Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease

Journal of Medicinal Chemistry

Volumn 42, Issue 17, 1999, Pages 3227-3242

  Camps, Pelayo ^a   El Achab, Rachid ^a   Görbig, Diana Marina ^a   Morral, Jordi ^a   Muñoz Torrero, Diego ^a   Badia, Albert ^b   Baños, Josep Eladi ^b   Vivas, Nuria María ^b   Barril, Xavier ^a   Orozco, Modesto ^a   Luque, Francisco Javier ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; HUPERZINE A; QUINOLINE DERIVATIVE; TACRINE; TUBOCURARINE CHLORIDE;

ALZHEIMER DISEASE; ARTICLE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; MOLECULAR MODEL; REACTION ANALYSIS;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; CHOLINESTERASE INHIBITORS; DIAPHRAGM; MALE; MODELS, MOLECULAR; MUSCLE CONTRACTION; NEUROMUSCULAR JUNCTION; NEUROPROTECTIVE AGENTS; PHRENIC NERVE; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE; TORPEDO;

EID: 13044253491     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980620z     Document Type: Article

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