Targeting maladaptive glutathione responses in lung disease

Biochemical Pharmacology

Volumn 81, Issue 2, 2011, Pages 187-193

  Gould, Neal S ^a,c   Day, Brian J ^a,b,c  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Chronic obstructive pulmonary disease; Cystic fibrosis; Idiopathic pulmonary fibrosis; Infection and cigarette smoke; Glutamylcysteine ligase

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE;

AGING; AIRWAY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CYSTIC FIBROSIS; FIBROSING ALVEOLITIS; HUMAN; LUNG DISEASE; LUNG INJURY; NONHUMAN; PEPTIDE SYNTHESIS; PNEUMONIA; PRIORITY JOURNAL; PROTECTION; REVIEW;

EID: 78650180139     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.10.001     Document Type: Note

References (73)

1. A.M. Cantin, G.A. Fells, R.C. Hubbard, and R.G. Crystal Antioxidant macromolecules in the epithelial lining fluid of the normal human lower respiratory tract J Clin Invest 86 1990 962 971 (Pubitemid 20327389)
2. F.J. Kelly, M. Cotgrove, and I.S. Mudway Respiratory tract lining fluid antioxidants: the first line of defence against gaseous pollutants Cent Eur J Public Health 4 Suppl. 1996 11 14
3. B. Magi, E. Bargagli, L. Bini, and P. Rottoli Proteome analysis of bronchoalveolar lavage in lung diseases Proteomics 6 2006 6354 6369 (Pubitemid 44935519)
4. I. Noel-Georis, A. Bernard, P. Falmagne, and R. Wattiez Database of bronchoalveolar lavage fluid proteins J Chromatogr B: Analyt Technol Biomed Life Sci 771 2002 221 236 (Pubitemid 34457730)
5. V.L. Kinnula, and J.D. Crapo Superoxide dismutases in the lung and human lung diseases Am J Respir Crit Care Med 167 2003 1600 1619 (Pubitemid 36760673)
6. C.E. Cross, A. van der Vliet, C.A. O'Neill, S. Louie, and B. Halliwell Oxidants, antioxidants, and respiratory tract lining fluids Environ Health Perspect 102 Suppl. 10 1994 185 191
7. A.M. Cantin, S.L. North, R.C. Hubbard, and R.G. Crystal Normal alveolar epithelial lining fluid contains high levels of glutathione J Appl Physiol 63 1987 152 157 (Pubitemid 17107139)
8. A.F. Behndig, A. Blomberg, R. Helleday, S.T. Duggan, F.J. Kelly, and I.S. Mudway Antioxidant responses to acute ozone challenge in the healthy human airway Inhal Toxicol 21 2009 933 942
9. B.C. Schock, J. Koostra, S. Kwack, R.M. Hackman, A. Van Der Vliet, and C.E. Cross Ascorbic acid in nasal and tracheobronchial airway lining fluids Free Radic Biol Med 37 2004 1393 1401 (Pubitemid 39349239)
10. R. Slade, K. Crissman, J. Norwood, and G. Hatch Comparison of antioxidant substances in bronchoalveolar lavage cells and fluid from humans, guinea pigs, and rats Exp Lung Res 19 1993 469 484 (Pubitemid 23212956)
11. H. Fischer Mechanisms and function of DUOX in epithelia of the lung Antioxid Redox Signal 11 2009 2453 2465
12. A.M. Cantin, and R. Begin Glutathione and inflammatory disorders of the lung Lung 169 1991 123 138
13. P.E. Morris, and G.R. Bernard Significance of glutathione in lung disease and implications for therapy Am J Med Sci 307 1994 119 127 (Pubitemid 24065410)
14. H.M. Leitner, R. Kachadourian, and B.J. Day Harnessing drug resistance: using ABC transporter proteins to target cancer cells Biochem Pharmacol 74 2007 1677 1685 (Pubitemid 350088674)
15. C.V. Smith, D.P. Jones, T.M. Guenthner, L.H. Lash, and B.H. Lauterburg Compartmentation of glutathione: implications for the study of toxicity and disease Toxicol Appl Pharmacol 140 1996 1 12 (Pubitemid 26329456)
