Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 3, 2010, Pages

  Kumar, N S Nanda ^a   Singh, Satish K ^b   Rajendran, Vazhaikkurichi M ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diarrhea; K+ channels; Short circuit current; Stripped mucosa; Unidirectional fluxes

Indexed keywords

5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; 5,6 DICHLORO 1 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOLE 2 ONE; ANION; APAMIN; BARIUM ION; CHLORIDE CHANNEL BLOCKING AGENT; CHROMANOL 293B; GLIBENCLAMIDE; IBERIOTOXIN; NIFLUMIC ACID; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; POTASSIUM ION; RUBIDIUM 86; UNCLASSIFIED DRUG; 5,6 DICHLORO 1 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 5,6-DICHLORO-1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE; BENZIMIDAZOLE DERIVATIVE; CHLORIDE CHANNEL; CLCA PROTEIN, RAT; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNN4 PROTEIN, RAT; POTASSIUM; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON SECRETION; CONTROLLED STUDY; DIARRHEA; INTESTINE MUCOSA; ION CONDUCTANCE; MALE; NONHUMAN; POTASSIUM DEPLETION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RAT; SEROSA; SHORT CIRCUIT CURRENT; VOLTAGE CLAMP; ANIMAL; COLON; DRUG ANTAGONISM; DRUG POTENTIATION; GENETICS; IMPEDANCE; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIONS; BENZIMIDAZOLES; CHLORIDE CHANNELS; COLON; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTRIC IMPEDANCE; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; INTESTINAL MUCOSA; MALE; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77956994484     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00101.2010     Document Type: Article

References (35)

1. Al-Awqati Q. Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. J Clin Invest 110: 1599-1601, 2002.
2. Barmeyer C, Rahner C, Yang Y, Sigworth FJ, Binder HJ, Rajendran VM. Cloning and identification of tissue specific expression of kcnn4 splice variants in rat colon. Am J Physiol Cell Physiol. doi:10.1152/ajpcell.00091,. 2009.
3. Barrett KE, Keely SJ. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol 62: 535-572, 2000.
4. + and non-selective cation channels in the basolateral membrane of rat colonic crypt base cells. Pflügers Arch 432: 1011-1022, 1996.
5. Chou CC, Lunn CA, Murgolo NJ. KCa3.1 target and marker for cancer, autoimmune disorder and vascular inflammation? Expert Rev Mol Diagn 8: 179-187, 2008.
6. - secretion by benzimidazolones. II. Coordinate regulation of apical GCl and basolateral GK. Am J Physiol Lung Cell Mol Physiol 271: L785-L795, 1996.
7. + channel. Am J Physiol Lung Cell Mol Physiol 271: L775-L784, 1996.
8. + channels. Am J Physiol Cell Physiol 273: C531-C540, 1997.
9. 2+ channel blockers stimulate ileal and colonic water absorption. Gastroenterology 89: 858-866, 1985.
10. Fordtran JS. Speculations on the pathogenesis of diarrhea. Fed Proc 26: 1405-1414, 1967.
11. Fuller CM, Benos DJ. CFTR! Am J Physiol Cell Physiol 263: C267-C286, 1992.
12. Furness JB, Robbins HL, Selmer IS, Hunne B, Chen MX, Hicks GA, Moore S, Neylon CB. Expression of intermediate conductance potassium channel immunoreactivity in neurons and epithelial cells of the rat gastrointestinal tract. Cell Tissue Res 314: 179-189, 2003.
13. - secretion. Comp Biochem Physiol A Physiol 118: 271-275, 1997.
14. Gribkoff VK, Champigny G, Barbry P, Dworetzky SI, Meanwell NA, Lazdunski M. The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel. J Biol Chem 269: 10983-10986, 1994.
15. + secretion across distal colonic epithelium. Am J Physiol Cell Physiol 291: C636-C648, 2006.
16. + secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon. Am J Physiol Gastrointest Liver Physiol 285: G185-G196, 2003.
17. Krishnan S, Rajendran VM, Binder HJ. Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon. Am J Physiol Cell Physiol 285: C1246-C1254, 2003.
18. Mall M, Bleich M, Schurlein M, Kuhr J, Seydewitz HH, Brandis M, Greger R, Kunzelmann K. Cholinergic ion secretion in human colon requires coactivation by cAMP. Am J Physiol Gastrointest Liver Physiol 275: G1274-G1281, 1998.
19. - secretion by T84 cell monolayers. Am J Physiol Cell Physiol 250: C486-C494, 1986.
20. Ca channel diversity and smooth muscle cell function. Circ Res 85: e33-e43, 1999.
21. + channel in rat colonic crypt cells. Pflügers Arch 435: 267-272, 1998.
22. + channels by novel benzimidazolone. Eur J Pharmacol 251: 53-59, 1994.
23. Petri WA Jr, Miller M, Binder HJ, Levine MM, Dillingham R, Guerrant RL. Enteric infections, diarrhea, and their impact on function and development. J Clin Invest 118: 1277-1290, 2008.
24. -dependent Na/H exchange. Am J Physiol Gastrointest Liver Physiol 276: G73-G78, 1999.
25. - secretion by polarized monolayers of human colonic epithelial cells. J Clin Invest 98: 2066-2075, 1996.
26. + conductances. Demonstration of effi- cacy in intact rabbit colon and in an in vivo mouse model of cholera. J Clin Invest 100: 3111-3120, 1997.
27. Sangan P, Brill SR, Sangan S, Forbush B 3rd, Binder HJ. Basolateral K-Cl cotransporter regulates colonic potassium absorption in potassium depletion. J Biol Chem 275: 30813-30816, 2000.
28. Schmidt C, Kosche E, Baumeister B, Vetter H. Arachidonic acid metabolism and intracellular calcium concentration in inflammatory bowel disease. Eur J Gastroenterol Hepatol 7: 865-869, 1995.
29. Singh S, Syme CA, Singh AK, Devor DC, Bridges RJ. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther 296: 600-611, 2001.
30. Sweiry JH, Binder HJ. Active potassium absorption in rat distal colon. J Physiol 423: 155-170, 1990.
31. Van Dinter TG Jr, Fuerst FC, Richardson CT, Ana CA, Polter DE, Fordtran JS, Binder HJ. Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. Gastroenterology 129: 1268-1273, 2005.
32. + channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem 273: 21542-21553, 1998.
33. - secretion in rat distal colon. Am J Physiol Cell Physiol 287: C612-C621, 2004.
34. + channel (rSK4) of colonic crypts. Pflügers Arch 438: 437-444, 1999.
35. Zlatkina AR, Belousova EA, Vinitsky LI, Avtandilov GG, Chervonnaya LV. Cyclic nucleotide concentrations of rectal mucosa in ulcerative colitis. Scand J Gastroenterol 25: 341-344, 1990.