Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 25, Issue 3, 2012, Pages 207-221

  Aversa, Salvatore ^a   Pellegrino, Salvatore ^a   Barberi, Ignazio ^a   Reiter, Russel J ^b   Gitto, Eloisa ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b University of Texas Health Science Center at San Antonio   (United States)

Author keywords

free radicals; human; Melatonin; newborn; oxidative stress; preeclampsia; pregnancy

Indexed keywords

3 CHLOROTYROSINE; 3 NITROTYROSINE; 3,4 METHYLENEDIOXYAMPHETAMINE; ALLOPURINOL; ALPHA TOCOPHEROL; ANTIOXIDANT; CARBONYL DERIVATIVE; CATALASE; GLUTATHIONE PEROXIDASE; MELATONIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT HUMAN SUPEROXIDE DISMUTASE; SELENIUM; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; BRAIN DAMAGE; CHRONIC LUNG DISEASE; CIRCADIAN RHYTHM; DRUG EFFICACY; DRUG MECHANISM; FETUS DISTRESS; HEALTH CARE COST; HUMAN; HYPERTENSION; HYPOXEMIA; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOMODULATION; IMMUNOREACTIVITY; INTRAUTERINE GROWTH RETARDATION; LIPID PEROXIDATION; LONG TERM CARE; LUNG INJURY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NEWBORN HYPOXIA; NEWBORN SEPSIS; NONHUMAN; OXIDATIVE STRESS; PERINATAL ASPHYXIA; PREECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME; PRENATAL PERIOD; PRIORITY JOURNAL; PROTEINURIA; QUALITY OF LIFE; REPERFUSION INJURY; RESPIRATORY DISTRESS SYNDROME; RESUSCITATION; REVIEW; VERY LOW BIRTH WEIGHT;

ADULT; ANTIOXIDANTS; FEMALE; HUMANS; INFANT, NEWBORN; MELATONIN; OXIDATIVE STRESS; PERINATAL CARE; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; REACTIVE OXYGEN SPECIES; RESPIRATORY DISTRESS SYNDROME, NEWBORN;

EID: 84856822915     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2011.573827     Document Type: Review

References (251)

1. Halliwell B. Free radicals, antioxidants and human disease: curiosity, cause, or consequence? Lancet 1999;344:721-724.
2. Fridovich I. Oxygen toxicity: a radical explanation. J Exp Biol 1998;201:1203-1209. (Pubitemid 28278324)
3. Gitto E, Reiter RJ, Karbownik M, Tan DX, Gitto P, Barberi S, Barberi I. Causes of oxidative stress in the pre-and perinatal period. Biol Neonate 2002;81:146-157. (Pubitemid 34293652)
4. Halliwell B. Oxygen radicals as key mediators in neurological disease: fact or fiction? Ann Neurol 1992;32:S10-S15.
5. Saugstad OD. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta Paediatr 1996;85:1-4. (Pubitemid 26043198)
6. Sarker AH, Watanabe S, Seki S, Akiyama T, Okada S. Oxygen radical-induced single-strand DNA breaks and repair of the damage in a cell-free system. Mutat Res 1995;337:85-95.
7. Saugstad OD. Bronchopulmonary dysplasia-oxidative stress and antioxidants. Semin Neonatol 2003;8:39-49.
8. Saugstad OD. Oxidative stress in the newborn-A 30-year perspective. Biol Neonate 2005;88:228-236. (Pubitemid 41433555)
9. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res 1988;23:143-150. (Pubitemid 18095054)
10. Haynes RL, Folkerth RD, Keefe RJ, Sung I, Swzeda LI, Rosenberg PA, Volpe JJ, Kinney HC. Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol 2003;62:441-450. (Pubitemid 36560186)
11. Clyman RI, Saugstad OD, Mauray F. Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production. Circ Res 1989;64:1-8. (Pubitemid 19028498)
12. Archer SL, Peterson D, Nelson DP, De Master EG, Kelly B, Eaton JW, Weir EK. Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung. J Appl Physiol 1989;66:102-111. (Pubitemid 19056064)
13. Sanderud J, Bjoro K, Saugstad OD. Oxygen radicals stimulate thromboxane and prostacyclin synthesis and induce vasocon-striction in pig lungs. Scand J Clin Lab Invest 1993;53:447-455. (Pubitemid 23244218)
14. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1993;1:57-60.
15. Allegra M, Reiter RJ, Tan DX, Gentile C, Tesoriere L, Livrea MA. The chemistry of melatonin's interaction with reactive species. J Pineal Res 2003;34:1-10. (Pubitemid 36140351)
16. Jarzynka MJ, Passey DK, Johnson DA, Konduro NV, Fitz NF, Radio NM, Rasenick M, Benloucif S, Melan MA, Witt-Enderby PA. Microtubules modulate melatonin receptors involved in phase shifting circadian activity rhythms: in vitro and in vivo evidence. J Pineal Res 2009;46:161-171.
17. Reiter RJ. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991;12:151-180.
18. Reiter RJ, Paredes SD, Manchester LC, Tan DX. Reducing oxidative/nitrosative stress: a newly-discovered genre for mela-tonin. Crit Rev Biochem Mol Biol 2009;44:175-200.
19. Reiter RJ, Tan DX, Manchester LC, Terron MP, Flores LJ, Koppisetti SD. Medical implications of melatonin: receptor-mediated and receptor-independent actions. Adv Med Sci 2007;52:11-28.
20. Reiter RJ, Tan DX, Fuentes-Broto L. Melatonin: a multitasking molecule. Progr Brain Res 2010;181:127-150.
21. Reiter RJ. Melatonin: lowering the high price of free radicals. News Physiol Sci 2000;15:246-250.
22. Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009;46:109-126.
23. Paradies G, Petrosillo G, Paradies V, Reiter RJ, Ruggiero FM. Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. J Pineal Res 2010;48:297-310.
24. Leon J, Acuna-Castroviejo D, Sainz, RM, Mayo JC, Tan DX, Reiter RJ. Melatonin and mitochondrial malfunction. Life Sci 2004;75:765-790.
25. 2θ-mediated permeability transition and beyond in rat brain astrocytes. J Pineal Res 2010;48:20-38.
26. Pablos MI, Reiter RJ, Ortiz GG, Guerrero JM. Rhythms of glutathione peroxidase and glutathione reductase in brain or chick and their inhibition by light. Neurochem Int 1998;32:69-75. (Pubitemid 28020239)
27. Barlow-Walden LR, Reiter RJ, Abe M, Pablos MI, Menendez-Pelaez A, Chen LD, Poeggeler B. Melatonin stimulates glu-tathione peroxidase activity. Neurochem Int 1995;26:497-502.
