메뉴 건너뛰기




Volumn 18, Issue 10, 2012, Pages 1434-1445

Non-systemic drugs: A critical review

Author keywords

Absorption; Gastrointestinal tract; Non absorbed drugs; Non systemic drugs; Tight junctions

Indexed keywords

AST 120; BACTERIUM LIPOPOLYSACCHARIDE; BILE ACID SEQUESTRANT; CLOSTRIDIUM DIFFICILE TOXIN A; COLESEVELAM; DEFERASIROX; DEFEROXAMINE MESYLATE; EZETIMIBE; INTESTINE ENZYME; LARAZOTIDE; PHOSPHATE BINDING AGENT; PHOSPHOLIPASE A2 INHIBITOR; PLACEBO; POLYSTYRENESULFONATE CALCIUM; POLYSTYRENESULFONATE SODIUM; POTASSIUM; TETRAHYDROLIPSTATIN; UREMIC TOXIN;

EID: 84857771313     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212799504858     Document Type: Article
Times cited : (64)

References (139)
  • 1
    • 77955296167 scopus 로고    scopus 로고
    • Recent advances in retrometabolic drug design (RMDD) and development
    • Bodor N, Buchwald P: Recent advances in retrometabolic drug design (RMDD) and development. Pharmazie 2010, 65:395-403.
    • (2010) Pharmazie , vol.65 , pp. 395-403
    • Bodor, N.1    Buchwald, P.2
  • 2
    • 3042687583 scopus 로고    scopus 로고
    • Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites
    • Bodor N, Buchwald P: Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites. Mol.Biotechnol. 2004, 26:123-32.
    • (2004) Mol.Biotechnol , vol.26 , pp. 123-132
    • Bodor, N.1    Buchwald, P.2
  • 3
    • 0034787366 scopus 로고    scopus 로고
    • Retrometabolic drug design--novel aspects, future directions
    • Bodor N: Retrometabolic drug design--novel aspects, future directions. Pharmazie 2001, 56 Suppl 1:S67-74.
    • (2001) Pharmazie , vol.56 , Issue.SUPPL. 1
    • Bodor, N.1
  • 4
    • 0033966357 scopus 로고    scopus 로고
    • Soft drug design: General principles and recent applications
    • Bodor N, Buchwald P: Soft drug design: general principles and recent applications. Med.Res.Rev. 2000, 20:58-101.
    • (2000) Med.Res.Rev , vol.20 , pp. 58-101
    • Bodor, N.1    Buchwald, P.2
  • 5
    • 35649009910 scopus 로고    scopus 로고
    • Intestinal permeability and its relevance for absorption and elimination
    • Lennernas H: Intestinal permeability and its relevance for absorption and elimination. Xenobiotica 2007, 37:1015-51.
    • (2007) Xenobiotica , vol.37 , pp. 1015-1051
    • Lennernas, H.1
  • 6
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv.Drug Deliv.Rev. 2001, 46:3-26.
    • (2001) Adv.Drug Deliv.Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 7
    • 0344984493 scopus 로고    scopus 로고
    • Web-based cheminformatics and molecular property prediction tools supporting drug design and development at Novartis
    • Ertl P, Muhlbacher J, Rohde B, Selzer P: Web-based cheminformatics and molecular property prediction tools supporting drug design and development at Novartis. SAR QSAR.Environ.Res. 2003, 14:321-8.
    • (2003) SAR QSAR.Environ.Res , vol.14 , pp. 321-328
    • Ertl, P.1    Muhlbacher, J.2    Rohde, B.3    Selzer, P.4
  • 8
    • 0034609833 scopus 로고    scopus 로고
    • Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties
    • Ertl P, Rohde B, Selzer P: Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. J.Med.Chem. 2000, 43:3714-7.
    • (2000) J.Med.Chem , vol.43 , pp. 3714-3717
    • Ertl, P.1    Rohde, B.2    Selzer, P.3
  • 10
    • 21744458087 scopus 로고    scopus 로고
    • Nanoparticle uptake by the oral route: Fulfilling its potential?
    • Florence AT: Nanoparticle uptake by the oral route: Fulfilling its potential? Drug Discovery Today: Technologies 2005, 2:75-82.
    • (2005) Drug Discovery Today: Technologies , vol.2 , pp. 75-82
    • Florence, A.T.1
  • 15
    • 85038463666 scopus 로고    scopus 로고
    • SalixPharmaceuticals: Rifaximin package insert http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/GastrointestinalDrugsAdvisoryCommittee/UCM201081.pdf 2010.
    • (2010) SalixPharmaceuticals: Rifaximin Package Insert
  • 16
    • 33847081694 scopus 로고    scopus 로고
    • What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs
    • Roffey SJ, Obach RS, Gedge JI, Smith DA: What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs. Drug Metab Rev. 2007, 39:17-43.
    • (2007) Drug Metab Rev , vol.39 , pp. 17-43
    • Roffey, S.J.1    Obach, R.S.2    Gedge, J.I.3    Smith, D.A.4
  • 17
    • 40549109907 scopus 로고    scopus 로고
    • The density of small tight junction pores varies among cell types and is increased by expression of claudin-2
    • van Itallie CM, Holmes J, Bridges A, et al. The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J.Cell Sci. 2008, 121:298-305.
    • (2008) J.Cell Sci , vol.121 , pp. 298-305
    • van Itallie, C.M.1    Holmes, J.2    Bridges, A.3
  • 18
    • 56349169898 scopus 로고    scopus 로고
    • Molecular mechanism of intestinal permeability: Interaction at tight junctions
    • Hossain Z, Hirata T: Molecular mechanism of intestinal permeability: interaction at tight junctions. Mol.Biosyst. 2008, 4:1181-5.
