Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles

Physiological Genomics

Volumn 42 A, Issue 3, 2010, Pages 200-210

  Donowitz, M ^a   Singh, S ^a   Singh, P ^a   Salahuddin, F F ^a   Chen, Y ^a   Chakraborty, M ^a   Murtazina, R ^a   Gucek, M ^a   Cole, R N ^a   Zachos, N C ^a   Kovbasnjuk, O ^a   Broere, N ^b   Smalley Freed, W G ^c   Reynolds, A B ^c   Hubbard, A L ^a   Seidler, U ^d   Weinman, E ^e   De Jonge, H R ^b   Hogema, B M ^b   Li, X ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

PDZ domains; Proliferation; Signal transduction; Small intestinal Na absorption

Indexed keywords

BETA CATENIN; BINDING PROTEIN; BROXURIDINE; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CARRIER PROTEIN; CYTOSKELETON PROTEIN; ENZYME; EZRIN; GAP JUNCTION PROTEIN; MUTANT PROTEIN; PHOSPHOLIPASE C BETA3; PROTEIN P120; PROTEOME; SCAFFOLD PROTEIN; SIGNAL PEPTIDE; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 3; TRANSMEMBRANE CONDUCTANCE REGULATOR; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CELL DIVISION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; FUNCTIONAL PROTEOMICS; IMMUNOBLOTTING; INTESTINE BRUSH BORDER MEMBRANE; KNOCKOUT MOUSE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEMBRANE TRANSPORT; MEMBRANE VESICLE; MOUSE; NONHUMAN; NULL CELL; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SECRETION; SMALL INTESTINE ABSORPTION; SODIUM ABSORPTION; STAINING; TIGHT JUNCTION; WILD TYPE;

ANIMALS; BETA CATENIN; CADHERINS; CHROMATOGRAPHY, ION EXCHANGE; FEMALE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; JEJUNUM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MICROVILLI; PHOSPHOPROTEINS; PROTEOME; PROTEOMICS; SODIUM-HYDROGEN ANTIPORTER; TANDEM MASS SPECTROMETRY; TRANSPORT VESICLES;

MUS;

EID: 78649757218     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00001.2010     Document Type: Article

References (53)

