메뉴 건너뛰기




Volumn 33, Issue 2, 2009, Pages 155-164

Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes

Author keywords

Autoantibody appearance; Cow's milk formula exposure; Interaction; PTPN22; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUTAMATE DECARBOXYLASE ANTIBODY; HLA DQ ANTIGEN; INSULIN ANTIBODY; ISLET ANTIGEN 2 ANTIBODY; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PANCREAS ISLET CELL ANTIBODY; UNCLASSIFIED DRUG;

EID: 68249089241     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2009.04.003     Document Type: Article
Times cited : (59)

References (52)
  • 1
    • 0029982537 scopus 로고    scopus 로고
    • Genetic analysis of autoimmune disease
    • Vyse T.J., and Todd J.A. Genetic analysis of autoimmune disease. Cell 85 (1996) 311-318
    • (1996) Cell , vol.85 , pp. 311-318
    • Vyse, T.J.1    Todd, J.A.2
  • 2
    • 33845775174 scopus 로고    scopus 로고
    • Genetic determinants of type 1 diabetes across populations
    • Jahromi M.M., and Eisenbarth G.S. Genetic determinants of type 1 diabetes across populations. Ann N Y Acad Sci 1079 (2006) 289-299
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 289-299
    • Jahromi, M.M.1    Eisenbarth, G.S.2
  • 3
    • 27144512284 scopus 로고    scopus 로고
    • Genetic susceptibility to type 1 diabetes
    • Maier L.M., and Wicker L.S. Genetic susceptibility to type 1 diabetes. Curr Opin Immunol 17 (2005) 601-608
    • (2005) Curr Opin Immunol , vol.17 , pp. 601-608
    • Maier, L.M.1    Wicker, L.S.2
  • 4
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • Bottini N., Musumeci L., Alonso A., Rahmouni S., Nika K., Rostamkhani M., et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 36 (2004) 337-338
    • (2004) Nat Genet , vol.36 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3    Rahmouni, S.4    Nika, K.5    Rostamkhani, M.6
  • 5
    • 33646524724 scopus 로고    scopus 로고
    • Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes
    • Hermann R., Lipponen K., Kiviniemi M., Kakko T., Veijola R., Simell O., et al. Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes. Diabetologia 49 (2006) 1198-1208
    • (2006) Diabetologia , vol.49 , pp. 1198-1208
    • Hermann, R.1    Lipponen, K.2    Kiviniemi, M.3    Kakko, T.4    Veijola, R.5    Simell, O.6
  • 6
    • 2542505445 scopus 로고    scopus 로고
    • Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents
    • Hummel M., Bonifacio E., Schmid S., Walter M., Knopff A., and Ziegler A.G. Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann Intern Med 140 (2004) 882-886
    • (2004) Ann Intern Med , vol.140 , pp. 882-886
    • Hummel, M.1    Bonifacio, E.2    Schmid, S.3    Walter, M.4    Knopff, A.5    Ziegler, A.G.6
  • 7
    • 39149094629 scopus 로고    scopus 로고
    • Insulin as an autoantigen in NOD/human diabetes
    • Zhang L., Nakayama M., and Eisenbarth G.S. Insulin as an autoantigen in NOD/human diabetes. Curr Opin Immunol 20 (2008) 111-118
    • (2008) Curr Opin Immunol , vol.20 , pp. 111-118
    • Zhang, L.1    Nakayama, M.2    Eisenbarth, G.S.3
  • 8
    • 0033816148 scopus 로고    scopus 로고
    • Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group
    • Paronen J., Knip M., Savilahti E., Virtanen S.M., Ilonen J., Åkerblom H.K., et al. Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group. Diabetes 49 (2000) 1657-1665
    • (2000) Diabetes , vol.49 , pp. 1657-1665
    • Paronen, J.1    Knip, M.2    Savilahti, E.3    Virtanen, S.M.4    Ilonen, J.5    Åkerblom, H.K.6
  • 10
    • 0033032385 scopus 로고    scopus 로고
    • Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes
    • Vaarala O., Knip M., Paronen J., Hämäläinen A.M., Muona P., Väätäinen M., et al. Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes 48 (1999) 1389-1394
    • (1999) Diabetes , vol.48 , pp. 1389-1394
    • Vaarala, O.1    Knip, M.2    Paronen, J.3    Hämäläinen, A.M.4    Muona, P.5    Väätäinen, M.6
  • 11
