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Volumn 17, Issue 19, 2010, Pages 2070-2095

Clinical uses of melatonin: Evaluation of human trials

Author keywords

Aging; Anesthesia; Arterial hypertension; Chronic fatigue syndrome; Clinical trials; Crohn's disease; Depression; Diabetes; Fibromyalgia; Gastric mucosa; Glaucoma; Hemodialysis; In vitro fertilization; Infectious diseases; Irritable bowel syndrome; Jet lag; Macular degeneration; Melatonin; Neonatal care; Neurological diseases; Rheumatoid arthritis; Shift work; Sleep disturbances; Smith magenis syndrome; Ulcerative colitis

Indexed keywords

5 METHOXYINDOLEACETIC ACID; 5 METHOXYTRYPTAMINE; 5 METHOXYTRYPTOPHOL; ACICLOVIR; BROMOCRIPTINE; CAPTOPRIL PLUS HYDROCHLOROTHIAZIDE; CISPLATIN; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FATTY ACID; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; INTERLEUKIN 2; IRINOTECAN; MAGNESIUM; MELATONIN; MESALAZINE; METFORMIN; MITOXANTRONE; MORPHINE; PACLITAXEL; PHOSPHATE; RETINOID; SOMATOSTATIN; TRIPTORELIN; UNINDEXED DRUG; VITAMIN D; ZINC ACETATE;

EID: 77953482835     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710791233689     Document Type: Article
Times cited : (288)

References (261)
  • 1
    • 33947460818 scopus 로고    scopus 로고
    • Isolation of melatonin, the pineal gland factor that lightens melanocytes
    • Lerner, A.B.; Case, J.D.; Takahashi, Y.; Lee, Y.; Mori, W. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J. Am. Chem. Soc., 1958, 80, 2587.
    • (2587) J. Am. Chem. Soc , vol.1958 , pp. 80
    • Lerner, A.B.1    Case, J.D.2    Takahashi, Y.3    Lee, Y.4    Mori, W.5
  • 2
    • 40849139436 scopus 로고    scopus 로고
    • Acute allograft rejection and immunosup-pression: Influence on endogenous melatonin secretion
    • Cardell, M.; Jung, F.J.; Zhai, W.; Hillinger, S.; Welp, A.; Manz, B.; Weder, W.; Korom, S. Acute allograft rejection and immunosup-pression: influence on endogenous melatonin secretion. J. Pineal Res., 2008, 44, 261-266.
    • (2008) J. Pineal Res , vol.44 , pp. 261-266
    • Cardell, M.1    Jung, F.J.2    Zhai, W.3    Hillinger, S.4    Welp, A.5    Manz, B.6    Weder, W.7    Korom, S.8
  • 4
    • 36849017964 scopus 로고    scopus 로고
    • Melatonin prevents the injury-induced decline of Akt/fork head transcription factors phosphorylation
    • Koh, P.O. Melatonin prevents the injury-induced decline of Akt/fork head transcription factors phosphorylation. J. Pineal Res., 2008, 44, 101-106.
    • (2008) J. Pineal Res , vol.44 , pp. 101-106
    • Koh, P.O.1
  • 5
    • 49549117289 scopus 로고    scopus 로고
    • Dynamic physiological and molecular changes in gastric ulcer healing achieved by melatonin and its precursor L-tryptophan in rats
    • Konturek, P.C.; Konturek, S.J.; Burnat, G.; Brzozowski, T.; Brzozowska, I.; Reiter, R.J. Dynamic physiological and molecular changes in gastric ulcer healing achieved by melatonin and its precursor L-tryptophan in rats. J. Pineal Res., 2008, 45, 180-190.
    • (2008) J. Pineal Res , vol.45 , pp. 180-190
    • Konturek, P.C.1    Konturek, S.J.2    Burnat, G.3    Brzozowski, T.4    Brzozowska, I.5    Reiter, R.J.6
  • 6
    • 39149122800 scopus 로고    scopus 로고
    • Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats
    • Lin, C.H.; Huang, J.Y.; Ching, C.H.; Chuang, J.I. Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. J. Pineal Res., 2008, 44, 205-213.
    • (2008) J. Pineal Res , vol.44 , pp. 205-213
    • Lin, C.H.1    Huang, J.Y.2    Ching, C.H.3    Chuang, J.I.4
  • 8
    • 36849034462 scopus 로고    scopus 로고
    • Melatonin, endocrine pancreas and diabetes
    • Peschke, E. Melatonin, endocrine pancreas and diabetes. J. Pineal Res., 2008, 44, 26-40.
    • (2008) J. Pineal Res , vol.44 , pp. 26-40
    • Peschke, E.1
  • 9
    • 67649905028 scopus 로고    scopus 로고
    • Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease
    • Olcese, J.M.; Cao, C.; Mori, T.; Mamcarz, M.B.; Maxwell, A.; Runfeldt, M.J.; Wang, L.; Zhang, C.; Lin, X.; Zhang, G.; Arendash, G.W. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J. Pineal Res., 2009, 47, 82-96.
    • (2009) J. Pineal Res , vol.47 , pp. 82-96
    • Olcese, J.M.1    Cao, C.2    Mori, T.3    Mamcarz, M.B.4    Maxwell, A.5    Runfeldt, M.J.6    Wang, L.7    Zhang, C.8    Lin, X.9    Zhang, G.10    Arendash, G.W.11
  • 10
    • 0015729974 scopus 로고
    • Retinal and pineal hydroxyindole-O-methyl transferases in the rat: Changes following cervical sympathectomy, pinealectomy or blinding
    • Nagle, C.A.; Cardinali, D.P.; Rosner, J.M. Retinal and pineal hydroxyindole-O-methyl transferases in the rat: changes following cervical sympathectomy, pinealectomy or blinding Endocrinology, 1973, 92, 1560-1564.
    • (1973) Endocrinology , vol.92 , pp. 1560-1564
    • Nagle, C.A.1    Cardinali, D.P.2    Rosner, J.M.3
  • 11
    • 17544369648 scopus 로고    scopus 로고
    • Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina
    • Iuvone, P.M.; Tosini, G.; Pozdeyev, N.; Haque, R.; Klein, D.C.; Chaurasia, S.S. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog. Retin. Eye Res., 2005, 24, 433-456.
    • (2005) Prog. Retin. Eye Res , vol.24 , pp. 433-456
    • Iuvone, P.M.1    Tosini, G.2    Pozdeyev, N.3    Haque, R.4    Klein, D.C.5    Chaurasia, S.S.6
  • 12
    • 0042578211 scopus 로고
    • Localisation of 2-[I125]-iodomelatonin binding sites in the mammalian retina
    • Blazynski, C.; Dubocovich, M. Localisation of 2-[I125]-iodomelatonin binding sites in the mammalian retina. J. Neuro-chem., 1991, 57, 685-689.
    • (1991) J. Neuro-chem , vol.57 , pp. 685-689
    • Blazynski, C.1    Dubocovich, M.2
  • 13
    • 0018375112 scopus 로고
    • Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea pigs Cavia porcellus
    • Pang, S.F.; Yew, D.T. Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea pigs Cavia porcellus. Experientia, 1979, 35, 213-233.
    • (1979) Experientia , vol.35 , pp. 213-233
    • Pang, S.F.1    Yew, D.T.2
  • 14
    • 55849146641 scopus 로고    scopus 로고
    • Blood-retinal barrier in hypoxic ischaemic conditions: Basic concepts, clinical features and management
    • Kaur, C.; Foulds, W.S.; Ling, E.A. Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Prog. Retin. Eye Res., 2008, 27, 622-647.
    • (2008) Prog. Retin. Eye Res , vol.27 , pp. 622-647
    • Kaur, C.1    Foulds, W.S.2    Ling, E.A.3
  • 15
    • 0028106939 scopus 로고
    • Osborne.; N.N.; Chidlow, G. The presence of functional melatonin receptors in the iris-ciliary processes of the rabbit eye
    • Osborne.; N.N.; Chidlow, G. The presence of functional melatonin receptors in the iris-ciliary processes of the rabbit eye. Exp. Eye Res., 1994, 59, 3-9.
    • (1994) Exp. Eye Res , vol.59 , pp. 3-9
  • 16
    • 0035970595 scopus 로고    scopus 로고
    • Involvement of melatonin MT(3) receptors in the regulation of intraocular pressure in rabbits
    • Pintor, J.; Martin, L.; Pelaez, T.; Hoyle, C.H.; Peral, A. Involvement of melatonin MT(3) receptors in the regulation of intraocular pressure in rabbits. Eur. J. Pharmacol., 2001, 416, 251-254.
    • (2001) Eur. J. Pharmacol , vol.416 , pp. 251-254
    • Pintor, J.1    Martin, L.2    Pelaez, T.3    Hoyle, C.H.4    Peral, A.5
  • 17
    • 32244439134 scopus 로고    scopus 로고
    • Effects of melatonin in age-related macular degeneration
    • Yi, C.; Pan, X.; Yan, H.; Guo, M.; Pierpaoli, W. Effects of melatonin in age-related macular degeneration. Ann. NY Acad. Sci., 2005, 1057, 384-392.
    • (2005) Ann. NY Acad. Sci , vol.1057 , pp. 384-392
    • Yi, C.1    Pan, X.2    Yan, H.3    Guo, M.4    Pierpaoli, W.5
  • 18
    • 0023778646 scopus 로고
    • Effect of melatonin on intraocular pressure
    • Samples, J.R.; Krause, G.; Lewy, A.J. Effect of melatonin on intraocular pressure. Curr. Eye Res., 1988, 7, 649-653.
    • (1988) Curr. Eye Res , vol.7 , pp. 649-653
    • Samples, J.R.1    Krause, G.2    Lewy, A.J.3
  • 19
    • 63849106922 scopus 로고    scopus 로고
    • Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia
    • Ismail, S.A.; Mowafi, H.A. Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. Anesth. Analg., 2009, 108,1146-51.
    • (2009) Anesth. Analg , vol.108 , pp. 1146-1151
    • Ismail, S.A.1    Mowafi, H.A.2
  • 21
    • 0025190203 scopus 로고
    • Inhibition of human platelet aggregation and thromboxane-B2 production by melatonin: Evidence for a diurnal variation
    • Del Zar, M.M.; Martinuzzo, M.; Falcon, C.; Cardinali, D.P.; Carreras, L.O.; Vacas, M.I. Inhibition of human platelet aggregation and thromboxane-B2 production by melatonin: evidence for a diurnal variation. J. Clin. Endocrinol. Metab., 1990, 70, 246-251.
    • (1990) J. Clin. Endocrinol. Metab , vol.70 , pp. 246-251
    • Del Zar, M.M.1    Martinuzzo, M.2    Falcon, C.3    Cardinali, D.P.4    Carreras, L.O.5    Vacas, M.I.6
  • 22
    • 33746604323 scopus 로고    scopus 로고
    • Opposite circadian rhythms in melatonin and tissue factor pathway inhibitor type 1: Does daylight affect coagulation?
    • Dahm, A.; Osterud, B.; Hjeltnes, N.; Sandset, P.M.; Iversen P.O. Opposite circadian rhythms in melatonin and tissue factor pathway inhibitor type 1: does daylight affect coagulation? J. Thromb. Haemost., 2006, 4, 1840-1842.
    • (2006) J. Thromb. Haemost , vol.4 , pp. 1840-1842
    • Dahm, A.1    Osterud, B.2    Hjeltnes, N.3    Sandset, P.M.4    Iversen, P.O.5
  • 23
    • 39149142497 scopus 로고    scopus 로고
    • Oral melatonin reduces blood coagulation activity: A placebo-controlled study in healthy young men
    • Wirtz, P.H.; Spillmann, M.; Bärtschi, C.; Ehlert, U.; von Känel, R. Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men. J. Pineal Res., 2008, 44, 127-33.
