Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

Neurogastroenterology and Motility

Volumn 22, Issue 3, 2010, Pages

  Eutamene, H ^a   Bradesi, S ^b   Larauche, M ^b   Theodorou, V ^a   Beaufrand, C ^a   Ohning, G ^c   Fioramonti, J ^a   Cohen, M ^d   Bryant, A P ^e   Kurtz, C ^e   Currie, M G ^e   Mayer, E A ^b   Bueno, L ^a  

^a CNRS   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e Ironwood Pharmaceuticals   (United States)

Author keywords

Guanylate cyclase C; Irritable bowel syndrome; Linaclotide; Visceral pain

Indexed keywords

ANTINOCICEPTIVE AGENT; GUANYLATE CYCLASE; GUANYLATE CYCLASE C; LINACLOTIDE; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG; WATER;

ABDOMINAL WALL MUSCULATURE; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; COLITIS; COLON DISEASE; COLORECTAL DISTENSION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENCY; ELASTICITY; ENZYME ACTIVATION; FEMALE; HYPERALGESIA; HYPERSENSITIVITY; IMMOBILIZATION STRESS; INTESTINE DISTENSION; INTESTINE WALL; LOW DRUG DOSE; MALE; MOUSE; MUSCLE CONTRACTILITY; NONHUMAN; PRESSURE; PRIORITY JOURNAL; RAT; VISCERAL PAIN; WILD TYPE;

ABDOMEN; ANALYSIS OF VARIANCE; ANIMALS; COLON; ELECTRODES, IMPLANTED; ELECTROMYOGRAPHY; FEMALE; GUANYLATE CYCLASE; HYPERALGESIA; INFLAMMATION; MALE; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PAIN; PEPTIDES; RATS; RATS, WISTAR; RESTRAINT, PHYSICAL; STATISTICS, NONPARAMETRIC; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL; TRINITROBENZENESULFONIC ACID;

EID: 76349088961     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01385.x     Document Type: Article

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