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Volumn 7, Issue 3, 2012, Pages 400-405

Huprine Derivatives as Sub-Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X-ray Crystallography

(7) Ronco, Cyril a,b Carletti, Eugénie c Colletier, Jacques Philippe c Weik, Martin c Nachon, Florian d Jean, Ludovic a,b Renard, Pierre Yves a,b,e

a Normandie Université (France)

b UNIVERSITÉ DE ROUEN (France)

c INSTITUT DE BIOLOGIE STRUCTURALE (France)

d INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES (France)

e INSTITUT UNIVERSITAIRE DE FRANCE (France)

Author keywords

Acetylcholinesterase; Huprines; Inhibitors; Molecular modeling; X ray crystallography

Indexed keywords

CHOLINESTERASE INHIBITOR; HUPRINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINOQUINOLINES; ANIMALS; BRAIN; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DOGS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MODELS, MOLECULAR; SOLUTIONS; STEREOISOMERISM; THERMODYNAMICS;

EID: 84857720222 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201100438 Document Type: Article

Times cited : (33)

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