28. Mohan N, Sadeghi K, Reiter RJ, Meltz ML. The neurohormone melatonin inhibits cytosine, mitogen and ionizing radiation induced NF-kB. Biochem Mol Biol Int 1995;37:1063-1070. (Pubitemid 26181750)
29. Chuang JI, Mohan N, Meltz ML, Reiter RJ. Effect of melatonin of NF-kB DNA-binding activity in rat spleen. Cell Biol Int 1996;20:687-692. (Pubitemid 26402163)
30. Sewerynek E, Reiter RJ, Melchiorri D, Ortiz GG, Lewinski A. Oxidative damage in the liver induced by ischemia-reperfusion: protection by melatonin. Hepatogastroenterology 1996;43:898-905. (Pubitemid 26308371)
31. Drazen DL, Nelson RJ. Melatonin receptor subtype MT2 (Mel 1b) and not MT1 (Mel 1a) is associated with melatonin-induced enhancement of cell-mediated and humoral immunity. Neu-roendocrinology 2001;74:178-184. (Pubitemid 32786217)
32. Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ. A review of the multiple actions of melatonin on the immune system. Endocrine 2005;27:189-200. (Pubitemid 41558451)
33. Bengtsson MW, Jedstedt G, Flemstrom G. Duodenal bicarbonate secretion in rats: stimulation by intra-arterial and luminal guanylin and uroguanylin. Acta Physiol Scand 2007;191:309-317. (Pubitemid 350077451)
34. Nelson CS, Marino JL, Allen CN. Melatonin receptor potentiation of cyclic AMP and the cystic fibrosis transmem-brane conductance regulator ion channel. J Pineal Res 1999;26:113-121. (Pubitemid 29136729)
35. Legris GJ, Will PC, Hopfer U. Inhibition of amiloride-sensitive sodium conductance by indoleamines. Proc Nat Acad Sci USA 1982;79:2046-2050. (Pubitemid 12088566)
36. Sjoblom M, Flemstrom G. Melatonin in the duodenal lumen is a potent stimulant of mucosal bicarbonate secretion. J Pineal Res 2003;34:288-293. (Pubitemid 36469776)
37. Tekbas OF, Ogur R, Korkmaz A, Kilic A, Reiter RJ. Melatonin as an antibiotic: new insights into the actions of this ubiquitous molecule. J Pineal Res 2008;44:222-226. (Pubitemid 351255501)
38. Wisdom SJ, Wilson R, Mckillop JH, Walker JJ. Antioxidant systems in normal pregnancy and in pregnancy hypertension. Am J Obstet Gynecol 1991;6:1701-1705.
39. Walsh SW, Wang Y. Secretion of lipid peroxides by the human placenta. Am J Obstet Gynecol 1993;169:1462-1466. (Pubitemid 24009179)
40. Walsh SW, Wang Y, Jesse R. Peroxide induces vasoconstriction in the human placenta by stimulating thromboxane. Am J Obstet Gynecol 1993;169:1007-1012. (Pubitemid 23317545)
41. Walsh SW, Vaughan JE, Wang Y, Roberts LJ. Placental isoprostane is significantly increased in preeclampsia. FASEB J 2000;14:1289-1296. (Pubitemid 30439737)
42. Hubel CA. Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med 1999;222:222-235.
43. Gupta S, Agarwal A, Sharma RK. The role of placental oxidative stress and lipid peroxidation in preeclampsia. Obstet Gynecol Surv 2005;60:807-816. (Pubitemid 41698019)
44. Vanderlelie J, Venardos K, Clifton VL, Gude NM, Clarke FM, Perkins AV. Increased biological oxidation and reduced antioxidant enzyme activity in preeclamptic placentae. Placenta 2005;26:53-58. (Pubitemid 40123676)
45. Atamer Y, Kocyigit Y, Yokus B, Atamer A, Erden AC. Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. Eur J Obstet Gynecol Reprod Biol 2005;119:60-66. (Pubitemid 40289099)
46. Walsh SW, Wang Y. Deficient glutathione peroxidase activity in preeclampsia is associated with increased placental production of thromboxane and lipid peroxides. Am J Obstet Gynecol 1993;169:1456-1461.
47. Walsh SW, Wang Y. Trophoblast and placental villous coreproduction of lipid peroxides, thromboxane, and prostacy-clin in preeclampsia. J Clin Endocrinol Metab 1995;80:1888-1893.
48. Many A, Hubel CA, Fisher SJ, Roberts JM, Zhou Y. Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia. Am J Pathol 2000;156:321-331. (Pubitemid 30644466)
49. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996;271:C1424-C1437.
50. Poranen AK, Ekblad U, Uotila P, Ahotupa M. Lipid peroxida-tion and antioxidants in normal and pre-eclamptic pregnancies. Placenta 1996;17:401-405. (Pubitemid 26381677)
51. Wang Y, Walsh SW. Antioxidant activities and mRNA expression of superoxide dismutase, catalase, and glutathione peroxidase in normal and preeclamptic placentas. J Soc Gynecol Investig 1996;3:179-184. (Pubitemid 26242202)
52. Cummings DR. Human birth seasonality and sunshine. Am J Human Biol 2010;22:316-324.
53. Bronson FH. Seasonal variation in human reproduction: environmental factors. Q Rev Biol 1995;70:141-164.
54. Henkel R, Menkveld R, Kleinhappl M, Schill WB. Seasonal changes in human sperm chromatin condensation. J Assist Reprod Genet 2001;18:371-377. (Pubitemid 32726992)
55. Partonen T. Short note: melatonin-dependent infertility. Med Hypotheses 1999;52:269-270. (Pubitemid 29199810)
56. Okatani Y, Sagara Y. Enhanced nocturnal melatonin secretion in women with functional secondary amenorrhea: relationship to opioid system and endogenous estrogen levels. Horm Res 1995;43:194-199.
57. Walker AB, English J, Arendt J, MacFarlane JA. Hypogonado-trophic hypogonadism and primary amenorrhea associated with increased melatonin secretion from a cystic pineal lesion. Clin Endocr (Oxf) 1996;45:353-356. (Pubitemid 26306704)
58. Bellastella A, Sinisi AA, Criscuolo T, De Bellis A, Carella C, Iono S, Sinisi AM, Pariato F, Venditto T, Pisano G. Melatonin and the pituitary-thyroid axis status in blind adults: a possible resetting after puberty. Clin Endocrinol (Oxf) 1995;43:707-711. (Pubitemid 26015017)
59. Bellastella A, Criscuolo T, Sinisi AA, Iorio S, Mazzuca A, Pariato F, Faggianao M. Influence of blindness on plasma luteinizing hormone, follicle-stimulating hormone, prolactin, and testosterone levels in prepubertal boys. J Clin Endocrinol Metab 1987;64:862-864. (Pubitemid 17044560)
60. Woo MM, Tai CJ, Kang SK, Nathwani PS, Pang SF, Leung PC. Direct action of melatonin in human granulosa-luteal cells. J Clin Endocrinol Metab 2001;86:4789-4797. (Pubitemid 33020521)
61. Nakamura Y, Tamura H, Takayama H, Kato H. Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertil Steril 2003;80:1012-1016. (Pubitemid 37230040)
62. Takasaki A, Kakamura Y, Tamura H, Sugino N. Melatonin as a new drug for improving oocyte quality. Reprod Med Biol 2003;2:139-144.