    • (2008) Mol.Biosyst , vol.4 , pp. 1181-1185
    • Hossain, Z.1    Hirata, T.2
  • 19
    • 16244418685 scopus 로고    scopus 로고
    • Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium
    • Salamat-Miller N, Johnston TP: Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium. Int.J.Pharm. 2005, 294:201-16.
    • (2005) Int.J.Pharm , vol.294 , pp. 201-216
    • Salamat-Miller, N.1    Johnston, T.P.2
  • 20
    • 33645048437 scopus 로고    scopus 로고
    • The development of pharmacodynamics as a pharmaceutical science: A personal perspective
    • Levy G: The development of pharmacodynamics as a pharmaceutical science: a personal perspective. Ann.Pharmacother. 2006, 40:520-23.
    • (2006) Ann.Pharmacother , vol.40 , pp. 520-523
    • Levy, G.1
  • 21
    • 36349011932 scopus 로고    scopus 로고
    • Non-invasive quantification of small bowel water content by MRI: A validation study
    • Hoad CL, Marciani L, Foley S, et al. Non-invasive quantification of small bowel water content by MRI: a validation study. Phys.Med.Biol. 2007, 52:6909-22.
    • (2007) Phys.Med.Biol , vol.52 , pp. 6909-6922
    • Hoad, C.L.1    Marciani, L.2    Foley, S.3
  • 22
    • 75149175153 scopus 로고    scopus 로고
    • Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
    • Marciani L, Cox EF, Hoad CL, et al. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome. Gastroenterology 2010, 138:469-77.
    • (2010) Gastroenterology , vol.138 , pp. 469-477
    • Marciani, L.1    Cox, E.F.2    Hoad, C.L.3
  • 23
    • 0034815195 scopus 로고    scopus 로고
    • Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers
    • Carriere F, Renou C, Ransac S, et al. Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers. Am.J.Physiol Gastrointest.Liver Physiol 2001, 281:G16-28.
    • (2001) Am.J.Physiol Gastrointest.Liver Physiol , vol.281
    • Carriere, F.1    Renou, C.2    Ransac, S.3
  • 24
    • 0030612696 scopus 로고    scopus 로고
    • RenaGel, a novel calcium- and aluminium-free phosphate binder, inhibits phosphate absorption in normal volunteers
    • Burke SK, Slatopolsky EA, Goldberg DI: RenaGel, a novel calcium- and aluminium-free phosphate binder, inhibits phosphate absorption in normal volunteers. Nephrol Dial Transplant 1997, 12:1640-4.
    • (1997) Nephrol Dial Transplant , vol.12 , pp. 1640-1644
    • Burke, S.K.1    Slatopolsky, E.A.2    Goldberg, D.I.3
  • 25
    • 80053357718 scopus 로고    scopus 로고
    • Pharmacology, efficacy and safety of oral phosphate binders
    • Hutchison AJ, Smith CP, Brenchley PE: Pharmacology, efficacy and safety of oral phosphate binders. Nat.Rev.Nephrol. 2011, 7:578-89.
    • (2011) Nat.Rev.Nephrol , vol.7 , pp. 578-589
    • Hutchison, A.J.1    Smith, C.P.2    Brenchley, P.E.3
  • 31
    • 80555148939 scopus 로고    scopus 로고
    • FGF23 induces left ventricular hypertrophy
    • Faul C, Amaral AP, Oskouei B, et al. FGF23 induces left ventricular hypertrophy. J.Clin.Invest 2011, 121:4393-408.
    • (2011) J.Clin.Invest , vol.121 , pp. 4393-4408
    • Faul, C.1    Amaral, A.P.2    Oskouei, B.3
  • 32
    • 77950310181 scopus 로고    scopus 로고
    • Apical potassium (BK) channels and enhanced potassium secretion in human colon
    • Sandle GI, Hunter M: Apical potassium (BK) channels and enhanced potassium secretion in human colon. QJM. 2010, 103:85-9.
    • (2010) QJM , vol.103 , pp. 85-89
    • Sandle, G.I.1    Hunter, M.2
  • 33
    • 77956994484 scopus 로고    scopus 로고
    • Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon
    • Nanda Kumar NS, Singh SK, Rajendran VM: Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon. Am.J.Physiol Gastrointest.Liver Physiol 2010, 299:G707-14.
    • (2010) Am.J.Physiol Gastrointest.Liver Physiol , vol.299
    • Nanda Kumar, N.S.1    Singh, S.K.2    Rajendran, V.M.3
  • 35
    • 79953720277 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial
    • Pitt B, Anker SD, Bushinsky DA, Kitzman DW, Zannad F, Huang IZ: Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial. Eur.Heart J. 2011, 32:820-8.
    • (2011) Eur.Heart J , vol.32 , pp. 820-828
    • Pitt, B.1    Anker, S.D.2    Bushinsky, D.A.3    Kitzman, D.W.4    Zannad, F.5    Huang, I.Z.6
  • 37
    • 85038452773 scopus 로고    scopus 로고
    • Assignee: In vivo use of water absorbent polymers. United States Patent S6908609B2
    • Simon J, Strickland AD, Inventors, Dow Global Technologies Inc., Assignee: In vivo use of water absorbent polymers. United States Patent S6908609B2 2005.
    • (2005) Inventors, Dow Global Technologies Inc
    • Simon, J.1    Strickland, A.D.2
  • 39
    • 79961214888 scopus 로고    scopus 로고
    • Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: Randomised controlled trial
    • Slagman MC, Waanders F, Hemmelder MH, Woittiez AJ, Janssen WM, Lambers Heerspink HJ, et al. Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: randomised controlled trial. BMJ 2011, 343:d4366.
