After the Gwas rush: Nuggets of insight into the pathogenesis of autoimmune disease

Seminars in Immunology

Volumn 21, Issue 6, 2009, Pages 313-317

  Danska, Jayne S ^a   Poussier, Philippe ^b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b Sunnybrook Health Sciences Centre   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA DQ2 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 12P40; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 3 RECEPTOR; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22;

AUTOIMMUNE DISEASE; CELIAC DISEASE; EDITORIAL; ENTERITIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HLA SYSTEM; HUMAN; IMMUNOGENETICS; IMMUNOPATHOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PSORIASIS; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INTESTINAL DISEASES;

EID: 70949087368     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2009.10.007     Document Type: Editorial

References (20)

1. Fan Y., Rudert W.A., Grupillo M., He J., Sisino G., and Trucco M. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 28 (2009) 2812-2824
2. Nejentsev S., Walker N., Riches D., Egholm M., and Todd J.A. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324 (2009) 387-389
3. Hindorff L.A., Sethupathy P., Junkins H.A., Ramos E.M., Mehta J.P., Collins F.S., et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 106 (2009) 9362-9367
4. Goldstein D.B. Common genetic variation and human traits. N Engl J Med 360 (2009) 1696-1698
5. Manolio T.A., Collins F.S., Cox N.J., Goldstein D.B., Hindorff L.A., Hunter D.J., et al. Finding the missing heritability of complex diseases. Nature 461 (2009) 747-753
6. McCarroll S.A., Huett A., Kuballa P., Chilewski S.D., Landry A., Goyette P., et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008)
7. Weiss L.A., Shen Y., Korn J.M., Arking D.E., Miller D.T., Fossdal R., et al. Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med 358 (2008) 667-675
8. Weiss L.A., Pan L., Abney M., and Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet 38 (2006) 218-222
9. Kurz T., and Ober C. The role of environmental tobacco smoke in genetic susceptibility to asthma. Curr Opin Allergy Clin Immunol 4 (2004) 335-339
10. Braun-Fahrlander C. Environmental exposure to endotoxin and other microbial products and the decreased risk of childhood atopy: evaluating developments since April 2002. Curr Opin Allergy Clin Immunol 3 (2003) 325-329
11. Kusel M.M., de Klerk N.H., Kebadze T., Vohma V., Holt P.G., Johnston S.L., et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 119 (2007) 1105-1110
12. Jackson D.J., Gangnon R.E., Evans M.D., Roberg K.A., Anderson E.L., Pappas T.E., et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 178 (2008) 667-672
13. Rutgeerts P., Goboes K., Peeters M., Hiele M., Penninckx F., Aerts R., et al. Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet 338 (1991) 771-774
14. D'Haens G.R., Geboes K., Peeters M., Baert F., Penninckx F., and Rutgeerts P. Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 114 (1998) 262-267
15. Dendrou C.A., Plagnol V., Fung E., Yang J.H., Downes K., Cooper J.D., et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 41 (2009) 1011-1015
16. The environmental determinants of diabetes in the young (TEDDY) study: study design. Pediatr Diabetes 8 (2007) 286-298
17. The environmental determinants of diabetes in the young (TEDDY) study. Ann N Y Acad Sci 1150 (2008) 1-13
18. Barrett J.C., Clayton D.G., Concannon P., Akolkar B., Cooper J.D., Erlich H.A., et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009)
19. Maier L.M., Lowe C.E., Cooper J., Downes K., Anderson D.E., Severson C., et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 5 (2009) e1000322
20. Krueger G.G., Langley R.G., Leonardi C., Yeilding N., Guzzo C., Wang Y., et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 356 (2007) 580-592