    • (2008) J. Pineal Res , vol.44 , pp. 127-133
    • Wirtz, P.H.1    Spillmann, M.2    Bärtschi, C.3    Ehlert, U.4    von Känel, R.5
  • 24
    • 42149094558 scopus 로고    scopus 로고
    • Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men: A randomized placebo-controlled study
    • Wirtz, P.H.; Bärtschi, C.; Spillmann, M.; Ehlert, U.; von Känel, R. Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men: a randomized placebo-controlled study. J. Pineal Res., 2008, 44, 358-65.
    • (2008) J. Pineal Res , vol.44 , pp. 358-365
    • Wirtz, P.H.1    Bärtschi, C.2    Spillmann, M.3    Ehlert, U.4    von Känel, R.5
  • 25
    • 0030473928 scopus 로고    scopus 로고
    • The pineal hormone melatonin in hematology and its potential efficacy in the treatment of thrombocytopenia
    • Lissoni, P.; Tancini, G.; Barni, S.; Paolorossi, F.; Rossini, F.; Maffé, P.; Di Bella, L. The pineal hormone melatonin in hematology and its potential efficacy in the treatment of thrombocytopenia. Recenti Prog. Med., 1996, 87, 582-585.
    • (1996) Recenti Prog. Med , vol.87 , pp. 582-585
    • Lissoni, P.1    Tancini, G.2    Barni, S.3    Paolorossi, F.4    Rossini, F.5    Maffé, P.6    Di Bella, L.7
  • 26
    • 0028362803 scopus 로고
    • Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin
    • Huether, G. Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin. Ann. N.Y. Acad. Sci., 1994, 719, 146-158.
    • (1994) Ann. N.Y. Acad. Sci , vol.719 , pp. 146-158
    • Huether, G.1
  • 27
    • 14344250929 scopus 로고    scopus 로고
    • Melatonin as an organoprotector in the stomach and the pancreas
    • Jaworek, J.; Brzozowski, T.; Konturek, S.J. Melatonin as an organoprotector in the stomach and the pancreas. J. Pineal Res., 2005, 38, 73-83.
    • (2005) J. Pineal Res , vol.38 , pp. 73-83
    • Jaworek, J.1    Brzozowski, T.2    Konturek, S.J.3
  • 29
    • 68249129060 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • Hardeland, R.; Tan, D.X.; Reiter, R.J. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J. Pineal Res., 2009, 47, 109-26.
    • (2009) J. Pineal Res , vol.47 , pp. 109-126
    • Hardeland, R.1    Tan, D.X.2    Reiter, R.J.3
  • 30
    • 77953493628 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • Reiter, R.J.; Paredes, S.D; Manchester, L.C.; Tan, D.X. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. Crit. Rev. Biochem. Mol., Biol. 2009, 44, 125-200.
    • (2009) Crit. Rev. Biochem. Mol., Biol , vol.44 , pp. 125-200
    • Reiter, R.J.1    Paredes, S.D.2    Manchester, L.C.3    Tan, D.X.4
  • 32
    • 67949094437 scopus 로고    scopus 로고
    • Chojnacki. The effect of melatonin on oxidative DNA damage in gastric mucosa cells of patients with functional dyspepsia
    • Klupińska, G.; Popawski, T.; Smigielski, J.; Basiak, J.; Chojnacki. The effect of melatonin on oxidative DNA damage in gastric mucosa cells of patients with functional dyspepsia. J. Pol. Merkur. Lekarski, 2009, 26, 366-369.
    • (2009) J. Pol. Merkur. Lekarski , vol.26 , pp. 366-369
    • Klupińska, G.1    Popawski, T.2    Smigielski, J.3    Basiak, J.4
  • 34
    • 33745366578 scopus 로고    scopus 로고
    • Irritable bowel syndrome: Recent and novel therapeutic approaches. Irritable bowel syndrome: Recent and novel therapeutic approaches
    • Andresen, V.; Camilleri, M. Irritable bowel syndrome: recent and novel therapeutic approaches. Irritable bowel syndrome: recent and novel therapeutic approaches. Drugs, 2006, 66, 1073-1088.
    • (2006) Drugs , vol.66 , pp. 1073-1088
    • Andresen, V.1    Camilleri, M.2
  • 35
    • 0030567960 scopus 로고    scopus 로고
    • Melatonin modulates cholinergic transmission by blocking nicotinic channels in the guinea-pig sub-mucous plexus
    • Barajas-Lopez, C.; Peres, A.L.; Espinosa-Luna, R.; Reyes-Vázquez, C; Prieto-Gómez, B. Melatonin modulates cholinergic transmission by blocking nicotinic channels in the guinea-pig sub-mucous plexus. Eur. J. Pharmacol., 1996, 312, 319-325.
    • (1996) Eur. J. Pharmacol , vol.312 , pp. 319-325
    • Barajas-Lopez, C.1    Peres, A.L.2    Espinosa-Luna, R.3    Reyes-Vázquez, C.4    Prieto-Gómez, B.5
  • 36
    • 0033757166 scopus 로고    scopus 로고
    • + channels attenuated melatonin-induced relaxation of serotonin-contracted rat gastric fundus. Can
    • + channels attenuated melatonin-induced relaxation of serotonin-contracted rat gastric fundus. Can. J. Physiol. Pha-macol., 2000, 78, 799-806.
    • (2000) J. Physiol. Pha-macol , vol.78 , pp. 799-806
    • Storr, M.1    Schusdziarra, V.2    Allescher, H.D.3
  • 37
    • 63949084370 scopus 로고    scopus 로고
    • The effects of melatonin on colonic transit time in normal controls and IBS patients
    • Lu, W.Z.; Song, G.H.; Gwee, K.A.; Ho, K.Y. The effects of melatonin on colonic transit time in normal controls and IBS patients. Dig. Dis. Sci., 2009, 54, 1087-1093.
    • (2009) Dig. Dis. Sci , vol.54 , pp. 1087-1093
    • Lu, W.Z.1    Song, G.H.2    Gwee, K.A.3    Ho, K.Y.4
  • 38
    • 27744489454 scopus 로고    scopus 로고
    • Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: A double-blind placebo-controlled study Aliment
    • Lu, W.Z.; Gwee, K.A.; Moochhalla, S.; Ho, K.Y. Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study Aliment. Pharmacol. Ther., 2005, 22, 927-934.
    • (2005) Pharmacol. Ther , vol.22 , pp. 927-934
    • Lu, W.Z.1    Gwee, K.A.2    Moochhalla, S.3    Ho, K.Y.4
  • 39
    • 25444517619 scopus 로고    scopus 로고
    • Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: A randomised, double blind, placebo controlled study
    • Song, G.H.; Leng, P.H.; Gwee, K.A.; Moochhala, S.M.; Ho, K.Y. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study. Gut, 2005, 54, 1402-1407.
    • (2005) Gut , vol.54 , pp. 1402-1407
    • Song, G.H.1    Leng, P.H.2    Gwee, K.A.3    Moochhala, S.M.4    Ho, K.Y.5
  • 41
  • 42
    • 61949356612 scopus 로고    scopus 로고
    • Melatonin and ulcerative colitis: Evidence, biological mechanisms, and future research
    • Terry, P.D.; Villinger, F.; Bubenik, G.A.; Sitaraman, S.V. Melatonin and ulcerative colitis: evidence, biological mechanisms, and future research. Inflamm. Bowel Dis., 2009, 15, 134-140.
    • (2009) Inflamm. Bowel Dis , vol.15 , pp. 134-140
    • Terry, P.D.1    Villinger, F.2    Bubenik, G.A.3    Sitaraman, S.V.4
  • 43
    • 0037254010 scopus 로고    scopus 로고
    • Melatonin for ulcerative colitis?
    • Mann, S. Melatonin for ulcerative colitis? Am. J. Gastroenterol., 2003, 98, 232-233.
    • (2003) Am. J. Gastroenterol , vol.98 , pp. 232-233
    • Mann, S.1
  • 44
    • 51649109708 scopus 로고    scopus 로고
    • Melatonin usage in ulcerative colitis: A case report
    • Maldonado, M.D.; Calvo, J.R. Melatonin usage in ulcerative colitis: a case report. J. Pineal Res., 2008, 45, 339-40.
    • (2008) J. Pineal Res , vol.45 , pp. 339-340
    • Maldonado, M.D.1    Calvo, J.R.2
  • 46
    • 0014145872 scopus 로고
    • Experimental hypertension in pinealectomized rats
    • Zanoboni, A.; Zanoboni-Muciaccia, W. Experimental hypertension in pinealectomized rats. Life Sci. 1967, 6, 2327-2331.
    • (1967) Life Sci , vol.6 , pp. 2327-2331
    • Zanoboni, A.1    Zanoboni-Muciaccia, W.2
  • 47
    • 0017288926 scopus 로고
    • Relationship between metabolic rhythm in the pineal body and the systemic blood pressure. IRCS
    • Hisada, T.; Ozono, S.; Sato, K.; Watanabe, Y.; Watanabe, M. Relationship between metabolic rhythm in the pineal body and the systemic blood pressure. IRCS J. Med. Sci., 1976, 4, 142-143.
    • (1976) J. Med. Sci , vol.4 , pp. 142-143
    • Hisada, T.1    Ozono, S.2    Sato, K.3    Watanabe, Y.4    Watanabe, M.5
  • 48
    • 0017183792 scopus 로고
    • The effect of melatonin on pinealectomy-induced hypertension in the rat
    • Holmes, S.W.; Sugden, D. The effect of melatonin on pinealectomy-induced hypertension in the rat. Br. J. Pharmacol., 1976, 56, 360-361.
    • (1976) Br. J. Pharmacol , vol.56 , pp. 360-361
    • Holmes, S.W.1    Sugden, D.2
  • 49
    • 68249122123 scopus 로고    scopus 로고
    • The circadian melatonin rhythm and its modulation: Possible impact on hypertension
    • Reiter, R.J.; Tan, D.X.; Korkmaz, A. The circadian melatonin rhythm and its modulation: possible impact on hypertension. J. Hypertens., 2009, 27, S17-20.
    • (2009) J. Hypertens , vol.27
    • Reiter, R.J.1    Tan, D.X.2    Korkmaz, A.3
  • 51
    • 0033135083 scopus 로고    scopus 로고
    • Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men
    • Arangino, S.; Cagnacci, A.; Angiolucci, M.; Vacca, A.; Longu, G.; Volpe, A.; Melis, G.B. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am. J. Cardiol., 1999, 83, 1417-1419.
    • (1999) Am. J. Cardiol , vol.83 , pp. 1417-1419
    • Arangino, S.1    Cagnacci, A.2    Angiolucci, M.3    Vacca, A.4    Longu, G.5    Volpe, A.6    Melis, G.B.7
  • 52
    • 0033253638 scopus 로고    scopus 로고
    • Effects of melatonin alone and in combination with aceten on chronostructure of diurnal hemodynamic rhythms in patients with hypertension stage II
    • Zaslavskaia, R.M.; Shakirova, A.N.; Komarov, F.I.; Teǐblium, M.M.; Akhmetov, K.Z. Effects of melatonin alone and in combination with aceten on chronostructure of diurnal hemodynamic rhythms in patients with hypertension stage II. Ter. Arkh., 1999, 71, 21-24.
    • (1999) Ter. Arkh , vol.71 , pp. 21-24
    • Zaslavskaia, R.M.1    Shakirova, A.N.2    Komarov, F.I.3    Teǐblium, M.M.4    Akhmetov, K.Z.5
  • 53
    • 0033644776 scopus 로고    scopus 로고
    • Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hipertensión
    • Zaslavskaia, R.M.; Komarov, F.I.; Shakirova, A.N.; Te blium, M.M.; Akhmetov, K.Z. Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hipertensión. Klin. Med., (Mosk.), 2000, 78, 41-44.
