiotica 2007, 37:1015-51.
-
(2007)
Xenobiotica
, vol.37
, pp. 1015-1051
-
-
Lennernas, H.1
-
6
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv.Drug Deliv.Rev. 2001, 46:3-26.
-
(2001)
Adv.Drug Deliv.Rev
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
7
-
-
0344984493
-
Web-based cheminformatics and molecular property prediction tools supporting drug design and development at Novartis
-
Ertl P, Muhlbacher J, Rohde B, Selzer P: Web-based cheminformatics and molecular property prediction tools supporting drug design and development at Novartis. SAR QSAR.Environ.Res. 2003, 14:321-8.
-
(2003)
SAR QSAR.Environ.Res
, vol.14
, pp. 321-328
-
-
Ertl, P.1
Muhlbacher, J.2
Rohde, B.3
Selzer, P.4
-
8
-
-
0034609833
-
Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties
-
Ertl P, Rohde B, Selzer P: Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. J.Med.Chem. 2000, 43:3714-7.
-
(2000)
J.Med.Chem
, vol.43
, pp. 3714-3717
-
-
Ertl, P.1
Rohde, B.2
Selzer, P.3
-
9
-
-
0037030653
-
Molecular properties that influence the oral bioavailability of drug candidates
-
Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD: Molecular properties that influence the oral bioavailability of drug candidates. J.Med.Chem. 2002, 45:2615-23.
-
(2002)
J.Med.Chem
, vol.45
, pp. 2615-2623
-
-
Veber, D.F.1
Johnson, S.R.2
Cheng, H.Y.3
Smith, B.R.4
Ward, K.W.5
Kopple, K.D.6
-
10
-
-
21744458087
-
Nanoparticle uptake by the oral route: Fulfilling its potential?
-
Florence AT: Nanoparticle uptake by the oral route: Fulfilling its potential? Drug Discovery Today: Technologies 2005, 2:75-82.
-
(2005)
Drug Discovery Today: Technologies
, vol.2
, pp. 75-82
-
-
Florence, A.T.1
-
11
-
-
0036195952
-
Absorption of colesevelam hydrochloride in healthy volunteers
-
Heller DP, Burke SK, Davidson DM, Donovan JM: Absorption of colesevelam hydrochloride in healthy volunteers. Ann.Pharmacother. 2002, 36:398-403.
-
(2002)
Ann.Pharmacother
, vol.36
, pp. 398-403
-
-
Heller, D.P.1
Burke, S.K.2
Davidson, D.M.3
Donovan, J.M.4
-
12
-
-
0036071145
-
Sevelamer, a phosphate-binding polymer, is a non-absorbed compound
-
Plone MA, Petersen JS, Rosenbaum DP, Burke SK: Sevelamer, a phosphate-binding polymer, is a non-absorbed compound. Clin Pharmacokinet 2002, 41:517-23.
-
(2002)
Clin Pharmacokinet
, vol.41
, pp. 517-523
-
-
Plone, M.A.1
Petersen, J.S.2
Rosenbaum, D.P.3
Burke, S.K.4
-
13
-
-
0018385391
-
Distribution of loperamide in the intestinal wall
-
van Nueten JM, Helsen L, Michiels M, Heykants JJ: Distribution of loperamide in the intestinal wall. Biochem.Pharmacol. 1979, 28:1433-4.
-
(1979)
Biochem.Pharmacol
, vol.28
, pp. 1433-1434
-
-
van Nueten, J.M.1
Helsen, L.2
Michiels, M.3
Heykants, J.J.4
-
15
-
-
85038463666
-
-
SalixPharmaceuticals: Rifaximin package insert http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/GastrointestinalDrugsAdvisoryCommittee/UCM201081.pdf 2010.
-
(2010)
SalixPharmaceuticals: Rifaximin Package Insert
-
-
-
16
-
-
33847081694
-
What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs
-
Roffey SJ, Obach RS, Gedge JI, Smith DA: What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs. Drug Metab Rev. 2007, 39:17-43.
-
(2007)
Drug Metab Rev
, vol.39
, pp. 17-43
-
-
Roffey, S.J.1
Obach, R.S.2
Gedge, J.I.3
Smith, D.A.4
-
17
-
-
40549109907
-
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2
-
van Itallie CM, Holmes J, Bridges A, et al. The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J.Cell Sci. 2008, 121:298-305.
-
(2008)
J.Cell Sci
, vol.121
, pp. 298-305
-
-
van Itallie, C.M.1
Holmes, J.2
Bridges, A.3
-
18
-
-
56349169898
-
Molecular mechanism of intestinal permeability: Interaction at tight junctions
-
Hossain Z, Hirata T: Molecular mechanism of intestinal permeability: interaction at tight junctions. Mol.Biosyst. 2008, 4:1181-5.
-
(2008)
Mol.Biosyst
, vol.4
, pp. 1181-1185
-
-
Hossain, Z.1
Hirata, T.2
-
19
-
-
16244418685
-
Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium
-
Salamat-Miller N, Johnston TP: Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium. Int.J.Pharm. 2005, 294:201-16.
-
(2005)
Int.J.Pharm
, vol.294
, pp. 201-216
-
-
Salamat-Miller, N.1
Johnston, T.P.2
-
20
-
-
33645048437
-
The development of pharmacodynamics as a pharmaceutical science: A personal perspective
-
Levy G: The development of pharmacodynamics as a pharmaceutical science: a personal perspective. Ann.Pharmacother. 2006, 40:520-23.
-
(2006)
Ann.Pharmacother
, vol.40
, pp. 520-523
-
-
Levy, G.1
-
21
-
-
36349011932
-
Non-invasive quantification of small bowel water content by MRI: A validation study
-
Hoad CL, Marciani L, Foley S, et al. Non-invasive quantification of small bowel water content by MRI: a validation study. Phys.Med.Biol. 2007, 52:6909-22.
-
(2007)
Phys.Med.Biol
, vol.52
, pp. 6909-6922
-
-
Hoad, C.L.1
Marciani, L.2
Foley, S.3
-
22
-
-
75149175153
-
Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
-
Marciani L, Cox EF, Hoad CL, et al. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome. Gastroenterology 2010, 138:469-77.
-
(2010)
Gastroenterology
, vol.138
, pp. 469-477
-
-
Marciani, L.1
Cox, E.F.2
Hoad, C.L.3
-
23
-
-
0034815195
-
Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers
-
Carriere F, Renou C, Ransac S, et al. Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers. Am.J.Physiol Gastrointest.Liver Physiol 2001, 281:G16-28.
-
(2001)
Am.J.Physiol Gastrointest.Liver Physiol
, vol.281
-
-
Carriere, F.1
Renou, C.2
Ransac, S.3
-
24
-
-
0030612696
-
RenaGel, a novel calcium- and aluminium-free phosphate binder, inhibits phosphate absorption in normal volunteers
-
Burke SK, Slatopolsky EA, Goldberg DI: RenaGel, a novel calcium- and aluminium-free phosphate binder, inhibits phosphate absorption in normal volunteers. Nephrol Dial Transplant 1997, 12:1640-4.
