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2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion
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Description of ecto-purinergic regulation of duodenal bicarbonate secretion
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2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 2009; 296:G424-G432. Description of ecto-purinergic regulation of duodenal bicarbonate secretion.
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Dong, X.1
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Gender specific protection of estrogen against gastric acid-induced duodenal injury: Stimulation of duodenal mucosal bicarbonate secretion
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Well performed mechanistic study of the effect of estrogens on duodenal bicarbonate secretion performed in mice
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Smith A, Contreras C, Ko KH, et al. Gender specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion. Endocrinol 2008; 149:4554-4566. Well performed mechanistic study of the effect of estrogens on duodenal bicarbonate secretion performed in mice.
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Smith, A.1
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Estrogen and isoflavone attenuate stress-induced gastric mucosal injury by inhibiting decreases in gastric tissue levels of CGRP in ovariectomized rats
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Shimozawa N, Okajima K, Harada N. Estrogen and isoflavone attenuate stress-induced gastric mucosal injury by inhibiting decreases in gastric tissue levels of CGRP in ovariectomized rats. Am J Physiol Gastrointest Liver Physiol 2007; 292:G615-G619.
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Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications
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Lanza, F.L.1
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12
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47249103379
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Lansoprazole protects and heals gastric mucosa from nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal
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In-depth study of the mechanism of lanzoprazole gastroprotection possibly unrelated to its antisecretory properties
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Maity P, Bindu S, Choubey V, et al. Lansoprazole protects and heals gastric mucosa from nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal. J Biol Chem 2008; 283: 14391-14401. In-depth study of the mechanism of lanzoprazole gastroprotection possibly unrelated to its antisecretory properties.
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Maity, P.1
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Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug
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Uejima, M.1
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Kataoka, K.3
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14
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38549158018
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Nonsteroidal anti-inflammatory druginduced small intestinal damage is Toll-like receptor 4 dependent
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NSAID-induced small intestinal damage may be modified by innate immune responses including toll-like receptor signaling
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Watanabe T, Higuchi K, Kobata A, et al. Nonsteroidal anti-inflammatory druginduced small intestinal damage is Toll-like receptor 4 dependent. Gut 2008; 57:181-187. NSAID-induced small intestinal damage may be modified by innate immune responses including toll-like receptor signaling.
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Watanabe, T.1
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15
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0025785964
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Properties of the descending limb of the spinobulbospinal micturition reflex pathway in the cat
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Kruse, M.N.1
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Noto, H.3
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16
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53449097279
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Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7
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Describes a unique and well described mechanism gastric injury from aspirin via tight junction disruption
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Oshima T, Miwa H, Joh T. Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7. Am J Physiol Cell Physiol 2008; 295:C800-C806. Describes a unique and well described mechanism gastric injury from aspirin via tight junction disruption.
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Am J Physiol Cell Physiol
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Oshima, T.1
Miwa, H.2
Joh, T.3
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The protective effect of rebamipide on paracellular permeability of rat gastric epithelial cells
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Joh, T.1
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Ghrelin protects against ethanol-induced gastric ulcers in rats: Studies on the mechanisms of action
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Sibilia, V.1
Rindi, G.2
Pagani, F.3
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19
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44349100318
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Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk
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Interesting study on the interrelations between ghrelin, COX activity, the nitric oxide pathway, and gastroprotection
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Sibilia V, Pagani F, Rindi G, et al. Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk. Br J Pharmacol 2008; 154:688-697. Interesting study on the interrelations between ghrelin, COX activity, the nitric oxide pathway, and gastroprotection.
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Br J Pharmacol
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Sibilia, V.1
Pagani, F.2
Rindi, G.3
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20
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Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A
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Bengtsson MW, Makela K, Sjoblom M, et al. Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A. Am J Physiol Gastrointest Liver Physiol 2007; 293: G501-G509.
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Bengtsson, M.W.1
Makela, K.2
Sjoblom, M.3
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21
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41749120775
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Effect of orexin-a on ischemia-reperfusioninduced gastric damage in rats
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Orexin-A exhibits a gastroprotective effect by decreasing neutrophil activation and lipid peroxidation
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Bülbül M, Tan R, Gemici B, et al. Effect of orexin-a on ischemia-reperfusioninduced gastric damage in rats. J Gastroenterol 2008; 43:202-207. Orexin-A exhibits a gastroprotective effect by decreasing neutrophil activation and lipid peroxidation.
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Bülbül, M.1
Tan, R.2
Gemici, B.3
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22
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44349090953
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Gastroprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory afferent neuropeptides and nitric oxide
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Another study on the gastroprotective effects of orexin invoking well described protective mechanisms
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Brzozowski T, Konturek PC, Sliwowski Z, et al. Gastroprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory afferent neuropeptides and nitric oxide. Regul Pept 2008; 148:6-20. Another study on the gastroprotective effects of orexin invoking well described protective mechanisms.
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Regul Pept
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Brzozowski, T.1
Konturek, P.C.2
Sliwowski, Z.3
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23
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CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo
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Rad R, Brenner L, Bauer S, et al. CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo. Gastroenterology 2006; 131:525-537.
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Rad, R.1
Brenner, L.2
Bauer, S.3
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24
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52649153066
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Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
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Insightful and original study of the connection between Helicobacter pylori infection and ulcer diseases invoking the immune system
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Robinson K, Kenefeck R, Pidgeon EL, et al. Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut 2008; 57:1375-1385. Insightful and original study of the connection between Helicobacter pylori infection and ulcer diseases invoking the immune system.
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Gut
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Robinson, K.1
Kenefeck, R.2
Pidgeon, E.L.3
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25
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38649132571
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Helicobacter pylori gastritis in children is associated with a regulatory T-cell response
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Another study relating to H. pylori infection-related ulcer disease to the immune system
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Harris PR, Wright SW, Serrano C, et al. Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 2008; 134:491-499. Another study relating to H. pylori infection-related ulcer disease to the immune system.