    • (2011) BMJ , vol.343
    • Slagman, M.C.1    Waanders, F.2    Hemmelder, M.H.3    Woittiez, A.J.4    Janssen, W.M.5    Lambers Heerspink, H.J.6
  • 40
    • 77049173625 scopus 로고
    • Some aspects of cation exchange resins as therapeutic agents for sodium removal
    • McChesney EW, Nachod FC, Tainter ML: Some aspects of cation exchange resins as therapeutic agents for sodium removal. Ann N Y Acad Sci 1953, 57:252-9.
    • (1953) Ann N Y Acad Sci , vol.57 , pp. 252-259
    • McChesney, E.W.1    Nachod, F.C.2    Tainter, M.L.3
  • 41
    • 77049183622 scopus 로고
    • Cation exchange resins in congestive heart failure
    • Orgain ES: Cation exchange resins in congestive heart failure. Med Clin North Am 1954, 11:419-30.
    • (1954) Med Clin North Am , vol.11 , pp. 419-430
    • Orgain, E.S.1
  • 44
    • 28944453591 scopus 로고    scopus 로고
    • Hydroxamic acid-containing hydrogels for nonabsorbed iron chelation therapy: Synthesis, characterization, and biological evaluation
    • Polomoscanik SC, Cannon CP, Neenan TX, et al. Hydroxamic acid-containing hydrogels for nonabsorbed iron chelation therapy: synthesis, characterization, and biological evaluation. Biomacromolecules. 2005, 6:2946-53.
    • (2005) Biomacromolecules , vol.6 , pp. 2946-2953
    • Polomoscanik, S.C.1    Cannon, C.P.2    Neenan, T.X.3
  • 45
    • 24144459870 scopus 로고    scopus 로고
    • Identification of an intestinal heme transporter
    • Shayeghi M, Latunde-Dada GO, Oakhill JS, et al. Identification of an intestinal heme transporter. Cell 2005, 122:789-801.
    • (2005) Cell , vol.122 , pp. 789-801
    • Shayeghi, M.1    Latunde-Dada, G.O.2    Oakhill, J.S.3
  • 46
    • 64749115172 scopus 로고    scopus 로고
    • Lipid-lowering drugs acting at the level of the gastrointestinal tract
    • Filippatos TD, Mikhailidis DP: Lipid-lowering drugs acting at the level of the gastrointestinal tract. Curr.Pharm.Des 2009, 15:490-516.
    • (2009) Curr.Pharm.Des , vol.15 , pp. 490-516
    • Filippatos, T.D.1    Mikhailidis, D.P.2
  • 47
    • 37249083878 scopus 로고    scopus 로고
    • Long term pharmacotherapy for obesity and overweight: Updated meta-analysis
    • Rucker D, Padwal R, Li SK, Curioni C, Lau DC: Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ 2007, 335:1194-9.
    • (2007) BMJ , vol.335 , pp. 1194-1199
    • Rucker, D.1    Padwal, R.2    Li, S.K.3    Curioni, C.4    Lau, D.C.5
  • 50
    • 85038477247 scopus 로고    scopus 로고
    • Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010, MEDI-280
    • M: NPC1L1 as the target of Ezetimibe. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010, MEDI-280.
    • NPC1L1 As the Target of Ezetimibe
  • 51
    • 77953699732 scopus 로고    scopus 로고
    • NPC1L1 and cholesterol transport
    • Betters JL, Yu L: NPC1L1 and cholesterol transport. FEBS Lett. 2010, 584:2740-7.
    • (2010) FEBS Lett , vol.584 , pp. 2740-2747
    • Betters, J.L.1    Yu, L.2
  • 52
    • 79955595071 scopus 로고    scopus 로고
    • Vitamin D intestinal absorption is not a simple passive diffusion: Evidences for involvement of cholesterol transporters
    • Reboul E, Goncalves A, Comera C, et al. Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters. Mol.Nutr.Food Res. 2011, 55:691-702.
    • (2011) Mol.Nutr.Food Res , vol.55 , pp. 691-702
    • Reboul, E.1    Goncalves, A.2    Comera, C.3
  • 53
    • 79959348919 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of ezetimibe analogs as possible cholesterol absorption inhibitors
    • Wang Y, Haiqian, Huang W, Zhang H, Zhou J: Synthesis and biological evaluation of ezetimibe analogs as possible cholesterol absorption inhibitors. Lett.Drug Des.Discovery 2011, 8:500-5.
    • (2011) Lett.Drug Des.Discovery , vol.8 , pp. 500-505
    • Wang, Y.1    Haiqian Huang, W.2    Zhang, H.3    Zhou, J.4
  • 54
    • 78149281356 scopus 로고    scopus 로고
    • Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure-activity studies and in vivo efficacy
    • Howell KL, DeVita RJ, Garcia-Calvo M, et al. Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure-activity studies and in vivo efficacy. Bioorg.Med.Chem.Lett. 2010, 20:6929-32.
    • (2010) Bioorg.Med.Chem.Lett , vol.20 , pp. 6929-6932
    • Howell, K.L.1    Devita, R.J.2    Garcia-Calvo, M.3
  • 56
    • 85038462627 scopus 로고    scopus 로고
    • Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-284
    • Fessard TC, Li DB, Abdelkafi H, et al. Non-systemic cholesterol absorption inhibitors. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-284.
    • Non-systemic Cholesterol Absorption Inhibitors
    • Fessard, T.C.1    Li, D.B.2    Abdelkafi, H.3
  • 59
    • 85038452261 scopus 로고    scopus 로고
    • Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-281
    • H: Development of KT6-971: A C-glycoside of NPC1L1 transporter inhibitor. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 2010,MEDI-281.