63. Tamura H, Takasaki A, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Shimamura K, et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res 2008;44:280-287. (Pubitemid 351392942)
64. Reppert SM. Maternal entrainment of the developing circadian system. Ann NY Acad Sci 1985;453:162-169. (Pubitemid 16169257)
65. Kivela A. Serum melatonin during human pregnancy. Acta Endocrinol (Copenhagen) 1991;124:233-237.
66. Jimenez-Jorge S, Guerrero JM, Jimenez-Caliani AJ, Naranjo MC, Lardone PJ, Carrillo-Vico A, Osuna C, Molinero P. Evidence for melatonin synthesis in the rat brain during development. J Pineal Res 2007;42:240-246. (Pubitemid 46365060)
67. Tauman R, Zisapel N, Laudon M, Nehama H, Sivan Y. Melatonin production in infants. Pediatr Neurol 2002;26:379-382.
68. Seron-Ferre M, Torres-Farfan C, Forcelledo ML, Valenzuela GJ. The development of circadian rhythms in the fetus and neonate. Semin Perinatol 2001;25:363-370. (Pubitemid 33140480)
69. Reppert SM, Schwartz WJ. Functional activity of the supra-chiasmatic nucleus in the fetal primate. Neurosci Lett 1984;46:145-149. (Pubitemid 14147481)
70. Thomas L, Purvis CC, Drew JE, Abramovich DR, Williams LM. Melatonin receptors in human fetal brain. J Pineal Res 2002;33:218-224.
71. Wu YH, Zhou JN, Balesar R, Unmehopa V, Bao A, Jockers R, Van Heerikhuize J, Swaab DF. Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland. J Comp Neurol 2006;499:897-910.
72. Marra G, Anti M, Percesepe A, Armelao A, Ficarelli R, Coco C, Rinelli A, Vecchio FM, D'Arcangelo E. Circadian variations of epithelial cell proliferation in human rectal crypts. Gastroenter-ology 1994;106:982-987. (Pubitemid 24109284)
73. Reiter RJ, Tan DX, Maldonado MD. Melatonin as an antioxidant: physiology versus pharmacology. J Pineal Res 2005;39:215-216. (Pubitemid 41140762)
74. Hardeland R. Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 2005;27:119-130. (Pubitemid 41558444)
75. Tan DX, Reiter RJ, Manchester LC, Yan MT, El-Sawi M, Sainz RM, Mayo JC, Kohen R, Allegra M, Hardeland R. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem 2002;2:181-188.
76. Tan DX, Manchester LC, Tevron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007;42:28-42. (Pubitemid 44924323)
77. Mayo JC, Sainz RM, Antonlin I, Herrera F, Martin V, Rodriguez C. Melatonin regulation of antioxidant enzyme gene expression. Cell Mol Life Sci 2002;59:1706-1713. (Pubitemid 35346974)
78. Garcia-Perganeda A, Pozo D, Guerrero JM, Calvo JR. Signal transduction for melatonin in human lymphocytes: involvement of a pertussis-toxin sensitive G protein. J Immunol 1997; 159:3774-3781. (Pubitemid 127469632)
79. Barjavel MJ, Mamdouh Z, Raghbate N, Bakouche O. Differential expression of the melatonin receptor in human mono-cytes. J Immunol 1998;160:1191-1197. (Pubitemid 28093414)
80. Lopez-Gonzalez MA, Calvo JR, Segura JJ. Characterization of melatonin binding sites in human peripheral blood neutrophils. Biotech Ther 1993;4:253-262. (Pubitemid 23333071)
81. Saito S. Cytokine network at the feto-maternal interface. J Reprod Immunol 2001;47:87-103. (Pubitemid 30621429)
82. Currier NL, Sun LZY, Miller SC. Exogenous melatonin: quantitative enhancement in vivo of cells mediating non-specific immunity. J Neuroimmunol 2000;104:101-108. (Pubitemid 30125399)
83. Tabiasco J, Rabot M, Aguerre-Girr M, ElCosta H, Berrebi A, Parant O, Laskarin G, Juretic K, Bensussan A, Rukavina D, et al. Human decidual NK cells: unique phenotype and functional properties-a review. Placenta 2006;27:s34-s39.
84. Brzezinski A, Fibich T, Cohen M, Schenker JG, Laufer N. Effects of melatonin on progesterone production by human granulosa lutein cells in culture. Fertil Steril 1992;58:526-529.
85. Zisapel N. Melatonin-dopamine interactions: from basic neu-rochemistry to a clinical setting. Cell Mol Neurobiol 2002;21:605-616. (Pubitemid 34538858)
86. Juszaczak M, Stempniak B. Melatonin inhibits the substance P-induced secretion of vasopressin and oxytocin from the rat hypothalamo-neurohypophysial system: in vitro studies. Brain Res Bull 2003;59:393-397. (Pubitemid 36042834)
87. Jauniaux E, Hempstock J, Greenwold N, Burton GJ. Tropho-blastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol 2003;162:115-125. (Pubitemid 36041994)
88. Wiktor H, Kankofer M, Schmerold I. Oxidative DNA damage in placentas from normal and preeclamptic pregnancies. Virchow Arch 2004;445:74-78. (Pubitemid 39044272)
89. Atamer Y, Kocyigit Y, Yokus B, Dada KA, Lopucki M, Niedermüller H. Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. Eur J Obstet Gynecol Reprod Biol 2005;119:60-66. (Pubitemid 40289099)
90. Simko F, Paulis L. Melatonin as a potent antihypertensive treatment. J Pineal Res 2007;42:319-322.
91. Reiter RJ, Tan DX, Korkmaz A. The circadian melatonin rhythm and its modulation: possible impact on hypertension. J Hyperten 2009;27 (Suppl 6):S17-S20.
92. Cagnacci A, Arangino A, Angiolucci M, Maschio E, Melis GB. Influences of melatonin administration on the circulation of women. Am J Physiol 1998;81:29-33.
93. Escames G, Khaldy H, Leon J, Gonzalez L, Acuna-Castroviejo D. Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine. J Hypertens 2004;22:629-635. (Pubitemid 38368498)
94. Scheer FAJL, Van Montfrans GA, Somersen EJW, Mairoho J, Buijs RM. Daily nighttime melatonin reduces blood pressure in male subjects with essential hypertension. Hypertension 2004;43:192-197. (Pubitemid 38174173)
95. Cornelissen G, Sitka U, Tarquini B, Mainardi G, Panero C, Cugini P, Weinert D, Romoli F, Cassanas G, Maggioni C, et al. Chronobiologic approach to blood pressure during pregnancy and early extrauterine life. Prog Clin Biol Res 1990;341a:585-594.