-
(1997)
Nephrol Dial Transplant
, vol.12
, pp. 1640-1644
-
-
Burke, S.K.1
Slatopolsky, E.A.2
Goldberg, D.I.3
-
25
-
-
80053357718
-
Pharmacology, efficacy and safety of oral phosphate binders
-
Hutchison AJ, Smith CP, Brenchley PE: Pharmacology, efficacy and safety of oral phosphate binders. Nat.Rev.Nephrol. 2011, 7:578-89.
-
(2011)
Nat.Rev.Nephrol
, vol.7
, pp. 578-589
-
-
Hutchison, A.J.1
Smith, C.P.2
Brenchley, P.E.3
-
27
-
-
84857705353
-
-
United States Patent 7767768B2
-
Chang H, Charmot D, Connor E, Roger F, inventors, Ilypsa Inc, Assignee: Crosslinked amine polymers. United States Patent 7767768B2 2010.
-
(2010)
Inventors, Ilypsa Inc, Assignee: Crosslinked Amine Polymers
-
-
Chang, H.1
Charmot, D.2
Connor, E.3
Roger, F.4
-
28
-
-
72049102165
-
Intestinal npt2b plays a major role in phosphate absorption and homeostasis
-
Sabbagh Y, O'Brien SP, Song W, Boulanger JH, Stockmann A, Arbeeny C, Schiavi SC: Intestinal npt2b plays a major role in phosphate absorption and homeostasis. J.Am Soc.Nephrol. 2009, 20:2348-58.
-
(2009)
J.Am Soc.Nephrol
, vol.20
, pp. 2348-2358
-
-
Sabbagh, Y.1
O'Brien, S.P.2
Song, W.3
Boulanger, J.H.4
Stockmann, A.5
Arbeeny, C.6
Schiavi, S.C.7
-
29
-
-
85038459577
-
-
Proceedings of the XLVIII ERA-EDTA Congress, Prague 2011
-
Henley C, Davis J, Lee P, Wong S, Salyers K, Wagner M: A small molecule, non-competitive inhibitor of sodium-phosphate (NaPi2b) with low oral bioavailability attenuates cellular and intestinal phosphate transport and reduce serum phosphate in hyperphosphatemic rats. Proceedings of the XLVIII ERA-EDTA Congress, Prague 2011 http://www.abstracts2view.com/era/view.php?nu=ERA11L_996 2011.
-
(2011)
A Small Molecule, Non-competitive Inhibitor of Sodium-phosphate (NaPi2b) With Low Oral Bioavailability Attenuates Cellular and Intestinal Phosphate Transport and Reduce Serum Phosphate In Hyperphosphatemic Rats
-
-
Henley, C.1
Davis, J.2
Lee, P.3
Wong, S.4
Salyers, K.5
Wagner, M.6
-
30
-
-
84857734115
-
Novel Non-Systemic NaP2b Inhibitors Block Intestinal Phosphate Uptake
-
Navre M, Labonte ED, Carreras C, et al: Novel Non-Systemic NaP2b Inhibitors Block Intestinal Phosphate Uptake. Proceedings of ASN meeting 2011, Philadelphia, JASN Abstract Supplement 2011, 22:TH-OR020.
-
(2011)
Proceedings of ASN Meeting 2011, Philadelphia, JASN Abstract Supplement
, vol.22
-
-
Navre, M.1
Labonte, E.D.2
Carreras, C.3
-
31
-
-
80555148939
-
FGF23 induces left ventricular hypertrophy
-
Faul C, Amaral AP, Oskouei B, et al. FGF23 induces left ventricular hypertrophy. J.Clin.Invest 2011, 121:4393-408.
-
(2011)
J.Clin.Invest
, vol.121
, pp. 4393-4408
-
-
Faul, C.1
Amaral, A.P.2
Oskouei, B.3
-
32
-
-
77950310181
-
Apical potassium (BK) channels and enhanced potassium secretion in human colon
-
Sandle GI, Hunter M: Apical potassium (BK) channels and enhanced potassium secretion in human colon. QJM. 2010, 103:85-9.
-
(2010)
QJM
, vol.103
, pp. 85-89
-
-
Sandle, G.I.1
Hunter, M.2
-
33
-
-
77956994484
-
Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon
-
Nanda Kumar NS, Singh SK, Rajendran VM: Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon. Am.J.Physiol Gastrointest.Liver Physiol 2010, 299:G707-14.
-
(2010)
Am.J.Physiol Gastrointest.Liver Physiol
, vol.299
-
-
Nanda Kumar, N.S.1
Singh, S.K.2
Rajendran, V.M.3
-
35
-
-
79953720277
-
Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial
-
Pitt B, Anker SD, Bushinsky DA, Kitzman DW, Zannad F, Huang IZ: Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial. Eur.Heart J. 2011, 32:820-8.
-
(2011)
Eur.Heart J
, vol.32
, pp. 820-828
-
-
Pitt, B.1
Anker, S.D.2
Bushinsky, D.A.3
Kitzman, D.W.4
Zannad, F.5
Huang, I.Z.6
-
36
-
-
84857699466
-
-
European Patent Application 2269589A3
-
Charmot D, Chang H, Klearner G, Cope J, Liu M, Liu F, et al, Inventors, ILypsa Inc, Assignee: Ion binding polymers and uses thereof. European Patent Application 2269589A3 2011.
-
(2011)
Inventors, ILypsa Inc, Assignee: Ion Binding Polymers and Uses Thereof
-
-
Charmot, D.1
Chang, H.2
Klearner, G.3
Cope, J.4
Liu, M.5
Liu, F.6
-
38
-
-
84857703763
-
-
WO 2007038801A2
-
Liu F, Chang H, Charmot D, Liu M, Connor E, Inventors, Ilypsa Inc, Assignee: Monovalent cation-binding compositions comprising core-shell particles having crosslinked polyvinylic shells, and methods of use thereof. WO 2007038801A2 2007.
-
(2007)
Inventors, Ilypsa Inc, Assignee: Monovalent Cation-binding Compositions Comprising Core-shell Particles Having Crosslinked Polyvinylic Shells, and Methods of Use Thereof
-
-
Liu, F.1
Chang, H.2
Charmot, D.3
Liu, M.4
Connor, E.5
-
39
-
-
79961214888
-
Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: Randomised controlled trial
-
Slagman MC, Waanders F, Hemmelder MH, Woittiez AJ, Janssen WM, Lambers Heerspink HJ, et al. Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: randomised controlled trial. BMJ 2011, 343:d4366.