    • Development of KT6-971: A C-glycoside of NPC1L1 Transporter Inhibitor
  • 60
    • 36649019823 scopus 로고    scopus 로고
    • Biologically active polymeric sequestrants:Design, synthesis, and therapeutic applications
    • Dahl PK, Huval C, Holmes-Farley SR: Biologically active polymeric sequestrants:Design, synthesis, and therapeutic applications. Pure Appl.Chem 2007, 79:1521-30.
    • (2007) Pure Appl.Chem , vol.79 , pp. 1521-1530
    • Dahl, P.K.1    Huval, C.2    Holmes-Farley, S.R.3
  • 62
    • 84857716618 scopus 로고    scopus 로고
    • Role of bile acid sequestrants in the treatment of type 2 diabetes
    • Takebayashi K, Aso Y, Inukai T: Role of bile acid sequestrants in the treatment of type 2 diabetes. World J.Diabetes 2010, 1:146-52.
    • (2010) World J.Diabetes , vol.1 , pp. 146-152
    • Takebayashi, K.1    Aso, Y.2    Inukai, T.3
  • 63
    • 33646016599 scopus 로고    scopus 로고
    • Bile acid reabsorption inhibitors (BARI): Novel hypolipidemic drugs
    • Kramer W, Glombik H: Bile acid reabsorption inhibitors (BARI): novel hypolipidemic drugs. Current Medicinal Chemistry 2006, 13:997-1016.
    • (2006) Current Medicinal Chemistry , vol.13 , pp. 997-1016
    • Kramer, W.1    Glombik, H.2
  • 64
    • 84857718366 scopus 로고    scopus 로고
    • Inhibition of Apical Sodium-Dependent Bile Acid Transporter (Asbt) as a Novel Treatment for Diabetes
    • Chen L, Yao X, Young A, et al. Inhibition of Apical Sodium-Dependent Bile Acid Transporter (Asbt) as a Novel Treatment for Diabetes. Am.J.Physiol Endocrinol.Metab 2011.
    • (2011) Am.J.Physiol Endocrinol.Metab
    • Chen, L.1    Yao, X.2    Young, A.3
  • 65
    • 0030947679 scopus 로고    scopus 로고
    • Established and Emerging Strategies for Inhibition of Cholesterol Absorption
    • Homan R, Krause R: Established and Emerging Strategies for Inhibition of Cholesterol Absorption. Current Pharmaceutical Design 1997,29-44.
    • (1997) Current Pharmaceutical Design , pp. 29-44
    • Homan, R.1    Krause, R.2
  • 66
    • 0036838450 scopus 로고    scopus 로고
    • Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice
    • Huggins KW, Boileau AC, Hui DY: Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice. Am J Physiol Endocrinol Metab 2002, 283:E994-1001.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Huggins, K.W.1    Boileau, A.C.2    Hui, D.Y.3
  • 67
    • 80054111473 scopus 로고    scopus 로고
    • Group 1B phospholipase A2 deficiency protects against diet-induced hyperlipidemia in mice
    • Hollie NI, Hui DY: Group 1B phospholipase A2 deficiency protects against diet-induced hyperlipidemia in mice. J.Lipid Res. 2011.
    • (2011) J.Lipid Res
    • Hollie, N.I.1    Hui, D.Y.2
  • 68
    • 77954451182 scopus 로고    scopus 로고
    • Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: The molecular link between group 1B phospholipase A2 and diet-induced obesity
    • Labonte ED, Pfluger PT, Cash JG, et al. Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesity. FASEB J. 2010, 24:2516-24.
    • (2010) FASEB J , vol.24 , pp. 2516-2524
    • Labonte, E.D.1    Pfluger, P.T.2    Cash, J.G.3
  • 69
    • 70350303586 scopus 로고    scopus 로고
    • The phospholipase A(2) inhibitor methyl indoxam suppresses diet-induced obesity and glucose intolerance in mice
    • Hui DY, Cope MJ, Labonte ED, et al. The phospholipase A(2) inhibitor methyl indoxam suppresses diet-induced obesity and glucose intolerance in mice. Br.J Pharmacol 2009, 157:1263-69.
    • (2009) Br.J Pharmacol , vol.157 , pp. 1263-1269
    • Hui, D.Y.1    Cope, M.J.2    Labonte, E.D.3
  • 71
    • 0037204196 scopus 로고    scopus 로고
    • Clinical practice. Antibiotic-associated diarrhea
    • Bartlett JG: Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 2002, 346:334-339.
    • (2002) N Engl J Med , vol.346 , pp. 334-339
    • Bartlett, J.G.1
  • 74
    • 0036467063 scopus 로고    scopus 로고
    • Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile
    • Kyne L, Hamel MB, Polavaram R, Kelly CP: Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 2002, 34:346-53.
    • (2002) Clin Infect Dis , vol.34 , pp. 346-353
    • Kyne, L.1    Hamel, M.B.2    Polavaram, R.3    Kelly, C.P.4
  • 75
    • 0034917210 scopus 로고    scopus 로고
    • GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis
    • Kurtz CB, Cannon EP, Brezzani A, et al. GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis. Antimicrob.Agents Chemother. 2001, 45:2340-7.
    • (2001) Antimicrob.Agents Chemother , vol.45 , pp. 2340-2347
    • Kurtz, C.B.1    Cannon, E.P.2    Brezzani, A.3
  • 76
    • 3042855154 scopus 로고    scopus 로고
    • Toxin binding of tolevamer, a polyanionic drug that protects against antibiotic-associated diarrhea
    • Braunlin W, Xu Q, Hook P, et al. Toxin binding of tolevamer, a polyanionic drug that protects against antibiotic-associated diarrhea. Biophys J 2004, 87:534-9.
