Herpesvirus entry mediator-Ig treatment during immunization aggravates rheumatoid arthritis in the collagen-induced arthritis model

Journal of Immunology

Volumn 182, Issue 5, 2009, Pages 3139-3145

  Pierer, Matthias ^a   Schulz, Anett ^a   Rossol, Manuela ^a   Kendzia, Eva ^a   Kyburz, Diego ^b   Haentzschel, Holm ^a   Baerwald, Christoph ^a   Wagner, Ulf ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; COLLAGEN TYPE 2; GAMMA INTERFERON; HERPESVIRUS ENTRY MEDIATOR; HYBRID PROTEIN; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2A ANTIBODY; INTERFERON; INTERLEUKIN 6; LYMPHOTOXIN; LYMPHOTOXIN ALPHA BETA; AUTOANTIBODY; BTLA PROTEIN, MOUSE; HERPESVIRUS ENTRY MEDIATOR LIGAND; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN RECEPTOR; LYMPHOTOXIN BETA RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; DISEASE SEVERITY; HISTOPATHOLOGY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; VIRUS ENTRY; ANIMAL; ARTHRITIS; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; DBA MOUSE; DISEASE MODEL; DRUG ANTAGONISM; GENETICS; HERPES SIMPLEX VIRUS 1; HUMAN; IMMUNOLOGY; METABOLISM; PATHOLOGY;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CD4-POSITIVE T-LYMPHOCYTES; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; LYMPHOTOXIN BETA RECEPTOR; MICE; MICE, INBRED DBA; RECEPTORS, IMMUNOLOGIC; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 14; RECOMBINANT FUSION PROTEINS; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14;

EID: 64849105620     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0713715     Document Type: Article

References (33)