-
(2011)
BMJ
, vol.343
-
-
Slagman, M.C.1
Waanders, F.2
Hemmelder, M.H.3
Woittiez, A.J.4
Janssen, W.M.5
Lambers Heerspink, H.J.6
-
40
-
-
77049173625
-
Some aspects of cation exchange resins as therapeutic agents for sodium removal
-
McChesney EW, Nachod FC, Tainter ML: Some aspects of cation exchange resins as therapeutic agents for sodium removal. Ann N Y Acad Sci 1953, 57:252-9.
-
(1953)
Ann N Y Acad Sci
, vol.57
, pp. 252-259
-
-
McChesney, E.W.1
Nachod, F.C.2
Tainter, M.L.3
-
41
-
-
77049183622
-
Cation exchange resins in congestive heart failure
-
Orgain ES: Cation exchange resins in congestive heart failure. Med Clin North Am 1954, 11:419-30.
-
(1954)
Med Clin North Am
, vol.11
, pp. 419-430
-
-
Orgain, E.S.1
-
42
-
-
84857697138
-
RDX5791, a Non-Systemic NHE3 Inhibitor, Normalizes Blood Pressure and Reduces Salt-Induced Organ Damage in Uremic Rats
-
Spencer AG, Navre M, Plato CF, et al: RDX5791, a Non-Systemic NHE3 Inhibitor, Normalizes Blood Pressure and Reduces Salt-Induced Organ Damage in Uremic Rats. Proceeding of ASN meeting 2011 Philadelphia JASN Abstract Supplement 2011, 22:SA-OR430.
-
(2011)
Proceeding of ASN Meeting 2011 Philadelphia JASN Abstract Supplement
, vol.22
-
-
Spencer, A.G.1
Navre, M.2
Plato, C.F.3
-
44
-
-
28944453591
-
Hydroxamic acid-containing hydrogels for nonabsorbed iron chelation therapy: Synthesis, characterization, and biological evaluation
-
Polomoscanik SC, Cannon CP, Neenan TX, et al. Hydroxamic acid-containing hydrogels for nonabsorbed iron chelation therapy: synthesis, characterization, and biological evaluation. Biomacromolecules. 2005, 6:2946-53.
-
(2005)
Biomacromolecules
, vol.6
, pp. 2946-2953
-
-
Polomoscanik, S.C.1
Cannon, C.P.2
Neenan, T.X.3
-
45
-
-
24144459870
-
Identification of an intestinal heme transporter
-
Shayeghi M, Latunde-Dada GO, Oakhill JS, et al. Identification of an intestinal heme transporter. Cell 2005, 122:789-801.
-
(2005)
Cell
, vol.122
, pp. 789-801
-
-
Shayeghi, M.1
Latunde-Dada, G.O.2
Oakhill, J.S.3
-
46
-
-
64749115172
-
Lipid-lowering drugs acting at the level of the gastrointestinal tract
-
Filippatos TD, Mikhailidis DP: Lipid-lowering drugs acting at the level of the gastrointestinal tract. Curr.Pharm.Des 2009, 15:490-516.
-
(2009)
Curr.Pharm.Des
, vol.15
, pp. 490-516
-
-
Filippatos, T.D.1
Mikhailidis, D.P.2
-
47
-
-
37249083878
-
Long term pharmacotherapy for obesity and overweight: Updated meta-analysis
-
Rucker D, Padwal R, Li SK, Curioni C, Lau DC: Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ 2007, 335:1194-9.
-
(2007)
BMJ
, vol.335
, pp. 1194-1199
-
-
Rucker, D.1
Padwal, R.2
Li, S.K.3
Curioni, C.4
Lau, D.C.5
-
48
-
-
84857729255
-
-
United States Patent 6572850B1
-
Mandeville H, Boie M, Allston MA, Garigapati VR, inventors, GelTex Pharmaceuticals Inc., Assignee: Lipase inhibiting polymers. United States Patent 6572850B1 2003.
-
(2003)
Inventors, GelTex Pharmaceuticals Inc., Assignee: Lipase Inhibiting Polymers
-
-
Mandeville, H.1
Boie, M.2
Allston, M.A.3
Garigapati, V.R.4
-
49
-
-
84857746939
-
-
United States Patent 6299868B1
-
Jozefiak T, Holmes Farley S, Mandeville H, et al, Inventors, GelTex Pharmaceuticals Inc., Assignee: Fat-binding polymers. United States Patent 6299868B1 2001.
-
(2001)
Inventors, GelTex Pharmaceuticals Inc., Assignee: Fat-binding Polymers
-
-
Jozefiak, T.1
Holmes Farley, S.2
Mandeville, H.3
-
50
-
-
85038477247
-
-
Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010, MEDI-280
-
M: NPC1L1 as the target of Ezetimibe. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010, MEDI-280.
-
NPC1L1 As the Target of Ezetimibe
-
-
-
51
-
-
77953699732
-
NPC1L1 and cholesterol transport
-
Betters JL, Yu L: NPC1L1 and cholesterol transport. FEBS Lett. 2010, 584:2740-7.
-
(2010)
FEBS Lett
, vol.584
, pp. 2740-2747
-
-
Betters, J.L.1
Yu, L.2
-
52
-
-
79955595071
-
Vitamin D intestinal absorption is not a simple passive diffusion: Evidences for involvement of cholesterol transporters
-
Reboul E, Goncalves A, Comera C, et al. Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters. Mol.Nutr.Food Res. 2011, 55:691-702.
-
(2011)
Mol.Nutr.Food Res
, vol.55
, pp. 691-702
-
-
Reboul, E.1
Goncalves, A.2
Comera, C.3
-
53
-
-
79959348919
-
Synthesis and biological evaluation of ezetimibe analogs as possible cholesterol absorption inhibitors
-
Wang Y, Haiqian, Huang W, Zhang H, Zhou J: Synthesis and biological evaluation of ezetimibe analogs as possible cholesterol absorption inhibitors. Lett.Drug Des.Discovery 2011, 8:500-5.
-
(2011)
Lett.Drug Des.Discovery
, vol.8
, pp. 500-505
-
-
Wang, Y.1
Haiqian Huang, W.2
Zhang, H.3
Zhou, J.4
-
54
-
-
78149281356
-
Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure-activity studies and in vivo efficacy
-
Howell KL, DeVita RJ, Garcia-Calvo M, et al. Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure-activity studies and in vivo efficacy. Bioorg.Med.Chem.Lett. 2010, 20:6929-32.
-
(2010)
Bioorg.Med.Chem.Lett
, vol.20
, pp. 6929-6932
-
-
Howell, K.L.1
Devita, R.J.2
Garcia-Calvo, M.3
-
55
-
-
85038464874
-
-
Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-285
-
Morriello GJ, Moyes CR, Lin P, et al. Discovery of second generation cholesterol absorption inhibitors. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-285.
-
Discovery of Second Generation Cholesterol Absorption Inhibitors
-
-
Morriello, G.J.1
Moyes, C.R.2
Lin, P.3
-
56
-
-
85038462627
-
-
Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-284
-
Fessard TC, Li DB, Abdelkafi H, et al. Non-systemic cholesterol absorption inhibitors. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-284.
