메뉴 건너뛰기




Volumn 88, Issue , 2012, Pages 115-140

Identification, Functional Characterization, and Pathobiological Significance of GLI1 Isoforms in Human Cancers

Author keywords

GLI1; GLI1 N; GLI2; Sonic Hedgehog; TGF ; TGLI1; VEGF A

Indexed keywords


EID: 84857700991     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394622-5.00006-7     Document Type: Chapter
Times cited : (21)

References (93)
  • 3
  • 4
    • 28344447457 scopus 로고    scopus 로고
    • CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis
    • Baumann P., Cremers N., Kroese F., Orend G., Chiquet-Ehrismann R., Uede T., Yagita H., Sleeman J.P. CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis. Cancer Res. 2005, 65:10783-10793.
    • (2005) Cancer Res. , vol.65 , pp. 10783-10793
    • Baumann, P.1    Cremers, N.2    Kroese, F.3    Orend, G.4    Chiquet-Ehrismann, R.5    Uede, T.6    Yagita, H.7    Sleeman, J.P.8
  • 5
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G., Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer 2003, 3:401-410.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 7
    • 59049104614 scopus 로고    scopus 로고
    • Protein kinase Cδ negatively regulates Hedgehog signaling by inhibition of Gli1 activity
    • Cai Q., Li J., Gao T., Xie J., Evers B.M. Protein kinase Cδ negatively regulates Hedgehog signaling by inhibition of Gli1 activity. J. Biol. Chem. 2009, 284:2150-2158.
    • (2009) J. Biol. Chem. , vol.284 , pp. 2150-2158
    • Cai, Q.1    Li, J.2    Gao, T.3    Xie, J.4    Evers, B.M.5
  • 8
    • 84855343985 scopus 로고    scopus 로고
    • Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells
    • Cao X., Geradts J., Dewhirst M.W., Lo H.W. Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. Oncogene 2012, 31:104-115.
    • (2012) Oncogene , vol.31 , pp. 104-115
    • Cao, X.1    Geradts, J.2    Dewhirst, M.W.3    Lo, H.W.4
  • 10
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • Clement V., Sanchez P., de Tribolet N., Radovanovic I., Ruiz i Altaba A. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 2007, 17:165-172.
    • (2007) Curr. Biol. , vol.17 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    de Tribolet, N.3    Radovanovic, I.4    Ruiz i Altaba, A.5
  • 11
    • 70949087325 scopus 로고    scopus 로고
    • Gli1 is a potential target for alleviating multidrug resistance of gliomas
    • Cui D., Xu Q., Wang K., Che X. Gli1 is a potential target for alleviating multidrug resistance of gliomas. J. Neurol. Sci. 2010, 288:156-166.
    • (2010) J. Neurol. Sci. , vol.288 , pp. 156-166
    • Cui, D.1    Xu, Q.2    Wang, K.3    Che, X.4
  • 13
    • 69249200489 scopus 로고    scopus 로고
    • The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin
    • Das S., Harris L.G., Metge B.J., Liu S., Riker A.I., Samant R.S., Shevde L.A. The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin. J. Biol. Chem. 2009, 284:22888-22897.
    • (2009) J. Biol. Chem. , vol.284 , pp. 22888-22897
    • Das, S.1    Harris, L.G.2    Metge, B.J.3    Liu, S.4    Riker, A.I.5    Samant, R.S.6    Shevde, L.A.7
  • 14
    • 34547120220 scopus 로고    scopus 로고
    • Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
    • Dennler S., Andre J., Alexaki I., Li A., Magnaldo T., ten Dijke P., Wang X.J., Verrecchia F., Mauviel A. Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 2007, 67:6981-6986.
    • (2007) Cancer Res. , vol.67 , pp. 6981-6986
    • Dennler, S.1    Andre, J.2    Alexaki, I.3    Li, A.4    Magnaldo, T.5    ten Dijke, P.6    Wang, X.J.7    Verrecchia, F.8    Mauviel, A.9
  • 16
    • 0038813753 scopus 로고    scopus 로고
    • Characterization of the physical interaction of Gli proteins with SUFU proteins
    • Dunaeva M., Michelson P., Kogerman P., Toftgard R. Characterization of the physical interaction of Gli proteins with SUFU proteins. J. Biol. Chem. 2003, 278:5116-5122.