16. N. Chikhi, N. Holic, G. Guellaen, and Y. Laperche Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species Comp Biochem Physiol B: Biochem Mol Biol 122 1999 367 380 (Pubitemid 29221969)
17. C. Bai, L.A. Brown, and D.P. Jones Glutathione transport by type II cells in perfused rat lung Am J Physiol 267 1994 L447 L455
18. L.H. Lash, T.M. Hagen, and D.P. Jones Exogenous glutathione protects intestinal epithelial cells from oxidative injury Proc Natl Acad Sci USA 83 1986 4641 4645 (Pubitemid 16075457)
19. L.H. Lash, and D.P. Jones Transport of glutathione by renal basal-lateral membrane vesicles Biochem Biophys Res Commun 112 1983 55 60 (Pubitemid 13095805)
20. B.J. Day, A.M. van Heeckeren, E. Min, and L.W. Velsor Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection Infect Immun 72 2004 2045 2051 (Pubitemid 38419916)
21. C. Kariya, H. Leitner, E. Min, C. van Heeckeren, A. van Heeckeren, and B.J. Day A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration Am J Physiol Lung Cell Mol Physiol 292 2007 L1590 L1597
22. C. Kariya, H.W. Chu, J. Huang, H. Leitner, R.J. Martin, and B.J. Day Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stress Infect Immun 76 2008 4455 4462
23. H.M. Brechbuhl, N. Gould, R. Kachadourian, W.R. Riekhof, D.R. Voelker, and B.J. Day Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2 J Biol Chem 285 2010 16582 16587
24. J.J. Haddad Glutathione depletion is associated with augmenting a proinflammatory signal: evidence for an antioxidant/pro-oxidant mechanism regulating cytokines in the alveolar epithelium Cytokines Cell Mol Ther 6 2000 177 187 (Pubitemid 32834917)
25. J.J. Haddad, and H.L. Harb l-gamma-glutamyl-l-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)? Mol Immunol 42 2005 987 1014
26. E.M. Drost, K.M. Skwarski, J. Sauleda, N. Soler, J. Roca, and A. Agusti Oxidative stress and airway inflammation in severe exacerbations of COPD Thorax 60 2005 293 300 (Pubitemid 40522365)
27. Gould NS, Min E, Gauthier S, Chu HW, Martin R, Day BJ. Aging adversely affects the cigarette smoke induced glutathione adaptive response in the lung. Am J Respir Crit Care Med 2010; doi:10.1162/rccm.201003-0442OC.
28. K. Ito, and P.J. Barnes COPD as a disease of accelerated lung aging Chest 135 2009 173 180
29. R.T. Abboud, and S. Vimalanathan Pathogenesis of COPD. Part I. The role of protease-antiprotease imbalance in emphysema Int J Tuberc Lung Dis 12 2008 361 367 (Pubitemid 351507246)
30. E. Cavarra, M. Lucattelli, F. Gambelli, B. Bartalesi, S. Fineschi, and A. Szarka Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress Am J Physiol Lung Cell Mol Physiol 281 2001 L412 L427
31. J.E. Gadek, G.A. Fells, R.L. Zimmerman, S.I. Rennard, and R.G. Crystal Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema J Clin Invest 68 1981 889 898 (Pubitemid 11023517)
32. B.G. Cosio, and A. Agusti Update in chronic obstructive pulmonary disease Am J Respir Crit Care Med 181 2009 655 660
33. R. Peto, A.D. Lopez, J. Boreham, M. Thun, and C. Heath Jr. Mortality from tobacco in developed countries: indirect estimation from national vital statistics Lancet 339 1992 1268 1278
34. G.L. Snider Chronic obstructive pulmonary disease: risk factors, pathophysiology and pathogenesis Annu Rev Med 40 1989 411 429 (Pubitemid 19145366)