-
Non-systemic Cholesterol Absorption Inhibitors
-
-
Fessard, T.C.1
Li, D.B.2
Abdelkafi, H.3
-
57
-
-
85038463901
-
-
Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-283
-
Jaehne G, Heuer HO, Schaefer HL, et al. Canosimibe: Design, synthesis, and in vivo activity of a nonsystemic inhibitor of cholesterol absorption. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-283.
-
Canosimibe: Design, Synthesis, and In Vivo Activity of a Nonsystemic Inhibitor of Cholesterol Absorption
-
-
Jaehne, G.1
Heuer, H.O.2
Schaefer, H.L.3
-
58
-
-
85038458401
-
-
Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-282
-
Starke I, Ostlund-Lindqvist AM: Novel potent dipeptide substituted azetidinones as cholesterol absorption inhibitors with low systemic uptake. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-282.
-
Novel Potent Dipeptide Substituted Azetidinones As Cholesterol Absorption Inhibitors With Low Systemic Uptake
-
-
Starke, I.1
Ostlund-Lindqvist, A.M.2
-
59
-
-
85038452261
-
-
Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-281
-
H: Development of KT6-971: A C-glycoside of NPC1L1 transporter inhibitor. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-281.
-
Development of KT6-971: A C-glycoside of NPC1L1 Transporter Inhibitor
-
-
-
60
-
-
36649019823
-
Biologically active polymeric sequestrants:Design, synthesis, and therapeutic applications
-
Dahl PK, Huval C, Holmes-Farley SR: Biologically active polymeric sequestrants:Design, synthesis, and therapeutic applications. Pure Appl.Chem 2007, 79:1521-30.
-
(2007)
Pure Appl.Chem
, vol.79
, pp. 1521-1530
-
-
Dahl, P.K.1
Huval, C.2
Holmes-Farley, S.R.3
-
61
-
-
0035991563
-
Bile acid binding to sevelamer HCl
-
Braunlin W, Zhorov E, Guo A, Apruzzese W, Xu Q, Hook P, Smisek DL, Mandeville WH, Holmes-Farley SR: Bile acid binding to sevelamer HCl. Kidney Int. 2002, 62:611-9.
-
(2002)
Kidney Int
, vol.62
, pp. 611-619
-
-
Braunlin, W.1
Zhorov, E.2
Guo, A.3
Apruzzese, W.4
Xu, Q.5
Hook, P.6
Smisek, D.L.7
Mandeville, W.H.8
Holmes-Farley, S.R.9
-
62
-
-
84857716618
-
Role of bile acid sequestrants in the treatment of type 2 diabetes
-
Takebayashi K, Aso Y, Inukai T: Role of bile acid sequestrants in the treatment of type 2 diabetes. World J.Diabetes 2010, 1:146-52.
-
(2010)
World J.Diabetes
, vol.1
, pp. 146-152
-
-
Takebayashi, K.1
Aso, Y.2
Inukai, T.3
-
63
-
-
33646016599
-
Bile acid reabsorption inhibitors (BARI): Novel hypolipidemic drugs
-
Kramer W, Glombik H: Bile acid reabsorption inhibitors (BARI): novel hypolipidemic drugs. Current Medicinal Chemistry 2006, 13:997-1016.
-
(2006)
Current Medicinal Chemistry
, vol.13
, pp. 997-1016
-
-
Kramer, W.1
Glombik, H.2
-
64
-
-
84857718366
-
Inhibition of Apical Sodium-Dependent Bile Acid Transporter (Asbt) as a Novel Treatment for Diabetes
-
Chen L, Yao X, Young A, et al. Inhibition of Apical Sodium-Dependent Bile Acid Transporter (Asbt) as a Novel Treatment for Diabetes. Am.J.Physiol Endocrinol.Metab 2011.
-
(2011)
Am.J.Physiol Endocrinol.Metab
-
-
Chen, L.1
Yao, X.2
Young, A.3
-
65
-
-
0030947679
-
Established and Emerging Strategies for Inhibition of Cholesterol Absorption
-
Homan R, Krause R: Established and Emerging Strategies for Inhibition of Cholesterol Absorption. Current Pharmaceutical Design 1997,29-44.
-
(1997)
Current Pharmaceutical Design
, pp. 29-44
-
-
Homan, R.1
Krause, R.2
-
66
-
-
0036838450
-
Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice
-
Huggins KW, Boileau AC, Hui DY: Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice. Am J Physiol Endocrinol Metab 2002, 283:E994-1001.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
Huggins, K.W.1
Boileau, A.C.2
Hui, D.Y.3
-
67
-
-
80054111473
-
Group 1B phospholipase A2 deficiency protects against diet-induced hyperlipidemia in mice
-
Hollie NI, Hui DY: Group 1B phospholipase A2 deficiency protects against diet-induced hyperlipidemia in mice. J.Lipid Res. 2011.
-
(2011)
J.Lipid Res
-
-
Hollie, N.I.1
Hui, D.Y.2
-
68
-
-
77954451182
-
Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: The molecular link between group 1B phospholipase A2 and diet-induced obesity
-
Labonte ED, Pfluger PT, Cash JG, et al. Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesity. FASEB J. 2010, 24:2516-24.
-
(2010)
FASEB J
, vol.24
, pp. 2516-2524
-
-
Labonte, E.D.1
Pfluger, P.T.2
Cash, J.G.3
-
69
-
-
70350303586
-
The phospholipase A(2) inhibitor methyl indoxam suppresses diet-induced obesity and glucose intolerance in mice
-
Hui DY, Cope MJ, Labonte ED, et al. The phospholipase A(2) inhibitor methyl indoxam suppresses diet-induced obesity and glucose intolerance in mice. Br.J Pharmacol 2009, 157:1263-69.
-
(2009)
Br.J Pharmacol
, vol.157
, pp. 1263-1269
-
-
Hui, D.Y.1
Cope, M.J.2
Labonte, E.D.3
-
70
-
-
84857743323
-
-
United States Patent 7666898B2
-
Chang H, Charmot D, Glinka T, et al. Inventors, Ilypsa Inc., assignee: Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors. United States Patent 7666898B2 2010.
-
(2010)
Inventors, Ilypsa Inc., Assignee: Multivalent Indole Compounds and Use Thereof As Phospholipase-A2 Inhibitors
-
-
Chang, H.1
Charmot, D.2
Glinka, T.3
-
71
-
-
0037204196
-
Clinical practice. Antibiotic-associated diarrhea
-
Bartlett JG: Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 2002, 346:334-339.
