An evidence-based systematic review of annatto (Bixa orellana L.) by the natural standard research collaboration

Journal of Dietary Supplements

Volumn 9, Issue 1, 2012, Pages 57-77

  Ulbricht, Catherine ^h   Windsor, Regina C ^b   Brigham, Ashley ^a   Bryan, J Katherine ^b   Conquer, Julie ^c   Costa, Dawn ^b   Giese, Nicole ^b   Guilford, Jacquelyn ^b   Higdon, Elizabeth R B ^b   Holmes, Kyla ^d   Isaac, Richard ^b   Jingst, Sara ^a   Kats, Juila ^a   Peery, Laurie ^d   Rusie, Erica ^b   Savinainen, Anneli ^e   Schoen, Todd ^f   Stock, Tera ^g   Tanguay Colucci, Shaina ^b   Weissner, Wendy ^b  

^a NORTHEASTERN UNIVERSITY   (United States)

^b Natural Standard   (United States)

^c RGB Consulting   (Canada)

^d Appalachian College of Pharmacy   (United States)

^e MILLENNIUM PHARMACEUTICALS INC   (United States)

^f ST JOHN FISHER COLLEGE   (United States)

^g MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLANT EXTRACT;

BIXACEAE; HUMAN; PHYTOTHERAPY; REVIEW; TRADITIONAL MEDICINE;

BIXACEAE; HUMANS; MEDICINE, TRADITIONAL; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84857394948     PISSN: 19390211     EISSN: 1939022X     Source Type: Journal    
DOI: 10.3109/19390211.2012.653530     Document Type: Review

References (55)