96. Nakamura Y, Tamura H, Kashida S, Takayama H, Yamagata Y, Karube A, Sugino N, Kato H. Changes of serum melatonin level and its relationship to fetoplacental unit during pregnancy. J Pineal Res 2001;30:29-33. (Pubitemid 32056608)
97. Tranquilli AL, Turi A, Giannubilo, Garbati E. Circadian melatonin concentration rhythm is lost in pregnant women with altered blood pressure rhythm. Gynecol Endocrinol 2004;18:124-129. (Pubitemid 38328090)
98. Peled N, Shorer Z, Peled E, Pillar G. Melatonin effect on seizures in children with severe neurologic deficit disorders. Epilepsia 2001;42:1208-1210. (Pubitemid 32947944)
99. Molina-Carballo A, Munoz-Hoyos A, Reiter RJ, Sanchez-Forte M, Moreno-Madrid F, Rufo-Campos M, Molina-Font JA, Acuna-Castroviego D. Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years experience. J Pineal Res 1997; 23:97-105. (Pubitemid 127731744)
100. Sharkey JT, Cable C, Olcese J. Melatonin synergizes with oxytocin to enhance contractility of human myometrial smooth muscle cells. J Clin Endocrinol 2009;94:421-427.
101. Yuo JH, Carter LB, Reiter RJ, Jevtovic-Todorovic V. Melatonin reduces the severity of anesthesia-induced apoptotic neurode-generation in the developing rat brain. Neurobiol Dis 2006;25:522-530. (Pubitemid 43277535)
102. Wakatsuki A, Okatani Y, Lzumiya C, Ikenoue N. Melatonin protects against ischemia and reperfusion oxidative and lipid damage in fetal rat brain. J Pineal Res 1999;26:147-152. (Pubitemid 29183117)
103. Milczarek R, Hollmann A, Sokolowska E, Kaletha K, Klimek J. Melatonin enhances antioxidant action of a-tocopherol and ascorbate against NADPH-and iron-dependent lipid peroxida-tion in human placental mitochondria. J Pineal Res 2010; 49:149-155.
104. Tamura H, Nakamura Y, Terron MP, Flores LJ, Manchester LC, Tan DX, Sugino N, Reiter RJ. Melatonin and pregnancy in the human. Reprod Toxicol 2008;25:291-303.
105. Rizzo P, Raffone E, Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol Sci 2010;14:555-561.
106. Golightly E, Jabbour HN, Norman JE. Endocrine immune interactions in human parturition. Mol Cell Endocrinol 2011;335:52-59.
107. Shoji H, Koletzko B. Oxidative stress and antioxidant protection in the perinatal period. Curr Opin Clin Nutr Metab Care 2007;10:324-328. (Pubitemid 46596709)
108. Auguelles S, Markado MJ, Ayala A. Correlation between circulating biomarkers of oxidative stress of maternal and umbilical cord blood at birth. Free Radic Res 2006;40:565-570. (Pubitemid 43832510)
109. Fogel I, Pinchuk I, Kupferminc MJ, Lichtenberg D, Fainarn O. Oxidative stress in the fetal circulation does not depend on mode of delivery. Am J Obstet Gynecol 2005;193:241-246. (Pubitemid 40991852)
110. Hracsko Z, Safar Z, Orvos H, Novak Z, Pal A, Varga IS. Evaluation of oxidative stress markers after vaginal delivery or caesarean section. In Vivo 2007;21:703-706. (Pubitemid 47232676)
111. Laurie S, Mataz Z, Boaz M, Fux A, Golan A, Sadan O. Different degrees of fetal oxidative stress in elective and emergent caesarean section. Neonatology 2007;92:111-115. (Pubitemid 47230737)
112. Scher M. Perinatal asphyxia: timing and mechanisms of injury in neonatal encephalopathy. Curr Neurol Neurosci Rep 2001;1: 175-184.
113. Harris ED. Regulation of antioxidant enzymes. FASEB J 1992;6:2675-2683.
114. Palmer C, Brucklacher RM, Christensen MA, Vannucci RC. Carbohydrate and energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 1990;10:227-235. (Pubitemid 20096194)
115. Yager JY, Brucklacher RM, Vannucci RC. Cerebral energy metabolism during hypoxia-ischemia and early recovery in immature rats. Am J Physiol 1992;262:H672-H677.
116. Berger R, Gjedde A, Heck J, Müller E, Kriegistein J, Jensen A. Extension of the 2-deoxyglucose method to the fetus in utero: theory and normal values for the cerebral glucose consumption in fetal guinea pigs. J Neurochem 1994;63:271-279. (Pubitemid 24184928)
117. Vannucci RC, Christensen MA, Yager JY. Nature, time-course and extent of cerebral edema in the perinatal hypoxic-ischemic brain damage. Pediatr Neurol 1993;9:29-34. (Pubitemid 23070093)
118. Berger R, Garnier J. Perinatal brain injury. J Perinatol Med 2000;28:261-285.
119. Halliwell B, Gutteridge JC. Role of free radicals and catalytic ions in human disease: an overview. Meth Enzymol 1990;186:1-85. (Pubitemid 20279941)
120. Buonocore G, Zani S, Sargentini I, Gioia D, Signorini C, Bracci R. Hypoxia-induced free iron released in the red cells of newborn infants. Acta Pediatr 1998;87:77-81. (Pubitemid 28086610)
121. Ferrali M, Signorini C, Ciccoli L, Comporti M. Iron release and membrane damage in erythrocytes exposed to oxidizing agents, phenylhydrazine, divicine and isouramil. Biochem J 1992; 285:295-301.
122. Buonocore G, Gioia D, DeFilippo M, Piccolini E, Bracci R. Superoxide anion release by polymorphonuclear leukocytes in whole blood of newborns and mothers during the peripartal period. Pediatr Res 1994;36:619-622. (Pubitemid 24331368)
123. Crow JP, Beckman JS. The importance of superoxide in nitric-oxide- dependent toxicity: evidence for peroxynitrite-mediated injury. Adv Exp Med Biol 1996;387:147-161. (Pubitemid 26259242)
124. Szabo C, Oshima H. DNA damage induced by peroxynitrite: subsequent biological effects. Nitric Oxide 1997;1:373-385. (Pubitemid 28076545)
125. Crow JP, Beckman JS. The role of peroxynitrite in nitric oxide-mediated toxicity. Curr Top Microbiol Immunol 1995;196:57-73.