-
(2002)
N Engl J Med
, vol.346
, pp. 334-339
-
-
Bartlett, J.G.1
-
73
-
-
0023199032
-
Differential effects of Clostridium difficile toxins A and B on rabbit ileum
-
Triadafilopoulos G, Pothoulakis C, O'Brien MJ, LaMont JT: Differential effects of Clostridium difficile toxins A and B on rabbit ileum. Gastroenterology 1987, 93:273-9.
-
(1987)
Gastroenterology
, vol.93
, pp. 273-279
-
-
Triadafilopoulos, G.1
Pothoulakis, C.2
O'Brien, M.J.3
Lamont, J.T.4
-
74
-
-
0036467063
-
Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile
-
Kyne L, Hamel MB, Polavaram R, Kelly CP: Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 2002, 34:346-53.
-
(2002)
Clin Infect Dis
, vol.34
, pp. 346-353
-
-
Kyne, L.1
Hamel, M.B.2
Polavaram, R.3
Kelly, C.P.4
-
75
-
-
0034917210
-
GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis
-
Kurtz CB, Cannon EP, Brezzani A, et al. GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis. Antimicrob.Agents Chemother. 2001, 45:2340-7.
-
(2001)
Antimicrob.Agents Chemother
, vol.45
, pp. 2340-2347
-
-
Kurtz, C.B.1
Cannon, E.P.2
Brezzani, A.3
-
76
-
-
3042855154
-
Toxin binding of tolevamer, a polyanionic drug that protects against antibiotic-associated diarrhea
-
Braunlin W, Xu Q, Hook P, et al. Toxin binding of tolevamer, a polyanionic drug that protects against antibiotic-associated diarrhea. Biophys J 2004, 87:534-9.
-
(2004)
Biophys J
, vol.87
, pp. 534-539
-
-
Braunlin, W.1
Xu, Q.2
Hook, P.3
-
77
-
-
79957761288
-
Super toxins from a super bug: Structure and function of Clostridium difficile toxins
-
Davies AH, Roberts AK, Shone CC, Acharya KR: Super toxins from a super bug: structure and function of Clostridium difficile toxins. Biochem.J. 2011, 436:517-26.
-
(2011)
Biochem.J
, vol.436
, pp. 517-526
-
-
Davies, A.H.1
Roberts, A.K.2
Shone, C.C.3
Acharya, K.R.4
-
78
-
-
0028358924
-
Oligosaccharide sequences attached to an inert support (SYNSORB) as potential therapy for antibiotic-associated diarrhea and pseudomembranous colitis
-
Heerze LD, Kelm MA, Talbot JA, Armstrong GD: Oligosaccharide sequences attached to an inert support (SYNSORB) as potential therapy for antibiotic-associated diarrhea and pseudomembranous colitis. J Infect Dis 1994, 169:1291-6.
-
(1994)
J Infect Dis
, vol.169
, pp. 1291-1296
-
-
Heerze, L.D.1
Kelm, M.A.2
Talbot, J.A.3
Armstrong, G.D.4
-
79
-
-
84857767445
-
-
WO2006044577A1
-
Mong TK, Charmot D, Buysse JM, Chang H, Cope MJ, Goka E, inventors, Ilypsa Inc, Assignee: Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle. WO2006044577A1 2006.
-
(2006)
Inventors, Ilypsa Inc, Assignee: Pharmaceutical Compositions Comprising a Toxin-binding Oligosaccharide and A Polymeric Particle
-
-
Mong, T.K.1
Charmot, D.2
Buysse, J.M.3
Chang, H.4
Cope, M.J.5
Goka, E.6
-
80
-
-
59749084849
-
Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection
-
Louie T, Miller M, Donskey C, Mullane K, Goldstein EJ: Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection. Antimicrob.Agents Chemother. 2009, 53:223-8.
-
(2009)
Antimicrob.Agents Chemother
, vol.53
, pp. 223-228
-
-
Louie, T.1
Miller, M.2
Donskey, C.3
Mullane, K.4
Goldstein, E.J.5
-
81
-
-
82955240575
-
Fidaxomicin: In Clostridium difficile Infection
-
Duggan ST: Fidaxomicin: In Clostridium difficile Infection. Drugs 2011, 71:2445-56.
-
(2011)
Drugs
, vol.71
, pp. 2445-2456
-
-
Duggan, S.T.1
-
82
-
-
0033770123
-
Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: Biological and clinical significance
-
Caradonna L, Amati L, Magrone T, Pellegrino NM, Jirillo E, Caccavo D: Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J.Endotoxin Res.FIELD Full Journal Title:Journal of Endotoxin Research 2000, 6:205-14.
-
(2000)
J.Endotoxin Res.FIELD Full Journal Title:Journal of Endotoxin Research
, vol.6
, pp. 205-214
-
-
Caradonna, L.1
Amati, L.2
Magrone, T.3
Pellegrino, N.M.4
Jirillo, E.5
Caccavo, D.6
-
83
-
-
0037879075
-
Non-alcoholic fatty liver disease: Lumen-liver interactions and possible role for probiotics
-
Solga SF, Diehl AM: Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics. J Hepatol 2003, 38:681-7.
-
(2003)
J Hepatol
, vol.38
, pp. 681-687
-
-
Solga, S.F.1
Diehl, A.M.2
-
84
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56:1761-72.
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
-
85
-
-
27644438235
-
The importance of the gastrointestinal system in the pathogenesis of heart failure
-
Krack A, Sharma R, Figulla HR, Anker SD: The importance of the gastrointestinal system in the pathogenesis of heart failure. European Heart Journal 2005, 26:2368-74.
-
(2005)
European Heart Journal
, vol.26
, pp. 2368-2374
-
-
Krack, A.1
Sharma, R.2
Figulla, H.R.3
Anker, S.D.4
-
86
-
-
33845532053
-
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
-
Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006, 12:1365-71.
-
(2006)
Nat Med
, vol.12
, pp. 1365-1371
-
-
Brenchley, J.M.1
Price, D.A.2
Schacker, T.W.3
-
88
-
-
26844558196
-
Identification and analysis of multivalent proteolytically resistant peptides from gluten: Implications for celiac sprue
-
Shan L, Qiao SW, Rentz-Hansen H, et al. Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. J.Proteome.Res. 2005, 4:1732-41.
-
(2005)
J.Proteome.Res
, vol.4
, pp. 1732-1741
-
-
Shan, L.1
Qiao, S.W.2
Rentz-Hansen, H.3
-
90
-
-
84856744117
-
Safety, Tolerability, and Activity of ALV003: Results from Two Phase 1 Single, Escalating-Dose Clinical Trials
-
Siegel M, Garber ME, Spencer AG, Botwick W, Kumar P, Williams RN, et al. Safety, Tolerability, and Activity of ALV003: Results from Two Phase 1 Single, Escalating-Dose Clinical Trials. Dig.Dis.Sci. 2011.
