The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted

Journal of Autoimmunity

Volumn 37, Issue 4, 2011, Pages 263-272

  Iobagiu, Cristina ^a,b   Magyar, Anna ^c   Nogueira, Leonor ^a,b   Cornillet, Martin ^a   Sebbag, Mireille ^a   Arnaud, Jacques ^a   Hudecz, Ferenc ^d   Serre, Guy ^a,b  

^a France   (France)

^b CHU PURPAN   (France)

^c EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^d EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Anti citrullinated protein autoantibodies (ACPA); B Cell epitopes; Citrullination; Fibrin; Rheumatoid arthritis

Indexed keywords

AUTOANTIBODY; CITRULLINE; EPITOPE; FIBRIN;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ANTIGENICITY; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RHEUMATOID ARTHRITIS;

ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; CITRULLINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FIBRIN; HUMANS; IMMUNODOMINANT EPITOPES; MODELS, CHEMICAL; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; SYNOVIAL MEMBRANE;

EID: 82955187521     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.07.003     Document Type: Article

References (38)

1. Klareskog L., Ronnelid J., Lundberg K., Padyukov L., Alfredsson L. Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol 2008, 26:651-675.
2. Sebbag M., Clavel C., Nogueira L., Arnaud J., Serre G. Autoimmune response to posttranslationally modified (citrullinated) proteins: prime suspect in the pathophysiology of rheumatoid arthritis. The epigenetics of autoimmune diseases 2009, 279-308. John Wiley and Sons. M. Zouali (Ed.).
3. Nogueira L., Sebbag M., Chapuy-Regaud S., Clavel C., Fournié B., Cantagrel A., et al. Autoantibodies to deiminated fibrinogen are the most efficient serological criterion for the diagnosis of rheumatoid arthritis. Arthritis Res 2002, 4(Suppl. 4):90.
4. Vander Cruyssen B., Cantaert T., Nogueira L., Clavel C., De Rycke L., Dendoven A., et al. Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays. Arthritis Res Ther 2006, 8:R122.
5. Nielen M.M., van Schaardenburg D., Reesink H.W., van de Stadt R.J., van der Horst-Bruinsma I.E., de Koning M.H., et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004, 50:380-386.
6. Forslind K., Ahlmen M., Eberhardt K., Hafstrom I., Svensson B. Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP). Ann Rheum Dis 2004, 63:1090-1095.
7. Girbal-Neuhauser E., Durieux J.J., Arnaud M., Dalbon P., Sebbag M., Vincent C., et al. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol 1999, 162:585-594.
8. Schellekens G.A., de Jong B.A., van den Hoogen F.H., van de Putte L.B., van Venrooij W.J. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998, 101:273-281.
9. Masson-Bessière C., Sebbag M., Girbal-Neuhauser E., Nogueira L., Vincent C., Senshu T., et al. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 2001, 166:4177-4184.
10. Nogueira L., Chapuy-Regaud S., Constantin A., Clavel C., Sebbag M., Cantagrel A., et al. Autoantibodies to deiminated fibrinogen are the most efficient serological criterion for early rheumatoid arthritis diagnosis. Arthritis Res Ther 2003, 5(Suppl. 1):18.
11. Masson-Bessière C., Sebbag M., Durieux J.J., Nogueira L., Vincent C., Girbal-Neuhauser E., et al. In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum. Clin Exp Immunol 2000, 119:544-552.
12. Chapuy-Regaud S., Sebbag M., Baeten D., Clavel C., Foulquier C., De Keyser F., et al. Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitides. J Immunol 2005, 174:5057-5064.
13. Clavel C., Nogueira L., Laurent L., Iobagiu C., Vincent C., Sebbag M., et al. Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum 2008, 58:678-688.
14. Foulquier C., Sebbag M., Clavel C., Chapuy-Regaud S., Al Badine R., Méchin M.C., et al. Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation. Arthritis Rheum 2007, 56:3541-3553.
15. Hueber W., Kidd B.A., Tomooka B.H., Lee B.J., Bruce B., Fries J.F., et al. Antigen microarray profiling of autoantibodies in rheumatoid arthritis. Arthritis Rheum 2005, 52:2645-2655.