    • (2000) Klin. Med., (Mosk.) , vol.78 , pp. 41-44
    • Zaslavskaia, R.M.1    Komarov, F.I.2    Shakirova, A.N.3    Te blium, M.M.4    Akhmetov, K.Z.5
  • 55
    • 0842332600 scopus 로고    scopus 로고
    • Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
    • Scheer, F.; van Montfrans, G.A.; van Someren, E.; Mairuhu, G.; Buijs, R.M. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension, 2004, 43, 192-197.
    • (2004) Hypertension , vol.43 , pp. 192-197
    • Scheer, F.1    van Montfrans, G.A.2    van Someren, E.3    Mairuhu, G.4    Buijs, R.M.5
  • 57
    • 0036264490 scopus 로고    scopus 로고
    • Melatonin and the cardiovascular system
    • Sewerynek, E. Melatonin and the cardiovascular system. Neuro Endocrinol. Lett., 2002, 23, 79-83.
    • (2002) Neuro Endocrinol. Lett , vol.23 , pp. 79-83
    • Sewerynek, E.1
  • 58
    • 36849030791 scopus 로고    scopus 로고
    • Light/dark patterns of soluble vascular cell adhesion molecule-1 in relation to melatonin in patients with ST-segment elevation myocardial infarction
    • Dominguez-Rodriguez, A.; Abreu-Gonzalez, P.; Garcia-Gonzalez, M.J.; Samimi-Fard, S.; Kaski, J.C.; Reiter, R.J. Light/dark patterns of soluble vascular cell adhesion molecule-1 in relation to melatonin in patients with ST-segment elevation myocardial infarction. J. Pineal Res., 2008, 44, 65-69.
    • (2008) J. Pineal Res , vol.44 , pp. 65-69
    • Dominguez-Rodriguez, A.1    Abreu-Gonzalez, P.2    Garcia-Gonzalez, M.J.3    Samimi-Fard, S.4    Kaski, J.C.5    Reiter, R.J.6
  • 59
    • 34248564577 scopus 로고    scopus 로고
    • A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty. The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: Study design and rationale
    • Dominguez-Rodriguez, A.; Abreu-Gonzalez, P., Garcia-Gonzalez, M.J., Kaski, J.C.; Reiter R.J.; Jimenez-Sosa, A. A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty. The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: study design and rationale. Contemp. Clin. Trials., 2007, 28, 532-539.
    • (2007) Contemp. Clin. Trials , vol.28 , pp. 532-539
    • Dominguez-Rodriguez, A.1    Ez, P.2    Garcia-Gonzalez, M.J.3    Kaski, J.C.4    Reiter, R.J.5    Jimenez-Sosa, A.6
  • 60
    • 58149311469 scopus 로고    scopus 로고
    • Melatonin in combined therapy of patients with stable angina and arterial hypertension
    • Zaslavskaia, R.M.; Shcherban, E.A.; Logvinenko, S.I. Melatonin in combined therapy of patients with stable angina and arterial hypertension. Klin. Med., (Mosk.), 2008, 86, 64-67.
    • (2008) Klin. Med., (Mosk.) , vol.86 , pp. 64-67
    • Zaslavskaia, R.M.1    Shcherban, E.A.2    Logvinenko, S.I.3
  • 61
    • 74349111287 scopus 로고    scopus 로고
    • Melatonin for nondippers with coronary artery disease: Assessment of blood pressure profile and heart rate variability
    • Rechciński, T.; Trzos, E.; Wierzbowska-Drabik, K.; Krzemińska-Pakuła, M.; Kurpesa, M. Melatonin for nondippers with coronary artery disease: assessment of blood pressure profile and heart rate variability. Hypertens. Res., 2010, 33(1):56-61.
    • (2010) Hypertens. Res , vol.33 , Issue.1 , pp. 56-61
    • Rechciński, T.1    Trzos, E.2    Wierzbowska-Drabik, K.3    Krzemińska-Pakuła, M.4    Kurpesa, M.5
  • 62
    • 0029741066 scopus 로고    scopus 로고
    • Evidence for circadian rhythm of insulin secretion
    • Boden, G.; Ruiz, J.; Urbain, J.L.; Chen, X. Evidence for circadian rhythm of insulin secretion. Am. J. Physiol., 1996, 271, E246-E252.
    • (1996) Am. J. Physiol , vol.271
    • Boden, G.1    Ruiz, J.2    Urbain, J.L.3    Chen, X.4
  • 65
    • 0035072930 scopus 로고    scopus 로고
    • Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women
    • Cagnacci, A.; Arangino, S.; Renzi, A.; Paoletti, A.M.; Melis, G.B.; Cagnaci, P.; Volpe, A. Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women. Clin. Endocrinol., 2001, 54, 339-346.
    • (2001) Clin. Endocrinol , vol.54 , pp. 339-346
    • Cagnacci, A.1    Arangino, S.2    Renzi, A.3    Paoletti, A.M.4    Melis, G.B.5    Cagnaci, P.6    Volpe, A.7
  • 66
    • 33746501888 scopus 로고    scopus 로고
    • Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin
    • Kadhim, H.M; Ismail, S.H.; Hussein, K.I.; Bakir, I.H.; Sahib, A.S.; Khalaf, B.H.; Hussein S.A. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J. Pineal Res., 2006, 41, 189-193.
    • (2006) J. Pineal Res , vol.41 , pp. 189-193
    • Kadhim, H.M.1    Ismail, S.H.2    Hussein, K.I.3    Bakir, I.H.4    Sahib, A.S.5    Khalaf, B.H.6    Hussein, S.A.7
  • 67
    • 34547112397 scopus 로고    scopus 로고
    • Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin
    • Hussain, S.A.; Khadim, H.M.; Khalaf, B.H.; Ismail, S.H.; Hussein, K.I.; Sahib, A.S. Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin. Saudi Med. J., 2006, 27, 1483-1488.
    • (2006) Saudi Med. J , vol.27 , pp. 1483-1488
    • Hussain, S.A.1    Khadim, H.M.2    Khalaf, B.H.3    Ismail, S.H.4    Hussein, K.I.5    Sahib, A.S.6
  • 70
    • 36849040010 scopus 로고    scopus 로고
    • Melatonininsulin interactions in patients with metabolic syndrome
    • Robeva, R.; Kirilo, G.; Tomova, A.; Kumanov, P. Melatonininsulin interactions in patients with metabolic syndrome. J. Pineal Res., 2008; 44, 52-56.
    • (2008) J. Pineal Res , vol.44 , pp. 52-56
    • Robeva, R.1    Kirilo, G.2    Tomova, A.3    Kumanov, P.4
  • 71
    • 0033768749 scopus 로고    scopus 로고
    • Actions of melatonin in the reduction of oxidative stress
    • Reiter, R.J.; Tan, D.X.; Osuna, C.; Gitto, E. Actions of melatonin in the reduction of oxidative stress. J. Biomed. Sci., 2000, 7, 444-458.
    • (2000) J. Biomed. Sci , vol.7 , pp. 444-458
    • Reiter, R.J.1    Tan, D.X.2    Osuna, C.3    Gitto, E.4
  • 74
    • 0026633931 scopus 로고
    • The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice
    • Hansson, I.; Holmdahl, R.; Mattsson, R. The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice. J. Neuroimmunol. 1992, 39, 23-30.
    • (1992) J. Neuroimmunol , vol.39 , pp. 23-30
    • Hansson, I.1    Holmdahl, R.2    Mattsson, R.3
  • 75
    • 34548641697 scopus 로고    scopus 로고
    • Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin
    • Forrest, C.M.; Mackay, G.M.; Stoy, N.; Stone, T.W.; Darlington, L.G. Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Br. J. Clin. Pharmacol., 2007, 64, 517-526.
    • (2007) Br. J. Clin. Pharmacol , vol.64 , pp. 517-526
    • Forrest, C.M.1    Mackay, G.M.2    Stoy, N.3    Stone, T.W.4    Darlington, L.G.5
  • 78
    • 0036845030 scopus 로고    scopus 로고
    • Role of antioxidants in chronic fatigue syndrome in mice. Ind
    • Singh, A.; Garg, V.; Gupta, S.; Kulkarni, S.K. Role of antioxidants in chronic fatigue syndrome in mice. Ind. J. Exp. Biol., 2002, 40, 1240-1244.
    • (2002) J. Exp. Biol , vol.40 , pp. 1240-1244
    • Singh, A.1    Garg, V.2    Gupta, S.3    Kulkarni, S.K.4
  • 79
    • 0036433031 scopus 로고    scopus 로고
    • Therapy of circadian rhythm disorders in chronic fatigue syndrome: No symptomatic improvement with melatonin or phototherapy
    • Williams, G.; Waterhouse, J.; Mugarza, J.; Minors, D.; Hayden, K. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur. J. Clin. Invest., 2002, 32, 831-837.
    • (2002) Eur. J. Clin. Invest , vol.32 , pp. 831-837
    • Williams, G.1    Waterhouse, J.2    Mugarza, J.3    Minors, D.4    Hayden, K.5
  • 80
    • 33645213164 scopus 로고    scopus 로고
    • Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion
    • van Heukelom, R.O.; Prins, J.B.; Smits, M.G.; Bleijenberg, G. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Eur. J. Neurol., 2006, 13, 55-60.
    • (2006) Eur. J. Neurol , vol.13 , pp. 55-60
    • van Heukelom, R.O.1    Prins, J.B.2    Smits, M.G.3    Bleijenberg, G.4
  • 81
    • 39149089285 scopus 로고    scopus 로고
    • Melatonin as an antibiotic: New insights into the actions of this ubiquitous molecule
    • Tekbas O.F.; Ogur R.; Korkmaz A.; Kilic A.; Reiter RJ. Melatonin as an antibiotic: new insights into the actions of this ubiquitous molecule. J. Pineal Res., 2008, 44, 222-226.
    • (2008) J. Pineal Res , vol.44 , pp. 222-226
    • Tekbas, O.F.1    Ogur, R.2    Korkmaz, A.3    Kilic, A.4    Reiter, R.J.5
  • 84
    • 42149095472 scopus 로고    scopus 로고
    • Regression of herpes viral infection symptoms using melatonin and SB-73: Comparison with Acyclovir
    • Nunes O.S.; Pereira R.S. Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with Acyclovir. J. Pineal Res., 2008, 44, 373-378.
    • (2008) J. Pineal Res , vol.44 , pp. 373-378
    • Nunes, O.S.1    Pereira, R.S.2
  • 85
  • 86
    • 27644592833 scopus 로고    scopus 로고
    • Putting cancer to sleep at night: The neuroendocrine/ circadian melatonin signal
    • Blask, D.E.; Dauchy, R.T.; Sauer L.A. Putting cancer to sleep at night: the neuroendocrine/ circadian melatonin signal. Endocrinology, 2005, 27, 178-188.
    • (2005) Endocrinology , vol.27 , pp. 178-188
    • Blask, D.E.1    Dauchy, R.T.2    Sauer, L.A.3
  • 88
    • 33750557481 scopus 로고    scopus 로고
    • Melatonin in cancer management: Progress and promise
    • Jung, B.; Ahmad, N. Melatonin in cancer management: progress and promise. Cancer Res., 2006; 66, 9789-9793.
    • (2006) Cancer Res , vol.66 , pp. 9789-9793
    • Jung, B.1    Ahmad, N.2
  • 89
    • 33749317848 scopus 로고    scopus 로고
    • Therapeutic treatments potentially mediated by melatonin receptors: Potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy
    • Witt-Enderby, P.A.; Radio N.M.; Doctor J.S.; Davis, V.L. Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy. J. Pineal Res., 2006, 41, 297-305.
