Apical potassium (BK) channels and enhanced potassium secretion in human colon

QJM: An International Journal of Medicine

Volumn 103, Issue 2, 2009, Pages 85-89

  Sandle, G I ^a   Hunter, M ^b  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM ION;

APICAL MEMBRANE; CELL MEMBRANE CONDUCTANCE; COLON; DIARRHEA; EPITHELIUM CELL; HOMEOSTASIS; HUMAN; INTESTINE INFECTION; OGILVIE SYNDROME; PRIORITY JOURNAL; REVIEW; ULCERATIVE COLITIS; VILLOUS ADENOMA;

EID: 77950310181     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcp159     Document Type: Review

References (33)

1. Hawker PC, Mashiter KE, Turnberg LA. Mechanisms of transport of Na, Cl, and K in the human colon. Gastroenterology 1978; 74:1241-7.
2. Sandle GI, Hayslett JP, Binder HJ. The effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut 1986; 27:309-16.
3. Sandle GI, Gaiger E, Tapster S, Goodship THJ. Enhanced rectal potassium secretion in chronic renal insufficiency: evidence for large intestinal potassium adaptation in man. Clin Sci 1986; 71:393-401.
4. Mathialahan T, MacLennan KA, Sandle LN, Verbeke C, Sandle GI. Enhanced large intestinal potassium permeability in end-stage renal disease. J Pathol 2005; 206:46-51.
5. Sandle GI, Perry M, Mathialahan T, Linley JE, Robinson P, Hunter M, MacLennan KA. Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis. J Pathol 2007; 212:66-73.
6. Older J, Older P, Colker J, Brown R. Secretory villous adenomas that cause depletion syndrome. Arch Intern Med 1999; 159:879-80.
7. Baker EH, Sandle GI. Complications of laxative abuse. In: Coggins CH, ed. Annual Review of Medicine. Palo Alto, CA, Annual Reviews Inc., 1996:127-34.
8. Foster E, Sandle GI, Hayslett JP, Binder H. Cyclic adenosine monophosphate stimulates potassium secretion in the rat colon. Gastroenterology 1983; 84:324-30.
9. Foster E, Sandle GI, Hayslett JP, Binder H. Dietary potassium modulates active potassium absorption and secretion in rat distal colon. Am J Physiol 1986; 251:G619-26.
10. Hayslett JP, Binder HJ. Mechanisms of potassium adaptation. Am J Physiol 1982; 243:F103-12.
11. Schon DA, Silva P, Hayslett JP. Mechanisms of potassium excretion in renal insufficiency. Am J Physiol 1974; 227:1323-30.
12. Foster ES, Jones WJ, Hayslett JP, Binder HJ. Role of aldosterone and dietary potassium in potassium adaptation in the distal colon of the rat. Gastroenterology 1985; 88:41-6.
13. Binder HJ. Intestinal fluid and electrolyte movement. In: Boron WF, Boulpaep EL, eds, Medical Physiology. Philadelphia, Elsevier Saunders, 2005:931-46.
14. Sandle GI, McNicholas CM, Lomax RB. Potassium channels in colonic crypts. Lancet 1994; 343:23-5.
15. Lomax RB, Warhurst G, Sandle GI. Characteristics of two basolateral potassium channel populations in human colonic crypts. Gut 1996; 38:243-7.
16. Billich CO, Levitan R. Effects of sodium concentration and osmolarity on water and electrolyte absorption from the intact human colon. J Clin Invest 1969; 48:1336-47.
17. Rask-Madsen J. Simultaneous measurement of electrical polarization and electrolyte transport by the entire normal and inflamed human colon during in vivo perfusion. Scand J Gastroenterol 1973; 8:327-36.
18. Wills NK, Alles WP, Sandle GI, Binder HJ. Apical membrane properties and amiloride binding kinetics of the human descending colon. Am J Physiol 1984; 247:G749-57.
19. + secretion occurs via BK channels. J Am Soc Nephrol 2006; 17:1275-82.
20. Hayes CP, McLeod ME, Robinson RR. An extrarenal mechanism for the maintenance of potassium balance in severe chronic renal failure. Trans Assoc Am Phys 1967; 80:207-16.
21. Sandle GI, Gaiger E, Tapster S, Goodship THJ. Evidence for large intestinal control of potassium homoeostasis in uraemic patients undergoing long-term dialysis. Clin Sci 1987; 73:247-52.
22. Mathialahan T, Sandle GI. Dietary potassium and laxatives as regulators of colonic potassium secretion in end-stage renal disease. Nephrol Dial Transplant 2003; 18:341-7.
23. Perry MD, Sandle GI. Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin. Am J Physiol 2009; 297:G159-67.
24. 2 concentrations determined by equilibrium in vivo dialysis of faeces in patients with ulcerative colitis and healthy controls. Gut 1984; 25:1271-8.
25. Chen L, Tian L, MacDonald S, McClafferty H, Hammond MS, Huibant JM, et al. Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) α-subunits generated from a single site of splicing. J Biol Chem 2005; 280:33599-609.
26. Speelman P, Butler T, Kabir I, Ali A, Banwell J. Colonic dysfunction during cholera infection. Gastroenterology 1986; 91:1164-70.
27. Guerrant RL, Ganguly U, Casper G, Moore EJ, Pierce NF, Carpenter CC. Effect of Escherichia coli on fluid transport across canine small bowel. Mechanism and time-course with enterotoxin and whole bacterial cells. J Clin Invest 1973; 52:1707-14.
28. McDonel JL. In vivo effects of Clostridium perfringens enteropathogenic factors in the rat ileum. Infect Immun 1974; 10:1156-62.
29. Lauritsen K, Laursen LS, Bukhave K, Rask-Madsen J. In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis. Gastroenterology 1988; 95:11-7.
30. van Dinter TG, Fuerst FC, Richardson CT, Ana CA, Polter DE, Fordtran JS, et al. Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. Gastroenterology 2005; 129:1268-73.
31. + channels associated with severe potassium secretory diarrhoea after haemorrhagic shock. Nephrol Dial Transplant 2008; 23:3350-2.
32. Farack UM, Nell G, Lueg O, Rummel W. Independence of the activation of mucus and potassium secretion on the inhibition of sodium and water absorption by deoxycholate in rat colon. Naunyn-Schmei Arch Pharm 1982; 321:336-40.
33. Aziz Q, Al-Hazza A, Bowley KA, Sandle GI, Hunter M. Electrophysiological evidence for KCNE3/KCNQ1 expression in human colonic crypts. J Physiol 2002; 544P:104P