-
(2011)
Dig.Dis.Sci
-
-
Siegel, M.1
Garber, M.E.2
Spencer, A.G.3
Botwick, W.4
Kumar, P.5
Williams, R.N.6
-
91
-
-
85038462728
-
-
Lahdeaho M, Maki M, Kaukinen K, Laurila K, Marcantonio A, Adelman DC: ALV003, a novel glutenase, attenuates gluten-induced small intestinal mucosal injury in celiac disease patients: a randomized controlled phase 2a clinical trial. http://uegw.congress-online.com/guest/ID089e48b3490d24/AbstractView?ABSID=1440 8 2011.
-
(2011)
ALV003, a Novel Glutenase, Attenuates Gluten-induced Small Intestinal Mucosal Injury In Celiac Disease Patients: A Randomized Controlled Phase 2a Clinical Trial
, vol.8
-
-
Lahdeaho, M.1
Maki, M.2
Kaukinen, K.3
Laurila, K.4
Marcantonio, A.5
Adelman, D.C.6
-
92
-
-
33646426645
-
Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
-
Drago S, El AR, Di PM, et al. Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand.J Gastroenterol 2006, 41:408-19.
-
(2006)
Scand.J Gastroenterol
, vol.41
, pp. 408-419
-
-
Drago, S.1
El, A.R.2
Di, P.M.3
-
93
-
-
34547852241
-
The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: A proof of concept study
-
Paterson BM, Lammers KM, Arrieta MC, Fasano A, Meddings JB: The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment.Pharmacol.Ther. 2007, 26:757-66.
-
(2007)
Aliment.Pharmacol.Ther
, vol.26
, pp. 757-766
-
-
Paterson, B.M.1
Lammers, K.M.2
Arrieta, M.C.3
Fasano, A.4
Meddings, J.B.5
-
94
-
-
0028466186
-
Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis
-
Niwa T, Ise M: Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J.Lab Clin.Med. 1994, 124:96-104.
-
(1994)
J.Lab Clin.Med
, vol.124
, pp. 96-104
-
-
Niwa, T.1
Ise, M.2
-
95
-
-
0032891014
-
Urinary indoxyl sulfate is a clinical factor that affects the progression of renal failure
-
Niwa T, Aoyama I, Takayama F, et al. Urinary indoxyl sulfate is a clinical factor that affects the progression of renal failure. Miner.Electrolyte Metab 1999, 25:118-22.
-
(1999)
Miner.Electrolyte Metab
, vol.25
, pp. 118-122
-
-
Niwa, T.1
Aoyama, I.2
Takayama, F.3
-
96
-
-
84943010134
-
Indoxyl sulfate is a nephro-vascular toxin
-
Niwa T: Indoxyl sulfate is a nephro-vascular toxin. J.Ren Nutr. 2010,20:S2-6.
-
(2010)
J.Ren Nutr
, vol.20
-
-
Niwa, T.1
-
97
-
-
0242669257
-
Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells
-
Motojima M, Hosokawa A, Yamato H, Muraki T, Yoshioka T: Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells. Kidney Int. 2003, 63:1671-80.
-
(2003)
Kidney Int
, vol.63
, pp. 1671-1680
-
-
Motojima, M.1
Hosokawa, A.2
Yamato, H.3
Muraki, T.4
Yoshioka, T.5
-
98
-
-
0030686486
-
Indoxyl sulfate and progression of renal failure: Effects of a low-protein diet and oral sorbent on indoxyl sulfate production in uremic rats and undialyzed uremic patients
-
Niwa T, Tsukushi S, Ise M, et al. Indoxyl sulfate and progression of renal failure: effects of a low-protein diet and oral sorbent on indoxyl sulfate production in uremic rats and undialyzed uremic patients. Miner.Electrolyte Metab 1997, 23:179-84.
-
(1997)
Miner.Electrolyte Metab
, vol.23
, pp. 179-184
-
-
Niwa, T.1
Tsukushi, S.2
Ise, M.3
-
99
-
-
78751644527
-
Oral adsorbent AST-120 ameliorates tubular injury in chronic renal failure patients by reducing proteinuria and oxidative stress generation
-
Nakamura T, Sato E, Fujiwara N, et al. Oral adsorbent AST-120 ameliorates tubular injury in chronic renal failure patients by reducing proteinuria and oxidative stress generation. Metabolism 2011,60:260-64.
-
(2011)
Metabolism
, vol.60
, pp. 260-264
-
-
Nakamura, T.1
Sato, E.2
Fujiwara, N.3
-
100
-
-
68849123039
-
Effect of a carbonaceous oral adsorbent on the progression of CKD: A multicenter, randomized, controlled trial
-
Akizawa T, Asano Y, Morita S, et al. Effect of a carbonaceous oral adsorbent on the progression of CKD: a multicenter, randomized, controlled trial. Am.J.Kidney Dis. 2009, 54:459-67.
-
(2009)
Am.J.Kidney Dis
, vol.54
, pp. 459-467
-
-
Akizawa, T.1
Asano, Y.2
Morita, S.3
-
101
-
-
64149095859
-
Long-term effects of the oral adsorbent, AST-120, in patients with chronic renal failure
-
Maeda K, Hamada C, Hayashi T, et al. Long-term effects of the oral adsorbent, AST-120, in patients with chronic renal failure. J.Int.Med.Res. 2009, 37:205-13.
-
(2009)
J.Int.Med.Res
, vol.37
, pp. 205-213
-
-
Maeda, K.1
Hamada, C.2
Hayashi, T.3
-
102
-
-
29144467932
-
Protein-bound advanced glycation end-products (AGEs) as bioactive amino acid derivatives in foods
-
Henle T: Protein-bound advanced glycation end-products (AGEs) as bioactive amino acid derivatives in foods. Amino.Acids 2005, 29:313-22.
-
(2005)
Amino.Acids
, vol.29
, pp. 313-322
-
-
Henle, T.1
-
103
-
-
0041859310
-
Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients
-
Uribarri J, Peppa M, Cai W, et al. Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients. Am.J.Kidney Dis. 2003, 42:532-8.
-
(2003)
Am.J.Kidney Dis
, vol.42
, pp. 532-538
-
-
Uribarri, J.1
Peppa, M.2
Cai, W.3
-
104
-
-
0037369890
-
Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients
-
Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, He C, Vlassara H: Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients. J.Am.Soc.Nephrol. 2003, 14:728-31.
-
(2003)
J.Am.Soc.Nephrol
, vol.14
, pp. 728-731
-
-
Uribarri, J.1
Peppa, M.2
Cai, W.3
Goldberg, T.4
Lu, M.5
He, C.6
Vlassara, H.7
-
105
-
-
33750440810
-
Oral adsorbent AST-120 decreases serum levels of AGEs in patients with chronic renal failure
-
Ueda S, Yamagishi S, Takeuchi M, et al. Oral adsorbent AST-120 decreases serum levels of AGEs in patients with chronic renal failure. Mol.Med. 2006, 12:180-4.
