Impact of CFTR ΔF508 mutation on prostaglandin E2 production and type IIA phospholipase A2 expression by pulmonary epithelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 289, Issue 5 33-5, 2005, Pages

  Medjane, Samir ^a   Raymond, Benoit ^a   Wu, Yongzheng ^a   Touqui, Lhousseine ^a,b  

^a INSERM   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

Arachidonic acid metabolism; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Inflammation

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR PROTEIN, HUMAN; DNA; MESSENGER RNA; PHOSPHOLIPASE A; PLA2G2A PROTEIN, HUMAN; PROSTAGLANDIN SYNTHASE;

ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; MUTATION; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL LINE; EPITHELIUM CELL; GENE DELETION; GENE EXPRESSION; GENETICS; LUNG; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; TRACHEA;

BASE SEQUENCE; CELL LINE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DINOPROSTONE; DNA; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; LUNG; PHOSPHOLIPASES A; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SEQUENCE DELETION; TRACHEA;

EID: 27144514336     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00466.2004     Document Type: Article

References (33)

1. Aronoff DM, Canetti C, and Peters-Golden M. Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP. J Immunol 173: 559-565, 2004.
2. Berguerand M, Klapisz E, Thomas G, Humbert L, Jouniaux AM, Olivier JL, Bereziat G, and Masliah J. Differential stimulation of cytosolic phospholipase A2 by bradykinin in human cystic fibrosis cell lines. Am J Respir Cell Mol Biol 17: 481-490, 1997.
3. Braquet P, Touqui L, Shen TY, and Vargaftig BB. Perspectives in platelet-activating factor research. Pharmacol Rev 39: 97-145, 1987.
4. Caristi S, Piraino G, Cucinotta M, Valenti A, Loddo S, and Teti D. PGE2 induces IL-8 gene transcription by activating C/EBP homologous protein in human T lymphocytes. J Biol Chem 280: 14433-14442, 2005.
5. Davis PB, Drumm M, and Konstan MW. Cystic fibrosis. Am J Respir Crit Care Med 154: 1229-1256, 1996.
6. Denning GM, Anderson MP, Amara JF, Marshall J, Smith AE, and Welsh MJ. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive. Nature 358: 761-764, 1992.
7. Dennis EA. Phospholipase A2 in eicosanoid generation. Am J Respir Crit Care Med 161: S32-S35, 2000.
8. Egan ME, Glockner-Pagel J, Ambrose C, Cahill PA, Pappoe L, Balamuth N, Cho E, Canny S, Wagner CA, Geibel J, and Caplan MJ. Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells. Nat Med 8: 485-492, 2002.
9. Fiedler MA, Wernke-Dollries K, and Stark JM. Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132. Am J Respir Cell Mol Biol 19: 259-268, 1998.
10. Fink J, Steer JH, Joyce DA, McWilliam AS, and Stewart GA. Proinflammatory effects of Burkholderia cepacia on cystic fibrosis respiratory epithelium. FEMS Immunol Med Microbiol 38: 273-282, 2003.
11. Franson R, Patriarca P, and Elsbach P. Phospholipid metabolism by phagocytic cells. Phospholipases A2 associated with rabbit polymorphonuclear leukocyte granules. J Lipid Res 15: 380-388, 1974.
12. Gibson RL, Burns JL, and Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med 168: 918-951, 2003.
13. Goudeau B, Huetz F, Samson S, Di Santo JP, Cumano A, Beg A, Israel A, and Memet S. IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival. Proc Natl Acad Sci USA 100: 15800-15805, 2003.
14. Guillot L, Medjane S, Le-Barillec K, Balloy V, Danel C, Chignard M, and Si-Tahar M. Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J Biol Chem 279: 2712-2718, 2004.
15. Hyde SC, Emsley P, Hartshorn MJ, Mimmack MM, Gileadi U, Pearce SR, Gallagher MP, Gill DR, Hubbard RE, and Higgins CF. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346: 362-365, 1990.
16. Kemp JP. Recent advances in the management of asthma using leukotriene modifiers. Am J Respir Med 2: 139-156, 2003.
17. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, and Riches DW. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 151: 1075-1082, 1995.
18. Konstan MW, Walenga RW, Hilliard KA, and Hilliard JB. Leukotriene B4 markedly elevated in the epithelial lining fluid of patients with cystic fibrosis. Am Rev Respir Dis 148: 896-901, 1993.
19. Kuwata H, Yamamoto S, Miyazaki Y, Shimbara S, Nakatani Y, Suzuki H, Ueda N, Murakami M, and Kudo I. Studies on a mechanism by which cytosolic phospholipase A2 regulates the expression and function of type IIA secretory phospholipase A2. J Immunol 165: 4024-4031, 2000.
20. Lemnaouar M, Chastre E, Paul A, Mergey M, Veissiere D, Cherqui G, Barbry P, Simon-Bouy B, Fanen P, Gespach C, and Picard J. Oncogene-mediated propagation of tracheal epithelial cells from two cystic fibrosis fetuses with different mutations Characterization of CFT-1 and CFT-2 cells in culture. Eur J Clin Invest 23: 151-160, 1993.
21. Lio YC, Reynolds LJ, Balsinde J, and Dennis EA. Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta 1302: 55-60, 1996.
22. 2+-induced arachidonic acid release by epithelial cells. DNA Cell Biol 16: 749-759, 1997.
23. Muhlebach MS, Stewart PW, Leigh MW, and Noah TL. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Am J Respir Crit Care Med 160: 186-191, 1999.
24. Ratjen F and Doring G. Cystic fibrosis. Lancet 361: 681-689, 2003.
25. Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou JL, Drumm ML, Iannuzzi MC, Collins FS, and Tsui LC. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1073, 1989.
26. Rodgers HC, Pang L, Holland E, Corbett L, Range S, and Knox AJ. Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids. Am J Physiol Lung Cell Mol Physiol 283: L612-L618, 2002.
27. Schevitz RW, Bach NJ, Carlson DG, Chirgadze NY, Clawson DK, Dillard RD, Draheim SE, Hartley LW, Jones ND, Mihelich ED, Olkowski JL, Snyder DW, Sommers C, and Wery JP. Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat Struct Biol 2: 458-465, 1995.
28. 2-induced interleukin-6 release by a human airway epithelial cell line. Am J Physiol Lung Cell Mol Physiol 280: L127-L133, 2001.
29. Touqui L and Alaoui-El-Azher M. Mammalian secreted phospholipases A2 and their pathophysiological significance in inflammatory diseases. Curr Mol Med 1: 739-754, 2001.
30. Venkatakrishnan A, Stecenko AA, King G, Blackwell TR, Brigham KL, Christman JW, and Blackwell TS. Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol 23: 396-403, 2000.
31. Ward CL and Kopito RR. Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins. J Biol Chem 269: 25710-25718, 1994.
32. Xu Y, Clark JC, Aronow BJ, Dey CR, Liu C, Wooldridge JL, and Whitsett JA. Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiency. J Biol Chem 278: 7674-7682, 2003.
33. Zeitlin PL, Lu L, Rhim J, Cutting G, Stellen G, Kieffer KA, Craig R, and Guggino WB. A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection. Am J Respir Cell Mol Biol 4: 313-319, 1991.