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Volumn 46, Issue 6, 2011, Pages 2193-2205

New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation

(3) Rouleau, Julien a Iorga, Bogdan I a Guillou, Catherine a

a CNRS (France)

Author keywords

amyloid aggregation; Acetylcholinesterase inhibitors; Alzheimer's disease; Butyrylcholinesterase; Molecular modeling; N 3 Isobutyrylcycloxobuxidine F derivatives; Synthesis

Indexed keywords

[(3 METHOXYBENZYL)(METHYL)AMINO] 16ALPHA HYDROXY 4BETA,14ALPHA DIMETHYL 9,19 CYCLO [2' ISOPROPYL 5',6' DIHYDRO 4' ALPHAH [1',3']THIAZINO[4',5':3,4]] 5ALPHA,9BETA PREGNAN 11 ONE; ACETYLCHOLINE; AMYLOID BETA PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; OXAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HYDROPHOBICITY; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; PROTEIN AGGREGATION; PROTEIN PROTEIN INTERACTION;

ACETYLCHOLINESTERASE; AMYLOID BETA-PEPTIDES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 79955604149 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2011.02.073 Document Type: Article

Times cited : (38)

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