-
(2006)
Mol.Med
, vol.12
, pp. 180-184
-
-
Ueda, S.1
Yamagishi, S.2
Takeuchi, M.3
-
106
-
-
79951775260
-
Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients
-
Kakuta T, Tanaka R, Hyodo T, et al. Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients. Am.J.Kidney Dis. 2011, 57:422-31.
-
(2011)
Am.J.Kidney Dis
, vol.57
, pp. 422-431
-
-
Kakuta, T.1
Tanaka, R.2
Hyodo, T.3
-
107
-
-
0037406406
-
Review on uremic toxins: Classification, concentration, and interindividual variability
-
Vanholder R, De Smet R, Glorieux G, et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003, 63:1934-43.
-
(2003)
Kidney Int
, vol.63
, pp. 1934-1943
-
-
Vanholder, R.1
de Smet, R.2
Glorieux, G.3
-
108
-
-
78249257806
-
New uremic toxins - which solutes should be removed?
-
Glorieux G, Vanholder R: New uremic toxins - which solutes should be removed? Contrib.Nephrol. 2011, 168:117-28.
-
(2011)
Contrib.Nephrol
, vol.168
, pp. 117-128
-
-
Glorieux, G.1
Vanholder, R.2
-
109
-
-
0026948511
-
Extrarenal clearance of oxalate increases with progression of renal failure in the rat
-
Costello JF, Smith M, Stolarski C, Sadovnic MJ: Extrarenal clearance of oxalate increases with progression of renal failure in the rat. J.Am.Soc.Nephrol. 1992, 3:1098-104.
-
(1992)
J.Am.Soc.Nephrol
, vol.3
, pp. 1098-1104
-
-
Costello, J.F.1
Smith, M.2
Stolarski, C.3
Sadovnic, M.J.4
-
110
-
-
49049106988
-
Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria
-
Grujic D, Salido EC, Shenoy BC, et al. Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria. Am.J.Nephrol. 2009, 29:86-93.
-
(2009)
Am.J.Nephrol
, vol.29
, pp. 86-93
-
-
Grujic, D.1
Salido, E.C.2
Shenoy, B.C.3
-
111
-
-
22844441856
-
Systematic review on the management of chronic constipation in North America
-
Brandt LJ, Prather CM, Quigley EM, Schiller LR, Schoenfeld P, Talley NJ: Systematic review on the management of chronic constipation in North America. Am.J.Gastroenterol. 2005, 100 Suppl 1:S5-21.
-
(2005)
Am.J.Gastroenterol.
, vol.100
, Issue.SUPPL 1
-
-
Brandt, L.J.1
Prather, C.M.2
Quigley, E.M.3
Schiller, L.R.4
Schoenfeld, P.5
Talley, N.J.6
-
112
-
-
2442629629
-
Epidemiology of constipation in North America: A systematic review
-
Higgins PD, Johanson JF: Epidemiology of constipation in North America: a systematic review. Am.J.Gastroenterol. 2004, 99:750-59.
-
(2004)
Am.J.Gastroenterol
, vol.99
, pp. 750-759
-
-
Higgins, P.D.1
Johanson, J.F.2
-
113
-
-
33846409428
-
Different segmental transit times in patients with irritable bowel syndrome and normal colonic transit time: Is there a correlation with symptoms?
-
Bouchoucha M, Devroede G, Dorval E, Faye A, Arhan P, Arsac M: Different segmental transit times in patients with irritable bowel syndrome and normal colonic transit time: is there a correlation with symptoms? Tech.Coloproctol. 2006, 10:287-96.
-
(2006)
Tech.Coloproctol
, vol.10
, pp. 287-296
-
-
Bouchoucha, M.1
Devroede, G.2
Dorval, E.3
Faye, A.4
Arhan, P.5
Arsac, M.6
-
114
-
-
72449189690
-
-
Neurogastroenterol.Motil
-
Seidl H, Gundling F, Pehl C, Pfeiffer A, Schepp W, Schmidt T: Small bowel motility in functional chronic constipation. Neurogastroenterol.Motil. 2009.
-
(2009)
Small Bowel Motility In Functional Chronic Constipation
-
-
Seidl, H.1
Gundling, F.2
Pehl, C.3
Pfeiffer, A.4
Schepp, W.5
Schmidt, T.6
-
116
-
-
60749099506
-
Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation
-
Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation. Am.J.Gastroenterol. 2009, 104:125-32.
-
(2009)
Am.J.Gastroenterol
, vol.104
, pp. 125-132
-
-
-
117
-
-
78649690668
-
Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
-
Johnston JM, Kurtz CB, Macdougall JE, et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology 2010, 139:1877-86.
-
(2010)
Gastroenterology
, vol.139
, pp. 1877-1886
-
-
Johnston, J.M.1
Kurtz, C.B.2
Macdougall, J.E.3
-
118
-
-
84856985617
-
RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit
-
Spencer AG, Jacobs J, Leadbetter MR, et al. RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit. Proceedings of the Drug Disease Week 2011 Chicago Gastroenterology 2011, 140:S-99.
-
(2011)
Proceedings of the Drug Disease Week 2011 Chicago Gastroenterology
, vol.140
-
-
Spencer, A.G.1
Jacobs, J.2
Leadbetter, M.R.3
-
119
-
-
84857764997
-
The Safety, Tolerability, Systemic Exposure, and Effect on Bowel Habits of Single and Multiple Doses of the Intestinal Sodium Re-Uptake Inhibitor RDX5791 in Normal Healthy Volunteers
-
Rosenbaum DP, Spencer AG, Jacobs J, Charmot D: The Safety, Tolerability, Systemic Exposure, and Effect on Bowel Habits of Single and Multiple Doses of the Intestinal Sodium Re-Uptake Inhibitor RDX5791 in Normal Healthy Volunteers. Proceeding of the ACG meeting 2011 Washington DC American Journal of Gastroenterology 2011, 106:S504.
-
(2011)
Proceeding of the ACG Meeting 2011 Washington DC American Journal of Gastroenterology
, vol.106
-
-
Rosenbaum, D.P.1
Spencer, A.G.2
Jacobs, J.3
Charmot, D.4
-
120
-
-
84856988935
-
Visceral Antinociceptive Effects of RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor on Stress-Induced Colorectal Hypersensitivity to Distension in Rats
-
Eutamene E, Charmot D, Navre M, Bueno L: Visceral Antinociceptive Effects of RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor on Stress-Induced Colorectal Hypersensitivity to Distension in Rats. Proceedings of the DDW meeting 2011 Chicago IL Gastroenterology 2011, 140:S57-S58.
-
(2011)
Proceedings of the DDW Meeting 2011 Chicago IL Gastroenterology
, vol.140
-
-
Eutamene, E.1
Charmot, D.2
Navre, M.3
Bueno, L.4
-
121
-
-
76349088961
-
Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain
-
Eutamene H, Bradesi S, Larauche M, et al. Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol.Motil. 2010, 22:e312-e384.