    • (2003) J. Biol. Chem. , vol.278 , pp. 5116-5122
    • Dunaeva, M.1    Michelson, P.2    Kogerman, P.3    Toftgard, R.4
  • 17
    • 0029821890 scopus 로고    scopus 로고
    • Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
    • Epstein D.J., Marti E., Scott M.P., McMahon A.P. Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 1996, 122:2885-2894.
    • (1996) Development , vol.122 , pp. 2885-2894
    • Epstein, D.J.1    Marti, E.2    Scott, M.P.3    McMahon, A.P.4
  • 18
    • 66349097441 scopus 로고    scopus 로고
    • Development of mammary tumors by conditional expression of GLI1
    • Fiaschi M., Rozell B., Bergstrom A., Toftgard R. Development of mammary tumors by conditional expression of GLI1. Cancer Res. 2009, 69:4810-4817.
    • (2009) Cancer Res. , vol.69 , pp. 4810-4817
    • Fiaschi, M.1    Rozell, B.2    Bergstrom, A.3    Toftgard, R.4
  • 19
    • 0027728787 scopus 로고
    • Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: Some amplica do not include MDM2
    • Forus A., Florenes V.A., Maelandsmo G.M., Meltzer P.S., Fodstad O., Myklebost O. Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: Some amplica do not include MDM2. Cell Growth Differ. 1993, 4:1065-1070.
    • (1993) Cell Growth Differ. , vol.4 , pp. 1065-1070
    • Forus, A.1    Florenes, V.A.2    Maelandsmo, G.M.3    Meltzer, P.S.4    Fodstad, O.5    Myklebost, O.6
  • 21
    • 79251492356 scopus 로고    scopus 로고
    • Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells
    • Hsieh A., Ellsworth R., Hsieh D. Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells. J. Cell. Physiol. 2011, 226:1118-1127.
    • (2011) J. Cell. Physiol. , vol.226 , pp. 1118-1127
    • Hsieh, A.1    Ellsworth, R.2    Hsieh, D.3
  • 24
    • 0030795109 scopus 로고    scopus 로고
    • Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1
    • Hynes M., Stone D.M., Dowd M., Pitts-Meek S., Goddard A., Gurney A., Rosenthal A. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 1997, 19:15-26.
    • (1997) Neuron , vol.19 , pp. 15-26
    • Hynes, M.1    Stone, D.M.2    Dowd, M.3    Pitts-Meek, S.4    Goddard, A.5    Gurney, A.6    Rosenthal, A.7
  • 25
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev. 2001, 15:3059-3087.
    • (2001) Genes Dev. , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 26
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham P.W., Nakano Y., Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat. Rev. Genet. 2011, 12:393-406.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 27
    • 34347253037 scopus 로고    scopus 로고
    • Oncogenic KRAS activates Hedgehog signaling pathway in pancreatic cancer cells
    • Ji Z., Mei F.C., Xie J., Cheng X. Oncogenic KRAS activates Hedgehog signaling pathway in pancreatic cancer cells. J. Biol. Chem. 2007, 282:14048-14055.
    • (2007) J. Biol. Chem. , vol.282 , pp. 14048-14055
    • Ji, Z.1    Mei, F.C.2    Xie, J.3    Cheng, X.4
  • 28
    • 0032576777 scopus 로고    scopus 로고
    • Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    • Jiang J., Struhl G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 1998, 391:493-496.
    • (1998) Nature , vol.391 , pp. 493-496
    • Jiang, J.1    Struhl, G.2
  • 29
    • 0031019090 scopus 로고    scopus 로고
    • GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome
    • Kang S., Graham J.M., Olney A.H., Biesecker L.G. GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome. Nat. Genet. 1997, 15:266-268.
    • (1997) Nat. Genet. , vol.15 , pp. 266-268
    • Kang, S.1    Graham, J.M.2    Olney, A.H.3    Biesecker, L.G.4
  • 30
    • 32444449871 scopus 로고    scopus 로고
    • GLI transcription factors: Mediators of oncogenic Hedgehog signalling
    • Kasper M., Regl G., Frischauf A.M., Aberger F. GLI transcription factors: Mediators of oncogenic Hedgehog signalling. Eur. J. Cancer 2006, 42:437-445.