1. Gommerman, J. L., F. Mackay, E. Donskoy, W. Meier, P. Martin, and J. L. Browning. 2002. Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway. J. Clin. Invest. 110: 1359-1369.
2. Mackay, F., G. R. Majeau, P. Lawton, P. S. Hochman, and J. L. Browning. 1997. Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice. Eur. J. Immunol. 27: 2033-2042.
3. Takemura, S., A. Braun, C. Crowson, P. J. Kurtin, R. H. Cofield, W. M. O'Fallon, J. J. Goronzy, and C. M. Weyand. 2001. Lymphoid neogenesis in rheumatoid synovitis. J. Immunol. 167: 1072-1080.
4. Granger, S. W., and C. F. Ware. 2001. Turning on LIGHT. J. Clin. Invest. 108: 1741-1742.
5. Shaikh, R. B., S. Santee, S. W. Granger, K. Butrovich, T. Cheung, M. Kronenberg, H. Cheroutre, and C. F. Ware. 2001. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. J. Immunol. 167: 6330-6337.
6. Tamada, K., K. Shimozaki, A. I. Chapoval, Y. Zhai, J. Su, S. F. Chen, S. L. Hsieh, S. Nagata, J. Ni, and L. Chen. 2000. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J. Immunol. 164: 4105-4110.
7. Tamada, K., K. Shimozaki, A. I. Chapoval, G. Zhu, G. Sica, D. Flies, T. Boone, H. Hsu, Y. X. Fu, S. Nagata, et al. 2000. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat. Med. 6: 283-289.
8. Wang, J., J. C. Lo, A. Foster, P. Yu, H. M. Chen, Y. Wang, K. Tamada, L. Chen, and Y. X. Fu. 2001. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J. Clin. Invest. 108: 1771-1780.
9. Mackay, F., J. L. Browning, P. Lawton, S. A. Shah, M. Comiskey, A. K. Bhan, E. Mizoguchi, C. Terhorst, and S. J. Simpson. 1998. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology 115: 1464-1475.
10. Scheu, S., J. Alferink, T. Potzel, W. Barchet, U. Kalinke, and K. Pfeffer. 2002. Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin β in mesenteric lymph node genesis. J. Exp. Med. 195: 1613-1624.
11. Gonzalez, L. C., K. M. Loyet, J. Calemine-Fenaux, V. Chauhan, B. Wranik, W. Ouyang, and D. L. Eaton. 2005. A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator. Proc. Natl. Acad. Sci. USA 102: 1116-1121.
12. Sedy, J. R., M. Gavrieli, K. G. Potter, M. A. Hurchla, R. C. Lindsley, K. Hildner, S. Scheu, K. Pfeffer, C. F. Ware, T. L. Murphy, and K. M. Murphy. 2005. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6: 90-98.
13. + T cells through interaction with herpesvirus entry mediator. Nat. Immunol. 9: 176-185.
14. Wang, Y., S. K. Subudhi, R. A. Anders, J. Lo, Y. L. Sun, S. Blink, Y. G. Wang, J. Wang, X. J. Liu, K. Mink, et al. 2005. The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J. Clin. Invest. 115: 711-717.
15. Fava, R. A., E. Notidis, J. Hunt, V. Szanya, N. Ratcliffe, A. Ngam-Ek, A. R. De Fougerolles, A. Sprague, and J. L. Browning. 2003. A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis. J. Immunol. 171: 115-126.
16. Han, S. H., X. J. Zhang, E. Marinova, Z. Ozen, R. Bheekha-Escura, L. J. Guo, D. Wansley, G. Booth, Y. X. Fu, and B. Zheng. 2005. Blockade of lymphotoxin pathway exacerbates autoimmune arthritis by enhancing the Th1 response. Arthritis Rheum. 52: 3202-3209.
17. Chin, R. K., M. Zhu, P. A. Christiansen, W. Liu, C. Ware, L. Peltonen, X. Zhang, L. Guo, S. Han, B. Zheng, and Y. X. Fu. 2006. Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J. Immunol. 177: 290-297.
18. Rooney, I., K. Butrovich, and C. F. Ware. 2000. Expression of lymphotoxins and their receptor-Fc fusion proteins by baculovirus. Methods Enzymol. 322: 345-363.
19. Murphy, K. M., C. A. Nelson, and J. R. Sedy. 2006. Balancing co-stimulation and inhibition with BTLA and HVEM. Nat. Rev. Immunol. 6: 671-681.
20. Shi, G., H. Luo, X. Wan, T. W. Salcedo, J. Zhang, and J. Wu. 2002. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood 100: 3279-3286.
21. Wan, X., J. Zhang, H. Luo, G. Shi, E. Kapnik, S. Kim, P. Kanakaraj, and J. Wu. 2002. A TNF family member LIGHT transduces costimulatory signals into human T cells. J. Immunol. 169: 6813-6821.
22. Eissner, G., S. Kirchner, H. Lindner, W. Kolch, P. Janosch, M. Grell, P. Scheurich, R. Andreesen, and E. Holler. 2000. Reverse signaling through transmembrane TNF confers resistance to lipopolysaccharide in human monocytes and macrophages. J. Immunol. 164: 6193-6198.
23. Wiley, S. R., R. G. Goodwin, and C. A. Smith. 1996. Reverse signaling via CD30 ligand. J. Immunol. 157: 3635-3639.
24. Latchman, Y., C. R. Wood, T. Chernova, D. Chaudhary, M. Borde, I. Chernova, Y. Iwai, A. J. Long, J. A. Brown, R. Nunes, et al. 2001. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2: 261-268.
25. Lee, K. M., E. Chuang, M. Griffin, R. Khattri, D. K. Hong, W. Zhang, D. Straus, L. E. Samelson, C. B. Thompson, and J. A. Bluestone. 1998. Molecular basis of T cell inactivation by CTLA-4. Science 282: 2263-2266.
26. Cheung, T. C., I. R. Humphreys, K. G. Potter, P. S. Norris, H. M. Shumway, B. R. Tran, G. Patterson, R. Jean-Jacques, M. Yoon, P. G. Spear, et al. 2005. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proc. Natl. Acad. Sci. USA 102: 13218-13223.
27. Compaan, D. M., L. C. Gonzalez, I. Tom, K. M. Loyet, D. Eaton, and S. G. Hymowitz. 2005. Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex. J. Biol. Chem. 280: 39553-39561.
28. + T cells. J. Immunol. 175: 6420-6427.
29. Hurchla, M. A., J. R. Sedy, and K. M. Murphy. 2007. Unexpected role of B and T lymphocyte attenuator in sustaining cell survival during chronic allostimulation. J. Immunol. 178: 6073-6082.
30. Mauri, D. N., R. Ebner, R. I. Montgomery, K. D. Kochel, T. C. Cheung, G. L. Yu, S. Ruben, M. Murphy, R. J. Eisenberg, G. H. Cohen, et al. 1998. LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity 8: 21-30.
31. Duhen, T., C. Pasero, F. Mallet, B. Barbarat, D. Olive, and R. T. Costello. 2004. LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation. Eur. J. Immunol. 34: 3534-3541.
32. Kim, W. J., Y. J. Kang, E. M. Koh, K. S. Ahn, H. S. Cha, and W. H. Lee. 2005. LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro-inflammatory cytokines and MMP-9 in macrophages. Immunology 114: 272-279.
33. Pierer, M., F. Brentano, J. Rethage, U. Wagner, H. Hantzschel, R. E. Gay, S. Gay, and D. Kyburz. 2007. The TNF superfamily member LIGHT contributes to survival and activation of synovial fibroblasts in rheumatoid arthritis. Rheumatology 46: 1063-1070.