    • (2006) J. Pineal Res , vol.41 , pp. 297-305
    • Witt-Enderby, P.A.1    Radio, N.M.2    Doctor, J.S.3    Davis, V.L.4
  • 92
    • 0035037747 scopus 로고    scopus 로고
    • Direct antiproliferative effects of melatonin on two metastatic cell sublines of mouse melanoma (B16BL6 and PG19)
    • Cos, S.; Garcia-Bolado, A.; Sánchez-Barceló, E.J. Direct antiproliferative effects of melatonin on two metastatic cell sublines of mouse melanoma (B16BL6 and PG19). Melanoma Res., 2001, 11, 197-201.
    • (2001) Melanoma Res , vol.11 , pp. 197-201
    • Cos, S.1    Garcia-Bolado, A.2    Sánchez-Barceló, E.J.3
  • 93
    • 62249177913 scopus 로고    scopus 로고
    • Melatonin and breast cancer: Cellular mechanisms, clinical studies and future perspectives
    • Grant, S.G.; Melan, M.A.; Latimer, J.J.; Witt-Enderby, P.A. Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. Expert Rev. Mol. Med., 2009, 11, 1-15.
    • (2009) Expert Rev. Mol. Med , vol.11 , pp. 1-15
    • Grant, S.G.1    Melan, M.A.2    Latimer, J.J.3    Witt-Enderby, P.A.4
  • 94
    • 0033580776 scopus 로고    scopus 로고
    • Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro
    • Mediavilla, M.D.; Cos, S.; Sánchez-Barceló, E.J. Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro. Life Sci., 1999, 65, 415-20.
    • (1999) Life Sci , vol.65 , pp. 415-420
    • Mediavilla, M.D.1    Cos, S.2    Sánchez-Barceló, E.J.3
  • 95
    • 33645473088 scopus 로고    scopus 로고
    • Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade
    • Radio, N.M.; Doctor, J.S.; Witt-Enderby, P.A. Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. J. Pineal Res., 2006, 40, 332-342.
    • (2006) J. Pineal Res , vol.40 , pp. 332-342
    • Radio, N.M.1    Doctor, J.S.2    Witt-Enderby, P.A.3
  • 96
    • 0032188888 scopus 로고    scopus 로고
    • Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells
    • Cos, S.; Fernández, R.; Güézmes, A.; Sánchez-Barceló, E.J. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res., 1998, 58, 4383-4390.
    • (1998) Cancer Res , vol.58 , pp. 4383-4390
    • Cos, S.1    Fernández, R.2    Güézmes, A.3    Sánchez-Barceló, E.J.4
  • 100
    • 0037389137 scopus 로고    scopus 로고
    • Melatonin counteracts the inhibitory effect of PGE2 on IL-2 production in human lymphocytes via its mt1 membrane receptor
    • Carrillo-Vico, A.; García-Mauriño, S.; Calvo, J.R.; Guerrero, J.M. Melatonin counteracts the inhibitory effect of PGE2 on IL-2 production in human lymphocytes via its mt1 membrane receptor. FASEB J., 2003, 17, 755-757.
    • (2003) FASEB J , vol.17 , pp. 755-757
    • Carrillo-Vico, A.1    García-Mauriño, S.2    Calvo, J.R.3    Guerrero, J.M.4
  • 101
    • 0042913095 scopus 로고    scopus 로고
    • Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro
    • Leon-Blanco, M.M.; Guerrero, J.M.; Reiter, R.J.; Calvo, J.R.; Pozo, D. Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro. J.Pineal Res., 2003, 35, 204-211.
    • (2003) J.Pineal Res , vol.35 , pp. 204-211
    • Leon-Blanco, M.M.1    Guerrero, J.M.2    Reiter, R.J.3    Calvo, J.R.4    Pozo, D.5
  • 102
    • 48549093576 scopus 로고    scopus 로고
    • Melatonin downregulates hTERT expression induced by either natural estrogens (17beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells
    • Martínez-Campa, C.M.; Alonso-González, C.; Mediavilla, M.D.; Cos, S.; González, A.; Sanchez-Barcelo, E.J. Melatonin downregulates hTERT expression induced by either natural estrogens (17beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells. Cancer Lett., 2008, 268, 272-277.
    • (2008) Cancer Lett , vol.268 , pp. 272-277
    • Martínez-Campa, C.M.1    Alonso-González, C.2    Mediavilla, M.D.3    Cos, S.4    González, A.5    Sanchez-Barcelo, E.J.6
  • 106
    • 0031138297 scopus 로고    scopus 로고
    • The validity of melatonin as an oncostatic agent
    • Panzer, A.; Viljoen, M. The validity of melatonin as an oncostatic agent. J. Pineal Res., 1997, 22, 184-202.
    • (1997) J. Pineal Res , vol.22 , pp. 184-202
    • Panzer, A.1    Viljoen, M.2
  • 107
    • 27744573253 scopus 로고    scopus 로고
    • Melatonin in the treatment of cancer: A systematic review of randomized controlled trials and meta-analysis
    • Mills, E.; Wu, P.; Seely, D.; Guyatt, G. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J. Pineal Res., 2005, 39, 360-366.
    • (2005) J. Pineal Res , vol.39 , pp. 360-366
    • Mills, E.1    Wu, P.2    Seely, D.3    Guyatt, G.4
  • 108
    • 0028934479 scopus 로고
    • A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates
    • Barni, S.; Lissoni, P.; Cazzaniga, M.; Ardizzoia, A.; Meregalli, S.; Fossati, V.; Fumagalli, L.; Brivio, F.; Tancini, G. A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates. Oncology, 1995, 52, 243-245.
    • (1995) Oncology , vol.52 , pp. 243-245
    • Barni, S.1    Lissoni, P.2    Cazzaniga, M.3    Ardizzoia, A.4    Meregalli, S.5    Fossati, V.6    Fumagalli, L.7    Brivio, F.8    Tancini, G.9
  • 109
    • 0028899960 scopus 로고
    • Immunoendocrine therapy with low-dose subcutaneous interleukin-2 plus melatonin of locally advanced or metastatic endocrine tumors
    • Lissoni, P.; Barni, S.; Tancini, G.; Mainini, E.; Piglia, F.; Maestroni, G.J.; Lewinski, A. Immunoendocrine therapy with low-dose subcutaneous interleukin-2 plus melatonin of locally advanced or metastatic endocrine tumors. Oncology, 1995, 52, 163-1666.
    • (1995) Oncology , vol.52 , pp. 163-1666
    • Lissoni, P.1    Barni, S.2    Tancini, G.3    Mainini, E.4    Piglia, F.5    Maestroni, G.J.6    Lewinski, A.7
  • 110
    • 0029126045 scopus 로고
    • A biological study on the efficacy of lowdose subcutaneous interleukin-2 plus melatonin in the treatment of cancer-related thrombocytopenia
    • Lissoni, P.; Barni, S.; Brivio, F.; Rossini, F.; Fumagalli, L.; Ardizzoia, A.; Tancini, G.A. A biological study on the efficacy of lowdose subcutaneous interleukin-2 plus melatonin in the treatment of cancer-related thrombocytopenia. Oncology, 1995, 52, 360-362.
    • (1995) Oncology , vol.52 , pp. 360-362
    • Lissoni, P.1    Barni, S.2    Brivio, F.3    Rossini, F.4    Fumagalli, L.5    Ardizzoia, A.6    Tancini, G.A.7
  • 112
    • 0030056686 scopus 로고    scopus 로고
    • Is there a role for melatonin in the treatment of neoplastic cachexia? Is there a role for melatonin in the treatment of neoplastic cachexia
    • Lissoni, P.; Paolorossi, F.; Tancini, G.; Barni, S.; Ardizzoia, A.; Brivio F.; Zubelewicz, B.; Chatikhine, V. Is there a role for melatonin in the treatment of neoplastic cachexia? Is there a role for melatonin in the treatment of neoplastic cachexia? Eur. J. Cancer, 1996, 32, 1340-1343.
    • (1996) Eur. J. Cancer , vol.32 , pp. 1340-1343
    • Lissoni, P.1    Paolorossi, F.2    Tancini, G.3    Barni, S.4    Ardizzoia, A.5    Brivio, F.6    Zubelewicz, B.7    Chatikhine, V.8
  • 113
    • 0031055219 scopus 로고    scopus 로고
    • Reversal of clinical resistance to LHRH analogue in metastatic prostate cancer by the pineal hormone melatonin: Efficacy of LHRH analogue plus melatonin in patients progressing on LHRH analogue alone
    • Lissoni, P.; Cazzaniga, M.; Tancini, G.; Scardino, E.; Musci, R.; Barni, S.; Maffezzini, M.; Meroni, T.; Rocco, F.; Conti, A.; Maestroni, G. Reversal of clinical resistance to LHRH analogue in metastatic prostate cancer by the pineal hormone melatonin: efficacy of LHRH analogue plus melatonin in patients progressing on LHRH analogue alone. Eur. Urol., 1997, 31, 178-181.
    • (1997) Eur. Urol , vol.31 , pp. 178-181
    • Lissoni, P.1    Cazzaniga, M.2    Tancini, G.3    Scardino, E.4    Musci, R.5    Barni, S.6    Maffezzini, M.7    Meroni, T.8    Rocco, F.9    Conti, A.10    Maestroni, G.11
  • 114
    • 0031202122 scopus 로고    scopus 로고
    • A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state
    • Lissoni, P.; Paolorossi, F.; Ardizzoia, A.; Barni, S.; Chilelli, M.; Mancuso, M.; Tancini, G.; Conti, A.; Maestroni, G.J. A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state. J. Pineal Res., 1997, 23, 15-19.
    • (1997) J. Pineal Res , vol.23 , pp. 15-19
    • Lissoni, P.1    Paolorossi, F.2    Ardizzoia, A.3    Barni, S.4    Chilelli, M.5    Mancuso, M.6    Tancini, G.7    Conti, A.8    Maestroni, G.J.9
  • 115
    • 0032934895 scopus 로고    scopus 로고
    • Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: A phase II study
    • Lissoni, P.; Tancini, G.; Paolorossi, F.; Mandalà, M.; Ardizzoia, A.; Malugani, F.; Giani, L.; Barni, S. Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study. J. Pineal Res., 1999, 26, 169-173.
    • (1999) J. Pineal Res , vol.26 , pp. 169-173
    • Lissoni, P.1    Tancini, G.2    Paolorossi, F.3    Mandalà, M.4    Ardizzoia, A.5    Malugani, F.6    Giani, L.7    Barni, S.8
  • 116
    • 0033383164 scopus 로고    scopus 로고
    • Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status
    • Lissoni, P.; Barni, S.; Mandalà, M.; Ardizzoia, A.; Paolorossi, F.; Vaghi, M.; Longarini, R.; Malugani, F.; Tancini, G. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. Eur. J. Cancer, 1999, 35, 1688-1692.
    • (1999) Eur. J. Cancer , vol.35 , pp. 1688-1692
    • Lissoni, P.1    Barni, S.2    Mandalà, M.3    Ardizzoia, A.4    Paolorossi, F.5    Vaghi, M.6    Longarini, R.7    Malugani, F.8    Tancini, G.9
  • 117
    • 0034126546 scopus 로고    scopus 로고
    • Abrogation of the negative influence of opioids on IL-2 immunotherapy of renal cell cancer by melatonin
    • Lissoni, P.; Mandalà, M.; Brivio, F. Abrogation of the negative influence of opioids on IL-2 immunotherapy of renal cell cancer by melatonin. Eur. Urol., 2000, 38, 115-118.