    • (2004) Biophys J , vol.87 , pp. 534-539
    • Braunlin, W.1    Xu, Q.2    Hook, P.3
  • 77
    • 79957761288 scopus 로고    scopus 로고
    • Super toxins from a super bug: Structure and function of Clostridium difficile toxins
    • Davies AH, Roberts AK, Shone CC, Acharya KR: Super toxins from a super bug: structure and function of Clostridium difficile toxins. Biochem.J. 2011, 436:517-26.
    • (2011) Biochem.J , vol.436 , pp. 517-526
    • Davies, A.H.1    Roberts, A.K.2    Shone, C.C.3    Acharya, K.R.4
  • 78
    • 0028358924 scopus 로고
    • Oligosaccharide sequences attached to an inert support (SYNSORB) as potential therapy for antibiotic-associated diarrhea and pseudomembranous colitis
    • Heerze LD, Kelm MA, Talbot JA, Armstrong GD: Oligosaccharide sequences attached to an inert support (SYNSORB) as potential therapy for antibiotic-associated diarrhea and pseudomembranous colitis. J Infect Dis 1994, 169:1291-6.
    • (1994) J Infect Dis , vol.169 , pp. 1291-1296
    • Heerze, L.D.1    Kelm, M.A.2    Talbot, J.A.3    Armstrong, G.D.4
  • 80
    • 59749084849 scopus 로고    scopus 로고
    • Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection
    • Louie T, Miller M, Donskey C, Mullane K, Goldstein EJ: Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection. Antimicrob.Agents Chemother. 2009, 53:223-8.
    • (2009) Antimicrob.Agents Chemother , vol.53 , pp. 223-228
    • Louie, T.1    Miller, M.2    Donskey, C.3    Mullane, K.4    Goldstein, E.J.5
  • 81
    • 82955240575 scopus 로고    scopus 로고
    • Fidaxomicin: In Clostridium difficile Infection
    • Duggan ST: Fidaxomicin: In Clostridium difficile Infection. Drugs 2011, 71:2445-56.
    • (2011) Drugs , vol.71 , pp. 2445-2456
    • Duggan, S.T.1
  • 83
    • 0037879075 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: Lumen-liver interactions and possible role for probiotics
    • Solga SF, Diehl AM: Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics. J Hepatol 2003, 38:681-7.
    • (2003) J Hepatol , vol.38 , pp. 681-687
    • Solga, S.F.1    Diehl, A.M.2
  • 84
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56:1761-72.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3
  • 85
    • 27644438235 scopus 로고    scopus 로고
    • The importance of the gastrointestinal system in the pathogenesis of heart failure
    • Krack A, Sharma R, Figulla HR, Anker SD: The importance of the gastrointestinal system in the pathogenesis of heart failure. European Heart Journal 2005, 26:2368-74.
    • (2005) European Heart Journal , vol.26 , pp. 2368-2374
    • Krack, A.1    Sharma, R.2    Figulla, H.R.3    Anker, S.D.4
  • 86
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006, 12:1365-71.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3
  • 88
    • 26844558196 scopus 로고    scopus 로고
    • Identification and analysis of multivalent proteolytically resistant peptides from gluten: Implications for celiac sprue
    • Shan L, Qiao SW, Rentz-Hansen H, et al. Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. J.Proteome.Res. 2005, 4:1732-41.
    • (2005) J.Proteome.Res , vol.4 , pp. 1732-1741
    • Shan, L.1    Qiao, S.W.2    Rentz-Hansen, H.3
  • 90
    • 84856744117 scopus 로고    scopus 로고
    • Safety, Tolerability, and Activity of ALV003: Results from Two Phase 1 Single, Escalating-Dose Clinical Trials
    • Siegel M, Garber ME, Spencer AG, Botwick W, Kumar P, Williams RN, et al. Safety, Tolerability, and Activity of ALV003: Results from Two Phase 1 Single, Escalating-Dose Clinical Trials. Dig.Dis.Sci. 2011.
    • (2011) Dig.Dis.Sci
    • Siegel, M.1    Garber, M.E.2    Spencer, A.G.3    Botwick, W.4    Kumar, P.5    Williams, R.N.6
  • 92
    • 33646426645 scopus 로고    scopus 로고
    • Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
    • Drago S, El AR, Di PM, et al. Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand.J Gastroenterol 2006, 41:408-19.
    • (2006) Scand.J Gastroenterol , vol.41 , pp. 408-419
    • Drago, S.1    El, A.R.2    Di, P.M.3
  • 93
    • 34547852241 scopus 로고    scopus 로고
    • The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: A proof of concept study
    • Paterson BM, Lammers KM, Arrieta MC, Fasano A, Meddings JB: The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment.Pharmacol.Ther. 2007, 26:757-66.
    • (2007) Aliment.Pharmacol.Ther , vol.26 , pp. 757-766
    • Paterson, B.M.1    Lammers, K.M.2    Arrieta, M.C.3    Fasano, A.4    Meddings, J.B.5
  • 94
    • 0028466186 scopus 로고
    • Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis
    • Niwa T, Ise M: Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J.Lab Clin.Med. 1994, 124:96-104.
    • (1994) J.Lab Clin.Med , vol.124 , pp. 96-104
    • Niwa, T.1    Ise, M.2
  • 95
    • 0032891014 scopus 로고    scopus 로고
    • Urinary indoxyl sulfate is a clinical factor that affects the progression of renal failure
    • Niwa T, Aoyama I, Takayama F, et al. Urinary indoxyl sulfate is a clinical factor that affects the progression of renal failure. Miner.Electrolyte Metab 1999, 25:118-22.
    • (1999) Miner.Electrolyte Metab , vol.25 , pp. 118-122
    • Niwa, T.1    Aoyama, I.2    Takayama, F.3
  • 96
    • 84943010134 scopus 로고    scopus 로고
    • Indoxyl sulfate is a nephro-vascular toxin
    • Niwa T: Indoxyl sulfate is a nephro-vascular toxin. J.Ren Nutr. 2010,20:S2-6.