35. J.P. Janssens, J.C. Pache, and L.P. Nicod Physiological changes in respiratory function associated with ageing Eur Respir J 13 1999 197 205 (Pubitemid 29079244)
36. W. MacNee Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD) Biochem Soc Trans 37 2009 819 823
37. S. Teramoto, Y. Fukuchi, Y. Uejima, K. Teramoto, H. Ito, and H. Orimo Age-related changes in the antioxidant screen of the distal lung in mice Lung 172 1994 223 230 (Pubitemid 24176385)
38. J.H. Suh, S.V. Shenvi, B.M. Dixon, H. Liu, A.K. Jaiswal, and R.M. Liu Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid Proc Natl Acad Sci USA 101 2004 3381 3386 (Pubitemid 38338203)
39. B.K. Berdiev, Y.J. Qadri, and D.J. Benos Assessment of the CFTR and ENaC association Mol Biosyst 5 2009 123 127
40. H. Heijerman Infection and inflammation in cystic fibrosis: a short review J Cyst Fibros 4 Suppl. 2 2005 3 5 (Pubitemid 41131322)
41. S.J. Klebanoff Myeloperoxidase: friend and foe J Leukoc Biol 77 2005 598 625 (Pubitemid 40628741)
42. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001 Am J Respir Crit Care Med 165 2002 277 304
43. A.M. Cantin, R.C. Hubbard, and R.G. Crystal Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis Am Rev Respir Dis 139 1989 370 372 (Pubitemid 19057410)
44. Z. Borok, R. Buhl, G.J. Grimes, A.D. Bokser, R.C. Hubbard, and K.J. Holroyd Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis Lancet 338 1991 215 216
45. R.M. Liu, and K.A. Gaston Pravia Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis Free Radic Biol Med 48 2010 1 15
46. H. Jardine, W. MacNee, K. Donaldson, and I. Rahman Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1 J Biol Chem 277 2002 21158 21166 (Pubitemid 34952251)
47. K. Arsalane, C.M. Dubois, T. Muanza, R. Begin, F. Boudreau, and C. Asselin Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase Am J Respir Cell Mol Biol 17 1997 599 607 (Pubitemid 127499063)
48. R.M. Liu, Y. Liu, H.J. Forman, M. Olman, and M.M. Tarpey Glutathione regulates transforming growth factor-beta-stimulated collagen production in fibroblasts Am J Physiol Lung Cell Mol Physiol 286 2004 L121 L128
49. T.Y. Aw, G. Wierzbicka, and D.P. Jones Oral glutathione increases tissue glutathione in vivo Chem Biol Interact 80 1991 89 97
50. T.M. Hagen, G.T. Wierzbicka, A.H. Sillau, B.B. Bowman, and D.P. Jones Bioavailability of dietary glutathione: effect on plasma concentration Am J Physiol 259 1990 G524 G529
51. C. Bishop, V.M. Hudson, S.C. Hilton, and C. Wilde A pilot study of the effect of inhaled buffered reduced glutathione on the clinical status of patients with cystic fibrosis Chest 127 2005 308 317 (Pubitemid 41724591)
52. J.H. Roum, Z. Borok, N.G. McElvaney, G.J. Grimes, A.D. Bokser, and R. Buhl Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis J Appl Physiol 87 1999 438 443 (Pubitemid 29330711)
53. R. Pela, A.M. Calcagni, S. Subiaco, P. Isidori, A. Tubaldi, and C.M. Sanguinetti N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD Respiration 66 1999 495 500
54. J. Behr, K. Maier, B. Degenkolb, F. Krombach, and C. Vogelmeier Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression Am J Respir Crit Care Med 156 1997 1897 1901 (Pubitemid 28011799)