1. Bowden NA, Weidenhofer J, Scott RJ, Schall U, Todd J, Michie PT, Tooney PA. Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia. Schizophr Res 82: 175-183, 2006.
2. + exchanger 3 (NHE 3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice. Pflügers Arch 457: 1079-1091, 2009.
3. + exchanger 3 regulatory factor 1 (NHERF-1)-but Not NHERF-2 deficient mice. J Biol Chem 282: 37575-37584, 2007.
4. 2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes. J Physiol 581: 1235-1246, 2007.
5. Cunningham R, Esmaili A, Brown E, Biswas RS, Murtazina R, Donowitz M, Dijkman HB, van der Vlag J, Hogema BM, de Jonge HR, Shenolikar S, Wade JB, Weinman EJ. Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice. Am J Physiol Renal Physiol 294: F1001-F1007, 2008.
6. Davis MA, Ireton RC, Reynolds AB. A core function for p120-catenin in cadherin turnover. J Cell Biol 163: 525-534, 2003.
7. Davis MA, Reynolds AB. Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. Dev Cell 10: 21-31, 2006.
8. Donowitz M, Cha B, Zachos NC, Brett CL, Sharma A, Tse CM, Li X. NHERF family and NHE3 regulation. J Physiol 567: 3-11, 2005.
9. Donowitz M, Singh S, Salahuddin FF, Hogema BM, Chen Y, Gucek M, Cole RN, Ham A, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring J, de Jonge H, Li X. Proteome of murine jejunal brush border membrane vesicles. J Proteome Res 6: 4068-4079, 2007. (Pubitemid 350032570)
10. Fukumoto Y, Shintani Y, Reynolds AB, Johnson KR, Wheelock MJ. The regulatory or phosphorylation domain of p120-catenin controls Ecadherin dynamics at the plasma membrane. Exp Cell Res 314: 52-67, 2008. (Pubitemid 350180774)
11. Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell 76: 865-873, 1994.
12. Georgescu MM. NHERF1: molecular brake on the P13K pathway in breast cancer. Breast Cancer Res 10: 106, 2008.
13. Georgescu MM, Morales FC, Molina JR, Hayashi Y. Roles of NHERF1/EBP50 in cancer. Curr Mol Med 8: 459-468, 2008.
14. Gill RK, Saksena S, Alrefai WA, Sarwar Z, Goldstein JL, Carroll RE, Ramswarmy K, Dudeja PK. Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol 289: C846-C852, 2005.
15. Grenier JM, Wang L, Manji GA, Huang WJ, Al-Garawi A, Kelly R, Carlson A, Merriam S, Lora JM, Briskin M, DiStefano PS, Bertin J. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappa B and caspase-1. FEBS Lett 530: 73-78, 2002.
16. Guggino WB, Stanton BA. New insights into cystic fibrosis: molecular switches that regulate CFTR. Nat Rev Mol Cell Biol 7: 426-436, 2006.
17. +/Ha exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci USA 95: 8496-8501, 1998.
18. Helms C, Cao L, Kureger JG, Wisman EM, Chamian F, Gordon D, Hefferman M, Daw JA, Robarge J, Ott J, Kwok PY, Menter A, Bowcock AM. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet 35: 349-356, 2003.
19. Hernando N, Deliot N, Gisler SM, Lederer E, Weinman EJ, Biber J, Murer H. PDZ-domain interactions and apical expression of type lla Na/P(i) cotransporters. Proc Natl Acad Sci USA 99: 11957-11962, 2002.
20. Hillesheim J, Riederer B, Tuo B, Chen M, Manns M, Biber J, Yun C, Kocher O, Seidler U. Down regulation of small intestinal ion transport in PDZK1-(CAP70/NHERF3) deficient mice. Pflügers Arch 454: 575-586, 2007. (Pubitemid 46872904)
21. Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matarisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB. A novel role for p120 catenin in E-cadherin function. J Cell Biol 159: 465-476, 2002.
22. Jacques A, Bleau C, Turbide C, Beauchemin N, Lamontagne L. A synergistic interferon-gamma production is induced by mouse hepatitis virus in interleukin-12 (IL-12)/IL-18 activated natural killer cells and modulated by carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 1a receptor. Immunology 128: e551-e561, 2008.
23. Kellett GL, Brot-Laroche E, Mace OJ, Leturque A. Sugar absorption in the intestine: the role of GLUT2. Annu Rev Nutr 28: 35-54, 2008.
24. Kowalczyk AP, Reynolds AB. Protecting your tail: regulation of cadherin degradation by p120-catenin. Curr Opin Cell Biol 16: 522-527, 2004.
25. Kreimann EL, Morales FC, de Orbeta-Cruz J, Takahashi Y, Adams H, Liu TJ, McCrea PD, Georgescu MM. Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function. Oncogene 26: 5290-5299, 2007.
26. LaLonde DP, Bretscher A. The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50. Biochemistry 48: 2261-2271, 2009.
27. Lamprecht G, Hsieh CJ, Lissner S, Nold L, Heil A, Gaco V, Schafer J, Turner JR, Gregor M. Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium. J Biol Chem 284: 19744-19753, 2009.