16. Sebbag M., Moinard N., Auger I., Clavel C., Arnaud J., Nogueira L., et al. Epitopes of human fibrin recognized by the rheumatoid arthritis-specific autoantibodies to citrullinated proteins. Eur J Immunol 2006, 36:2250-2263.
17. Vincent C., Simon M., Sebbag M., Girbal-Neuhauser E., Durieux J.J., Cantagrel A., et al. Immunoblotting detection of autoantibodies to human epidermis filaggrin: a new diagnostic test for rheumatoid arthritis. J Rheumatol 1998, 25:838-846.
18. Geysen H.M., Rodda S.J., Mason T.J., Tribbick G., Schoofs P.G. Strategies for epitope analysis using peptide synthesis. J Immunol Methods 1987, 102:259-274.
19. Flegel M.S.R. A sensitive, general method for quantitative monitoring of continuous flow solid phase peptide synthesis. J Chem Soc Chem Commun 1990, 536-538.
20. Bosze S., Ligeti M., Magyar A., Medzihradszky-Schweiger H., Hudecz F. Enzymatic degradation of carbamoyl-nociceptin analogues. Peptides 2004, Proceedings of 3rd international and 28th European peptide symposium 2005, 900-901. KENES International, Israel. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds.).
21. Douguet D., Labesse G. Easier threading through web-based comparisons and cross-validations. Bioinformatics 2001, 17:752-753.
22. Guex N., Peitsch M.C. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 1997, 18:2714-2723.
23. Pechik I., Yakovlev S., Mosesson M.W., Gilliland G.L., Medved L. Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly. Biochemistry 2006, 45:3588-3597.
24. Perez M.L., Gomara M.J., Kasi D., Alonso A., Vinas O., Ercilla G., et al. Synthesis of overlapping fibrin citrullinated peptides and their use for diagnosing rheumatoid arthritis. Chem Biol Drug Des 2006, 68:194-200.
25. Sanmarti R., Graell E., Perez M.L., Ercilla G., Vinas O., Gomez-Puerta J.A., et al. Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis. Arthritis Res Ther 2009, 11:R135.
26. Perez M.L., Gomara M.J., Ercilla G., Sanmarti R., Haro I. Antibodies to citrullinated human fibrinogen synthetic peptides in diagnosing rheumatoid arthritis. J Med Chem 2007, 50:3573-3584.
27. Mahler M., Mierau R., Bluthner M. Fine-specificity of the anti-CENP-A B-cell autoimmune response. J Mol Med 2000, 78:460-467.
28. Vincent C., Nogueira L., Sebbag M., Chapuy-Regaud S., Arnaud M., Letourneur O., et al. Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis. Arthritis Rheum 2002, 46:2051-2058.
29. Neurath A.R., Strick N., Lee E.S. B cell epitope mapping of human immunodeficiency virus envelope glycoproteins with long (19- to 36-residue) synthetic peptides. J Gen Virol 1990, 71(Pt 1):85-95.
30. Palker T.J., Matthews T.J., Clark M.E., Cianciolo G.J., Randall R.R., Langlois A.J., et al. A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope. Proc Natl Acad Sci USA 1987, 84:2479-2483.
31. Gnann J.W., Nelson J.A., Oldstone M.B. Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus. J Virol 1987, 61:2639-2641.
32. Tolfvenstam T., Lundqvist A., Levi M., Wahren B., Broliden K. Mapping of B-cell epitopes on human parvovirus B19 non-structural and structural proteins. Vaccine 2000, 19:758-763.
33. Pau C.P., Lam L.L., Spira T.J., Black J.B., Stewart J.A., Pellett P.E., et al. Mapping and serodiagnostic application of a dominant epitope within the human herpesvirus 8 ORF 65-encoded protein. J Clin Microbiol 1998, 36:1574-1577.
34. De Paolis F., Beghetto E., Spadoni A., Montagnani F., Felici F., Oggioni M.R., et al. Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae. BMC Microbiol 2007, 7:113.
35. Mahler M., Bluthner M., Pollard K.M. Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. Clin Immunol 2003, 107:65-79.
36. McClain M.T., Heinlen L.D., Dennis G.J., Roebuck J., Harley J.B., James J.A. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med 2005, 11:85-89.
37. Schett G., Dumortier H., Hoefler E., Muller S., Steiner G. B-cell epitopes of the heterogeneous nuclear ribonucleoprotein A2: identification of a new specific antibody marker for active lupus disease. Ann Rheum Dis 2008, 729-735.
38. Tainer J.A., Getzoff E.D., Alexander H., Houghten R.A., Olson A.J., Lerner R.A., et al. The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature 1984, 312:127-134.