    • (2010) J.Ren Nutr , vol.20
    • Niwa, T.1
  • 97
    • 0242669257 scopus 로고    scopus 로고
    • Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells
    • Motojima M, Hosokawa A, Yamato H, Muraki T, Yoshioka T: Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells. Kidney Int. 2003, 63:1671-80.
    • (2003) Kidney Int , vol.63 , pp. 1671-1680
    • Motojima, M.1    Hosokawa, A.2    Yamato, H.3    Muraki, T.4    Yoshioka, T.5
  • 98
    • 0030686486 scopus 로고    scopus 로고
    • Indoxyl sulfate and progression of renal failure: Effects of a low-protein diet and oral sorbent on indoxyl sulfate production in uremic rats and undialyzed uremic patients
    • Niwa T, Tsukushi S, Ise M, et al. Indoxyl sulfate and progression of renal failure: effects of a low-protein diet and oral sorbent on indoxyl sulfate production in uremic rats and undialyzed uremic patients. Miner.Electrolyte Metab 1997, 23:179-84.
    • (1997) Miner.Electrolyte Metab , vol.23 , pp. 179-184
    • Niwa, T.1    Tsukushi, S.2    Ise, M.3
  • 99
    • 78751644527 scopus 로고    scopus 로고
    • Oral adsorbent AST-120 ameliorates tubular injury in chronic renal failure patients by reducing proteinuria and oxidative stress generation
    • Nakamura T, Sato E, Fujiwara N, et al. Oral adsorbent AST-120 ameliorates tubular injury in chronic renal failure patients by reducing proteinuria and oxidative stress generation. Metabolism 2011,60:260-64.
    • (2011) Metabolism , vol.60 , pp. 260-264
    • Nakamura, T.1    Sato, E.2    Fujiwara, N.3
  • 100
    • 68849123039 scopus 로고    scopus 로고
    • Effect of a carbonaceous oral adsorbent on the progression of CKD: A multicenter, randomized, controlled trial
    • Akizawa T, Asano Y, Morita S, et al. Effect of a carbonaceous oral adsorbent on the progression of CKD: a multicenter, randomized, controlled trial. Am.J.Kidney Dis. 2009, 54:459-67.
    • (2009) Am.J.Kidney Dis , vol.54 , pp. 459-467
    • Akizawa, T.1    Asano, Y.2    Morita, S.3
  • 101
    • 64149095859 scopus 로고    scopus 로고
    • Long-term effects of the oral adsorbent, AST-120, in patients with chronic renal failure
    • Maeda K, Hamada C, Hayashi T, et al. Long-term effects of the oral adsorbent, AST-120, in patients with chronic renal failure. J.Int.Med.Res. 2009, 37:205-13.
    • (2009) J.Int.Med.Res , vol.37 , pp. 205-213
    • Maeda, K.1    Hamada, C.2    Hayashi, T.3
  • 102
    • 29144467932 scopus 로고    scopus 로고
    • Protein-bound advanced glycation end-products (AGEs) as bioactive amino acid derivatives in foods
    • Henle T: Protein-bound advanced glycation end-products (AGEs) as bioactive amino acid derivatives in foods. Amino.Acids 2005, 29:313-22.
    • (2005) Amino.Acids , vol.29 , pp. 313-322
    • Henle, T.1
  • 103
    • 0041859310 scopus 로고    scopus 로고
    • Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients
    • Uribarri J, Peppa M, Cai W, et al. Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients. Am.J.Kidney Dis. 2003, 42:532-8.
    • (2003) Am.J.Kidney Dis , vol.42 , pp. 532-538
    • Uribarri, J.1    Peppa, M.2    Cai, W.3
  • 104
    • 0037369890 scopus 로고    scopus 로고
    • Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients
    • Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, He C, Vlassara H: Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients. J.Am.Soc.Nephrol. 2003, 14:728-31.
    • (2003) J.Am.Soc.Nephrol , vol.14 , pp. 728-731
    • Uribarri, J.1    Peppa, M.2    Cai, W.3    Goldberg, T.4    Lu, M.5    He, C.6    Vlassara, H.7
  • 105
    • 33750440810 scopus 로고    scopus 로고
    • Oral adsorbent AST-120 decreases serum levels of AGEs in patients with chronic renal failure
    • Ueda S, Yamagishi S, Takeuchi M, et al. Oral adsorbent AST-120 decreases serum levels of AGEs in patients with chronic renal failure. Mol.Med. 2006, 12:180-4.
    • (2006) Mol.Med , vol.12 , pp. 180-184
    • Ueda, S.1    Yamagishi, S.2    Takeuchi, M.3
  • 106
    • 79951775260 scopus 로고    scopus 로고
    • Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients
    • Kakuta T, Tanaka R, Hyodo T, et al. Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients. Am.J.Kidney Dis. 2011, 57:422-31.
    • (2011) Am.J.Kidney Dis , vol.57 , pp. 422-431
    • Kakuta, T.1    Tanaka, R.2    Hyodo, T.3
  • 107
    • 0037406406 scopus 로고    scopus 로고
    • Review on uremic toxins: Classification, concentration, and interindividual variability
    • Vanholder R, De Smet R, Glorieux G, et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003, 63:1934-43.
    • (2003) Kidney Int , vol.63 , pp. 1934-1943
    • Vanholder, R.1    de Smet, R.2    Glorieux, G.3
  • 108
    • 78249257806 scopus 로고    scopus 로고
    • New uremic toxins - which solutes should be removed?
    • Glorieux G, Vanholder R: New uremic toxins - which solutes should be removed? Contrib.Nephrol. 2011, 168:117-28.