126. Phelps DT, Ferro TJ, Higgins PJ, Shankar R, Parker DM, Johnson A. TNF-a induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C. Am J Physiol 1995;269:551-559.
127. Inoue S, Kawanishi S. Oxidative DNA damage induced by simultaneous generation of nitric oxide and peroxide. FEBS Lett 1995;371:86-88.
128. Salgo MG, Bermuzed E, Squadrito G, Pryor W. DNA damage and oxidation of thiol peroxynitrite causes in rat thymocytes. Arch Biochem Biophys 1995;322:500-505.
129. Szabo C, Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL. Endothelial dysfunction in endotoxic shock: importance of the activation of poly (ADP ribose) synthetase (PARS) by perox-ynitrite. J Clin Invest 1997;100:723-735. (Pubitemid 27340522)
130. Kothecha S. Lung growth: implication for the newborn infant. Arch Dis Child Fetal Neonatal 2000;82:F69-F74.
131. Bhandari V, Mauli KN, Kresch M. Hyperoxia causes an increase in antioxidant enzyme activity in adult and fetal rat type II pneumocytes. Lung 2000;178:53-60. (Pubitemid 30111717)
132. Ikegami M, Kallapur S, Michna J, Jobe AH. Lung injury and surfactant metabolism after hyperventilation of premature lambs. Pediatr Res 2000;47:398-404. (Pubitemid 30127049)
133. Lamb NJ, Gutteridge JMC, Baker C, Evans TW, Quinlan GJ. Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration and chlorination. Intens Care Med 1999;25:1738-1744. (Pubitemid 29455098)
134. Huertas JR, Palomino N, Ochoa JJ, Quiles JL, Ramirez-Tortosa MC, Battino M, Robles R, Mataix J. Lipid peroxidation and antioxidant erythrocyte membranes of full-term and preterm newborns. Biofactors 1998;8:133-137. (Pubitemid 28332797)
135. Esteban J, Morcillo JE, Cortjo J. Oxidative stress and pulmonary inflammation: pharmacological intervention with antioxidants. Pharmacol Res 1999;40:393-404.
136. Boda D, Nemeth I, Pinter S. Surface tension, glutathione content and redox ratio of the tracheal aspirate fluid of premature infants with IRDS. Biol Neonate 1998;74:281-288.
137. Banks BA, Ischiropoulos H, McClelland M, Ballard PL, Ballard RA. Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia. Pediatrics 1998;101:870-874. (Pubitemid 28204839)
138. Dellinger RP. Inhaled nitric oxide in acute lung injury and acute respiratory distress syndrome. Inability to translate physiologic benefit to clinical outcome benefit in adult clinical trials. Intens Care Med 1999;25:881-883.
139. Janssen YMW, Soultanakis R, Steece K, Heerdt E, Singh RJ, Joseph J, Kalyanaraman B. Depletion of nitric oxide causes cell cycle alterations, apoptosis and oxidative stress in pulmonary cells. Am J Physiol 1998;275:L1100-L1109.
140. Kim K, Whitin JC, Sukhova NM, Cohen HJ. Increases in extracellular glutathione peroxidase in plasma and lungs of mice exposed to hyperoxia. Pediatr Res 1999;46:715-721.
141. Ogihara T, Hirano K, Morinobu T, Kim HS, Hiroi M, Ogihara H, Tamai H. Raised concentrations of aldehyde lipid peroxida-tion products in premature infants with chronic lung disease. Arch Dis Child Fetal Neonatal Ed 1999;80:F21-F25. (Pubitemid 29129592)
142. Metnitz PGH, Bartens C, Fisher M, Fridich P, Steltzer H, Druml W. Antioxidant status in patient with acute respiratory distress syndrome. Intens Care Med 1999;25:180-185. (Pubitemid 29126844)
143. Vento G, Mele MC, Mordente A, Romagnoli C, Matassa PG, Zecca E, Zeppacosta B, Persichilli S. High total antioxidant activity and uric acid in tracheobronchial aspirate fluid of preterm infants during oxidative stress: an adaptive response to hyperoxia? Acta Paediatr 2000;89:336-342. (Pubitemid 30625360)
144. Yitig S, Yurdakok M, Kilinc K, Oran O, Erdem G, Tekinalp G. Serum malondialdehyde concentrations as a measure of oxygen free radical damage in preterm infants. Turk J Pediatr 1998; 40:177-183. (Pubitemid 128564079)
145. Perez EM, Weisman LE. Novel approaches to the prevention and therapy of neonatal bacterial sepsis. Clin Perinatol 1997;24:213-225.
146. Antonielli M. Sepsis and septic shock: pro-inflammatory or anti-inflammatory state? J Chemother 1999;6:536-540.
147. Lush CW, Kvietys PR. Microvascular dysfunction in sepsis. Microcirculation 2000;7:83-101.
148. Cohen J. The immunopathogenesis of sepsis. Nature 2002; 420:885-891. (Pubitemid 36019643)
149. Abraham E, Singer M. Mechanisms of sepsis-induced organ dysfunction. Crit Care Med 2007;35:2408-2416. (Pubitemid 47476242)
150. Basit A, Reutershan J, Morris MA, Solga M, Rose CE Jr, Ley K. ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space. Am J Physiol Lung Cell Mol Physiol 2006;291:L200-L207. (Pubitemid 44148104)
151. Cepinskas G, Savickiene J, Ionescu, CV, Kvietys PR. PMN transendothelial migration decreases nuclear NFkappaB in IL-1beta-activated endothelial cells: role of PECAM-1. J Cell Biol 2003;161:641-651. (Pubitemid 36578586)
152. Ley K, Reutershan J. Leucocyte-endothelial interactions in health and disease. Handb Exp Pharmacol 2006;176 (Pt 2):97-133.