    • 34250652014 scopus 로고    scopus 로고
    • Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin
    • Koczwara K., Muller D., Achenbach P., Ziegler A.G., and Bonifacio E. Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin. Clin Immunol 124 (2007) 77-82
    • (2007) Clin Immunol , vol.124 , pp. 77-82
    • Koczwara, K.1    Muller, D.2    Achenbach, P.3    Ziegler, A.G.4    Bonifacio, E.5
  • 12
    • 20044370128 scopus 로고    scopus 로고
    • Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study
    • Åkerblom H.K., Virtanen S.M., Ilonen J., Savilahti E., Vaarala O., Reunanen A., et al. Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study. Diabetologia 48 (2005) 829-837
    • (2005) Diabetologia , vol.48 , pp. 829-837
    • Åkerblom, H.K.1    Virtanen, S.M.2    Ilonen, J.3    Savilahti, E.4    Vaarala, O.5    Reunanen, A.6
  • 13
    • 33847124058 scopus 로고    scopus 로고
    • Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population
    • Holmberg H., Wahlberg J., Vaarala O., and Ludvigsson J. Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population. Br J Nutr 97 (2007) 111-116
    • (2007) Br J Nutr , vol.97 , pp. 111-116
    • Holmberg, H.1    Wahlberg, J.2    Vaarala, O.3    Ludvigsson, J.4
  • 14
    • 0035128517 scopus 로고    scopus 로고
    • Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity
    • Kimpimäki T., Erkkola M., Korhonen S., Kupila A., Virtanen S.M., Ilonen J., et al. Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity. Diabetologia 44 (2001) 63-69
    • (2001) Diabetologia , vol.44 , pp. 63-69
    • Kimpimäki, T.1    Erkkola, M.2    Korhonen, S.3    Kupila, A.4    Virtanen, S.M.5    Ilonen, J.6
  • 15
    • 40749097229 scopus 로고    scopus 로고
    • Early infant feeding and risk of type 1 diabetes mellitus-a nationwide population-based case-control study in pre-school children
    • Rosenbauer J., Herzig P., and Giani G. Early infant feeding and risk of type 1 diabetes mellitus-a nationwide population-based case-control study in pre-school children. Diabetes Metab Res Rev 24 (2008) 211-222
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 211-222
    • Rosenbauer, J.1    Herzig, P.2    Giani, G.3
  • 16
    • 33744948470 scopus 로고    scopus 로고
    • Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes
    • Virtanen S.M., Kenward M.G., Erkkola M., Kautiainen S., Krönberg-Kippilä C., Hakulinen T., et al. Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes. Diabetologia 49 (2006) 1512-1521
    • (2006) Diabetologia , vol.49 , pp. 1512-1521
    • Virtanen, S.M.1    Kenward, M.G.2    Erkkola, M.3    Kautiainen, S.4    Krönberg-Kippilä, C.5    Hakulinen, T.6
  • 17
    • 0141593569 scopus 로고    scopus 로고
    • Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies
    • Ziegler A.G., Schmid S., Huber D., Hummel M., and Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. Jama 290 (2003) 1721-1728
    • (2003) Jama , vol.290 , pp. 1721-1728
    • Ziegler, A.G.1    Schmid, S.2    Huber, D.3    Hummel, M.4    Bonifacio, E.5
  • 18
    • 0029976042 scopus 로고    scopus 로고
    • Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children
    • Pérez-Bravo F., Carrasco E., Gutierrez-Lopez M.D., Martinez M.T., Lopez G., and GarciadelosRios M. Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children. J Mol Med 74 (1996) 105-109
    • (1996) J Mol Med , vol.74 , pp. 105-109
    • Pérez-Bravo, F.1    Carrasco, E.2    Gutierrez-Lopez, M.D.3    Martinez, M.T.4    Lopez, G.5    GarciadelosRios, M.6
  • 19
    • 0027403160 scopus 로고
    • Early exposure to cow's milk and solid foods in infancy, genetic predisposition, and risk of IDDM
    • Kostraba J.N., Cruickshanks K.J., Lawlerheavner J., Jobim L.F., Rewers M.J., Gay E.C., et al. Early exposure to cow's milk and solid foods in infancy, genetic predisposition, and risk of IDDM. Diabetes 42 (1993) 288-295
    • (1993) Diabetes , vol.42 , pp. 288-295