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Gastroenterology
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, pp. 491-499
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Harris, P.R.1
Wright, S.W.2
Serrano, C.3
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26
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2442502597
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Helicobacter pylori interacts with the human single-domain trefoil protein TFF1
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Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis
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Vinall, L.E.1
King, M.2
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28
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57249086245
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Helicobacter pylori lipopolysaccharide interacts with TFF1 in a pH-dependent manner
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2054. Helicobacter pylori binding to TFF1 occurs in a pH dependent manner possibly acting a secreted decoy molecule preventing bacterial adhesion to gastric epithelial cells
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Reeves EP, Ali T, Leonard P, et al. Helicobacter pylori lipopolysaccharide interacts with TFF1 in a pH-dependent manner. Gastroenterology 2008; 135:2043-2054; 2054. Helicobacter pylori binding to TFF1 occurs in a pH dependent manner possibly acting a secreted decoy molecule preventing bacterial adhesion to gastric epithelial cells.
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Gastroenterology
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Reeves, E.P.1
Ali, T.2
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The spatial orientation of Helicobacter pylori in the gastric mucus
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Schreiber S, Konradt M, Groll C, et al. The spatial orientation of Helicobacter pylori in the gastric mucus. Proc Natl Acad Sci U S A 2004; 101:5024-5029.
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30
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34848919161
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Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis
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McGuckin MA, Every AL, Skene CD, et al. Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology 2007; 133:1210-1218.
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McGuckin, M.A.1
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Skene, C.D.3
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31
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41849088814
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Peroxiredoxin;1; I protects gastric mucosa from oxidative injury induced by H. Pylori infection
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Peroxiredoxin upregulation in H. pylori infection plays a gastroprotective role by reduction in oxidative injury
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Sato D, Yanaka A, Shibahara T, et al. Peroxiredoxin;1; I protects gastric mucosa from oxidative injury induced by H. pylori infection. J Gastroenterol Hepatol 2008; 23:652-659. Peroxiredoxin upregulation in H. pylori infection plays a gastroprotective role by reduction in oxidative injury.
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Sato, D.1
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32
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42049096735
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Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse model
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Metallothionein prevents H. pylori-induced gastric erosions by neutralization of ROS
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Mita M, Satoh M, Shimada A, et al. Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse model. Am J Physiol Gastrointest Liver Physiol 2008; 294:G877-G884. Metallothionein prevents H. pylori-induced gastric erosions by neutralization of ROS.
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Mita, M.1
Satoh, M.2
Shimada, A.3
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33
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59849102721
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Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation
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Helicobacter pylori alters membrane-bound occludins leading to disruption of gastric epithelial integrity
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Wroblewski LE, Shen L, Ogden S, et al. Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology 2009; 136:236-246. Helicobacter pylori alters membrane-bound occludins leading to disruption of gastric epithelial integrity.
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Wroblewski, L.E.1
Shen, L.2
Ogden, S.3
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34
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61849098796
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Helicobacter pylori vacuolating cytotoxin inhibits duodenal bicarbonate secretion by a histamine-dependent mechanism in mice
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Another means by which H. pylori can impair mucosal defensive mechanisms
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Tuo B, Song P, Wen G, et al. Helicobacter pylori vacuolating cytotoxin inhibits duodenal bicarbonate secretion by a histamine-dependent mechanism in mice. J Infect Dis 2009; 199:505-512. Another means by which H. pylori can impair mucosal defensive mechanisms.
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Tuo, B.1
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Differential regulation of ERK1/2 and p38 MAP kinases in VacA-induced apoptosis of gastric epithelial cells
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Ki MR, Lee HR, Goo MJ, et al. Differential regulation of ERK1/2 and p38 MAP kinases in VacA-induced apoptosis of gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol 2008; 294:G635-G647.
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Ki, M.R.1
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Goo, M.J.3
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36
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57449107624
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Novel single nucleotide polymorphism of the VEGF gene as a risk predictor for gastroduodenal ulcers
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Describes a novel VEGF gene polymorphism associated with increased risk of gastroduodenal ulcers and decreased transcriptional activity and angiogenesis
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Kim YS, Park SW, Kim MH, et al. Novel single nucleotide polymorphism of the VEGF gene as a risk predictor for gastroduodenal ulcers. J Gastroenterol Hepatol 2008; 23 (Suppl 2):S131-S139. Describes a novel VEGF gene polymorphism associated with increased risk of gastroduodenal ulcers and decreased transcriptional activity and angiogenesis.
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J Gastroenterol Hepatol
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Kim, Y.S.1
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Kim, M.H.3
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37
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52449092150
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A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner
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Well performed study of the effect of VEGF on experimental ulcer healing
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Dudar GK, D'Andrea LD, Di SR, et al. A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner. Am J Physiol Gastrointest Liver Physiol 2008; 295:G374-G381. Well performed study of the effect of VEGF on experimental ulcer healing.
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Dudar, G.K.1
D'andrea, L.D.2
Di, S.R.3
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection
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Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-1371.
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Brenchley, J.M.1
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Schacker, T.W.3
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39
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58949102533
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Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients
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HIV infection alters tight junction protein composition leading to increased intestinal permeability. Treatment with antiretrovirals appears to restore intestinal barrier integrity
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Epple HJ, Schneider T, Troeger H, et al. Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 2009; 58:220-227. HIV infection alters tight junction protein composition leading to increased intestinal permeability. Treatment with antiretrovirals appears to restore intestinal barrier integrity.
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Gut
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Epple, H.J.1
Schneider, T.2
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