153. Rawlingson A. Nitric oxide, inflammation and acute burn injury. Burns 2003;29:631-640. (Pubitemid 37230077)
154. Razavi HM, Wang L, Weicker S, Ouinlan GJ, Mumby S, McCormack DG, Mehta S. Pulmonary oxidant stress in murine sepsis is due to inflammatory cell nitric oxide. Crit Care Med 2005;33:1333-1339. (Pubitemid 40827386)
155. Mochida S, Matsura T, Yamashita A, Horie S, Ohata S, Kusumoto C, Nishida T, Minami Y, Inagaki Y, Ishibe Y, et al. Geranylgeranylacetone ameliorates inflammatory response to lipopolysaccharide (LPS) in murine macrophages: inhibition of LPS binding to the cell surface. J Clin Biochem Nutr 2007; 41:115-123. (Pubitemid 47529307)
156. Riedemann NC, Guo RF, Ward PA. Novel strategies for the treatment of sepsis. Nat Med 2003;9:517-524. (Pubitemid 36597096)
157. Liu L, Kubes P. Molecular mechanisms of leukocyte recruitment: organ-specific mechanisms of action. Thromb Haemost 2003;89:213-220. (Pubitemid 36227270)
158. Liu SF, Malik AB. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006;290:L622-L645. (Pubitemid 43738989)
159. Abraham E. Nuclear factor-kappa B and its role in sepsis associated organ failure. J Infect Dis 187 2003 (Suppl. 2);S364-S369. (Pubitemid 36724510)
160. Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res 2007;101:234-247. (Pubitemid 47344073)
161. Janssen-Heininger YM, Poynter ME, Baeuerle PA. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappa B. Free Radic Biol Med 2000;28:1317-1327. (Pubitemid 30621476)
162. Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, Miller M, Barchuk WT, Fischkoff S, Kaul M, et al. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 2004;32:2173-2182. (Pubitemid 39491795)
163. Bernard GR, Vincent JL, Laterre PF, La Rosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709. (Pubitemid 32204987)
164. Abraham E. Effects of recombinant human activated protein C in human models of endotoxin administration. Proc Am Thorac Soc 2005;2:243-247. (Pubitemid 41500853)
165. Ely EW, Bernard GR, Vincent JL. Activated protein C for severe sepsis. N Engl J Med 2002;347:1035-1036.
166. Batra S, Kumar R, Seema KR, Kapoor AK, Ray G. Alterations in antioxidant status during neonatal sepsis. Ann Trop Pediatr 2000;20:27-33. (Pubitemid 30171225)
167. Seema KR, Mandal RN, Tandon A, Randhawa VS, Mehta G, Batra S, Ray GN,
168. Kurt AN, Aygun AD, Godekmerdan A, Kurt A, Dogan Y, Yilmaz E. Serum IL-1b, IL-6, IL-8, and TNF-a levels in early diagnosis and management of neonatal sepsis. Mediators Inflamm 2007;2007:31397.
169. Mao GD, Thomas PD, Lopaschuk GD, Poznansky MJ. Superoxide dismutase (SOD)-catalase conjugates. J Biol Chem 1993;268:416-620.
170. Crapo JD, DeLong DM, Sjostrom K, Hasler GR, Drew RT. The failure of aerosolized superoxide dismutase to modify pulmonary oxygen toxicity. Am Rev Respir Dis 1977;115:1027-1033. (Pubitemid 8131439)
171. Matalon S, Holm BA, Baker RR, Whitfield MK, Freeman BA. Characterization of antioxidant activities of pulmonary surfactant mixtures. Biochim Biophys Acta 1990;1035:121-127. (Pubitemid 20251737)
172. Suresh GK, Davis JM, Soll RF. Superoxide dismutase for preventing chronic lung disease in mechanically ventilated preterm infants. Cochrane Database Syst Rev 2001;(1): CD001968.
173. Crapo J. Superoxide dismutase and tolerance to pulmonary oxygen toxicity. Chest 1975;67:39S-40S.
174. Crapo J, Barrio B, Foscue H, Slaelburne J. Structural and biochemical changes in rat lungs occurring during exposure to lethal and adaptive doses of oxygen. Am Rev Respir Dis 1980;122:123-143. (Pubitemid 10073551)
175. Paegle W, Bernhard W, Turndorf H. Intermittent exposure to 40 percent oxygen prolongs rat survival in 100 percent oxygen. Anesth Analg 1977;56:847-851. (Pubitemid 8235820)
176. Tierney D, Yang J, Ayers L. Enzymatic activity in rat lungs: some changes with exposure to 1 ATM oxygen. Chest 1975; 67:40S-42S.
177. Simon L. Protection against toxic effect of sustained hyperoxia on lung macrophages by superoxide dismutase. Clin Res 1980;28:432A.
178. Block ER, Fisher AB. Protection of hyperoxic-induced depression of pulmonary serotonin clearance by pretreatment with superoxide dismutase. Am Rev Respir 1977;116:441-447. (Pubitemid 8181301)
179. Rosenfeld W, Evans H, Concepcion L, Jhaveri R, Schaeffer H, Friedman A. Prevention of bronchopulmonary dysplasia by administration of bovine superoxide dismutase in preterm infants with respiratory distress syndrome. J Pediatr 1984;105: 781-785. (Pubitemid 15206712)
180. Davis JM, Rosenfeld WN, Richter SE, Parad MR, Gewolb IH, Spitzer AR, Carlo WA, Couser RJ, Price A, Flaster E, et al. Safety and pharmacokinetics of multiple doses of recombinant human CuZn superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome. Pediatrics 1997;100:24-30. (Pubitemid 27291004)
181. Davis JM, Parad RB, Michele T, Allred E, Price A, Rosenfeld W. North American Recombinant Human CuZnSOD Study Group: pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase. Pediatrics 2003;111:469-476. (Pubitemid 36330700)
182. Frosali S, Di Simplicio P, Perrone S, Di Giuseppe D, Longini M, Tanganelli D, Buonocore G. Glutathione recycling and antioxidant enzyme activities in erythrocytes of term and preterm newborns at birth. Biol Neonate 2004;85:188-194. (Pubitemid 38437701)
183. Vento M, Asensi M, Sastre J, Lloret A, Garcia-Sala F, Minana JB, Vina J. Hyperoxemia caused by resuscitation with pure oxygen may alter intracellular redox status by increasing oxidized glutathione in asphyxiated newly born infants. Semin Perinatol 2002;26:406-410. (Pubitemid 36133538)
184. Jankov RP, Negus A, Transwell AK. Antioxidants as therapy in the newborn: some word of caution. Pediatr Res 2001;50:681-687. (Pubitemid 33121635)
185. Karp WB, Robertson AF. Vitamin E in neonatology. Adv Pediatr 1986;33:127-147.
186. Johnson L, Bowen Jr FW, Abbasi S, Hermann N, Weston M, Sacks L, Porat R, Stahl G, Peckham G, Delivoria-Papadopoulos M, et al. Relationship of prolonged pharmacologic serum levels of vitamin E to incidence of sepsis and necrotizing enterocolitis in infants with birth weight 1,500 grams or less. Pediatrics 1985;75:619-638. (Pubitemid 15079510)
187. Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P, Lunec J. Vitamin C exhibits pro-oxidant properties. Nature 1998;392:559. (Pubitemid 28207702)
188. Saldanha RL, Cepeda EE, Poland RL. The effect of vitamin E prophylaxis on the incidence and severity of bronchopulmonary dysplasia. J Pediatr 1982;101:89-93. (Pubitemid 12078184)
189. Brion LP, Bell EF, Rughuveer TS. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2003;3:CD003665.
190. Tyson JE, Wright LL, Oh W, Kennedy KA, Mele L, Ehrenkranz RA, Stoll BJ, Lemons JA, Stevenson DK, Bauer CR, et al. Vitamin A supplementation for extremely-low-birth infants National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med 1999;340:1962-1968.
