Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling

Journal of Autoimmunity

Volumn 35, Issue 1, 2010, Pages 70-76

  Elo, Laura L ^a   Mykkänen, Juha ^a   Nikula, Tuomas ^a   Järvenpää, Henna ^a   Simell, Satu ^a   Aittokallio, Tero ^a   Hyöty, Heikki ^b,c   Ilonen, Jorma ^a,d   Veijola, Riitta ^e   Simell, Tuula ^a   Knip, Mikael ^c,f   Simell, Olli ^a   Lahesmaa, Riitta ^a,g  

^a UNIVERSITY OF TURKU   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e UNIVERSITY OF OULU   (Finland)

^f UNIVERSITY OF HELSINKI   (Finland)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Autoantibodies; Differential gene expression; Longitudinal data; Molecular networks; Pathway analysis; Prediabetes; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; T LYMPHOCYTE RECEPTOR; INSULIN;

ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME ANALYSIS; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; BIOLOGY; DIABETES MELLITUS, TYPE 1; EARLY DIAGNOSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROGNOSIS; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE;

ANTIGEN PRESENTATION; CHILD; CHILD, PRESCHOOL; COMPUTATIONAL BIOLOGY; DIABETES MELLITUS, TYPE 1; EARLY DIAGNOSIS; FEMALE; GENE EXPRESSION PROFILING; GENES, T-CELL RECEPTOR; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNE TOLERANCE; INSULIN; MALE; PROGNOSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77953286299     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2010.03.001     Document Type: Article

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