    • (2000) Eur. Urol , vol.38 , pp. 115-118
    • Lissoni, P.1    Mandalà, M.2    Brivio, F.3
  • 118
    • 0037524440 scopus 로고    scopus 로고
    • Biomodulation of cancer chemotherapy for metastatic colorectal cancer: A randomized study of weekly low-dose irinotecan alone versus irinotecan plus the oncostatic pineal hormone melatonin in metastatic colorectal cancer patients progressing on 5-fluorouracil-containing combinations
    • Cerea, G.; Vaghi, M.; Ardizzoia, A.; Villa, S.; Bucovec, R.; Mengo, S.; Gardani, G.; Tancini, G.; Lissoni, P. Biomodulation of cancer chemotherapy for metastatic colorectal cancer: a randomized study of weekly low-dose irinotecan alone versus irinotecan plus the oncostatic pineal hormone melatonin in metastatic colorectal cancer patients progressing on 5-fluorouracil-containing combinations. Anti Cancer Res., 2003, 23, 1951-1954.
    • (2003) Anti Cancer Res , vol.23 , pp. 1951-1954
    • Cerea, G.1    Vaghi, M.2    Ardizzoia, A.3    Villa, S.4    Bucovec, R.5    Mengo, S.6    Gardani, G.7    Tancini, G.8    Lissoni, P.9
  • 119
    • 0042412174 scopus 로고    scopus 로고
    • Melatonin slowed the early biochemical progression of hormonerefractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype
    • Shiu, S.Y.; Law, I.C.; Lau, K.W.; Tam, P.C.; Yip, A.W.; Ng, W.T. Melatonin slowed the early biochemical progression of hormonerefractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype. J. Pineal Res., 2003, 35, 177-182.
    • (2003) J. Pineal Res , vol.35 , pp. 177-182
    • Shiu, S.Y.1    Law, I.C.2    Lau, K.W.3    Tam, P.C.4    Yip, A.W.5    Ng, W.T.6
  • 120
    • 0038346728 scopus 로고    scopus 로고
    • Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: A randomized trial
    • Lissoni, P.; Chilelli, M.; Villa, S.; Cerizza, L.; Tancini, G. Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial. J. Pineal Res., 2003, 35, 12-15.
    • (2003) J. Pineal Res , vol.35 , pp. 12-15
    • Lissoni, P.1    Chilelli, M.2    Villa, S.3    Cerizza, L.4    Tancini, G.5
  • 121
    • 0042286457 scopus 로고    scopus 로고
    • Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: A phase II study
    • Lissoni, P.; Malugani, F.; Brivio, F.; Piazza, A.; Vintimilla, C.; Giani, L.; Tancini, G. Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: a phase II study. Neuro Endocrinol. Lett., 2003, 24, 259-62.
    • (2003) Neuro EndoCrinol. Lett , vol.24 , pp. 259-262
    • Lissoni, P.1    Malugani, F.2    Brivio, F.3    Piazza, A.4    Vintimilla, C.5    Giani, L.6    Tancini, G.7
  • 122
    • 34247855007 scopus 로고    scopus 로고
    • Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in chemotherapy-pretreated patients with advanced lung adenocarcinoma and low performance status
    • Norsa, A.; Martino, V. Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in chemotherapy-pretreated patients with advanced lung adenocarcinoma and low performance status. Cancer Biother. Radiopharm., 2007, 22, 50-55.
    • (2007) Cancer Biother. Radiopharm , vol.22 , pp. 50-55
    • Norsa, A.1    Martino, V.2
  • 123
    • 34249716813 scopus 로고    scopus 로고
    • Biochemotherapy with immunomodulating pineal hormones other than melatonin: 5-methoxytryptamine as a new oncostatic pineal agent
    • Lissoni, P. Biochemotherapy with immunomodulating pineal hormones other than melatonin: 5-methoxytryptamine as a new oncostatic pineal agent. Pathol. Biol., (Paris), 2007, 55, 198-200.
    • (2007) Pathol. Biol., (Paris) , vol.55 , pp. 198-200
    • Lissoni, P.1
  • 124
    • 34249739700 scopus 로고    scopus 로고
    • Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms
    • Lissoni, P. Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms. Pathol. Biol., (Paris), 2007, 55, 201-204.
    • (2007) Pathol. Biol., (Paris) , vol.55 , pp. 201-204
    • Lissoni, P.1
  • 125
    • 45949084571 scopus 로고    scopus 로고
    • A study of immunoendocrine strategies with pineal indoles and interleukin-2 to prevent radiotherapy-induced lymphocytopenia in cancer patients
    • Lissoni, P., Rovelli, F.; Brivio, F.; Fumagalli, L.; Brera, G. A study of immunoendocrine strategies with pineal indoles and interleukin-2 to prevent radiotherapy-induced lymphocytopenia in cancer patients. In Vivo, 2008, 22, 397-400.
    • (2008) In Vivo , vol.22 , pp. 397-400
    • Lissoni, P.1    Rovelli, F.2    Brivio, F.3    Fumagalli, L.4    Brera, G.5
  • 127
    • 67650832311 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Long-lasting remission with combination of cyclophosphamide, somatostatin, bromocriptine, retinoids, melatonin, and ACTH
    • Todisco, M. Chronic lymphocytic leukemia: long-lasting remission with combination of cyclophosphamide, somatostatin, bromocriptine, retinoids, melatonin, and ACTH. Cancer Biother. Radiopharm., 2009, 24, 353-355.
    • (2009) Cancer Biother. Radiopharm , vol.24 , pp. 353-355
    • Todisco, M.1
  • 128
    • 0036797512 scopus 로고    scopus 로고
    • Melatonin: Reducing the toxicity and increasing the efficacy of drugs
    • Reiter, R.J.; Tan, D.X.; Sainz, R.M.; Mayo, J.C. Melatonin: reducing the toxicity and increasing the efficacy of drugs. J. Pharm. Pharmacol., 2002, 54, 1299-1321.
    • (2002) J. Pharm. Pharmacol , vol.54 , pp. 1299-1321
    • Reiter, R.J.1    Tan, D.X.2    Sainz, R.M.3    Mayo, J.C.4
  • 129
    • 33645500581 scopus 로고    scopus 로고
    • Circulating melatonin levels: Possible link between Parkinsońs disease and cancer risk?
    • Schernhammer, E.; Chen, H.; Ritz, B. Circulating melatonin levels: possible link between Parkinsońs disease and cancer risk? Cancer Causes Control, 2006, 17, 577-582.
    • (2006) Cancer Causes Control , vol.17 , pp. 577-582
    • Schernhammer, E.1    Chen, H.2    Ritz, B.3
  • 130
    • 33646115424 scopus 로고    scopus 로고
    • Blood 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and melatonin levels in patients with either Huntington's disease or chronic brain injury
    • Christofides, J.; Bridel, M.; Egerton, M.; Mackay, G.M.; Forrest, C.M.; Stoy, N.; Darlington, L.G.; Stone, T.W. Blood 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and melatonin levels in patients with either Huntington's disease or chronic brain injury. J. Neurochem., 2006, 97, 1078-1088.
    • (2006) J. Neurochem , vol.97 , pp. 1078-1088
    • Christofides, J.1    Bridel, M.2    Egerton, M.3    Mackay, G.M.4    Forrest, C.M.5    Stoy, N.6    Darlington, L.G.7    Stone, T.W.8
  • 131
    • 33644772081 scopus 로고    scopus 로고
    • Endogenous melatonin. LDOPA from autoxidation in the striatal extracellular compartment of the freely moving rat: Potential implication for long-term L-DOPA therapy in Parkinsońs disease
    • Rocchitta, G.; Migheli, R.; Esposito, G.; Marchetti, B.; Desole, M.S.; Miele, E.; Serra, P.A. Endogenous melatonin. LDOPA from autoxidation in the striatal extracellular compartment of the freely moving rat: potential implication for long-term L-DOPA therapy in Parkinsońs disease. J. Pineal Res., 2006, 40, 204-213.
    • (2006) J. Pineal Res , vol.40 , pp. 204-213
    • Rocchitta, G.1    Migheli, R.2    Esposito, G.3    Marchetti, B.4    Desole, M.S.5    Miele, E.6    Serra, P.A.7
  • 133
    • 0344492689 scopus 로고    scopus 로고
    • Monozygotic twins with Alzheimer's disease treated with melatonin: Case report
    • Brusco, L.I.; Márquez, M.; Cardinali, D.P. Monozygotic twins with Alzheimer's disease treated with melatonin: Case report. J. Pineal Res., 1998, 25, 260-263
    • (1998) J. Pineal Res , vol.25 , pp. 260-263
    • Brusco, L.I.1    Márquez, M.2    Cardinali, D.P.3
  • 135
    • 0041817939 scopus 로고    scopus 로고
    • Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia
    • Asayama, K.; Yamadera, H.; Ito, T.; Suzuki, H.; Kudo, Y.; Endo, S. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J. Nippon Med. Sch., 2003, 70, 334-341.
    • (2003) J. Nippon Med. Sch , vol.70 , pp. 334-341
    • Asayama, K.1    Yamadera, H.2    Ito, T.3    Suzuki, H.4    Kudo, Y.5    Endo, S.6
  • 136
    • 0346490300 scopus 로고    scopus 로고
    • Alzheimer's Disease Cooperative Study. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease
    • Singer, C.; Tractenberg, R.E.; Kaye J.; Schafer, K.; Gamst, A.; Grundman, M.; Thomas, R.; Thal, L.J. Alzheimer's Disease Cooperative Study. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep, 2003, 26, 893-901.
    • (2003) Sleep , vol.26 , pp. 893-901
    • Singer, C.1    Tractenberg, R.E.2    Kaye, J.3    Schafer, K.4    Gamst, A.5    Grundman, M.6    Thomas, R.7    Thal, L.J.8
  • 137
    • 60849138397 scopus 로고    scopus 로고
    • Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease
    • Gehrman, P.R.; Connor, D.J.; Martin, J.L.; Shochat, T; Corey-Bloom, J.; Ancoli-Israel, S. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am. J. Geriatr. Psychiatry, 2009, 17, 166-169.
    • (2009) Am. J. Geriatr. PsyChiatry , vol.17 , pp. 166-169
    • Gehrman, P.R.1    Connor, D.J.2    Martin, J.L.3    Shochat, T.4    Corey-Bloom, J.5    Ancoli-Israel, S.6
  • 138
    • 34848894332 scopus 로고    scopus 로고
    • Possible therapeutic value of melatonin in mild cognitive impairment: A retrospective study
    • Furio, A.M.; Brusco, L.I.; Cardinali, D.P. Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study. J. Pineal Res., 2007, 43, 404-409.
    • (2007) J. Pineal Res , vol.43 , pp. 404-409
    • Furio, A.M.1    Brusco, L.I.2    Cardinali, D.P.3
  • 139
  • 140
    • 0035562519 scopus 로고    scopus 로고
    • Melatonin-dopamine interactions: From basic neurochemistry to a clinical setting
    • Zisapel, N. Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting. Cell Mol. Neurobiol., 2001, 21, 605-616.
    • (2001) Cell Mol. Neurobiol , vol.21 , pp. 605-616
    • Zisapel, N.1
  • 141
    • 0032973751 scopus 로고    scopus 로고
    • A therapeutic role for melatonin antagonism in experimental models of Parkinson's disease
    • Willis, G.L.; Armstrong, S.M. A therapeutic role for melatonin antagonism in experimental models of Parkinson's disease. Physiol. Behav., 1999, 66, 785-795.