    • (2011) Contrib.Nephrol , vol.168 , pp. 117-128
    • Glorieux, G.1    Vanholder, R.2
  • 109
    • 0026948511 scopus 로고
    • Extrarenal clearance of oxalate increases with progression of renal failure in the rat
    • Costello JF, Smith M, Stolarski C, Sadovnic MJ: Extrarenal clearance of oxalate increases with progression of renal failure in the rat. J.Am.Soc.Nephrol. 1992, 3:1098-104.
    • (1992) J.Am.Soc.Nephrol , vol.3 , pp. 1098-1104
    • Costello, J.F.1    Smith, M.2    Stolarski, C.3    Sadovnic, M.J.4
  • 110
    • 49049106988 scopus 로고    scopus 로고
    • Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria
    • Grujic D, Salido EC, Shenoy BC, et al. Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria. Am.J.Nephrol. 2009, 29:86-93.
    • (2009) Am.J.Nephrol , vol.29 , pp. 86-93
    • Grujic, D.1    Salido, E.C.2    Shenoy, B.C.3
  • 112
    • 2442629629 scopus 로고    scopus 로고
    • Epidemiology of constipation in North America: A systematic review
    • Higgins PD, Johanson JF: Epidemiology of constipation in North America: a systematic review. Am.J.Gastroenterol. 2004, 99:750-59.
    • (2004) Am.J.Gastroenterol , vol.99 , pp. 750-759
    • Higgins, P.D.1    Johanson, J.F.2
  • 113
    • 33846409428 scopus 로고    scopus 로고
    • Different segmental transit times in patients with irritable bowel syndrome and normal colonic transit time: Is there a correlation with symptoms?
    • Bouchoucha M, Devroede G, Dorval E, Faye A, Arhan P, Arsac M: Different segmental transit times in patients with irritable bowel syndrome and normal colonic transit time: is there a correlation with symptoms? Tech.Coloproctol. 2006, 10:287-96.
    • (2006) Tech.Coloproctol , vol.10 , pp. 287-296
    • Bouchoucha, M.1    Devroede, G.2    Dorval, E.3    Faye, A.4    Arhan, P.5    Arsac, M.6
  • 116
    • 60749099506 scopus 로고    scopus 로고
    • Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation
    • Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation. Am.J.Gastroenterol. 2009, 104:125-32.
    • (2009) Am.J.Gastroenterol , vol.104 , pp. 125-132
  • 117
    • 78649690668 scopus 로고    scopus 로고
    • Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    • Johnston JM, Kurtz CB, Macdougall JE, et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology 2010, 139:1877-86.
    • (2010) Gastroenterology , vol.139 , pp. 1877-1886
    • Johnston, J.M.1    Kurtz, C.B.2    Macdougall, J.E.3
  • 118
    • 84856985617 scopus 로고    scopus 로고
    • RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit
    • Spencer AG, Jacobs J, Leadbetter MR, et al. RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit. Proceedings of the Drug Disease Week 2011 Chicago Gastroenterology 2011, 140:S-99.
    • (2011) Proceedings of the Drug Disease Week 2011 Chicago Gastroenterology , vol.140
    • Spencer, A.G.1    Jacobs, J.2    Leadbetter, M.R.3
  • 119
    • 84857764997 scopus 로고    scopus 로고
    • The Safety, Tolerability, Systemic Exposure, and Effect on Bowel Habits of Single and Multiple Doses of the Intestinal Sodium Re-Uptake Inhibitor RDX5791 in Normal Healthy Volunteers
    • Rosenbaum DP, Spencer AG, Jacobs J, Charmot D: The Safety, Tolerability, Systemic Exposure, and Effect on Bowel Habits of Single and Multiple Doses of the Intestinal Sodium Re-Uptake Inhibitor RDX5791 in Normal Healthy Volunteers. Proceeding of the ACG meeting 2011 Washington DC American Journal of Gastroenterology 2011, 106:S504.
    • (2011) Proceeding of the ACG Meeting 2011 Washington DC American Journal of Gastroenterology , vol.106
    • Rosenbaum, D.P.1    Spencer, A.G.2    Jacobs, J.3    Charmot, D.4
  • 120
    • 84856988935 scopus 로고    scopus 로고
    • Visceral Antinociceptive Effects of RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor on Stress-Induced Colorectal Hypersensitivity to Distension in Rats
    • Eutamene E, Charmot D, Navre M, Bueno L: Visceral Antinociceptive Effects of RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor on Stress-Induced Colorectal Hypersensitivity to Distension in Rats. Proceedings of the DDW meeting 2011 Chicago IL Gastroenterology 2011, 140:S57-S58.
    • (2011) Proceedings of the DDW Meeting 2011 Chicago IL Gastroenterology , vol.140
    • Eutamene, E.1    Charmot, D.2    Navre, M.3    Bueno, L.4
  • 121
    • 76349088961 scopus 로고    scopus 로고
    • Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain
    • Eutamene H, Bradesi S, Larauche M, et al. Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol.Motil. 2010, 22:e312-e384.
    • (2010) Neurogastroenterol.Motil , vol.22
    • Eutamene, H.1    Bradesi, S.2    Larauche, M.3
  • 122
    • 80053912847 scopus 로고    scopus 로고
    • A randomized placebo-controlled phase IIb trial of a3309, a bile Acid transporter inhibitor, for chronic idiopathic constipation
    • Chey WD, Camilleri M, Chang L, Rikner L, Graffner H: A randomized placebo-controlled phase IIb trial of a3309, a bile Acid transporter inhibitor, for chronic idiopathic constipation. Am J.Gastroenterol. 2011, 106:1803-1812.