1. Adetuyi AO, Lajide L, Popoola AV. Effect of base media on the stability of annatto dye in industrial products. Pakistan J. Sci. Ind. Res. 2006;47(4):267.
2. Agner AR, Barbisan LF, Scolastici C, Salvadori DM. Absence of carcinogenic and anticarcinogenic effects of annatto in the rat liver medium-term assay. Food Chem Toxicol. 2004;42(10):1687-1693. (Pubitemid 39078515)
3. Agner AR, Bazo AP, Ribeiro LR, Salvadori DM. DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis. Mutat Res. 2005;582(1-2):146-154. (Pubitemid 40386930)
4. Alves de Lima RO, Azevedo L, Ribeiro LR, Salvadori DM. Study on the mutagenicity and antimutagenicity of a natural food colour (annatto) in mouse bone marrow cells. Food Chem Toxicol. 2003;41(2):189-192. (Pubitemid 35447870)
5. Antunes LM, Pascoal LM, Bianchi Mde L, Dias FL. Evaluation of the clastogenicity and anticlastogenicity of the carotenoid bixin in human lymphocyte cultures. Mutat Res. 2005;585(1-2):113-119. (Pubitemid 40980425)
6. Baelmans R, Deharo E, Bourdy G, Munoz V, Quenevo C, Sauvain M, Ginsburg H. A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part IV. Is a new haem polymerisation inhibition test pertinent for the detection of antimalarial natural products? J Ethnopharmacol. 2000;73(1-2):271-275.
7. Barcelos GR, Angeli JP, Serpeloni JM, Rocha BA, Mantovani MS, Antunes LM. Effect of annatto on micronuclei induction by direct and indirect mutagens in HepG2 cells. Environ Mol Mutagen. 2009;50(9):808-814.
8. Bautista AR, Moreira EL, Batista MS, Miranda MS, Gomes IC. Subacute toxicity assessment of annatto in rat. Food Chem Toxicol. 2004;42(4):625-629. (Pubitemid 38314834)
9. Braga FG, Bouzada ML, Fabri RL, de O Matos M, Moreira FO, Scio E, Coimbra ES. Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil. J Ethnopharmacol. 2007;111(2):396-402. (Pubitemid 46546458)
10. Bressani R, Porta-Espana de Barneon F, Braham JE, Elias LG, Gomez-Brenes R. Chemical composition, amino acid content and nutritive value of the protein of the annatto seed (Bixa orellana L.). Arch Latinoam Nutr. 1983;33(2):356-376.
11. CaceresA,MenendezH,MendezE,Cohobon E, Samayoa BE, Jauregui E, Peralta E, Carrillo,G. Antigonorrhoeal activity of plants used in Guatemala for the treatment of sexually transmitted diseases. J Ethnopharmacol. 1995;48(2):85-88.
12. Castello MC, PhatakA,ChandraN, SharonM.Antimicrobial activity of crude extracts fromplant parts and corresponding calli of Bixa orellana L. Indian J Exp Biol. 2002;40(12):1378-1381. (Pubitemid 35431697)
13. Ciscar F. Achiotin, an extract of achiote seeds (Bixa orellana L.), as a histologic stain for lipids. Stain Technol. 1965;40(5):249-251.
14. Coleman W. Molecular models of annatto seeds components. J Chem Educ. 2008;85(7): 1008-1009.
15. Cunha FG, Santos KG, Ataide CH, Epstein N, Barrozo MAS. Annatto powder production in a sprouted bed: An experimental and CFD study. Ind Eng Chem Res. 2009;48(2):976-982.
16. De Oliveira AC, Silva IB, Manhaes-Rocha DA, Paumgartten FJ. Induction of liver monooxygenases by annatto and bixin in female rats. Braz J Med Biol Res. 2003;36(1):113-118. (Pubitemid 36231200)
17. Ebo DG, Ingelbrecht S, Bridts CH, StevensWJ. Allergy for cheese: Evidence for an IgE-mediated reaction from the natural dye annatto. Allergy. 2009;64(10):1558-1560.
18. Fernandes AC, Almeida CA, Albano F, Laranja GA, Felzenszwalb I, Lage CL, de Sa CC, Moura AS, Kovary, K. Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice. J Nutr Biochem. 2002;13(7):411-420. (Pubitemid 34733010)
19. Fleischer TC, Ameade EP, Mensah ML, Sawer IK.Antimicrobial activity of the leaves and seeds of Bixa orellana. Fitoterapia. 2003;74(1-2):136-138. (Pubitemid 36287260)
20. Floch MH. Annatto, diet, and the irritable bowel syndrome. J Clin Gastroenterol. 2009;43(10):905-906.
21. Galindo-Cuspinera V, Westhoff DC, Rankin SA. Antimicrobial properties of commercial annatto extracts against selected pathogenic, lactic acid, and spoilage microorganisms. J Food Prot. 2003;66(6):1074-1078. (Pubitemid 36689343)
22. Gomez-Ortiz NM, Vázquez-Maldonado IA, Pérez-Espadas AR, Mena-Rejón GJ, Azamar-Barrios JA. Dye-sensitized solar cells with natural dyes extraced from achiote seeds. Sol Energy Mater. Sol. Cells. 2010;94(1):40-44.
23. Hagiwara A, Imai N, Doi Y, Nabae K, Hirota T, Yoshino H, Kawabe M, Tsushima Y, Aoki H, Yasuhara K, Koda T, Nakamura M, Shirai T. Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats. Cancer Lett. 2003;199(1):9-17. (Pubitemid 37088133)
24. Hagiwara A, Imai N, Ichihara T, Sano M, Tamano S, Aoki H, Yasuhara K, Koda T, Nakamura M, Shirai, T. A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats. Food Chem Toxicol. 2003;41(8):1157-1164. (Pubitemid 36782521)
25. Junior AC, Asad LM, Oliveira EB, Kovary K, Asad NR, Felzenszwalb I. Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress. Genet Mol Res. 2005;4(1):94-99. (Pubitemid 40605268)
26. Kovary K, Louvain TS, Costa e Silva MC, Albano F, Pires BB, Laranja GA, Lage CL, Felzenszwalb I. Biochemical behaviour of norbixin during in vitro DNAdamage induced by reactive oxygen species. Br J Nutr. 2001;85(4):431-440. (Pubitemid 32435536)
27. Lans CA. Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. J Ethnobiol Ethnomedicine. 2006;2:45.