55. A. Meyer, R. Buhl, and H. Magnussen The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis Eur Respir J 7 1994 431 436 (Pubitemid 24099000)
56. S.I. Hagiwara, Y. Ishii, and S. Kitamura Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice Am J Respir Crit Care Med 162 2000 225 231 (Pubitemid 30469825)
57. H. Tomioka, Y. Kuwata, K. Imanaka, K. Hashimoto, H. Ohnishi, and K. Tada A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary fibrosis Respirology 10 2005 449 455 (Pubitemid 43942613)
58. J.W. Fahey, and P. Talalay Antioxidant functions of sulforaphane: a potent inducer of phase II detoxication enzymes Food Chem Toxicol 37 1999 973 979 (Pubitemid 29481800)
59. S.A. Ritz, J. Wan, and D. Diaz-Sanchez Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract Am J Physiol Lung Cell Mol Physiol 292 2007 L33 L39
60. K. Liby, T. Hock, M.M. Yore, N. Suh, A.E. Place, and R. Risingsong The synthetic triterpenoids. CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling Cancer Res 65 2005 4789 4798 (Pubitemid 40740817)
61. D.P. Nichols, A.G. Ziady, S.L. Shank, J.F. Eastman, and P.B. Davis The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease Am J Physiol Lung Cell Mol Physiol 297 2009 L828 L836
62. N.M. Reddy, V. Suryanaraya, M.S. Yates, S.R. Kleeberger, P.M. Hassoun, and M. Yamamoto The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice Am J Respir Crit Care Med 180 2009 867 874
63. T.E. Sussan, T. Rangasamy, D.J. Blake, D. Malhotra, H. El-Haddad, and D. Bedja Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice Proc Natl Acad Sci USA 106 2009 250 255
64. C. To, S. Kulkarni, T. Pawson, T. Honda, G.W. Gribble, and M.B. Sporn The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex J Biol Chem 283 2008 11700 11713
65. M.M. Bridgeman, M. Marsden, C. Selby, D. Morrison, and W. MacNee Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue Thorax 49 1994 670 675 (Pubitemid 24219144)
66. E.R. Pacht, A.P. Timerman, M.G. Lykens, and A.J. Merola Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome Chest 100 1991 1397 1403
67. M.A. Baz, V.F. Tapson, V.L. Roggli, P. Van Trigt, and C.A. Piantadosi Glutathione depletion in epithelial lining fluid of lung allograft patients Am J Respir Crit Care Med 153 1996 742 746 (Pubitemid 26051357)
68. J.H. Roum, R. Buhl, N.G. McElvaney, Z. Borok, and R.G. Crystal Systemic deficiency of glutathione in cystic fibrosis J Appl Physiol 75 1993 2419 2424 (Pubitemid 24008354)
69. E.R. Pacht, P. Diaz, T. Clanton, J. Hart, and J.E. Gadek Alveolar fluid glutathione decreases in asymptomatic HIV-seropositive subjects over time Chest 112 1997 785 788 (Pubitemid 27410719)
70. A. Visca, C.T. Bishop, S.C. Hilton, and V.M. Hudson Improvement in clinical markers in CF patients using a reduced glutathione regimen: an uncontrolled, observational study J Cyst Fibros 7 2008 433 436
71. A. Witschi, S. Reddy, B. Stofer, and B.H. Lauterburg The systemic availability of oral glutathione Eur J Clin Pharmacol 43 1992 667 669
72. M. Griese, J. Ramakers, A. Krasselt, V. Starosta, S. Van Koningsbruggen, and R. Fischer Improvement of alveolar glutathione and lung function but not oxidative state in cystic fibrosis Am J Respir Crit Care Med 169 2004 822 828 (Pubitemid 38402458)
73. M. Kasielski, and D. Nowak Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease Respir Med 95 2001 448 456 (Pubitemid 32621997)