Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: Subnanomolar dual binding site acetylcholinesterase inhibitors

Journal of Medicinal Chemistry

Volumn 48, Issue 6, 2005, Pages 1701-1704

  Camps, Pelayo ^a   Formosa, Xavier ^a   Muñoz Torrero, Diego ^a   Petrignet, Julien ^a,c   Badia, Albert ^b   Clos, M Victòria ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITÉ DE LORRAINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; HUPERZINE A; HUPRINE Y; TACRINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; HUMAN; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; AMINOQUINOLINES; ANIMALS; BINDING SITES; BUTYRYLCHOLINESTERASE; CATTLE; CHOLINESTERASE INHIBITORS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 15444378025     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0496741     Document Type: Article

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