    • (1999) Physiol. Behav , vol.66 , pp. 785-795
    • Willis, G.L.1    Armstrong, S.M.2
  • 142
    • 9644275747 scopus 로고    scopus 로고
    • Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: A new mechanism involving antagonism of the melatonin receptor
    • Willi, G.L.; Robertson, A.D. Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: a new mechanism involving antagonism of the melatonin receptor. Pharmacol. Biochem. Behav., 2004, 79, 413-429.
    • (2004) Pharmacol. Biochem. Behav , vol.79 , pp. 413-429
    • Willi, G.L.1    Robertson, A.D.2
  • 144
    • 33847675291 scopus 로고    scopus 로고
    • Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model
    • Saravanan, K.S.; Sindhu, K.M.; Mohanakumar, K.P. Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model. J. Pineal Res., 2007, 42, 247-253.
    • (2007) J. Pineal Res , vol.42 , pp. 247-253
    • Saravanan, K.S.1    Sindhu, K.M.2    Mohanakumar, K.P.3
  • 145
    • 34447577880 scopus 로고    scopus 로고
    • +-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells
    • +-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells. J. Pineal Res,. 2007, 43, 115-120.
    • (2007) J. Pineal Res , vol.43 , pp. 115-120
    • Chetsawang, J.1    Govitrapong, P.2    Chetsewang, B.3
  • 146
    • 34548416796 scopus 로고    scopus 로고
    • Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease
    • Sharma, R.; Mc Millan, C.R.; Niles, L.P. Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease. J. Pineal Res., 2007, 43, 245-254.
    • (2007) J. Pineal Res , vol.43 , pp. 245-254
    • Sharma, R.1    Mc Millan, C.R.2    Niles, L.P.3
  • 147
    • 33644809553 scopus 로고    scopus 로고
    • Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease
    • Alvira, D.; Tajes, M.; Verdaguer, E.; Acuña-Castroviejo, D.; Folch, J.; Camins, A.; Pablos, M. Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease. J. Pineal Res., 2006, 40, 251-258.
    • (2006) J. Pineal Res , vol.40 , pp. 251-258
    • Alvira, D.1    Tajes, M.2    Verdaguer, E.3    Acuña-Castroviejo, D.4    Folch, J.5    Camins, A.6    Pablos, M.7
  • 149
  • 151
    • 34249072817 scopus 로고    scopus 로고
    • Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's-disease. A randomized, double blind, placebo-controlled study
    • Medeiros, C.A.; Carvalhedo de Bruin, P.F.; Lopes, L.A.; Magal-Hães, M.C.; de Lourdes Reabra, M.; de Bruin, V.M. Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's-disease. A randomized, double blind, placebo-controlled study. J. Neurol., 2007, 254, 459-64.
    • (2007) J. Neurol , vol.254 , pp. 459-464
    • Medeiros, C.A.1    Carvalhedo de Bruin, P.F.2    Lopes, L.A.3    Magal-Hães, M.C.4    de Lourdes Reabra, M.5    de Bruin, V.M.6
  • 153
    • 15444372059 scopus 로고    scopus 로고
    • Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex
    • Hancock, E.; O'Callaghan, F.; Osborne, J.P. Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. J. Child Neurol., 2005, 20, 78-80.
    • (2005) J. Child Neurol , vol.20 , pp. 78-80
    • Hancock, E.1    O'Callaghan, F.2    Osborne, J.P.3
  • 154
    • 44949175084 scopus 로고    scopus 로고
    • Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: A andomized controlled trial
    • Riemersma-van der Lek, R.F.; Swaab, D.F.; Twisk, J.; Hol, E.M.; Hoogendijk, W.J.; Van Someren, E.J. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a andomized controlled trial. JAMA, 2008, 299, 2642-2655.
    • (2008) JAMA , vol.299 , pp. 2642-2655
    • Riemersma1    van der Lek, R.F.2    Swaab, D.F.3    Twisk, J.4    Hol, E.M.5    Hoogendijk, W.J.6    van Someren, E.J.7
  • 155
    • 0015911332 scopus 로고
    • Nature and the time course of seizures associated with surgical removal of the pineal gland from parathyroidectomized rats
    • Reiter, R.J.; Blask, D.E.; Talbot, J.A.; Barnet, M.P. Nature and the time course of seizures associated with surgical removal of the pineal gland from parathyroidectomized rats. Exp. Neurol., 1973, 38, 386-397.
    • (1973) Exp. Neurol , vol.38 , pp. 386-397
    • Reiter, R.J.1    Blask, D.E.2    Talbot, J.A.3    Barnet, M.P.4
  • 156
    • 0017755164 scopus 로고
    • Epileptogenic action of intraventricularly injected antimelatonin antibody
    • Fariello, R.G.; Bubenik, G.A.; Brown, G.M.; Gorta, L.J. Epileptogenic action of intraventricularly injected antimelatonin antibody. Neurology, 1977, 27, 267-270.
    • (1977) Neurology , vol.27 , pp. 267-270
    • Fariello, R.G.1    Bubenik, G.A.2    Brown, G.M.3    Gorta, L.J.4
  • 157
    • 10544255343 scopus 로고    scopus 로고
    • Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats
    • Manev, H.; Uz, T.; Kharlamov, A.; Joo, J-Y. Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats. FASEB J., 1996, 10, 1546-1551.
    • (1996) FASEB J , vol.10 , pp. 1546-1551
    • Manev, H.1    Uz, T.2    Kharlamov, A.3    Joo, J.-Y.4
  • 161
    • 0034799173 scopus 로고    scopus 로고
    • Melatonin effect on seizures in children with severe neurologic deficit disorders
    • Peled, N.; Shorer, Z.; Peled, E.; Pillar, G. Melatonin effect on seizures in children with severe neurologic deficit disorders. Epilepsia, 2001, 42, 1208-1210.
    • (2001) EpilepSia , vol.42 , pp. 1208-1210
    • Peled, N.1    Shorer, Z.2    Peled, E.3    Pillar, G.4
  • 162
    • 14544279362 scopus 로고    scopus 로고
    • Effect of melatonin on intractable epilepsies
    • Saracz, J.; Rosdy, B. Effect of melatonin on intractable epilepsies. Orv. Hetil., 2004, 145, 2583-2587.
    • (2004) Orv. Hetil , vol.145 , pp. 2583-2587
    • Saracz, J.1    Rosdy, B.2
  • 163
    • 0033032486 scopus 로고    scopus 로고
    • Melatonin in epilepsy: First results of replacement therapy and first clinical results
    • Fauteck, J.; Schmidt, H.; Lerchl, A.; Kurlemann, G.; Wittkowski, W. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol. Signals Recept., 1999, 8, 105-110.
    • (1999) Biol. Signals Recept , vol.8 , pp. 105-110
    • Fauteck, J.1    Schmidt, H.2    Lerchl, A.3    Kurlemann, G.4    Wittkowski, W.5
  • 164
    • 18144441631 scopus 로고    scopus 로고
    • Proconvulsant effects of oral melatonin in neurologically disabled children
    • Sheldon, S.H. Proconvulsant effects of oral melatonin in neurologically disabled children. Lancet, 1998, 351, 1254.
    • (1998) Lancet , vol.351 , pp. 1254
    • Sheldon, S.H.1
  • 165
    • 0026822354 scopus 로고
    • Melatonin as a proconvulsive hormone in humans
    • Sandyk, R.; Tsagas, N.; Anninos, P.A. Melatonin as a proconvulsive hormone in humans. Int. J. Neurosci., 1992, 63, 125-135.
    • (1992) Int. J. Neurosci , vol.63 , pp. 125-135
    • Sandyk, R.1    Tsagas, N.2    Anninos, P.A.3
  • 166
    • 10644278744 scopus 로고    scopus 로고
    • Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: A randomized, double-blind,placebo-controlled trial
    • Gupta, M.; Gupta, Y.K.; Agarwal, S.; Aneja, S.; Kalaivani, M.; Kohli, K. Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind,placebo-controlled trial. Epilepsia, 2004, 45, 1636-1639.
    • (2004) Epilepsia , vol.45 , pp. 1636-1639
    • Gupta, M.1    Gupta, Y.K.2    Agarwal, S.3    Aneja, S.4    Kalaivani, M.5    Kohli, K.6
  • 167
    • 9144249625 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo controlled trial of melatonin addon therapy in epileptic children on valproate monotherapy: Effect on glutathione peroxidase and glutathione reductase enzymes
    • Gupta, M.; Gupta Y.K.; Agarwal, S.; Aneja, S.; Kohli, K. A randomized, double-blind, placebo controlled trial of melatonin addon therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes.Br. J. Clin. Pharmacol., 2004, 58, 542-547.
    • (2004) Br. J. Clin. Pharmacol , vol.58 , pp. 542-547
    • Gupta, M.1    Gupta, Y.K.2    Agarwal, S.3    Aneja, S.4    Kohli, K.5
  • 168
    • 3042580174 scopus 로고    scopus 로고
    • Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: A randomized, double-blind, placebo-controlled trial
    • Gupta, M.; Aneja, S.; Kohli, K. Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsy Behav., 2004, 5, 316-321.
    • (2004) Epilepsy Behav , vol.5 , pp. 316-321
    • Gupta, M.1    Aneja, S.2    Kohli, K.3
  • 169
    • 3242715008 scopus 로고    scopus 로고
    • Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: A double-blind, cross-over, placebo-controlled trial
    • Coppola, G.; Iervolino, G.; Mastrosimone, M.; La Torre, G.; Ruiu, F.; Pascotto A. Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. Brain Dev., 2004, 26, 373-376.
    • (2004) Brain Dev , vol.26 , pp. 373-376
    • Coppola, G.1    Iervolino, G.2    Mastrosimone, M.3    La Torre, G.4    Ruiu, F.5    Pascotto, A.6
  • 170
    • 33645235350 scopus 로고    scopus 로고
    • Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches. Med
    • Deshmukh, V.D. Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches. Med. Hypotheses., 2006, 66, 1146-1151.
    • (2006) Hypotheses , vol.66 , pp. 1146-1151
    • Deshmukh, V.D.1
  • 171
    • 20044377634 scopus 로고    scopus 로고
    • Melatonin, the pineal gland and their implications for headache disorders
    • Peres, M.F. Melatonin, the pineal gland and their implications for headache disorders. Cephalalgia, 2005, 25, 403-411.
    • (2005) Cephalalgia , vol.25 , pp. 403-411
    • Peres, M.F.1
  • 173
    • 0030986878 scopus 로고    scopus 로고
    • Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status migrainosus
    • Claustrat, B.; Brun, J.; Geoffriau, M.; Zaidan, R.; Mallo, C.; Cha-zot, G. Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status migrainosus. Cephalalgia, 1997, 17, 511-517.
    • (1997) Cephalalgia , vol.17 , pp. 511-517
    • Claustrat, B.1    Brun, J.2    Geoffriau, M.3    Zaidan, R.4    Mallo, C.5    Cha-Zot, G.6
  • 174
    • 0031949225 scopus 로고    scopus 로고
    • Melatonin-responsive headache in delayed sleep phase syndrome: Preliminary observations
    • Nagtegaal, J.E.; Smits, M.G.; Swart, A.C.; Kerkhof, G.A.; van der Meer, Y.G. Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. Headache,1998, 38, 303-307.
    • (1998) Headache , vol.38 , pp. 303-307
    • Nagtegaal, J.E.1    Smits, M.G.2    Swart, A.C.3    Kerkhof, G.A.4    van der Meer, Y.G.5
  • 175
    • 0029827884 scopus 로고    scopus 로고
    • Melatonin versus placebo in the prophylaxis of cluster headache: A double-blind pilot study with parallel groups
    • Leone, M.; D'Amico, D.; Moschiano, F.; Fraschini, F.; Bussone, G. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia, 1996, 16, 494-496.
