Effect of annatto on micronuclei induction by direct and indirect mutagens in HepG2 cells

Environmental and Molecular Mutagenesis

Volumn 50, Issue 9, 2009, Pages 808-814

  Barcelos, Gustavo Rafael Mazzaron ^a   Angeli, José Pedro Friedmann ^b   Serpeloni, Juliana Mara ^a   Rocha, Bruno Alves ^a   Mantovani, Mário Sérgio ^b   Antunes, Lusânia Maria Greggi ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Annatto; Antimutagenicity; Bixin; HepG2; Micronuclei

Indexed keywords

ANNATTO; ANTIMUTAGENIC AGENT; ANTIOXIDANT; BENZO[A]PYRENE; DOXORUBICIN; MESYLIC ACID METHYL ESTER; MUTAGENIC AGENT; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL ASSAY; CELL PROTECTION; CELL STRAIN HEPG2; CELL VIABILITY; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG EXPOSURE; GENE INDUCTION; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER PROTECTION; MICRONUCLEUS; MICRONUCLEUS TEST; MUTAGENIC ACTIVITY; MUTAGENICITY;

BENZO(A)PYRENE; BIXACEAE; CAROTENOIDS; CELL LINE; DOXORUBICIN; HUMANS; METHYL METHANESULFONATE; MICRONUCLEUS TESTS; MUTAGENS; PLANT EXTRACTS;

EID: 73249123072     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20494     Document Type: Article

References (40)