    • (2006) Eur. J. Cancer , vol.42 , pp. 437-445
    • Kasper, M.1    Regl, G.2    Frischauf, A.M.3    Aberger, F.4
  • 31
    • 77956574908 scopus 로고    scopus 로고
    • More than markers: Biological significance of cancer stem cell-defining molecules
    • Keysar S.B., Jimeno A. More than markers: Biological significance of cancer stem cell-defining molecules. Mol. Cancer Ther. 2010, 9:2450-2457.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2450-2457
    • Keysar, S.B.1    Jimeno, A.2
  • 32
    • 35349025857 scopus 로고    scopus 로고
    • Isolation of CD24(high) and CD24(low/-) cells from MCF-7: CD24 expression is positively related with proliferation, adhesion and invasion in MCF-7
    • Kim H.J., Kim J.B., Lee K.M., Shin I., Han W., Ko E., Bae J.Y., Noh D.Y. Isolation of CD24(high) and CD24(low/-) cells from MCF-7: CD24 expression is positively related with proliferation, adhesion and invasion in MCF-7. Cancer Lett. 2007, 258:98-108.
    • (2007) Cancer Lett. , vol.258 , pp. 98-108
    • Kim, H.J.1    Kim, J.B.2    Lee, K.M.3    Shin, I.4    Han, W.5    Ko, E.6    Bae, J.Y.7    Noh, D.Y.8
  • 33
    • 20444433526 scopus 로고    scopus 로고
    • Gli1 is important for medulloblastoma formation in Ptc1+/- mice
    • Kimura H., Stephen D., Joyner A., Curran T. Gli1 is important for medulloblastoma formation in Ptc1+/- mice. Oncogene 2005, 24:4026-4036.
    • (2005) Oncogene , vol.24 , pp. 4026-4036
    • Kimura, H.1    Stephen, D.2    Joyner, A.3    Curran, T.4
  • 34
    • 0025156778 scopus 로고
    • The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
    • Kinzler K.W., Vogelstein B. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell. Biol. 1990, 10:634-642.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 634-642
    • Kinzler, K.W.1    Vogelstein, B.2
  • 36
    • 0023930186 scopus 로고
    • The GLI gene is a member of the Kruppel family of zinc finger proteins
    • Kinzler K.W., Ruppert J.M., Bigner S.H., Vogelstein B. The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 1988, 332:371-374.
    • (1988) Nature , vol.332 , pp. 371-374
    • Kinzler, K.W.1    Ruppert, J.M.2    Bigner, S.H.3    Vogelstein, B.4
  • 39
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee J., Platt K.A., Censullo P., Ruiz i Altaba A. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 1997, 124:2537-2552.
    • (1997) Development , vol.124 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz i Altaba, A.4
  • 40
    • 70449366079 scopus 로고    scopus 로고
    • CD24 overexpression in cancer development and progression: A meta-analysis
    • Lee J.H., Kim S.H., Lee E.S., Kim Y.S. CD24 overexpression in cancer development and progression: A meta-analysis. Oncol. Rep. 2009, 22:1149-1156.
    • (2009) Oncol. Rep. , vol.22 , pp. 1149-1156
    • Lee, J.H.1    Kim, S.H.2    Lee, E.S.3    Kim, Y.S.4
  • 41
    • 31544480393 scopus 로고    scopus 로고
    • Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
    • Li X., Deng W., Nail C.D., Bailey S.K., Kraus M.H., Ruppert J.M., Lobo-Ruppert S.M. Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene 2006, 25:609-621.
    • (2006) Oncogene , vol.25 , pp. 609-621
    • Li, X.1    Deng, W.2    Nail, C.D.3    Bailey, S.K.4    Kraus, M.H.5    Ruppert, J.M.6    Lobo-Ruppert, S.M.7
  • 43
    • 58949100355 scopus 로고    scopus 로고
    • Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
    • Liao X., Siu M.K., Au C.W., Wong E.S., Chan H.Y., Ip P.P., Ngan H.Y., Cheung A.N. Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009, 30:131-140.
