Recent advances in gut nutrient chemosensing

Current Medicinal Chemistry

Volumn 19, Issue 1, 2012, Pages 28-34

  Nguyen, C A ^a   Akiba, Y ^a,b,c   Kaunitz, J D ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amino acids; Bile acids; Cholecystokinin; Diabetes; Enteroendocrine cells; Fatty acids; G Protein coupled receptors; Glucagon like peptide; Gut hormones; Metabotropic glutamate receptor; Obesity; SGLT1; TIR2 TIR3; Transgenic mice

Indexed keywords

ACID SENSING ION CHANNEL; BILE ACID; CALCIMIMETIC AGENT; CALCIUM SENSING RECEPTOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; GASTRIC INHIBITORY POLYPEPTIDE; INCRETIN; METABOTROPIC RECEPTOR; N OLEOYLETHANOLAMINE; SODIUM GLUCOSE COTRANSPORTER 1;

APPETITE; ARTICLE; BITTER TASTE; CALCIUM METABOLISM; CELL ISOLATION; ENTEROENDOCRINE CELL; FLUORESCENCE ACTIVATED CELL SORTING; FOOD INTAKE; GASTRIN RELEASE; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL SECRETION; GASTROINTESTINAL TRACT; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN DEGRADATION; SAVORY; SIGNAL TRANSDUCTION; STOMACH ACID SECRETION; SWEETNESS; TASTE BUD;

EID: 84857562898     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712803414033     Document Type: Article

References (90)