28. Lamprecht G, Seidler U. The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. Am J Physiol Gastrointest Liver Physiol 291: G766-G767, 2006.
29. Morales FC, Takahashi Y, Kreimann EL, Georgescu MM. Ezrin-radixin-moesin (ERM) binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia. Proc Natl Acad Sci USA 101: 17705-17710, 2004. (Pubitemid 40051950)
30. Moyer BD, Denton J, Karlson KH, Reynolds D, Wang S, Mickle JE, Milewski M, Cutting GR, Guggino WB, Li M, Stanton BA. A PDZ-interacting domain in CFTR is an apical membrane polarization signal. J Clin Invest 104: 1353-1361, 1999.
31. + exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. J Biol Chem 282: 25141-25151, 2007.
32. Nakamura T, Shibata N, Nishimoto-Shibata T, Feng D, Ikemoto M, Motojima K, Iso-O N, Tsukamoto K, Tsujimoto M, Arai H. Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1. Proc Natl Acad Sci USA 102: 13404-13409, 2005. (Pubitemid 41420860)
33. Prall F, Nollau P, Neumaier M, Haubeck HD, Drzeniek Z, Helmchen U, Loning T, Wagener C. CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues. J Histochem Cytochem 44: 35-41, 1996.
34. Ritzhaupt A, Ellis A, Hosie KB, Shirazi-Beechey SP. The characterization of butyrate transport across pig and human colonic luminal membrane. J Physiol 507: 819-830, 1998.
35. Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazl-Beechey SP. Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J Physiol 513: 719-732, 1998. (Pubitemid 29008104)
36. 2+- dependent intercellular adhesion molecule. Cell Growth Differ 1: 527-533, 1990.
37. Saotome I, Curto M, McClatchey AI. Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell 6: 855-864, 2004. (Pubitemid 38745419)
38. Seidler U, Singh AK, Cinar A, Chen M, Hillesheim J, Hogema B, Riederer B. The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport. Ann NY Acad Sci 1165: 249-260, 2009.
39. Shenolikar S, Voltz JW, Cunningham R, Weinman EJ. Regulation of ion transport by the NHERF family of PDZ proteins. Physiology 19: 362-369, 2004. (Pubitemid 39636084)
40. Shenolikar S, Voltz JW, Mink off CM, Wade JB, Weinman EJ. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate co transporter type lla and renal phosphate wasting. Proc Natl Acad Sci USA 99: 11470-11476, 2002.
41. Singh AK, Riederer B, Krabbenhoff A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest 119: 540-550, 2009.
42. Smalley-Freed WG, Efimov A, Burnett PE, Short SP, Davis MA, Gumucio DL, Washington MK, Coffey RJ, Reynolds AB. p120-catenin is essential for maintenance of barrier function, and intestinal homeostasis in mice. J Clin Invest 120: 1824-1835, 2010.
43. Takahashi Y, Morales FC, Kreimann EL, Georgescu MM. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J 25: 910-920, 2006.
44. Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. Expression of newly identified secretory C.EACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun 383: 340-346, 2009.
45. Thoreson MA, Anastasiadis PZ, Daniel JM, Ireton RC, Wheelock MJ, Johnson KR, Hummingbird DK, Reynolds AB. Selective uncoupling of P120 from E-cadherin disrupts strong adhesion. J Cell Biol 148: 189-202, 2000.
46. Tulk BM, Kapadia S, Edwards JC. CLlC1 inserts from the aqueous phase into phospholipid membranes, where it functions as an anion channel. Am J Physiol Cell Physiol 282: C1103-C1112, 2002.
47. Ulmasov B, Bruno J, Woost PG, Edwards JC. Tissue and subcellular distribution of CL1C1. BMC Cell Biol 8: 8, 2007.
48. Voltz JW, Weinman EJ, Shenolikar S. Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene 20: 6309-6314, 2001.
49. Weinman EJ, Boddeti A, Cunningham R, Akom M, Want F, Wang Y, Liu J, Steplock D, Shenolikar S, Wade JB. NHERF1 is required for renal adaptation to a low-phosphate diet. Am J Physiol Renal Physiol 285: F1225-F1232, 2003.
50. Weinman EJ, Cunningham R, Shenolikar S. NHERF and regulation of the renal sodium-hydrogen exchanger NHE3. Pflügers Arch 450: 137-144, 2005.
51. Weinman EJ, Hall RA, Friedman PA, Liu-Chen LY, Shenolikar S. The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. Annu Rev Physiol 68: 491-505, 2006.
52. + exchanger, NHE3, requires an associated regulatory protein. Proc Natl Acad Sci USA 94: 3010-3015, 1997.
53. Zimnicka AM, Maryon EB, Kaplan JH. Human copper transporter hCTR1 mediates basolateral uptake of copper into enterocytes: implications for copper homeostasis. J Biol Chem 282: 26471-26480, 2007.