    • (2009) Carcinogenesis , vol.30 , pp. 131-140
    • Liao, X.1    Siu, M.K.2    Au, C.W.3    Wong, E.S.4    Chan, H.Y.5    Ip, P.P.6    Ngan, H.Y.7    Cheung, A.N.8
  • 44
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S., Dontu G., Mantle I.D., Patel S., Ahn N.S., Jackson K.W., Suri P., Wicha M.S. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 2006, 66:6063-6071.
    • (2006) Cancer Res. , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.S.5    Jackson, K.W.6    Suri, P.7    Wicha, M.S.8
  • 45
    • 35148832569 scopus 로고    scopus 로고
    • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
    • Lo H.W., Hsu S.C., Xia W., Cao X., Shih J.Y., Wei Y., Abbruzzese J.L., Hortobagyi G.N., Hung M.C. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res. 2007, 67:9066-9076.
    • (2007) Cancer Res. , vol.67 , pp. 9066-9076
    • Lo, H.W.1    Hsu, S.C.2    Xia, W.3    Cao, X.4    Shih, J.Y.5    Wei, Y.6    Abbruzzese, J.L.7    Hortobagyi, G.N.8    Hung, M.C.9
  • 46
    • 70149107047 scopus 로고    scopus 로고
    • A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion
    • Lo H.W., Zhu H., Cao X., Aldrich A., Ali-Osman F. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. Cancer Res. 2009, 69:6790-6798.
    • (2009) Cancer Res. , vol.69 , pp. 6790-6798
    • Lo, H.W.1    Zhu, H.2    Cao, X.3    Aldrich, A.4    Ali-Osman, F.5
  • 47
    • 55249090050 scopus 로고    scopus 로고
    • A first-in-human, first-in-class, phase (ph) I study of systemic Hedgehog (Hh) pathway antagonist, GDC-0449, in patients (pts) with advanced solid tumors
    • (Meeting Abstracts)
    • LoRusso P.M., Rudin C.M., Borad M.J., Vernillet L., Darbonne W.C., Mackey H., DiMartino J.F., de Sauvage F., Low J.A., Von Hoff D.D. A first-in-human, first-in-class, phase (ph) I study of systemic Hedgehog (Hh) pathway antagonist, GDC-0449, in patients (pts) with advanced solid tumors. J. Clin. Oncol. 2008, 26:3516. (Meeting Abstracts).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3516
    • LoRusso, P.M.1    Rudin, C.M.2    Borad, M.J.3    Vernillet, L.4    Darbonne, W.C.5    Mackey, H.6    DiMartino, J.F.7    de Sauvage, F.8    Low, J.A.9    Von Hoff, D.D.10
  • 49
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum L., Beachy P.A. The Hedgehog response network: Sensors, switches, and routers. Science 2004, 304:1755-1759.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 53
    • 77953163539 scopus 로고    scopus 로고
    • CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer
    • Meyer M.J., Fleming J.M., Lin A.F., Hussnain S.A., Ginsburg E., Vonderhaar B.K. CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. Cancer Res. 2010, 70:4624-4633.
    • (2010) Cancer Res. , vol.70 , pp. 4624-4633
    • Meyer, M.J.1    Fleming, J.M.2    Lin, A.F.3    Hussnain, S.A.4    Ginsburg, E.5    Vonderhaar, B.K.6
  • 56
    • 80955181031 scopus 로고    scopus 로고
    • The Hedgehog's tale: Developing strategies for targeting cancer
    • Ng J.M., Curran T. The Hedgehog's tale: Developing strategies for targeting cancer. Nat. Rev. Cancer 2011, 11:493-501.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 57
    • 58149506283 scopus 로고    scopus 로고
    • GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
    • Nolan-Stevaux O., Lau J., Truitt M.L., Chu G.C., Hebrok M., Fernandez-Zapico M.E., Hanahan D. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 2009, 23:24-36.