191. Darlow BA, Graham PJ. Vitamin A supplementation for preventing morbidity and mortality in very low birth weight infants. Cochrane Database Syst Rev 2007;17:CD000501.
192. Wardle SP, Hughes A, Chen S, Shaw NJ. Randomized controlled trial of vitamin A supplementation in preterm infants to prevent chronic lung disease. Arch Dis Child Fetal Neonatal Ed 2001;84:F9-F13. (Pubitemid 32060163)
193. Darlow BA, Winterbourn CC, Inder TE, Graham PJ, Harding JE, Weston PJ, Austin NC, Elder DE, Mogridge N, Boss IH, et al. The effect of selenium supplementation on outcome in very low birth weight infants: a randomized controlled trial. New Zealand Neonatal Study Group. J Pediatr 2000;136:473-480. (Pubitemid 30469588)
194. Winterbourn CC, Chan T, Buss IH, Inder TE, Mogridge N, Darlow BA. Protein carbonyls and lipid peroxidation products as oxidation markers in preterm infant plasma: associations with chronic lung disease and retinopathy and effects of selenium supplementation. Pediatr Res 2000;48:84-90. (Pubitemid 30419175)
195. Darlow BA, Austin NC. Selenium supplementation to prevent short-term morbidity in preterm neonates. Cochrane Database Syst Rev 2003;4:CD003312.
196. Marro PJ, Baumgart S, Delivoria-Papadopoulos M, Zirin S, Corcoran L, McGavin SP, Davis LE, Clancy RR. Purine metabolism and inhibition of xanthine oxidase in severely hypoxic neonates going onto extracorporeal membrane oxyge-nation. Pediatr Res 1997;41(Pt 1):513-520.
197. Russell GA, Cooke RW. Randomised controlled trial of allopurinol prophylaxis in very preterm infants. Arch Dis Child Fetal Neonatal Ed 1995;73:F27-F31.
198. Chaudari T, McGuire W. Allopurinol for preventing mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy. Cochrane Database Syst Rev 2008;2:CD006817.
199. Stasica P, Ulanski P, Rosiak JM. Melatonin as a hydroxyl radical scavenger. J Pineal Res 1998;25:65-66. (Pubitemid 28319918)
200. Peyrot F, Ducrocq C. Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. J Pineal Res 2008;45:235-246.
201. Li XJ, Zhang LM, Gu J, Zhang AZ, Sun FY. Melatonin decreases production of hydroxyl radical during ischemia-reperfusion. Acta Pharmacol Sin 1997;18:394-396. (Pubitemid 27389438)
202. Tan DX, Manchester LC, Reiter RJ, Plummer BF, Hardies LJ, Weintraub ST, Vijayalaxmi, Shepherd AM. A novel melatonin metabolite, cyclic 3-hydroxymelatonin: a biomarker of in vivo hydroxyl radical generation. Biochem Biophys Res Commun 1998;253:614-620. (Pubitemid 29039192)
203. Reiter RJ, Tan DX, Manchester LC, Qi WB. Biochemical reactivity of melatonin with reactive oxygen and nitrogen: a review of the evidence. Cell Biochem Biophys 2001;34:237-256. (Pubitemid 33615836)
204. Zang LY, Cosma G, Gardner H, Vallyatan V. Scavenging of reactive oxygen species by melatonin. Biochim Biophys Acta 1998;1425:467-477.
205. Tan DX, Manchester LC, Reiter RJ, Qi WB, Karbownik M, Calvo JR. Significance of melatonin in antioxidative defense system: reactions and products. Biol Signals Recept 2000; 9:137-159. (Pubitemid 30481268)
206. Tan DX, Manchester LC, Burkhardt S, Sainz RM, Mayo JC, Kohen R, Shohami E, Huo YS, Hardeland R, Reiter RJ. N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant. FASEB J 2001;15:2294-2296.
207. Manda K, Ueno M, Anzai K. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 2007;424:386-393. (Pubitemid 46581663)
208. Hardeland R, Backhaus C, Fadavi A. Reactions of the NO redox forms NOθ, *NO and HNO (protonated NO-) with the melatonin metabolite N1-acetyl-5-methoxykynuramine. J Pineal Res 2007;43:382-388. (Pubitemid 47512270)
209. Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F. Melatonin, a peroxyl radical scavenger more efficient than vitamin E. Life Sci 1994;55:PL271-PL276. (Pubitemid 24290417)
210. Pieri C, Moroni F, Marra M, Marcheselli F, Recchioni R. Melatonin is an efficient antioxidant. Arch Gerontol Geriatrics 1995;20:159-165.
211. Reiter RJ, Tan DX, Osuna C, Gitto E. Actions of melatonin in the reduction of oxidative stress: a review. J Biomed Sci 2000;7:444-458.
212. Hardeland R, Poeggeler B, Pappolla MA. Mitochondrial actions of melatonin-an endeavor to identify their adaptive and cytoprotective mechanisms. Endokrinologie 2009;65:14-31.
213. Rodríguez C, Mayo JC, Sainz RM, Antolin I, Herrera F, Martin V, Reiter RJ. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004;36:1-9. (Pubitemid 38130283)
214. Kennaway DJ, Stamp GE, Goble FC. Development of melatonin production in infants and the impact of prematurity. J Clin Endocrinol Metab 1992;75:367-369.
215. Kennaway DJ, Goble FC, Stamp GE. Factors influencing the development of melatonin rhythmicity in humans. J Clin Endocrinol Metab 1996;81:1525-1532. (Pubitemid 26118587)
216. Sivan Y, Laudon M, Tauman R, Zisapel N. Melatonin production in healthy infants: evidence for seasonal variations. Pediatr Res 2001;49:63-68. (Pubitemid 32015001)
217. Ardura J, Gutierrez R, Andres J, Agapito T. Emergence and evolution of the circadian rhythm of melatonin in children. Horm Res 2003;59:66-72. (Pubitemid 36206663)
218. Muñoz-Hoyos A, Rodŕiguez-Cabezas T, Molina-Carballo A, Mart́inez-Sempere JJ, Ruiz-Cosano C, Acuña-Castroviejo D. Melatonin concentration in the umbilical artery and vein in human preterm and term neonates and neonates with acute fetal distress. J Pineal Res 1992;13:184-191. (Pubitemid 23058629)
219. Muñoz-Hoyos A, Jaldo-Alba F, Molina-Carballo A, Rodŕiguez-Cabezas T, Molina-Font JA, Acuñ a-Castroviejo D. Absence of plasma melatonin circadian rhythm during the first 72 h of life in human infants. J Clin Endocrinol Metab 1993;77:699-703. (Pubitemid 23298651)
220. Illnerova H, Buresova M, Presl J. Melatonin rhythm in human milk. J Clin Endocrinol Metab 1993;77:838-841. (Pubitemid 23298676)
221. Cubero J, Valero V, Sanchez J, Rivero M, Parvez H, Rodriguez AB, Barriga C. The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn. Neuro Endocrinol Lett 2005;26:657-661.