    • Kostraba, J.N.1    Cruickshanks, K.J.2    Lawlerheavner, J.3    Jobim, L.F.4    Rewers, M.J.5    Gay, E.C.6
  • 20
    • 0343091468 scopus 로고    scopus 로고
    • Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group
    • Virtanen S.M., Läärä E., Hyppönen E., Reijonen H., Räsänen L., Aro A., et al. Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group. Diabetes 49 (2000) 912-917
    • (2000) Diabetes , vol.49 , pp. 912-917
    • Virtanen, S.M.1    Läärä, E.2    Hyppönen, E.3    Reijonen, H.4    Räsänen, L.5    Aro, A.6
  • 21
    • 34249892413 scopus 로고    scopus 로고
    • Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations
    • Laine A.P., Holmberg H., Nilsson A., Ortqvist E., Kiviniemi M., Vaarala O., et al. Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations. Dis Markers 23 (2007) 139-145
    • (2007) Dis Markers , vol.23 , pp. 139-145
    • Laine, A.P.1    Holmberg, H.2    Nilsson, A.3    Ortqvist, E.4    Kiviniemi, M.5    Vaarala, O.6
  • 23
    • 0035079772 scopus 로고    scopus 로고
    • Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort
    • Kupila A., Muona P., Simell T., Arvilommi P., Savolainen H., Hämäläinen A.M., et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 44 (2001) 290-297
    • (2001) Diabetologia , vol.44 , pp. 290-297
    • Kupila, A.1    Muona, P.2    Simell, T.3    Arvilommi, P.4    Savolainen, H.5    Hämäläinen, A.M.6
  • 24
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial
    • Näntö-Salonen K., Kupila A., Simell S., Siljander H., Salonsaari T., Hekkala A., et al. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial. Lancet 372 (2008) 1746-1755
    • (2008) Lancet , vol.372 , pp. 1746-1755
    • Näntö-Salonen, K.1    Kupila, A.2    Simell, S.3    Siljander, H.4    Salonsaari, T.5    Hekkala, A.6
  • 25
    • 0036775166 scopus 로고    scopus 로고
    • Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population
    • Kimpimäki T., Kulmala P., Savola K., Kupila A., Korhonen S., Simell T., et al. Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population. J Clin Endocrinol Metab 87 (2002) 4572-4579
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4572-4579
    • Kimpimäki, T.1    Kulmala, P.2    Savola, K.3    Kupila, A.4    Korhonen, S.5    Simell, T.6
  • 26
    • 0029042730 scopus 로고
    • Triple-label hybridization assay for type-1 diabetes-related HLA alleles
    • Sjöroos M., Iitia A., Ilonen J., Reijonen H., and Lövgren T. Triple-label hybridization assay for type-1 diabetes-related HLA alleles. Biotechniques 18 (1995) 870-877
    • (1995) Biotechniques , vol.18 , pp. 870-877
    • Sjöroos, M.1    Iitia, A.2    Ilonen, J.3    Reijonen, H.4    Lövgren, T.5
  • 28
    • 4344602802 scopus 로고    scopus 로고
    • Type 1 diabetes is insulin -2221 MspI and CTLA-4 +49 A/G polymorphism dependent
    • Haller K., Kisand K., Nemvalts V., Laine A.P., Ilonen J., and Uibo R. Type 1 diabetes is insulin -2221 MspI and CTLA-4 +49 A/G polymorphism dependent. Eur J Clin Invest 34 (2004) 543-548
    • (2004) Eur J Clin Invest , vol.34 , pp. 543-548
    • Haller, K.1    Kisand, K.2    Nemvalts, V.3    Laine, A.P.4    Ilonen, J.5    Uibo, R.6
  • 29
    • 0242635990 scopus 로고    scopus 로고
    • A homogeneous high-throughput genotyping method based on competitive hybridization
    • Kiviniemi M., Nurmi J., Turpeinen H., Lövgren T., and Ilonen J. A homogeneous high-throughput genotyping method based on competitive hybridization. Clin Biochem 36 (2003) 633-640
    • (2003) Clin Biochem , vol.36 , pp. 633-640
    • Kiviniemi, M.1    Nurmi, J.2    Turpeinen, H.3    Lövgren, T.4    Ilonen, J.5
  • 30
    • 0034635768 scopus 로고    scopus 로고
    • Variation and trends in incidence of childhood diabetes in Europe
    • Eurodiab Ace Study Group. Variation and trends in incidence of childhood diabetes in Europe. Lancet 355 (2000) 873-876
    • (2000) Lancet , vol.355 , pp. 873-876
    • Eurodiab Ace Study Group1
  • 31