    • (1996) Cephalalgia , vol.16 , pp. 494-496
    • Leone, M.1    D'Amico, D.2    Moschiano, F.3    Fraschini, F.4    Bussone, G.5
  • 176
    • 0035741737 scopus 로고    scopus 로고
    • Melatonin in the preventive treatment of chronic cluster headache
    • Peres, M.F.; Rozen, T.D. Melatonin in the preventive treatment of chronic cluster headache. Cephalalgia, 2001, 21, 993-995.
    • (2001) Cephalalgia , vol.21 , pp. 993-995
    • Peres, M.F.1    Rozen, T.D.2
  • 177
    • 0141653009 scopus 로고    scopus 로고
    • Melatonin as treatment for idiopathic stabbing headache
    • Rozen, T.D. Melatonin as treatment for idiopathic stabbing headache. Neurology, 2003, 61, 865-866.
    • (2003) Neurology , vol.61 , pp. 865-866
    • Rozen, T.D.1
  • 180
    • 35648987668 scopus 로고    scopus 로고
    • Circadian rhythm sleep disorders: Part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review
    • Sack, R.L.; Auckley, D.; Auger, R.R.; Carskadon, M.A.; Wright, K.P.; Vitiello, M.V.; Zhdanova, I.V. Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review. Sleep, 2007, 30, 1460-1483.
    • (2007) Sleep , vol.30 , pp. 1460-1483
    • Sack, R.L.1    Auckley, D.2    Auger, R.R.3    Carskadon, M.A.4    Wright, K.P.5    Vitiello, M.V.6    Zhdanova, I.V.7
  • 181
    • 70350736706 scopus 로고    scopus 로고
    • Neurobiology of circadian systems
    • Schulz, P.; Steimer, T. Neurobiology of circadian systems. CNS Drugs, 2009, 23, 3-13.
    • (2009) CNS Drugs , vol.23 , pp. 3-13
    • Schulz, P.1    Steimer, T.2
  • 182
    • 0020691953 scopus 로고
    • Free-running activity rhythms in the rat: Entrainment by melatonin
    • Redman, J.; Armstrong, S.; Ng, K.T. Free-running activity rhythms in the rat: entrainment by melatonin. Science, 1983, 219, 1089-1091.
    • (1983) Science , vol.219 , pp. 1089-1091
    • Redman, J.1    Armstrong, S.2    Ng, K.T.3
  • 183
    • 0026661007 scopus 로고
    • Melatonin shifts human circadian rhythms according to a phase-response curve
    • Lewy, A.J.; Ahmed, S.; Jackson, J.M.; Sack, R.L. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol. Int., 1992, 9, 380-392.
    • (1992) Chronobiol. Int , vol.9 , pp. 380-392
    • Lewy, A.J.1    Ahmed, S.2    Jackson, J.M.3    Sack, R.L.4
  • 184
    • 0027653108 scopus 로고
    • The association between the nocturnal sleep gate and nocturnal onset of urinary 6-sulphatoxymelatonin
    • Tzischinsky, O.; Shlitner, A.; Lavie, P. The association between the nocturnal sleep gate and nocturnal onset of urinary 6-sulphatoxymelatonin. J. Biol. Rhythms, 1993, 8, 199-209.
    • (1993) J. Biol. Rhythms , vol.8 , pp. 199-209
    • Tzischinsky, O.1    Shlitner, A.2    Lavie, P.3
  • 185
    • 0031303763 scopus 로고    scopus 로고
    • Efficacy of melatonin as a sleeppromoting agent
    • Zhdanova, I.V.; Wurtman, R.J. Efficacy of melatonin as a sleeppromoting agent. J. Biol. Rhythms, 1997, 112, 644-50.
    • (1997) J. Biol. Rhythms , vol.112 , pp. 644-650
    • Zhdanova, I.V.1    Wurtman, R.J.2
  • 186
    • 0031021914 scopus 로고    scopus 로고
    • Melatonin in humans
    • Brzezinski, A. Melatonin in humans. N. Engl. J. Med., 1997, 336, 186-195.
    • (1997) N. Engl. J. Med , vol.336 , pp. 186-195
    • Brzezinski, A.1
  • 188
    • 7044263197 scopus 로고    scopus 로고
    • Melatonin, sleep, and circadian rhythms: Rationale for development of specific melatonin agonists
    • Turek, F.W.; Gillette, M.U. Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Sleep Med., 2004, 5, 523-532.
    • (2004) Sleep Med , vol.5 , pp. 523-532
    • Turek, F.W.1    Gillette, M.U.2
  • 190
    • 33646746401 scopus 로고    scopus 로고
    • Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent
    • Wyatt, J.K.; Dijk, D.J.; Ritz-de Cecco, A.; Ronda, J.M.; Czeisler, C.A. Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep, 2006, 29, 609-618.
    • (2006) Sleep , vol.29 , pp. 609-618
    • Wyatt, J.K.1    Dijk, D.J.2    Ritz-De Cecco, A.3    Ronda, J.M.4    Czeisler, C.A.5
  • 192
    • 0036051470 scopus 로고    scopus 로고
    • Melatonin for the prevention and treatment of jet lag
    • Art
    • Herxheimer, A.; Petrie, KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst. Rev., 2002, 2, Art. CD001520.
    • (2002) Cochrane Database Syst. Rev , vol.2
    • Herxheimer, A.1    Petrie, K.J.2
  • 193
    • 33947585771 scopus 로고    scopus 로고
    • Jet lag: Trends and coping strategies
    • Waterhouse, J. Jet lag: trends and coping strategies. Lancet, 2007, 369, 1117-1129.
    • (2007) Lancet , vol.369 , pp. 1117-1129
    • Waterhouse, J.1
  • 194
    • 0032860720 scopus 로고    scopus 로고
    • Jet lag: Clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial
    • Spitzer, R.L.; Terman, M.;Williams, J.B.; Terman, J.S.; Malt, U.F.; Singer, F.; Lewy, A.J. Jet lag: clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial. Am. J. Psychiatry, 1999, 156, 1392-1396.
    • (1999) Am. J. Psychiatry , vol.156 , pp. 1392-1396
    • Spitzer, R.L.1    Terman, M.2    Williams, J.B.3    Terman, J.S.4    Malt, U.F.5    Singer, F.6    Lewy, A.J.7
  • 195
    • 0033792846 scopus 로고    scopus 로고
    • Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones
    • Edwards, B.J.; Atkinson, G.; Waterhouse, J.; Reilly, T.; Godfrey, R.; Budgett, R. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics, 2000, 43, 1501-1513.
    • (2000) Ergonomics , vol.43 , pp. 1501-1513
    • Edwards, B.J.1    Atkinson, G.2    Waterhouse, J.3    Reilly, T.4    Godfrey, R.5    Budgett, R.6
  • 196
    • 0022622356 scopus 로고
    • Alleviation of jet lag by melatonin: Preliminary results of controlled double blind trial
    • Arendt, J.; Aldhous, M.; Marks, V. Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial. BMJ, 1986, 292, 1170.
    • (1986) BMJ , vol.292 , pp. 1170
    • Arendt, J.1    Aldhous, M.2    Marks, V.3
  • 197
    • 0024553018 scopus 로고
    • Chamberlain, K. Effect of melatonin on jet lag after long haul flights
    • Petrie, K.; Conaglen, J.V.; Thompson, L.; Chamberlain, K. Effect of melatonin on jet lag after long haul flights. BMJ, 1989, 298, 705-707.
    • (1989) BMJ , vol.298 , pp. 705-707
    • Petrie, K.1    Conaglen, J.V.2    Thompson, L.3
  • 198
    • 0026539748 scopus 로고
    • Melatonin and jet lag: Confirmatory result using a simplified protocol
    • Claustrat, B.; Brun, J.; David, M.; Sassolas, G.; Chazot, G. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol. Psychiatry, 1992, 32, 705-711.
    • (1992) Biol. Psychiatry , vol.32 , pp. 705-711
    • Claustrat, B.1    Brun, J.2    David, M.3    Sassolas, G.4    Chazot, G.5
  • 199
    • 0027253005 scopus 로고
    • A double-blind trial of melatonin as a treatment for jet lag in international cabin crew
    • Petrie, K.; Dawson, A.G.; Thompson, L.; Brook, R. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol. Psychiatry, 1993, 33, 526-530.
    • (1993) Biol. Psychiatry , vol.33 , pp. 526-530
    • Petrie, K.1    Dawson, A.G.2    Thompson, L.3    Brook, R.4
  • 201
    • 0031786860 scopus 로고    scopus 로고
    • Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag
    • Suhner, A.; Schlagenhauf, P.; Johnson, R.; Tschopp, A.; Steffen, R. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol. Int., 1998, 15, 655-666.
    • (1998) Chronobiol. Int , vol.15 , pp. 655-666
    • Suhner, A.1    Schlagenhauf, P.2    Johnson, R.3    Tschopp, A.4    Steffen, R.5
  • 202
    • 0034935211 scopus 로고    scopus 로고
    • Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag. Aviat
    • Suhner, A.; Schlagenhauf, P.; Hofer, I.; Johnson, R.; Tschopp, A.; Steffen, R. Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag. Aviat. Space Environ. Med., 2001, 72, 638-646.
    • (2001) Space Environ. Med , vol.72 , pp. 638-646
    • Suhner, A.1    Schlagenhauf, P.2    Hofer, I.3    Johnson, R.4    Tschopp, A.5    Steffen, R.6
  • 205
    • 2142711667 scopus 로고    scopus 로고
    • Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews
    • Paul, M.A.; Gray, G.; Sardana, T.M.; Pigeau, RA. Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews. Aviat. Space Environ. Med., 2004, 75, 439-443.
    • (2004) Aviat. Space Environ. Med , vol.75 , pp. 439-443
    • Paul, M.A.1    Gray, G.2    Sardana, T.M.3    Pigeau, R.A.4
  • 206
    • 0036161344 scopus 로고    scopus 로고
    • A multifactorial approach employing melatonin to accelerate resynchronization of sleep-wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes
    • Cardinali, D.P.; Bortman, G.P.; Liotta, G.; Pérez Lloret, S.; Albornoz, L.E.; Cutrera, R.A.; Batista, J.; Ortega Gallo, P. A multifactorial approach employing melatonin to accelerate resynchronization of sleep-wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes. J. Pineal Res., 2002, 32, 41-46.
    • (2002) J. Pineal Res , vol.32 , pp. 41-46
    • Cardinali, D.P.1    Bortman, G.P.2    Liotta, G.3    Pérez Lloret, S.4    Albornoz, L.E.5    Cutrera, R.A.6    Batista, J.7    Ortega Gallo, P.8
  • 207
    • 0031299112 scopus 로고    scopus 로고
    • Melatonin as a chronobiotic: Treatment of circadian desynchrony in night workers and the blind
    • Sack, R.L.; Lewy, A.J. Melatonin as a chronobiotic: treatment of circadian desynchrony in night workers and the blind. J. Biol. Rhythms, 1997, 12, 595-603.
    • (1997) J. Biol. Rhythms , vol.12 , pp. 595-603
    • Sack, R.L.1    Lewy, A.J.2
  • 208
    • 27644460972 scopus 로고    scopus 로고
    • Morning melatonin has limited benefit as a soporific for daytime sleep after night work
    • Smith, M.R.; Lee, C.; Crowley, S.J.; Fogg, L.F.; Eastman, C.I. Morning melatonin has limited benefit as a soporific for daytime sleep after night work. Chronobiol. Int., 2005, 22, 873-888.
    • (2005) Chronobiol. Int , vol.22 , pp. 873-888
    • Smith, M.R.1    Lee, C.2    Crowley, S.J.3    Fogg, L.F.4    Eastman, C.I.5
  • 209
    • 0027423034 scopus 로고
    • Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings
    • Folkard, S.; Arendt, J.; Clark, M. Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings. Chronobiol. Int., 1993, 10, 315-320.
