Neurotoxicity and persistent cognitive deficits induced by combined MDMA and alcohol exposure in adolescent rats

Addiction Biology

Volumn 15, Issue 4, 2010, Pages 413-423

  Hernandez Rabaza, Vicente ^a   Navarro Mora, Graciela ^a   Velazquez Sanchez, Clara ^a   Ferragud, Antonio ^a   Marin, Maria P ^b   Garcia Verdugo, Jose M ^c   Renau Piqueras, Jaime ^b   Canales, Juan J ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

Author keywords

3,4 Methylenedioxymethamphetamine (MDMA); adolescence; alcohol; cocaine; hippocampus; memory

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; BROXURIDINE; COCAINE; DOUBLECORTIN;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; GRANULE CELL; HIPPOCAMPUS; MALE; MAZE TEST; MENTAL PERFORMANCE; MICROGLIA; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

AGE FACTORS; ANIMALS; CELL DIFFERENTIATION; CELL SURVIVAL; DENDRITES; DENTATE GYRUS; DRUG SYNERGISM; ETHANOL; MALE; MAZE LEARNING; MENTAL RECALL; MICROGLIA; N-METHYLASPARTATE; NEUROGENESIS; NEUROTOXINS; ORIENTATION; RATS; RATS, LONG-EVANS; RETENTION (PSYCHOLOGY);

EID: 78649466662     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2010.00259.x     Document Type: Article

References (50)