28. Levy LW, Regalado E, Navarrete S, Watkins RH. Bixin and norbixin in human plasma: Determination and study of the absorption of a single dose of annatto food color. Analyst. 1997;122(9):977-980.
29. Lucas CD, Hallagan JB, Taylor SL. The role of natural color additives in food allergy. Adv Food Nutr Res. 2001;43:195-216.
30. Martinez-Tome M, Jimenez AM, Ruggieri S, Frega N, Strabbioli R, Murcia MA. Antioxidant properties of Mediterranean spices compared with common food additives. J Food Prot. 2001;64(9):1412-1419. (Pubitemid 32908091)
31. McCullagh JV, Ramos N. Separation of the carotenoid bixin from annatto seeds using thin-layer and column chromatograpy. J Chem Educ. 2008;85(7):948-950.
32. Mercandante AZ, Steck A, Rodriguez-Amaya D, Pfander H, Britton G. Isolation of methyl 9αZapo-6α-lycopenoate from Bixa orellana. Phytochemistry. 1996;41(4):1201-1203.
33. Morrison EY, Thompson H, Pascoe K, West M, Fletcher C. Extraction of an hyperglycaemic principle from the annatto (Bixa orellana), a medicinal plant in the West Indies. Trop Geogr Med. 1991;43(1-2):184-188.
34. Nish WA, Whisman BA, Goetz DW, Ramirez DA. Anaphylaxis to annatto dye: A case report. Ann Allergy. 1991;66(2):129-131.
35. Noppe H, Abuin Martinez SM Verheyden K, Van Loco J, Companyo Beltran R, De Brabander HF Determination of bixin and norbixin in meat using liquid chromatography and photodiode array detection Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2009 26 1 17-24.
36. Nunez VOtero R, Barona J, Saldarriaga M, Osorio RG, Fonnegra R, Jimenez SL, DiazA Quintana JC Neutralization of the edema-forming, defibrinating and coagulant effects of Bothrops asper venom by extracts of plants used by healers in Colombia Braz J Med Biol Res 2004 37 7 969-977. (Pubitemid 39029116)
37. Otero R, Nunez V, Barona J, Fonnegra R, Jimenez SL, Osorio RG, Saldarriaga M, Diaz A Snakebites and ethnobotany in the northwest region of Colombia. Part III: Neutralization of the haemorrhagic effect of Bothrops atrox venom J Ethnopharmacol 2000 73 1-2 233-241.
38. Ouyang D,Zhang R,Yi L,Xi Z A synergistic effect of Cu(2+) and norbixin on DNA damage Food Chem Toxicol 2008 46 8 2802-2807.
39. Oyedeji OA,Adeniyi BA,Ajayi O,Konig WA Essential oil composition of Piper guineense and its antimicrobial activity. Another chemotype from Nigeria. Phytother Res 2005 19 4 362-364.
40. Paumgartten FJ, De Carvalho RR, Araujo IB, Pinto FM, Borges OO, Souza CA, Kuriyama SN. Evaluation of the developmental toxicity of annatto in the rat. Food Chem Toxicol. 2002;40(11):1595-1601.
41. Pino JA, Correa MT. Chemical composition of the essential oil from annatto (Bixa orellana L.) seeds. J. Essent. Oil Res. 2003;15(2):66-67.
42. Polar-Cabrera K, Huo T, Schwartz SJ, Failla ML. Digestive stability and transport of norbixin, a 24-carbon carotenoid, across monolayers of Caco-2 cells. J Agric Food Chem. 2010;58(9):5789-5794.
43. Reddy MK, Alexander-Lindo RL, Nair MG. Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J Agric Food Chem. 2005;53(23):9268-9273. (Pubitemid 41735701)
44. Ribeiro LR, Mantovani MS, Ribeiro DA, Salvadori DM. Brazilian natural dietary components (annatto, propolis and mushrooms) protecting against mutation and cancer.HumExp Toxicol. 2006;25(5):267-272. (Pubitemid 43832830)
45. Rodrigues SM, Soares VL, de Oliveira TM, Gesteira AS, Otoni WC, Costa MG. Isolation and purification ofRNAfromtissues rich in polyphenols, polysaccharides, and pigments of annatto (Bixa orellana L.). Mol Biotechnol. 2007;37(3):220-224. (Pubitemid 350242560)
46. Rodriguez-Avila NL, Narvaez-Zapata JA, Aguilar-Espinosa ML, Rivera-Madrid R. Full-length gene enrichment by using an optimized RNA isolation protocol in Bixa orellana recalcitrant tissues. Mol Biotechnol. 2009;42(1):84-90.
47. Rojas JJ, Ochoa VJ,Ocampo SA,Munoz JF. Screening for antimicrobial activity of ten medicinal plants used in Colombian folkloric medicine: A possible alternative in the treatment of nonnosocomial infections. BMC Complement Altern Med. 2006;6:2.
48. Russell KR, Morrison EY, Ragoobirsingh D. The effect of annatto on insulin binding properties in the dog. Phytother Res. 2005;19(5):433-436. (Pubitemid 41285011)
49. Russell KR, Omoruyi FO, Pascoe KO, Morrison EY. Hypoglycaemic activity of Bixa orellana extract in the dog. Methods Find Exp Clin Pharmacol. 2008;30(4):301-305.
50. Schneider WP, Caron EL, Hinman JW. Occurrence of tomentosic acid in extracts of Bixa orellana. J Org Chem. 1965;30:2856-2857.
51. Scotter M. The chemistry and analysis of annatto food colouring: A review. Food Addit Contam. 2009;26(8):1123-1145.
52. Shilpi JA, Taufiq-Ur-RahmanM, Uddin SJ, Alam MS, Sadhu SK, Seidel V. Preliminary pharmacological screening of Bixa orellana L. leaves. J Ethnopharmacol. 2006;108(2):264-271. (Pubitemid 44635031)
53. Stein HL. Annatto and IBS. J Clin Gastroenterol. 2009;43(10):1014-1015.
54. Takahashi N, Goto T, Taimatsu A, Egawa K, Katoh S, Kusudo T, Sakamoto T, Ohyane C, Lee JY, Kim YI, Uemura T, Hirai S, Kawada T. Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation. Biochem Biophys Res Commun. 2009;390(4):1372-1376.
55. Taylor SL, Hefle SL. Ingredient and labeling issues associated with allergenic foods. Allergy. 2001;56(Suppl. 67):64-69. (Pubitemid 32545241)