    • (2009) Genes Dev. , vol.23 , pp. 24-36
    • Nolan-Stevaux, O.1    Lau, J.2    Truitt, M.L.3    Chu, G.C.4    Hebrok, M.5    Fernandez-Zapico, M.E.6    Hanahan, D.7
  • 60
    • 0027423758 scopus 로고
    • Crystal structure of a five-finger GLI-DNA complex: New perspectives on zinc fingers
    • Pavletich N.P., Pabo C.O. Crystal structure of a five-finger GLI-DNA complex: New perspectives on zinc fingers. Science 1993, 261:1701-1707.
    • (1993) Science , vol.261 , pp. 1701-1707
    • Pavletich, N.P.1    Pabo, C.O.2
  • 63
    • 75049085593 scopus 로고    scopus 로고
    • A survey of glioblastoma genomic amplifications and deletions
    • Rao S.K., Edwards J., Joshi A.D., Siu I.M., Riggins G.J. A survey of glioblastoma genomic amplifications and deletions. J. Neurooncol. 2010, 96(2):169-179.
    • (2010) J. Neurooncol. , vol.96 , Issue.2 , pp. 169-179
    • Rao, S.K.1    Edwards, J.2    Joshi, A.D.3    Siu, I.M.4    Riggins, G.J.5
  • 64
    • 0027978368 scopus 로고
    • Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2
    • Reifenberger G., Reifenberger J., Ichimura K., Meltzer P.S., Collins V.P. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res. 1994, 54:4299-4303.
    • (1994) Cancer Res. , vol.54 , pp. 4299-4303
    • Reifenberger, G.1    Reifenberger, J.2    Ichimura, K.3    Meltzer, P.S.4    Collins, V.P.5
  • 66
    • 33645220566 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
    • Riobo N.A., Lu K., Ai X., Haines G.M., Emerson C.P. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc. Natl. Acad. Sci. USA 2006, 103:4505-4510.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 4505-4510
    • Riobo, N.A.1    Lu, K.2    Ai, X.3    Haines, G.M.4    Emerson, C.P.5
  • 71
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H., Hui C., Nakafuku M., Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 1997, 124:1313-1322.
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 72
    • 78650355900 scopus 로고    scopus 로고
    • The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: A potential mechanism of therapeutic resistance
    • Schreck K.C., Taylor P., Marchionni L., Gopalakrishnan V., Bar E.E., Gaiano N., Eberhart C.G. The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: A potential mechanism of therapeutic resistance. Clin. Cancer Res. 2010, 16:6060-6070.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 6060-6070
    • Schreck, K.C.1    Taylor, P.2    Marchionni, L.3    Gopalakrishnan, V.4    Bar, E.E.5    Gaiano, N.6    Eberhart, C.G.7
  • 75
    • 33644849523 scopus 로고    scopus 로고
    • Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal
    • Sheng T., Chi S., Zhang X., Xie J. Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal. J. Biol. Chem. 2006, 281:9-12.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9-12
    • Sheng, T.1    Chi, S.2    Zhang, X.3    Xie, J.4
  • 76
    • 47249159395 scopus 로고    scopus 로고
    • Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal
    • Shimokawa T., Tostar U., Lauth M., Palaniswamy R., Kasper M., Toftgard R., Zaphiropoulos P.G. Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal. J. Biol. Chem. 2008, 283:14345-14354.
    • (2008) J. Biol. Chem. , vol.283 , pp. 14345-14354
    • Shimokawa, T.1    Tostar, U.2    Lauth, M.3    Palaniswamy, R.4    Kasper, M.5    Toftgard, R.6    Zaphiropoulos, P.G.7
  • 77
    • 62649094925 scopus 로고    scopus 로고
    • A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
    • Stecca B., Ruiz i Altaba A. A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J. 2009, 28:663-676.
    • (2009) EMBO J. , vol.28 , pp. 663-676
    • Stecca, B.1    Ruiz i Altaba, A.2
  • 79
    • 0033561641 scopus 로고    scopus 로고
    • GLI gene expression in bone and soft tissue sarcomas of adult patients correlates with tumor grade
    • Stein U., Eder C., Karsten U., Haensch W., Walther W., Schlag P.M. GLI gene expression in bone and soft tissue sarcomas of adult patients correlates with tumor grade. Cancer Res. 1999, 59:1890-1895.