1. Naito, Y. and Yoshikawa, T. Oxidative stress involvement and gene expression in indomethacin-induced gastropathy. Redox.Rep 2006, 11(6), 243-253 (Pubitemid 46062349)
2. Layer, P., Holst, J.J., Grandt, D., and Goebell, H. Ileal release of glucagonlike peptide-1 (GLP-1). Association with inhibition of gastric acid secretion in humans. Dig Dis Sci 1995, 40(5), 1074-1082
3. Dumoulin, V., Moro, F., Barcelo, A., Dakka, T., and Cuber, J.C. Peptide YY, glucagon-like peptide-1, and neurotensin responses to luminal factors in the isolated vascularly perfused rat ileum. Endocrinol. 1998, 139(9), 3780-3786 (Pubitemid 28512258)
4. Sternini, C., Anselmi, L., and Rozengurt, E. Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. Curr Opin Endocrinol.Diabetes Obes. 2008, 15(1), 73-78
5. Engelstoft, M.S., Egerod, K.L., Holst, B., and Schwartz, T.W. A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab 2008, 8(6), 447-449
6. Zhu, X., Hart, R., Chang, M.S., Kim, J.W., Lee, S.Y., Cao, Y.A., Mock, D., Ke, E., Saunders, B., Alexander, A., Grossoehme, J., Lin, K.M., Yan, Z., Hsueh, R., Lee, J., Scheuermann, R.H., Fruman, D.A., Seaman, W., Subramaniam, S., Sternweis, P., Simon, M.I., and Choi, S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol. 2004, 173(12), 7141-7149 (Pubitemid 39628149)
7. Polouliakh, N., Nock, R., Nielsen, F., and Kitano, H. G-protein coupled receptor signaling architecture of mammalian immune cells. PLoS.ONE. 2009, 4(1), e4189
8. McLaughlin, J.T., Lomax, R.B., Hall, L., Dockray, G.J., Thompson, D.G., and Warhurst, G. Fatty acids stimulate cholecystokinin secretion via an acyl chain length-specific, Ca2+-dependent mechanism in the enteroendocrine cell line STC-1. J Physiol 1998, 513 ( Pt 1)), 11-18 (Pubitemid 28528562)
9. Hopman, W.P., Jansen, J.B., Rosenbusch, G., and Lamers, C.B. Effect of equimolar amounts of long-chain triglycerides and medium-chain triglycerides on plasma cholecystokinin and gallbladder contraction. Am J Clin Nutr 1984, 39(3), 356-359 (Pubitemid 14154618)
10. Gautier, J.F., Choukem, S.P., and Girard, J. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes Metab 2008, 34 Suppl 2), S65-S72 (Pubitemid 352014865)
11. Estall, J.L. and Drucker, D.J. Glucagon-like Peptide-2. Annu.Rev.Nutr 2006, 26), 391-411
12. Wynne, K. and Bloom, S.R. The role of oxyntomodulin and peptide tyrosinetyrosine (PYY) in appetite control. Nat.Clin Pract.Endocrinol Metab 2006, 2(11), 612-620 (Pubitemid 44691297)
13. Reimann, F., Habib, A.M., Tolhurst, G., Parker, H.E., Rogers, G.J., and Gribble, F.M. Glucose sensing in L cells: a primary cell study. Cell Metab 2008, 8(6), 532-539
14. Samuel, B.S., Shaito, A., Motoike, T., Rey, F.E., Backhed, F., Manchester, J.K., Hammer, R.E., Williams, S.C., Crowley, J., Yanagisawa, M., and Gordon, J.I. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A 2008, 105(43), 16767-16772
15. Hofer, D. and Drenckhahn, D. Localisation of actin, villin, fimbrin, ezrin and ankyrin in rat taste receptor cells. Histochem Cell Biol 1999, 112(1), 79-86 (Pubitemid 29356307)
16. Adler, E., Hoon, M.A., Mueller, K.L., Chandrashekar, J., Ryba, N.J., and Zuker, C.S. A novel family of mammalian taste receptors. Cell 2000, 100(6), 693-702
17. Kinnamon, S.C. and Cummings, T.A. Chemosensory transduction mechanisms in taste. Annu.Rev.Physiol 1992, 54), 715-731
18. Geraedts, M.C., Troost, F.J., and Saris, W.H. Gastrointestinal targets to modulate satiety and food intake. Obes Rev. 2011, 12(6), 470-477
19. Chen, M.C., Wu, S.V., Reeve, J.R., Jr., and Rozengurt, E. Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels. Am J Physiol Cell Physiol 2006, 291(4), C726-C739 (Pubitemid 44497598)
20. Chandrashekar, J., Hoon, M.A., Ryba, N.J., and Zuker, C.S. The receptors and cells for mammalian taste. Nature 2006, 444(7117), 288-294 (Pubitemid 44764097)
21. Hofer, D., Puschel, B., and Drenckhahn, D. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci U.S A 1996, 93(13), 6631-6634
22. McLaughlin, S.K., McKinnon, P.J., and Margolskee, R.F. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 1992, 357(6379), 563-569
23. Jang, H.J., Kokrashvili, Z., Theodorakis, M.J., Carlson, O.D., Kim, B.J., Zhou, J., Kim, H.H., Xu, X., Chan, S.L., Juhaszova, M., Bernier, M., Mosinger, B., Margolskee, R.F., and Egan, J.M. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 2007, 104(38), 15069-15074 (Pubitemid 47619594)
