Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

Diabetologia

Volumn 50, Issue 4, 2007, Pages 779-789

  Larsen, L ^a   Tonnesen, M ^a   Ronn, S G ^a   Storling J ^a   Jorgensen S ^a   Mascagni, P ^b   Dinarello, C A ^c   Billestrup, N ^a   Mandrup Poulsen, T ^a,d  

^a STENO DIABETES CENTER   (Denmark)

^b Italfarmaco SpA   (Italy)

^c UNIVERSITY OF COLORADO   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Autoimmunity; Beta cells; Cell signalling; Histone deacetylases; IFN ; IL 1 ; Nitric oxide; Nuclear factor kappa B; SAHA; TSA

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYTOKINE; GAMMA INTERFERON; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; NITRIC OXIDE; TRICHOSTATIN A; VORINOSTAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL CULTURE; CELL FUNCTION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA HISTONE INTERACTION; DOWN REGULATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; IMMUNOBLOTTING; INSULIN RELEASE; NEWBORN; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CYTOKINES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HISTONE DEACETYLASES; INSULIN-SECRETING CELLS; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 33847676166     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0562-3     Document Type: Article

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