Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2003, Pages 1-4

  Savini, Luisa ^a   Gaeta, Alessandra ^a   Fattorusso, Caterina ^b   Catalanotti, Bruno ^b   Campiani, Giuseppe ^a   Chiasserini, Luisa ^a   Pellerano, Cesare ^a   Novellino, Ettore ^b   McKissic, Dawn ^c   Saxena, Ashima ^c  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DIVALENT CATION; NITROGEN; SULFUR DERIVATIVE; TACRINE DERIVATIVE;

ARTICLE; ATOM; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYPOTHESIS; MOLECULAR MODEL; MOLECULAR RECOGNITION; PROTEIN PROTEIN INTERACTION; VALIDATION PROCESS;

ACETYLCHOLINESTERASE; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 0037413568     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0255668     Document Type: Article

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