1. Ames BN, Gold LS. 1997. The prevention of cancer. Drug Metab Rev 30:201-223.
2. Antunes LMG, Pascoal LM, Bianchi MLP, Dias FL. 2005. Evaluation of the clastogenicity and anticlastogenicity of the carotenoid bixin in human lymphocyte cultures. Mutat Res 585:113-119.
3. Baird WM, Hooven LA, Mahadevan B. 2005. Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen 45:106-114.
4. Barcelos GRM, Shimabukuro F, Maciel MAM, Cólus IMS. 2007. Genotoxicity and antigenotoxicity of cashew (Anacardium occidentale L.) in V79 cells. Toxicol In Vitro 21:1468-1475.
5. Bhuvaneswari V, Nagini S. 2005. Lycopene: A review of its potential as an anticancer agent. Curr Med Chem Anticancer Agents 5:627-635.
6. Burton GW, Ingold KU. 1984. Beta-carotene - An unusual type of lipid antioxidant. Science 224:569-573.
7. Britton G. 1995. UV/visible spectroscopy. In: Britton G, Liaaen-Jensen S, Pfander H, editors. Carotenoids Spectroscopy. Birkhäuser: Basel. pp 13-62.
8. Briviba K, Sies H. 1994. Nonenzymatic antioxidant defense systems. In: Frie B, editor. Natural Antioxidants in Human Health and Diseases. San Diego: Academic Press. pp 119-121.
9. Carini M, Aldini G, Bombardeelli E, Morazzoni P, Maffei Facino R. 2000. UVB-induced hemolysis of rat erythrocytes: Protective effect of procyanidins from grape seeds. Life Sci 67:1799-1814.
10. Cutts SM, Nudelman A, Rephaeli A, Phillips DR. 2005. The power and potential of doxorubicin-DNA adducts. IUBMB Life 57:73-81.
11. Davies BH. 1976.Carotenoids. In: Goodwin TW, Editor. Chemistry and Biochemistry of Plant Pigments. London: Academic Press. pp 38-165.
12. Darroudi F, Natarajan AT. 1991. Use of human hepatoma cells for in vitro metabolic activation of chemical mutagens/carcinogens. Mutagen 6:339-403.
13. De Flora S. 1998. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutat Res 402:151-158.
14. Di Mascio P, Devasagayam TPA, Kaiser S, Sies HH. 1990. Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers. Biochem Soc Trans 18:1054-1056.
15. Doak SH, Jenkins GJ, Johnson GE, Quick E, Parry EM, Parry JM. 2007. Mehanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens. Cancer Res 67:3904-3911.
16. Ehrlich V, Darroudi F, Uhl M, Steinkellner H, Gann M, Majer BJ, Eisenbauer M, Knasmüller S. 2002. Genotoxic effects of ochratoxin A in human-derived hepatoma (HepG2) cells. Food Chem Toxicol 40:1085-1090.
17. Fenech M. 1993. The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285:35-44.
18. Ferguson LR. 1999. Prospects for cancer prevention. Mutat Res 428:329-338.
19. Ferguson LR. 2001. Role of plant polyphenols in genomic stability. Mutat Res 18:89-111.
20. Galindo-Cuspinera V, Lubran MB, Rankin SA. 2002. Comparison of volatile compounds in water- and oil-soluble annatto (Bixa orellana L.) extracts. J Agric Food Chem 50:2010-2015.
21. Halliwell B, Gutteridge JMC. 1999. Free Radicals in Biology and Medicine, 3rd ed. London:Oxford. p 936
22. Halliwell B. 2007. Dietary polyphenols: Good, bad, or indifferent for your health? Cardiovasc Res 73:341-347.
23. Halliwell B. 2008. Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 476:107-112.
24. Júnior AC, Asad LM, Oliveira EB, Kovary K, Asad NR, Felzenszwalb I. 2005. Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress. Genet Mol Res 31:94-99.
25. Kada T, Inoue T, Namiki N. 1982. Environmental desmutagens and antimutagens. In: Klekowski EJ, editor. Environ Mutagen and Plant Biology. New York: Praeger. pp 137-151.
26. Kaina B. 2004. Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: A long road traveled and still a far way to go. Cytogenet Genome Res 104:77-86.
27. Kuroda Y, Jain KA, Tezuka H, Kada T. 1992. Animutagenicity in cultured mammalian cells. Mutat Res 267:201-209.
28. Lee TK, Lau TC, Ng IO. 2002. Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines. Cancer Chemother Pharmacol 49:78-86.
29. Mirzayans R, Liuzzi M, Paterson MG. 1988. Methyl methanesulfonate-induced DNA damage and its repair in cultured human fibroblasts: Normal rates of induction and removal of alkali-labile sites in xeroderma pigmentosum (group A) cells. Carcinogenesis 12:2257-2263.
30. Parkinson A. 2001. Biotransformation of xenobiotics. In: Klassen CD, editor. Casarett and Doull's Toxicology: The Basic Science of Poisons. New York: McGraw-Hill. pp 133-224.
31. Plazar J, Zegura B, Lah TT, Filipic M. 2007. Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert-butyl hydroperoxide (t-BOOH) in HepG2 human hepatoma cells. Mutat Res 632:1-8.
32. Quiles JL, Huertas JR, Battino M, Matais J, Ramirez-Tortosa MC. 2002. Antioxidant nutrients and adriamycin toxicity. Toxicology 180:79-125.
33. Rao AV, Rao LG. 2007. Carotenoids and human health. Pharmacol Res 55:207-216.
34. Reddy MK, Alexander-Lindo RL, Nair MG. 2005. Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J Agric Food Chem 53:9268-9273.
35. Scolastici C, Alves de Lima RO, Barbisan LF, Ferreira AL, Ribeiro DA, Salvadori DMF. 2007. Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells. Toxicol In Vitro 21:840-845.
36. Scotter MJ, Thorpe SA, Reynolds SL, Wilson LA, Strutt PR. 1994. Characterisation of the principal colouring components of annatto using high performance liquid chromatography with photodiode-array detection. Food Addit Contam 11:301-315.
37. Titenko-Holland N, Windham G, Kolachana P, Reinisch F, Parvatham S, Osorio AM, Smith MT. 1997. Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathion-exposed workers. Mutat Res 338:85-95.
38. Thresiamma KC, George J, Kuttan R. 1998. Protective effect of curcumin, ellagic acid, and bixin on radiation induced genotoxicity. J Exp Clin Cancer Res 17:431-434.
39. Uhl M, Ecker S, Kassie F, Lhoste E, Chakraborty A, Mohn G, Knasmüller S. 2003. Effect of chrysin, a flavonoid compound on the mutagenic activity of 2 amino-1-methyl-6-phenylimidazol[4,5-b]pyridine (PhlP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (HegG20 cells). Arch Toxicol 77:477-484.
40. Wyatt MD, Pittman DL. 2006. Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chem Res Toxicol 19:1580-1594.