1. Aimone JB, Wiles J, Gage FH, (2006) Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci 9: 723-727.
2. Barrett SP, Darredeau C, Pihl RO, (2006) Patterns of simultaneous polysubstance use in drug using university students. Hum Psychopharmacol 21: 255-263.
3. Barrett SP, Gross SR, Garand I, Pihl RO, (2005) Patterns of simultaneous polysubstance use in Canadian rave attendees. Subst Use Misuse 40: 1525-1537.
4. Baumann MH, Wang X, Rothman RB, (2007) 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings. Psychopharmacology 189: 407-424.
5. Baumann MH, Zolkowska D, Kim I, Scheidweiler KB, Rothman RB, Huestis MA, (2009) Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat. Drug Metab Dispos 37: 2163-2170.
6. Bedi G, Redman J, (2008) Metamemory in recreational ecstasy polydrug users: what do self-reports of memory failures mean? J Psychopharmacol 22: 872-881.
7. Breen C, Degenhardt L, Kinner S, Bruno R, Jenkinson R, Matthews A, Newman J, (2006) Alcohol use and risk taking among regular ecstasy users. Subst Use Misuse 41: 1095-1109.
8. Burgess N, (2008) Spatial cognition and the brain. Ann N Y Acad Sci 1124: 77-97.
9. Buster MC, Witteveen E, Prins M, Van Ameijden EJ, Schippers G, Krol A, (2009) Transitions in drug use in a new generation of problem drug users in Amsterdam: a 6-year follow-up study. Eur Addict Res 15: 179-187.
10. Canales JJ, (2007) Adult neurogenesis and the memories of drug addiction. Eur Arch Psychiatry Clin Neurosci 257: 261-270.
11. Cassel JC, Riegert C, Rutz S, Koenig J, Rothmaier K, Cosquer B, Lazarus C, Birthelmer A, Jeltsch H, Jones BC, Jackisch R, (2005) Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat. Neuropsychopharmacology 30: 1870-1882.
12. Colado MI, Green AR, (1995) The spin trap reagent alpha-phenyl-N-tert- butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones. Eur J Pharmacol 280: 343-346.
13. Colussi-Mas J, Wise RJ, Howard A, Schenk S, (2010) Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine. Int J Neuropsychopharmacol doi: 10.1017/S1461145710000283
14. Colzato LS, Huizinga M, Hommel B, (2009) Recreational cocaine polydrug use impairs cognitive flexibility but not working memory. Psychopharmacology 207: 225-234.
15. Courtney KE, Polich J, (2009) Binge drinking in young adults: data, definitions, and determinants. Psychol Bull 135: 142-156.
16. Crews FT, Mdzinarishvili A, Kim D, He J, Nixon K, (2006) Neurogenesis in adolescent brain is potently inhibited by ethanol. Neuroscience 137: 437-445.
17. De La Torre R, Farre M, Ortuno J, Mas M, Brenneisen R, Roset PN, Segura J, Camí J, (2000) Non-linear pharmacokinetics of MDMA ('ecstasy') in humans. Br J Clin Pharmacol 49: 104-109.
18. De Sola S, Tarancon T, Pena-Casanova J, Espadaler JM, Langohr K, Poudevida S, Farré M, Verdejo-García A, De La Torre R, (2008) Auditory event-related potentials (P3) and cognitive performance in recreational ecstasy polydrug users: evidence from a 12-month longitudinal study. Psychopharmacology 200: 425-437.
19. Doetsch F, Hen R, (2005) Young and excitable: the function of new neurons in the adult mammalian brain. Curr Opin Neurobiol 15: 121-128.
20. Dominguez-Escriba L, Hernandez-Rabaza V, Soriano-Navarro M, Barcia JA, Romero FJ, Garcia-Verdugo JM, Canales JJ, (2006) Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus. Eur J Neurosci 24: 586-594.
21. Eichenbaum H, (2006) Remembering: functional organization of the declarative memory system. Curr Biol 16: R643-R645.
22. Eugenin EA, Eckardt D, Theis M, Willecke K, Bennett MV, Saez JC, (2001) Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha. Proc Natl Acad Sci U S A 98: 4190-4195.
23. Fernandez-Lizarbe S, Pascual M, Guerri C, (2009) Critical role of TLR4 response in the activation of microglia induced by ethanol. J Immunol 183: 4733-4744.
24. Ferragud A, Haro A, Sylvain A, Velazquez-Sanchez C, Hernandez-Rabaza V, Canales JJ, (2010) Enhanced habit-based learning and decreased neurogenesis in the adult hippocampus in a murine model of chronic social stress. Behav Brain Res 210: 134-139.
25. Ferragud A, Velazquez-Sanchez C, Hernandez-Rabaza V, Nacher A, Merino V, Carda M, Murga J, Canales JJ, (2009) A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat. Psychopharmacology 207: 281-289.
26. Ge S, Yang CH, Hsu KS, Ming GL, Song H, (2007) A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron 54: 559-566.
27. George O, Mandyam CD, Wee S, Koob GF, (2008) Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology 33: 2474-2482.
28. Green AR, Gabrielsson J, Marsden CA, Fone KC, (2009) MDMA: on the translation from rodent to human dosing. Psychopharmacology) 204: 375-378.
29. Grov C, Kelly BC, Parsons JT, (2009) Polydrug use among club-going young adults recruited through time-space sampling. Subst Use Misuse 44: 848-864.
30. Hadjiefthyvoulou F, Fisk JE, Montgomery C, Bridges NJ, (2010) Everyday and prospective memory deficits in ecstasy/polydrug users. J Psychopharmacol doi: 10.1177/0269881109359101
31. Hamida SB, Tracqui A, De Vasconcelos AP, Szwarc E, Lazarus C, Kelche C, Jones BC, Cassel JC, (2009) Ethanol increases the distribution of MDMA to the rat brain: possible implications in the ethanol-induced potentiation of the psychostimulant effects of MDMA. Int J Neuropsychopharmacol 12: 749-759.
32. Hernandez-Rabaza V, Barcia JA, Llorens-Martin M, Trejo JL, Canales JJ, (2007) Spared place and object-place learning but limited spatial working memory capacity in rats with selective lesions of the dentate gyrus. Brain Res Bull 72: 315-323.
33. Hernandez-Rabaza V, Dominguez-Escriba L, Barcia JA, Rosel JF, Romero FJ, Garcia-Verdugo JM, Canales JJ, (2006) Binge administration of 3,4-methylenedioxymethamphetamine ('ecstasy') impairs the survival of neural precursors in adult rat dentate gyrus. Neuropharmacology 51: 967-973. (Pubitemid 44550123)
34. Hernandez-Rabaza V, Llorens-Martin M, Velazquez-Sanchez C, Ferragud A, Arcusa A, Gumus HG, Gómez-Pinedo U, Pérez-Villalba A, Roselló J, Trejo JL, Barcia JA, Canales JJ, (2009) Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal. Neuroscience 159: 59-68.
35. Izco M, Orio L, O'Shea E, Colado MI, (2007) Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain. Psychopharmacology 189: 459-470.
36. Khairnar A, Plumitallo A, Frau L, Schintu N, Morelli M, (2009) Caffeine enhances astroglia and microglia reactivity induced by 3,4- methylenedioxymethamphetamine ('ecstasy') in mouse brain. Neurotox Res 17: 435-439.
37. Leuner B, Gould E, Shors TJ, (2006) Is there a link between adult neurogenesis and learning? Hippocampus 16: 216-224.
38. Mayer JL, Klumpers L, Maslam S, De Kloet ER, Joels M, Lucassen PJ, (2006) Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis. J Neuroendocrinol 18: 629-631.
39. Mueller M, Yuan J, Felim A, Neudorffer A, Peters FT, Maurer HH, McCann UD, Largeron M, Ricaurte GA, (2009) Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity. Drug Metab Dispos 37: 2079-2086.
40. Olton DS, (1987) The radial arm maze as a tool in behavioral pharmacology. Physiol Behav 40: 793-797.
41. Olton DS, Feustle WA, (1981) Hippocampal function required for nonspatial working memory. Exp Brain Res 41: 380-389.
42. Parrott AC, Milani RM, Parmar R, Turner JD, (2001) Recreational ecstasy/MDMA and other drug users from the UK and Italy: psychiatric symptoms and psychobiological problems. Psychopharmacology 159: 77-82.
43. Reagan-Shaw S, Nihal M, Ahmad N, (2008) Dose translation from animal to human studies revisited. FASEB J 22: 659-661.
44. Rosenthal D, Mallett S, Milburn N, Rotheram-Borus MJ, (2008) Drug use among homeless young people in Los Angeles and Melbourne. J Adolesc Health 43: 296-305.
45. Santucci AC, (2008) Adolescent cocaine residually impairs working memory and enhances fear memory in rats. Exp Clin Psychopharmacol 16: 77-85.
46. Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JE, García AD, Sofroniew MV, Kandel ER, Santarelli L, Hen R, Drew MR, (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A 103: 17501-17506.
47. Schulteis G, Archer C, Tapert SF, Frank LR, (2008) Intermittent binge alcohol exposure during the periadolescent period induces spatial working memory deficits in young adult rats. Alcohol 42: 459-467.
48. Squire LR, (2004) Memory systems of the brain: a brief history and current perspective. Neurobiol Learn Mem 82: 171-177.
49. Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S, (2006) Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16: 296-304.
50. Winstock AR, Griffiths P, Stewart D, (2001) Drugs and the dance music scene: a survey of current drug use patterns among a sample of dance music enthusiasts in the UK. Drug Alcohol Depend 64: 9-17.