24. Max, M., Shanker, Y.G., Huang, L., Rong, M., Liu, Z., Campagne, F., Weinstein, H., Damak, S., and Margolskee, R.F. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat.Genet 2001, 28(1), 58-63 (Pubitemid 32405818)
25. Montmayeur, J.P., Liberles, S.D., Matsunami, H., and Buck, L.B. A candidate taste receptor gene near a sweet taste locus. Nat.Neurosci 2001, 4(5), 492-498 (Pubitemid 32397186)
26. Nelson, G., Hoon, M.A., Chandrashekar, J., Zhang, Y., Ryba, N.J., and Zuker, C.S. Mammalian sweet taste receptors. Cell 2001, 106(3), 381-390 (Pubitemid 32772621)
27. Wong, G.T., Gannon, K.S., and Margolskee, R.F. Transduction of bitter and sweet taste by gustducin. Nature 1996, 381(6585), 796-800 (Pubitemid 26243121)
28. Fujita, Y., Wideman, R.D., Speck, M., Asadi, A., King, D.S., Webber, T.D., Haneda, M., and Kieffer, T.J. Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. Am J Physiol Endocrinol Metab 2009, 296(3), E473-E479
29. Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M., and Adler, E. Human receptors for sweet and umami taste. Proc Natl Acad Sci U.S A 2002, 99(7), 4692-4696 (Pubitemid 34286046)
30. Zhang, F., Klebansky, B., Fine, R.M., Xu, H., Pronin, A., Liu, H., Tachdjian, C., and Li, X. Molecular mechanism for the umami taste synergism. Proc Natl Acad Sci U S A 2008, 105(52), 20930-20934
31. Margolskee, R.F. Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem 2002, 277(1), 1-4 (Pubitemid 34952019)
32. Chandrashekar, J., Mueller, K.L., Hoon, M.A., Adler, E., Feng, L., Guo, W., Zuker, C.S., and Ryba, N.J. T2Rs function as bitter taste receptors. Cell 2000, 100(6), 703-711
33. ndres-Barquin, P.J. and Conte, C. Molecular basis of bitter taste: the T2R family of G protein-coupled receptors. Cell Biochem Biophys 2004, 41(1), 99-112 (Pubitemid 41270770)
34. Fredriksson, R., Lagerstrom, M.C., Lundin, L.G., and Schioth, H.B. The Gprotein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 2003, 63(6), 1256-1272 (Pubitemid 36627220)
35. Kroeze, W.K., Sheffler, D.J., and Roth, B.L. G-protein-coupled receptors at a glance. J Cell Sci 2003, 116(Pt 24), 4867-4869 (Pubitemid 38016693)
36. Brauner-Osborne, H., Wellendorph, P., and Jensen, A.A. Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr Drug Targets. 2007, 8(1), 169-184 (Pubitemid 46049458)
37. Choi, S., Lee, M., Shiu, A.L., Yo, S.J., and Aponte, G.W. Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes. Am J Physiol Gastrointest Liver Physiol 2007, 292(1), G98-G112 (Pubitemid 46090256)
38. Cordier-Bussat, M., Bernard, C., Levenez, F., Klages, N., Laser-Ritz, B., Philippe, J., Chayvialle, J.A., and Cuber, J.C. Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene. Diabetes 1998, 47(7), 1038-1045 (Pubitemid 28294545)
39. Lagerstrom, M.C. and Schioth, H.B. Structural diversity of G proteincoupled receptors and significance for drug discovery. Nat.Rev.Drug Discov. 2008, 7(4), 339-357
40. Akiba, Y., Watanabe, C., Mizumori, M., and Kaunitz, J.D. Luminal Lglutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am J Physiol Gastrointest Liver Physiol 2009, 297), G781-G791
41. McArthur, K.E., Isenberg, J.I., Hogan, D.L., and Dreier, S.J. Intravenous infusion of L-isomers of phenylalanine and tryptophan stimulate gastric acid secretion at physiologic plasma concentrations in normal subjects and after parietal cell vagotomy. J Clin Invest 1983, 71(5), 1254-1262 (Pubitemid 13098912)
42. Schubert, M.L. and Peura, D.A. Control of gastric acid secretion in health and disease. Gastroenterology 2008, 134(7), 1842-1860 (Pubitemid 351783299)
43. Levant, J.A., Walsh, J.H., and Isenberg, J.I. Stimulation of gastric secretion and gastrin release by single oral doses of calcium carbonate in man. N Engl.J Med 1973, 289(11), 555-558
44. Feng, J., Petersen, C.D., Coy, D.H., Jiang, J.K., Thomas, C.J., Pollak, M.R., and Wank, S.A. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Proc Natl Acad Sci U S A 2010, 107(41), 17791-17796
45. Busque, S.M., Kerstetter, J.E., Geibel, J.P., and Insogna, K. L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Am J Physiol Gastrointest Liver Physiol 2005, 289(4), G664-G669 (Pubitemid 41377172)
46. Geibel, J.P. and Hebert, S.C. The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract. Annu.Rev.Physiol 2009, 71), 205-217