    • 50949092228 scopus 로고    scopus 로고
    • Autoimmune mechanisms in type 1 diabetes
    • Knip M., and Siljander H. Autoimmune mechanisms in type 1 diabetes. Autoimmun Rev 7 (2008) 550-557
    • (2008) Autoimmun Rev , vol.7 , pp. 550-557
    • Knip, M.1    Siljander, H.2
  • 32
    • 0033429304 scopus 로고    scopus 로고
    • Worldwide increase in incidence of Type I diabetes-the analysis of the data on published incidence trends
    • Onkamo P., Väänänen S., Karvonen M., and Tuomilehto J. Worldwide increase in incidence of Type I diabetes-the analysis of the data on published incidence trends. Diabetologia 42 (1999) 1395-1403
    • (1999) Diabetologia , vol.42 , pp. 1395-1403
    • Onkamo, P.1    Väänänen, S.2    Karvonen, M.3    Tuomilehto, J.4
  • 33
    • 7644230152 scopus 로고    scopus 로고
    • The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes
    • Gillespie K.M., Bain S.C., Barnett A.H., Bingley P.J., Christie M.R., Gill G.V., et al. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet 364 (2004) 1699-1700
    • (2004) Lancet , vol.364 , pp. 1699-1700
    • Gillespie, K.M.1    Bain, S.C.2    Barnett, A.H.3    Bingley, P.J.4    Christie, M.R.5    Gill, G.V.6
  • 34
    • 0038222568 scopus 로고    scopus 로고
    • Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes-indication of an increased environmental pressure?
    • Hermann R., Knip M., Veijola R., Simell O., Laine A.P., Åkerblom H.K., et al. Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes-indication of an increased environmental pressure?. Diabetologia 46 (2003) 420-425
    • (2003) Diabetologia , vol.46 , pp. 420-425
    • Hermann, R.1    Knip, M.2    Veijola, R.3    Simell, O.4    Laine, A.P.5    Åkerblom, H.K.6
  • 35
    • 0035076548 scopus 로고    scopus 로고
    • Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States
    • Redondo M.J., Yu L., Hawa M., Mackenzie T., Pyke D.A., Eisenbarth G.S., et al. Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States. Diabetologia 44 (2001) 354-362
    • (2001) Diabetologia , vol.44 , pp. 354-362
    • Redondo, M.J.1    Yu, L.2    Hawa, M.3    Mackenzie, T.4    Pyke, D.A.5    Eisenbarth, G.S.6
  • 36
    • 0042697490 scopus 로고    scopus 로고
    • Environmental triggers and determinants of beta-cell autoimmunity and type 1 diabetes
    • Knip M. Environmental triggers and determinants of beta-cell autoimmunity and type 1 diabetes. Rev Endocr Metab Disord 4 (2003) 213-223
    • (2003) Rev Endocr Metab Disord , vol.4 , pp. 213-223
    • Knip, M.1
  • 37
    • 9444263686 scopus 로고    scopus 로고
    • Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY)
    • Norris J.M., Beaty B., Klingensmith G., Yu L., Hoffman M., Chase H.P., et al. Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY). Jama 276 (1996) 609-614
    • (1996) Jama , vol.276 , pp. 609-614
    • Norris, J.M.1    Beaty, B.2    Klingensmith, G.3    Yu, L.4    Hoffman, M.5    Chase, H.P.6
  • 38
    • 0642306552 scopus 로고    scopus 로고
    • Nutritional risk predictors of beta cell autoimmunity and type 1 diabetes at a young age
    • Virtanen S.M., and Knip M. Nutritional risk predictors of beta cell autoimmunity and type 1 diabetes at a young age. Am J Clin Nutr 78 (2003) 1053-1067
    • (2003) Am J Clin Nutr , vol.78 , pp. 1053-1067
    • Virtanen, S.M.1    Knip, M.2
  • 39
    • 24944506424 scopus 로고    scopus 로고
    • The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity
    • Hermann R., Laine A.P., Veijola R., Vahlberg T., Simell S., Lähde J., et al. The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity. Diabetologia 48 (2005) 1766-1775
    • (2005) Diabetologia , vol.48 , pp. 1766-1775
    • Hermann, R.1    Laine, A.P.2    Veijola, R.3    Vahlberg, T.4    Simell, S.5    Lähde, J.6
  • 40
    • 0031914003 scopus 로고    scopus 로고
    • Cow milk feeding induces antibodies to insulin in children-a link between cow milk and insulin-dependent diabetes mellitus?