    • (1999) Cancer Res. , vol.59 , pp. 1890-1895
    • Stein, U.1    Eder, C.2    Karsten, U.3    Haensch, W.4    Walther, W.5    Schlag, P.M.6
  • 81
    • 70349786795 scopus 로고    scopus 로고
    • Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival
    • ten Haaf A., Bektas N., von Serenyi S., Losen I., Arweiler E., Hartmann A., Knuchel R., Dahl E. Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival. BMC Cancer 2009, 9:298.
    • (2009) BMC Cancer , vol.9 , pp. 298
    • ten Haaf, A.1    Bektas, N.2    von Serenyi, S.3    Losen, I.4    Arweiler, E.5    Hartmann, A.6    Knuchel, R.7    Dahl, E.8
  • 83
    • 0033754122 scopus 로고    scopus 로고
    • The sonic hedgehog-patched-gli pathway in human development and disease
    • Villavicencio E.H., Walterhouse D.O., Iannaccone P.M. The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 2000, 67:1047-1054.
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 1047-1054
    • Villavicencio, E.H.1    Walterhouse, D.O.2    Iannaccone, P.M.3
  • 85
    • 77957784479 scopus 로고    scopus 로고
    • Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia
    • Wang G., Zhang Z., Xu Z., Yin H., Bai L., Ma Z., Decoster M.A., Qian G., Wu G. Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia. Biochim. Biophys. Acta 2010, 1803:1359-1367.
    • (2010) Biochim. Biophys. Acta , vol.1803 , pp. 1359-1367
    • Wang, G.1    Zhang, Z.2    Xu, Z.3    Yin, H.4    Bai, L.5    Ma, Z.6    Decoster, M.A.7    Qian, G.8    Wu, G.9
  • 86
    • 0023429079 scopus 로고
    • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
    • Wong A.J., Bigner S.H., Bigner D.D., Kinzler K.W., Hamilton S.R., Vogelstein B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl. Acad. Sci. USA 1987, 84:6899-6903.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Bigner, D.D.3    Kinzler, K.W.4    Hamilton, S.R.5    Vogelstein, B.6
  • 90
    • 75749139262 scopus 로고    scopus 로고
    • Activation of the hedgehog-signaling pathway in human cancer and the clinical implications
    • Yang L., Xie G., Fan Q., Xie J. Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 2010, 29:469-481.
    • (2010) Oncogene , vol.29 , pp. 469-481
    • Yang, L.1    Xie, G.2    Fan, Q.3    Xie, J.4
  • 91
    • 0037085379 scopus 로고    scopus 로고
    • Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation
    • Yoon J.W., Kita Y., Frank D.J., Majewski R.R., Konicek B.A., Nobrega M.A., Jacob H., Walterhouse D., Iannaccone P. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J. Biol. Chem. 2002, 277:5548-5555.
    • (2002) J. Biol. Chem. , vol.277 , pp. 5548-5555
    • Yoon, J.W.1    Kita, Y.2    Frank, D.J.3    Majewski, R.R.4    Konicek, B.A.5    Nobrega, M.A.6    Jacob, H.7    Walterhouse, D.8    Iannaccone, P.9
  • 92
    • 77955428416 scopus 로고    scopus 로고
    • NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53
    • Zbinden M., Duquet A., Lorente-Trigos A., Ngwabyt S.N., Borges I., Ruiz i Altaba A. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. EMBO J. 2010, 29:2659-2674.
    • (2010) EMBO J. , vol.29 , pp. 2659-2674
    • Zbinden, M.1    Duquet, A.2    Lorente-Trigos, A.3    Ngwabyt, S.N.4    Borges, I.5    Ruiz i Altaba, A.6
  • 93
    • 77953661272 scopus 로고    scopus 로고
    • The human glioma-associated oncogene homolog 1 (GLI1) family of transcription factors in gene regulation and diseases
    • Zhu H., Lo H.-W. The human glioma-associated oncogene homolog 1 (GLI1) family of transcription factors in gene regulation and diseases. Curr. Genomics 2010, 11:238-245.
    • (2010) Curr. Genomics , vol.11 , pp. 238-245
    • Zhu, H.1    Lo, H.-W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.