47. Andersson, S. Inhibitory effects of hydrochloric acid in the duodenum on gastrin-stimulated gastric secretion in Heidenhain pouch dogs. Acta Physiol Scand 1960, 50), 105-112
48. Akiba, Y. and Kaunitz, J.D. Duodenal chemosensing: Master control for epigastric sensation? J Gastroenterol Hepatol 2011, 26(1), 6-7
49. Conigrave, A.D., Quinn, S.J., and Brown, E.M. L-amino acid sensing by the extracellular Ca2+-sensing receptor. Proc Natl Acad Sci U S A 2000, 97(9), 4814-4819 (Pubitemid 30238640)
50. Christiansen, B., Hansen, K.B., Wellendorph, P., and Brauner-Osborne, H. Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations. Br J Pharmacol 2007, 150(6), 798-807 (Pubitemid 46440209)
51. Nakamura, E., Hasumura, M., San, G.A., Uneyama, H., and Torii, K. New frontiers in gut nutrient sensor research: luminal glutamate-sensing cells in rat gastric mucosa. J Pharmacol Sci 2010, 112(1), 13-18
52. Nelson, G., Chandrashekar, J., Hoon, M.A., Feng, L., Zhao, G., Ryba, N.J., and Zuker, C.S. An amino-acid taste receptor. Nature 2002, 416(6877), 199-202 (Pubitemid 34246480)
53. Akiba, Y. and Kaunitz, J.D. Luminal chemosensing in the duodenal mucosa. Acta Physiol (Oxf) 2010
54. Thompson, A.L., Lim-Fraser, M.Y., Kraegen, E.W., and Cooney, G.J. Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro. Am J Physiol Endocrinol Metab 2000, 279(3), E577-E584
55. Le, P.E., Loison, C., Struyf, S., Springael, J.Y., Lannoy, V., Decobecq, M.E., Brezillon, S., Dupriez, V., Vassart, G., Van, D.J., Parmentier, M., and Detheux, M. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 2003, 278(28), 25481-25489 (Pubitemid 36835299)
56. Ge, H., Li, X., Weiszmann, J., Wang, P., Baribault, H., Chen, J.L., Tian, H., and Li, Y. Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinol. 2008, 149(9), 4519-4526
57. Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M.A., Motoike, T., Kedzierski, R.M., and Yanagisawa, M. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A 2004, 101(4), 1045-1050 (Pubitemid 38160581)
58. Brown, A.J., Goldsworthy, S.M., Barnes, A.A., Eilert, M.M., Tcheang, L., Daniels, D., Muir, A.I., Wigglesworth, M.J., Kinghorn, I., Fraser, N.J., Pike, N.B., Strum, J.C., Steplewski, K.M., Murdock, P.R., Holder, J.C., Marshall, F.H., Szekeres, P.G., Wilson, S., Ignar, D.M., Foord, S.M., Wise, A., and Dowell, S.J. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 2003, 278(13), 11312-11319 (Pubitemid 36792688)
59. Briscoe, C.P., Tadayyon, M., Andrews, J.L., Benson, W.G., Chambers, J.K., Eilert, M.M., Ellis, C., Elshourbagy, N.A., Goetz, A.S., Minnick, D.T., Murdock, P.R., Sauls, H.R., Jr., Shabon, U., Spinage, L.D., Strum, J.C., Szekeres, P.G., Tan, K.B., Way, J.M., Ignar, D.M., Wilson, S., and Muir, A.I. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 2003, 278(13), 11303-11311 (Pubitemid 36792687)
60. Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., Tanaka, H., Maruyama, M., Satoh, R., Okubo, S., Kizawa, H., Komatsu, H., Matsumura, F., Noguchi, Y., Shinohara, T., Hinuma, S., Fujisawa, Y., and Fujino, M. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 2003, 422(6928), 173-176 (Pubitemid 36362750)
61. Edfalk, S., Steneberg, P., and Edlund, H. Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes 2008, 57(9), 2280-2287
62. Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., and Tsujimoto, G. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat.Med 2005, 11(1), 90-94 (Pubitemid 40215843)
63. Parker, H.E., Habib, A.M., Rogers, G.J., Gribble, F.M., and Reimann, F. Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia 2009, 52(2), 289-298
64. Sidhu, S.S., Thompson, D.G., Warhurst, G., Case, R.M., and Benson, R.S. Fatty acid-induced cholecystokinin secretion and changes in intracellular Ca2+ in two enteroendocrine cell lines, STC-1 and GLUTag. J Physiol 2000, 528 Pt 1), 165-176
65. Hara, T., Hirasawa, A., Ichimura, A., Kimura, I., and Tsujimoto, G. Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders. J Pharm Sci 2011
66. Overton, H.A., Babbs, A.J., Doel, S.M., Fyfe, M.C., Gardner, L.S., Griffin, G., Jackson, H.C., Procter, M.J., Rasamison, C.M., Tang-Christensen, M., Widdowson, P.S., Williams, G.M., and Reynet, C. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 2006, 3(3), 167-175
67. Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., and Tanaka, K. Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun 2002, 298(5), 714-719 (Pubitemid 35356798)