    • Vaarala O., Paronen J., Otonkoski T., and Åkerblom H.K. Cow milk feeding induces antibodies to insulin in children-a link between cow milk and insulin-dependent diabetes mellitus?. Scand J Immunol 47 (1998) 131-135
    • (1998) Scand J Immunol , vol.47 , pp. 131-135
    • Vaarala, O.1    Paronen, J.2    Otonkoski, T.3    Åkerblom, H.K.4
  • 41
    • 43849091645 scopus 로고    scopus 로고
    • Reduced CD4(+)T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant
    • Aarnisalo J., Treszl A., Svec P., Marttila J., Öling V., Simell O., et al. Reduced CD4(+)T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant. J Autoimmun (2008)
    • (2008) J Autoimmun
    • Aarnisalo, J.1    Treszl, A.2    Svec, P.3    Marttila, J.4    Öling, V.5    Simell, O.6
  • 43
    • 28444469783 scopus 로고    scopus 로고
    • Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
    • Vang T., Congia M., Macis M.D., Musumeci L., Orru V., Zavattari P., et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 37 (2005) 1317-1319
    • (2005) Nat Genet , vol.37 , pp. 1317-1319
    • Vang, T.1    Congia, M.2    Macis, M.D.3    Musumeci, L.4    Orru, V.5    Zavattari, P.6
  • 45
    • 0028881617 scopus 로고
    • The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription
    • Kennedy G.C., German M.S., and Rutter W.J. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat Genet 9 (1995) 293-298
    • (1995) Nat Genet , vol.9 , pp. 293-298
    • Kennedy, G.C.1    German, M.S.2    Rutter, W.J.3
  • 46
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese A., Zeller M., Fernandez Jr. A., Zalcberg L.J., Bartlett R.J., Ricordi C., et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 15 (1997) 293-297
    • (1997) Nat Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez Jr., A.3    Zalcberg, L.J.4    Bartlett, R.J.5    Ricordi, C.6
  • 47
    • 0034891347 scopus 로고    scopus 로고
    • Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes
    • Vafiadis P., Ounissi-Benkalha H., Palumbo M., Grabs R., Rousseau M., Goodyer C.G., et al. Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes. J Clin Endocrinol Metab 86 (2001) 3705-3710
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3705-3710
    • Vafiadis, P.1    Ounissi-Benkalha, H.2    Palumbo, M.3    Grabs, R.4    Rousseau, M.5    Goodyer, C.G.6
  • 48
    • 0028871202 scopus 로고
    • Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
    • Bennett S.T., Lucassen A.M., Gough S.C., Powell E.E., Undlien D.E., Pritchard L.E., et al. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 9 (1995) 284-292
    • (1995) Nat Genet , vol.9 , pp. 284-292
    • Bennett, S.T.1    Lucassen, A.M.2    Gough, S.C.3    Powell, E.E.4    Undlien, D.E.5    Pritchard, L.E.6
  • 49
    • 0001017310 scopus 로고    scopus 로고
    • IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus
    • Bennett S.T., Wilson A.J., Cucca F., Nerup J., Pociot F., McKinney P.A., et al. IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus. J Autoimmun 9 (1996) 415-421
    • (1996) J Autoimmun , vol.9 , pp. 415-421
    • Bennett, S.T.1    Wilson, A.J.2    Cucca, F.3    Nerup, J.4    Pociot, F.5    McKinney, P.A.6
  • 50
    • 0030175721 scopus 로고    scopus 로고
    • Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes
    • Vafiadis P., Bennett S.T., Colle E., Grabs R., Goodyer C.G., and Polychronakos C. Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes. J Autoimmun 9 (1996) 397-403
    • (1996) J Autoimmun , vol.9 , pp. 397-403
    • Vafiadis, P.1    Bennett, S.T.2    Colle, E.3    Grabs, R.4    Goodyer, C.G.5    Polychronakos, C.6
  • 51
    • 0036315824 scopus 로고    scopus 로고
    • Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes
    • Chentoufi A.A., and Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51 (2002) 1383-1390
    • (2002) Diabetes , vol.51 , pp. 1383-1390
    • Chentoufi, A.A.1    Polychronakos, C.2
  • 52
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis P., Bennett S.T., Todd J.A., Nadeau J., Grabs R., Goodyer C.G., et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 15 (1997) 289-292
    • (1997) Nat Genet , vol.15 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3    Nadeau, J.4    Grabs, R.5    Goodyer, C.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.