    • (2011) Am J.Gastroenterol , vol.106 , pp. 1803-1812
    • Chey, W.D.1    Camilleri, M.2    Chang, L.3    Rikner, L.4    Graffner, H.5
  • 124
    • 78649757218 scopus 로고    scopus 로고
    • Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles
    • Donowitz M, Singh S, Singh P, et al. Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics 2010, 42A:200-10.
    • (2010) Physiol Genomics , vol.42 A , pp. 200-210
    • Donowitz, M.1    Singh, S.2    Singh, P.3
  • 125
    • 35649003997 scopus 로고    scopus 로고
    • Proteome of murine jejunal brush border membrane vesicles
    • Donowitz M, Singh S, Salahuddin FF, et al. Proteome of murine jejunal brush border membrane vesicles. J.Proteome.Res. 2007, 6:4068-79.
    • (2007) J.Proteome.Res , vol.6 , pp. 4068-4079
    • Donowitz, M.1    Singh, S.2    Salahuddin, F.F.3
  • 126
    • 58749090731 scopus 로고    scopus 로고
    • Narrative review: Effect of bariatric surgery on type 2 diabetes mellitus
    • Vetter ML, Cardillo S, Rickels MR, Iqbal N: Narrative review: effect of bariatric surgery on type 2 diabetes mellitus. Ann.Intern.Med. 2009, 150:94-103.
    • (2009) Ann.Intern.Med , vol.150 , pp. 94-103
    • Vetter, M.L.1    Cardillo, S.2    Rickels, M.R.3    Iqbal, N.4
  • 128
    • 79955568606 scopus 로고    scopus 로고
    • Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery
    • Hansen EN, Tamboli RA, Isbell JM, et al. Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery. Am.J.Physiol Gastrointest.Liver Physiol 2011, 300:G795-802.
    • (2011) Am.J.Physiol Gastrointest.Liver Physiol , vol.300
    • Hansen, E.N.1    Tamboli, R.A.2    Isbell, J.M.3
  • 129
    • 39449124119 scopus 로고    scopus 로고
    • Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism
    • Thomas C, Auwerx J, Schoonjans K: Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism. Thyroid 2008, 18:167-74.
    • (2008) Thyroid , vol.18 , pp. 167-174
    • Thomas, C.1    Auwerx, J.2    Schoonjans, K.3
  • 130
    • 42449126696 scopus 로고    scopus 로고
    • A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release
    • Chu ZL, Carroll C, Alfonso J, et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology 2008, 149:2038-47.
    • (2008) Endocrinology , vol.149 , pp. 2038-2047
    • Chu, Z.L.1    Carroll, C.2    Alfonso, J.3
  • 131
    • 53249084471 scopus 로고    scopus 로고
    • Protease activated receptor 2: A new target for IBS treatment
    • Bueno L: Protease activated receptor 2: a new target for IBS treatment. Eur Rev.Med.Pharmacol.Sci. 2008, 12 Suppl 1:95-102.
    • (2008) Eur Rev.Med.Pharmacol.Sci , vol.12 , Issue.SUPPL. 1 , pp. 95-102
    • Bueno, L.1
  • 133
    • 80053616405 scopus 로고    scopus 로고
    • The PepT1-NOD2 Signaling Pathway Aggravates Induced Colitis in Mice
    • Dalmasso G, Nguyen HT, Ingersoll SA, et al. The PepT1-NOD2 Signaling Pathway Aggravates Induced Colitis in Mice. Gastroenterology 2011, 141:1334-45.
    • (2011) Gastroenterology , vol.141 , pp. 1334-1345
    • Dalmasso, G.1    Nguyen, H.T.2    Ingersoll, S.A.3
  • 134
    • 77957000911 scopus 로고    scopus 로고
    • PepT1 mediates transport of the proinflammatory bacterial tripeptide L- Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells
    • Dalmasso G, Nguyen HT, Charrier-Hisamuddin L, et al. PepT1 mediates transport of the proinflammatory bacterial tripeptide L- Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells. Am.J.Physiol Gastrointest.Liver Physiol 2010, 299:G687-96.
    • (2010) Am.J.Physiol Gastrointest.Liver Physiol , vol.299
    • Dalmasso, G.1    Nguyen, H.T.2    Charrier-Hisamuddin, L.3
  • 135
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor RB: Microbial influences in inflammatory bowel diseases. Gastroenterology 2008, 134:577-594.
    • (2008) Gastroenterology , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 136
    • 67651184136 scopus 로고    scopus 로고
    • The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract
    • Geibel JP, Hebert SC: The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract. Annu.Rev.Physiol 2009, 71:205-17.
    • (2009) Annu.Rev.Physiol , vol.71 , pp. 205-217
    • Geibel, J.P.1    Hebert, S.C.2
  • 137
    • 30744454043 scopus 로고    scopus 로고
    • Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera
    • Sonawane ND, Hu J, Muanprasat C, Verkman AS: Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. FASEB J 2006, 20:130-2.
    • (2006) FASEB J , vol.20 , pp. 130-132
    • Sonawane, N.D.1    Hu, J.2    Muanprasat, C.3    Verkman, A.S.4
  • 138
    • 34247208037 scopus 로고    scopus 로고
    • Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera
    • Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS: Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology 2007, 132:1234-44.
    • (2007) Gastroenterology , vol.132 , pp. 1234-1244
    • Sonawane, N.D.1    Zhao, D.2    Zegarra-Moran, O.3    Galietta, L.J.4    Verkman, A.S.5
  • 139
    • 73549100636 scopus 로고    scopus 로고
    • Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels
    • Tradtrantip L, Namkung W, Verkman AS. Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol.Pharmacol. 2010, 77:69-78.
    • (2010) Mol.Pharmacol , vol.77 , pp. 69-78
    • Tradtrantip, L.1    Namkung, W.2    Verkman, A.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.