68. Katsuma, S., Hirasawa, A., and Tsujimoto, G. Bile acids promote glucagonlike peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophys Res Commun 2005, 329(1), 386-390 (Pubitemid 40255465)
69. Maruyama, T., Tanaka, K., Suzuki, J., Miyoshi, H., Harada, N., Nakamura, T., Miyamoto, Y., Kanatani, A., and Tamai, Y. Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. J Endocrinol 2006, 191(1), 197-205 (Pubitemid 44756522)
70. Ohneda, A., Parada, E., Eisentraut, A.M., and Unger, R.H. Characterization of response of circulating glucagon to intraduodenal and intravenous administration of amino acids. J Clin Invest 1968, 47(10), 2305-2322
71. Bezencon, C., le, C.J., and Damak, S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 2007, 32(1), 41-49 (Pubitemid 46017873)
72. Sutto, Z., Conner, G.E., and Salathe, M. Regulation of human airway ciliary beat frequency by intracellular pH. J Physiol 2004, 560(Pt 2), 519-532 (Pubitemid 39440112)
73. Shirazi-Beechey, S.P., Hirayama, B.A., Wang, Y., Scott, D., Smith, M.W., and Wright, E.M. Ontogenic development of lamb intestinal sodium-glucose co-transporter is regulated by diet. J Physiol 1991, 437), 699-708
74. Dyer, J., Hosie, K.B., and Shirazi-Beechey, S.P. Nutrient regulation of human intestinal sugar transporter (SGLT1) expression. Gut 1997, 41(1), 56-59 (Pubitemid 27351640)
75. Moriya, R., Shirakura, T., Ito, J., Mashiko, S., and Seo, T. Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. Am J Physiol Endocrinol Metab 2009, 297(6), E1358-E1365
76. Margolskee, R.F., Dyer, J., Kokrashvili, Z., Salmon, K.S., Ilegems, E., Daly, K., Maillet, E.L., Ninomiya, Y., Mosinger, B., and Shirazi-Beechey, S.P. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U.S A 2007, 104(38), 15075-15080 (Pubitemid 47619595)
77. Holst, J.J. and Gromada, J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab 2004, 287(2), E199-E206 (Pubitemid 38943883)
78. Gallwitz, B. The evolving place of incretin-based therapies in type 2 diabetes. Pediatr Nephrol. 2010, 25(7), 1207-1217
79. Brown, E.M. Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR). Biochem Pharmacol 2010, 80(3), 297-307
80. Behar, J., Hitchings, M., and Smyth, R.D. Calcium stimulation of gastrin and gastric acid secretion: effect of small doses of calcium carbonate. Gut 1977, 18(6), 442-448 (Pubitemid 8139293)
81. Nayeb-Hashemi, H. and Kaunitz, J.D. Gastroduodenal mucosal defense. Curr Opin Gastroenterol 2009, 25(6), 537-543
82. Laine, L., Takeuchi, K., and Tarnawski, A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 2008, 135(1), 41-60 (Pubitemid 351899027)
83. Mizumori, M., Choi, Y., Guth, P.H., Engel, E., Kaunitz, J.D., and Akiba, Y. CFTR inhibition augments NHE3 activity during luminal high CO2 exposure in rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol 2008, 294(6), G1318-G1327
84. Mizumori, M., Meyerowitz, J., Takeuchi, T., Lim, S., Lee, P., Supuran, C.T., Guth, P.H., Engel, E., Kaunitz, J.D., and Akiba, Y. Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa. J Physiol 2006, 573(Pt 3), 827-842 (Pubitemid 43842519)
85. Jacobs, M.H. and Stewart, D.R. The role of carbonic anhydrases in certain ionic exchanges involving the erythrocyte. J.Gen.Physiol 1942, 25), 539-552
86. Ham, M., Mizumori, M., Watanabe, C., Wang, J.H., Inoue, T., Nakano, T., Guth, P.H., Engel, E., Kaunitz, J.D., Akiba, Y. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. J Pharmacol Exp Ther 2010, 335: 607-613.
87. Medjane, S., Raymond, B., Wu, Y., and Touqui, L. Impact of CFTR DeltaF508 mutation on prostaglandin E2 production and type IIA phospholipase A2 expression by pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol 2005, 289(5), L816-L824 (Pubitemid 41504413)
88. Akiba, Y., Mizumori, M., Guth, P.H., Engel, E., and Kaunitz, J.D. Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats. Am.J.Physiol Gastrointest.Liver Physiol 2007, 293(6), G1223-G1233 (Pubitemid 350255037)
89. Delzenne, N., Blundell, J., Brouns, F., Cunningham, K., De, G.K., Erkner, A., Lluch, A., Mars, M., Peters, H.P., and Westerterp-Plantenga, M. Gastrointestinal targets of appetite regulation in humans. Obes Rev. 2010, 11(3), 234-250
90. Rindi, G., Leiter, A.B., Kopin, A.S., Bordi, C., and Solcia, E. The "normal" endocrine cell of the gut: changing concepts and new evidences. Ann N Y Acad Sci 2004, 1014), 1-12 (Pubitemid 38594786)