-
(2010)
Neurogastroenterol.Motil
, vol.22
-
-
Eutamene, H.1
Bradesi, S.2
Larauche, M.3
-
122
-
-
80053912847
-
A randomized placebo-controlled phase IIb trial of a3309, a bile Acid transporter inhibitor, for chronic idiopathic constipation
-
Chey WD, Camilleri M, Chang L, Rikner L, Graffner H: A randomized placebo-controlled phase IIb trial of a3309, a bile Acid transporter inhibitor, for chronic idiopathic constipation. Am J.Gastroenterol. 2011, 106:1803-1812.
-
(2011)
Am J.Gastroenterol
, vol.106
, pp. 1803-1812
-
-
Chey, W.D.1
Camilleri, M.2
Chang, L.3
Rikner, L.4
Graffner, H.5
-
124
-
-
78649757218
-
Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles
-
Donowitz M, Singh S, Singh P, et al. Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics 2010, 42A:200-10.
-
(2010)
Physiol Genomics
, vol.42 A
, pp. 200-210
-
-
Donowitz, M.1
Singh, S.2
Singh, P.3
-
125
-
-
35649003997
-
Proteome of murine jejunal brush border membrane vesicles
-
Donowitz M, Singh S, Salahuddin FF, et al. Proteome of murine jejunal brush border membrane vesicles. J.Proteome.Res. 2007, 6:4068-79.
-
(2007)
J.Proteome.Res
, vol.6
, pp. 4068-4079
-
-
Donowitz, M.1
Singh, S.2
Salahuddin, F.F.3
-
126
-
-
58749090731
-
Narrative review: Effect of bariatric surgery on type 2 diabetes mellitus
-
Vetter ML, Cardillo S, Rickels MR, Iqbal N: Narrative review: effect of bariatric surgery on type 2 diabetes mellitus. Ann.Intern.Med. 2009, 150:94-103.
-
(2009)
Ann.Intern.Med
, vol.150
, pp. 94-103
-
-
Vetter, M.L.1
Cardillo, S.2
Rickels, M.R.3
Iqbal, N.4
-
128
-
-
79955568606
-
Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery
-
Hansen EN, Tamboli RA, Isbell JM, et al. Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery. Am.J.Physiol Gastrointest.Liver Physiol 2011, 300:G795-802.
-
(2011)
Am.J.Physiol Gastrointest.Liver Physiol
, vol.300
-
-
Hansen, E.N.1
Tamboli, R.A.2
Isbell, J.M.3
-
129
-
-
39449124119
-
Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism
-
Thomas C, Auwerx J, Schoonjans K: Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism. Thyroid 2008, 18:167-74.
-
(2008)
Thyroid
, vol.18
, pp. 167-174
-
-
Thomas, C.1
Auwerx, J.2
Schoonjans, K.3
-
130
-
-
42449126696
-
A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release
-
Chu ZL, Carroll C, Alfonso J, et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology 2008, 149:2038-47.
-
(2008)
Endocrinology
, vol.149
, pp. 2038-2047
-
-
Chu, Z.L.1
Carroll, C.2
Alfonso, J.3
-
131
-
-
53249084471
-
Protease activated receptor 2: A new target for IBS treatment
-
Bueno L: Protease activated receptor 2: a new target for IBS treatment. Eur Rev.Med.Pharmacol.Sci. 2008, 12 Suppl 1:95-102.
-
(2008)
Eur Rev.Med.Pharmacol.Sci
, vol.12
, Issue.SUPPL. 1
, pp. 95-102
-
-
Bueno, L.1
-
132
-
-
84857711509
-
Antagonism of protease activated receptor 2 protects against experimental colitis
-
Lohman RJ, Cotterell AJ, Suen JY, Liu L, Do TA, Vesey DA, Fairlie DP: Antagonism of protease activated receptor 2 protects against experimental colitis. J.Pharmacol.Exp.Ther. 2011.
-
(2011)
J.Pharmacol.Exp.Ther
-
-
Lohman, R.J.1
Cotterell, A.J.2
Suen, J.Y.3
Liu, L.4
Do, T.A.5
Vesey, D.A.6
Fairlie, D.P.7
-
133
-
-
80053616405
-
The PepT1-NOD2 Signaling Pathway Aggravates Induced Colitis in Mice
-
Dalmasso G, Nguyen HT, Ingersoll SA, et al. The PepT1-NOD2 Signaling Pathway Aggravates Induced Colitis in Mice. Gastroenterology 2011, 141:1334-45.
-
(2011)
Gastroenterology
, vol.141
, pp. 1334-1345
-
-
Dalmasso, G.1
Nguyen, H.T.2
Ingersoll, S.A.3
-
134
-
-
77957000911
-
PepT1 mediates transport of the proinflammatory bacterial tripeptide L- Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells
-
Dalmasso G, Nguyen HT, Charrier-Hisamuddin L, et al. PepT1 mediates transport of the proinflammatory bacterial tripeptide L- Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells. Am.J.Physiol Gastrointest.Liver Physiol 2010, 299:G687-96.
-
(2010)
Am.J.Physiol Gastrointest.Liver Physiol
, vol.299
-
-
Dalmasso, G.1
Nguyen, H.T.2
Charrier-Hisamuddin, L.3
-
135
-
-
38649115342
-
Microbial influences in inflammatory bowel diseases
-
Sartor RB: Microbial influences in inflammatory bowel diseases. Gastroenterology 2008, 134:577-594.
-
(2008)
Gastroenterology
, vol.134
, pp. 577-594
-
-
Sartor, R.B.1
-
136
-
-
67651184136
-
The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract
-
Geibel JP, Hebert SC: The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract. Annu.Rev.Physiol 2009, 71:205-17.
-
(2009)
Annu.Rev.Physiol
, vol.71
, pp. 205-217
-
-
Geibel, J.P.1
Hebert, S.C.2
-
137
-
-
30744454043
-
Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera
-
Sonawane ND, Hu J, Muanprasat C, Verkman AS: Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. FASEB J 2006, 20:130-2.
-
(2006)
FASEB J
, vol.20
, pp. 130-132
-
-
Sonawane, N.D.1
Hu, J.2
Muanprasat, C.3
Verkman, A.S.4
-
138
-
-
34247208037
-
Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera
-
Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS: Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology 2007, 132:1234-44.
-
(2007)
Gastroenterology
, vol.132
, pp. 1234-1244
-
-
Sonawane, N.D.1
Zhao, D.2
Zegarra-Moran, O.3
Galietta, L.J.4
Verkman, A.S.5
-
139
-
-
73549100636
-
Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels
-
Tradtrantip L, Namkung W, Verkman AS. Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol.Pharmacol. 2010, 77:69-78.
-
(2010)
Mol.Pharmacol
, vol.77
, pp. 69-78
-
-
Tradtrantip, L.1
Namkung, W.2
Verkman, A.S.3
|