222. Furman L, Minich NM, Hack M. Breast feeding of very low birth weight infants. J Hum Lact 1998;14:29-34. (Pubitemid 128503252)
223. Furman L, Taylor G, Minich N, Hack M. The effect of maternal milk on neonatal morbidity of very low-birth-weight infants. Arch Pediatr Adolesc Med 2003;157:66-71. (Pubitemid 36343420)
224. Furman L, Minich N. Efficiency of breastfeeding as compared to bottle-feeding in very low birth weight (VLBW, 51.5 kg) infants. J Perinatol 2004;24:706-713. (Pubitemid 39504411)
225. Gitto E, Reiter RJ, Sabatino G, Buonocore G, Romeo C, Gitto P, Bugge C, Trimarche G, Barberi I. Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment. J Pineal Res 2005;39:287-293. (Pubitemid 41337810)
226. Hamrick SE, Ferriero DM. The injury response in the term newborn brain: can we neuroprotect? Curr Opin Neurol 2003;16:147-154. (Pubitemid 36521199)
227. Miller SL, Yan EB, Castillo-Meléndez M, Jenkin G, Walker DW. Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion. Dev Neurosci 2005;27:200-210. (Pubitemid 41096227)
228. Maldonado MD, Murillo-Cabezas F, Terron MP, Flores LJ, Tan DX, Manchester LC, Reiter RJ. The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. J Pineal Res 2007;42:1-11. (Pubitemid 44924321)
229. Jou MJ, Peng TI, Yu PZ, Jou SB, Reiter RJ, Chen JY, Wu HY, Chen CC, Hsu LF. Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J Pineal Res 2007;43:389-403. (Pubitemid 47512271)
230. Samantaray S, Das A, Thakore NP, Matzelle, DD, Reiter RJ, Ray SK, Banik NL. Therapeutic potential of melatonin in traumatic central nervous system injury. J Pineal Res 2009;47:134-142.
231. Hong Y, Palaksha KJ, Park K, Park S, Kim HD, Reiter RJ, Chang KT. Melatonin plus excercise-based neurorehabilitative therapy for spinal cord injury. J Pineal Res 2010;49:201-209.
232. Kennaway DJ, Flanagan DE, Moore VM, Cockington RA, Robinson JS, Phillips DI. The impact of fetal size and length of gestation on 6-sulphatoxymelatonin excretion in adult life. J Pineal Res 2001;30:188-192. (Pubitemid 32245290)
233. Griefahn B, Blaszkewicz M, Brode P, Remer T. Do birth variable data predict melatonin production in 8-to 9-year-old children? Analysis of excreted 6-sulfatoxymelatonin. Horm Res 2004;62:156-160. (Pubitemid 39274251)
234. Muñoz-Hoyos A, Bonillo-Perales A, Á vila-Villegas R, González-Ripoll M, Uberos J, Florido-Nav́io J, Molina-Carballo A. Melatonin levels during the first week of life and their relation with the antioxidant response in the perinatal period. Neonatol-ogy 2007;92:209-216. (Pubitemid 47443000)
235. Tan DX, Manchester LC, Sáinz RM, Mayo JC, León J, Reiter RJ. Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production: a hypothesis. Endocrine 2005;27:149-158.
236. Fulia F, Gitto E, Cuzzocrea S, Reiter RJ, Dugo L, Gitto P, Barberi S, Cordaro S, Barberi I. Increased levels of malondial-dehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin. J Pineal Res 2001;31:343-349. (Pubitemid 33032950)
237. León J, Acuñ a-Castroviejo D, Escames G, Tan DX, Reiter RJ. Melatonin mitigates mitochondrial malfunction. J Pineal Res 2005;38:1-9. (Pubitemid 40139304)
238. Gitto E, Karbownik M, Reiter RJ, Tan DX, Cuzzocrea S, Chiurazzi P, Cordaro S, Corona G, Trimarchi G, Barberi I. Effects of melatonin treatment in septic newborns. Pediatr Res 2001;50:756-760. (Pubitemid 33121647)
239. Gitto E, Reiter RJ, Cordaro SP, La Rosa M, Chiurazzi P, Trimarchi G, Gitto P, Calabrò MP, Barberi I. Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin. Am J Perinatol 2004;21:209-216. (Pubitemid 38691520)
240. Gitto E, Reiter RJ, Amodio A, Romeo C, Cuzzocrea E, Sabatino G, Buonocore G, Cordaro V, Trimarchi G, Barberi I. Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin. J Pineal Res 2004;36:250-255. (Pubitemid 38530472)
241. Gitto E, Romeo C, Reiter RJ, Impellizeri P, Pesce S, Basile M, Antonuccio P, Trimarchi G, Barberi I. Melatonin reduces oxidative stress in surgical neonates. J Pediatr Surg 2004; 39:184-189. (Pubitemid 38146434)
242. Cuzzocrea S, Reiter RJ. Melatonin-immune system relationships. Curr Top Med Chem 2002;2:167-180.
243. Rodŕiguez MI, Escames G, López LC, Lopez A, Garcia JA, Ortiz F, Acuna-Castroviejo D. Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice. J Pineal Res 2007;42:272-279. (Pubitemid 46365065)
244. Jung KH, Hong SW, Zheng HM, Lee H, Lee DH, Lee SY, Hong SS. Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-realted factor 2 and nuclear factor-kappaB in rats. J Pineal Res 2010;48:239-250.
245. Gitto E, Pellegrino S, Gitto P, Barberi I, Reiter RJ. Oxidative stress of the newborn in the pre-and postnatal period and the clinical utility of melatonin. J Pineal Res 2009;46:128-139.
246. Tengattini S, Reiter RJ, Tan DX, Terron MP, Rodella LF, Rezzani R. Cardiovascular diseases: protective effects of melatonin. J Pineal Res 2008;44:16-25. (Pubitemid 350231106)
247. Peschke E. Melatonin, endocrine pancreas and diabetes. J Pineal Res 2008;44:26-40. (Pubitemid 350231107)
248. Jan JE, Reiter RJ, Wasdell MB, Bax M. The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders. J Pineal Res 2009;46:1-7.
249. Sanchez-Barcelo EJ, Mediavilla MD, Tan DX, Reiter RJ. Clinical uses of melatonin: evaluation of clinical trials. Curr Med Chem 2010;17:2070-2095.
250. Chan WY, Ng TB. Development of pre-implantation mouse embryos under the influence of pineal indoles. J Neural Transm Gen Sect 1994;96:19-29.
251. Jahnke G, Marr M, Myers C, Wilson R, Travols G, Price C. Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol Sci 1999;50:271-279. (Pubitemid 29407090)