    • (1993) Chronobiol. Int , vol.10 , pp. 315-320
    • Folkard, S.1    Arendt, J.2    Clark, M.3
  • 210
    • 56649097588 scopus 로고    scopus 로고
    • Efficacy and hypnotic effects of melatonin in shift-work nurses: Double-blind,placebo-controlled crossover trial
    • Sadeghniiat-Haghighi, K.; Aminian, O.; Pouryaghoub, G.; Yazdi, Z. Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind,placebo-controlled crossover trial. J. Circadian Rhythms., 2008, 29, 6-10.
    • (2008) J. Circadian Rhythms , vol.29 , pp. 6-10
    • Sadeghniiat-Haghighi, K.1    Aminian, O.2    Pouryaghoub, G.3    Yazdi, Z.4
  • 212
    • 0031778125 scopus 로고    scopus 로고
    • Does exogenous melatonin improve day sleep or night alertness in emergency physicians working night shifts?
    • Jorgensen, K.M.; Witting, M.D. Does exogenous melatonin improve day sleep or night alertness in emergency physicians working night shifts? Ann. Emerg. Med., 1998, 31, 699-704.
    • (1998) Ann. Emerg. Med , vol.31 , pp. 699-704
    • Jorgensen, K.M.1    Witting, M.D.2
  • 213
    • 0036407030 scopus 로고    scopus 로고
    • Role of morning melatonin administration and attenuation of sunlight exposure in improving adaptation of night-shift workers
    • Yoon, I.Y.; Song, B.G. Role of morning melatonin administration and attenuation of sunlight exposure in improving adaptation of night-shift workers. Chronobiol. Int., 2002, 19, 903-913.
    • (2002) Chronobiol. Int , vol.19 , pp. 903-913
    • Yoon, I.Y.1    Song, B.G.2
  • 216
    • 26444509034 scopus 로고    scopus 로고
    • Phase-dependent treatment of delayed sleep phase syndrome with melatonin
    • Mundey, K.; Benloucif, S.; Harsanyi, K.; Dubocovich, M.L.; Zee, P.C. Phase-dependent treatment of delayed sleep phase syndrome with melatonin. Sleep, 2005, 28, 271-1278.
    • (2005) Sleep , vol.28 , pp. 271-1278
    • Mundey, K.1    Benloucif, S.2    Harsanyi, K.3    Dubocovich, M.L.4    Zee, P.C.5
  • 219
    • 67650082539 scopus 로고    scopus 로고
    • Melatonin in treatment of chronic sleep disorders in adults with autism: A retrospective study
    • Galli-Carminati, G.; Deriaz, N.; Bertschy, G. Melatonin in treatment of chronic sleep disorders in adults with autism: a retrospective study. Swiss Med. Wkly., 2009, 139, 293-296.
    • (2009) Swiss Med. Wkly , vol.139 , pp. 293-296
    • Galli-Carminati, G.1    Deriaz, N.2    Bertschy, G.3
  • 223
    • 33748142996 scopus 로고    scopus 로고
    • Smith-Magenis syndrome: A case report of improved sleep after treatment with 1-adrenergic antagonists and melatonin
    • Carpizo, R.; Martínez, A.; Mediavilla, D.; González, M.; Abad, A.; Sánchez-Barceló, E.J. Smith-Magenis syndrome: a case report of improved sleep after treatment with 1-adrenergic antagonists and melatonin. J. Pediatrics, 2006, 149, 409-11.
    • (2006) J. Pediatrics , vol.149 , pp. 409-411
    • Carpizo, R.1    Martínez, A.2    Mediavilla, D.3    González, M.4    Abad, A.5    Sánchez-Barceló, E.J.6
  • 224
    • 0033536902 scopus 로고    scopus 로고
    • Facilitation of benzodiazepine discontinuation by melatonin: A new clinical approach
    • Garfinkel, D.; Zisapel, N.; Wainstein, J.; Laudon, M. Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. Arch. Intern. Med., 1999, 159, 2456-2460.
    • (1999) Arch. Intern. Med , vol.159 , pp. 2456-2460
    • Garfinkel, D.1    Zisapel, N.2    Wainstein, J.3    Laudon, M.4
  • 225
    • 62649174879 scopus 로고    scopus 로고
    • Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: A randomized, doubleblind, placebo-controlled study
    • Garzón, C.; Guerrero, J.M.; Aramburu, O.; Guzmán, T. Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, doubleblind, placebo-controlled study. Aging Clin. Exp. Res., 2009, 21, 38-42.
    • (2009) Aging Clin. Exp. Res , vol.21 , pp. 38-42
    • Garzón, C.1    Guerrero, J.M.2    Aramburu, O.3    Guzmán, T.4
  • 226
    • 69549090005 scopus 로고    scopus 로고
    • The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia
    • Luthringer, R.; Muzet, M.; Zisapel, N.; Staner, L. The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia. Int. Clin. Psychopharmacol., 2009, 24, 239-249.
    • (2009) Int. Clin. Psychopharmacol , vol.24 , pp. 239-249
    • Luthringer, R.1    Muzet, M.2    Zisapel, N.3    Staner, L.4
  • 228
    • 33745112194 scopus 로고    scopus 로고
    • The circadian body temperature rhythm in the elderly: Effect of single daily melatonin dosing
    • Gubin, D.G.; Gubin, G.D.; Waterhouse, J.; Weinert, D. The circadian body temperature rhythm in the elderly: effect of single daily melatonin dosing. Chronobiol. Int., 2006, 23, 639-658.
    • (2006) Chronobiol. Int , vol.23 , pp. 639-658
    • Gubin, D.G.1    Gubin, G.D.2    Waterhouse, J.3    Weinert, D.4
  • 229
    • 36348998533 scopus 로고    scopus 로고
    • Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: A double-blind randomized clinical trial
    • Peles, E.; Hetzroni, T.; Bar-Hamburger, R.; Adelson, M.; Schreiber, S. Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial. Addiction, 2007, 102, 1947-1953.
    • (2007) AddicTion , vol.102 , pp. 1947-1953
    • Peles, E.1    Hetzroni, T.2    Bar-Hamburger, R.3    Adelson, M.4    Schreiber, S.5
  • 230
    • 62249207349 scopus 로고    scopus 로고
    • Melatonin in relation to the strong and weak versions of the free radical theory of aging
    • Reiter, R.J.; Paredes, S.D.; Korkmaz, A.; Manchester, L.C.; Tan, D.X. Melatonin in relation to the strong and weak versions of the free radical theory of aging. Adv. Med. Sci., 2008, 53, 119-29.
    • (2008) Adv. Med. Sci , vol.53 , pp. 119-129
    • Reiter, R.J.1    Paredes, S.D.2    Korkmaz, A.3    Manchester, L.C.4    Tan, D.X.5
  • 231
    • 38149026387 scopus 로고    scopus 로고
    • Does melatonin play a role in aging processes?
    • Karasek, M. Does melatonin play a role in aging processes? J. Physiol. Pharmacol., 2007, 58, 105-113.
    • (2007) J. Physiol. Pharmacol , vol.58 , pp. 105-113
    • Karasek, M.1
  • 232
    • 0035131845 scopus 로고    scopus 로고
    • Effects of melatonin in perimenopausal and menopausal women: A randomized and placebo controlled study
    • Bellipanni, G.; Bianchi, P.; Pierpaoli, W.; Bulian, D.; Ilyia, E. Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study. Exp. Gerontol., 2001, 36, 297-310.
    • (2001) Exp. Gerontol , vol.36 , pp. 297-310
    • Bellipanni, G.1    Bianchi, P.2    Pierpaoli, W.3    Bulian, D.4    Ilyia, E.5
  • 235
    • 0031870926 scopus 로고    scopus 로고
    • Melatonin for the treatment of sleep disturbances in major depressive disorder
    • Dolberg, O.T.; Hirschmann, S.; Grunhaus, L. Melatonin for the treatment of sleep disturbances in major depressive disorder. Am. J. Psychiatry, 1998, 155, 1119-1121.
    • (1998) Am. J. Psychiatry , vol.155 , pp. 1119-1121
    • Dolberg, O.T.1    Hirschmann, S.2    Grunhaus, L.3
  • 236
    • 0032535994 scopus 로고    scopus 로고
    • Melatonin treatment of winter depression: A pilot study
    • Lewy, A.J.; Bauer, V.K.; Cutler, N.L.; Sack, R.L. Melatonin treatment of winter depression: a pilot study. Psychiatry Res., 1998, 77, 57-61.
    • (1998) Psychiatry Res , vol.77 , pp. 57-61
    • Lewy, A.J.1    Bauer, V.K.2    Cutler, N.L.3    Sack, R.L.4
  • 237
    • 0242418193 scopus 로고    scopus 로고
    • Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour
    • Leppämäki, S.; Partonen, T.; Vakkuri, O.; Lönnqvist, J.; Partinen, M.; Laudon, M. Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour. Eur. Neuro-psychopharmacol., 2003, 13, 137-145.
    • (2003) Eur. Neuro-Psychopharmacol , vol.13 , pp. 137-145
    • Leppämäki, S.1    Partonen, T.2    Vakkuri, O.3    Lönnqvist, J.4    Partinen, M.5    Laudon, M.6
  • 239
    • 37349120370 scopus 로고    scopus 로고
    • The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy
    • Caumo, W.; Torres, F.; Moreira, N.L.; Auzani, J.A.; Monteiro, C.A.; Londero, G.; Ribeiro, D.F.; Hidalgo, M.P. The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesth. Analg., 2007, 105, 1263-1271.
    • (2007) Anesth. Analg , vol.105 , pp. 1263-1271
    • Caumo, W.1    Torres, F.2    Moreira, N.L.3    Auzani, J.A.4    Monteiro, C.A.5    Londero, G.6    Ribeiro, D.F.7    Hidalgo, M.P.8
  • 240
    • 0033866939 scopus 로고    scopus 로고
    • The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: A double-blinded, placebo-controlled study Anesth
    • Naguib, M.; Samarkandi, A.H. The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study Anesth. Analg., 2000, 91, 473-479.
    • (2000) Analg , vol.91 , pp. 473-479
    • Naguib, M.1    Samarkandi, A.H.2
  • 241
    • 3342959093 scopus 로고    scopus 로고
    • Perioperativeeffects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance
    • Acil, M.; Basgul, E.; Celiker, V.; Karagöz, A.H.; Demir, B.; Aypar, U. Perioperativeeffects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance. Eur. J. Anaesthesiol., 2004, 21, 553-557.
    • (2004) Eur. J. Anaesthesiol , vol.21 , pp. 553-557
    • Acil, M.1    Basgul, E.2    Celiker, V.3    Karagöz, A.H.4    Demir, B.5    Aypar, U.6
  • 243
    • 67650083565 scopus 로고    scopus 로고
    • Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery
    • Kain, Z.N.; MacLaren, J.E.; Herrmann, L.; Mayes, L.; Rosenbaum, A.; Hata, J.; Lerman, J. Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. Anesthesiology, 2009, 111, 44-49.
    • (2009) Anesthesiology , vol.111 , pp. 44-49
    • Kain, Z.N.1    Maclaren, J.E.2    Herrmann, L.3    Mayes, L.4    Rosenbaum, A.5    Hata, J.6    Lerman, J.7
  • 244
    • 44649134701 scopus 로고    scopus 로고
    • Premedication with melatonin vs midazolam in anxious children
    • Isik, B.; Baygin, O.; Bodur, H. Premedication with melatonin vs midazolam in anxious children. Paediatr. Anaesth., 2008, 18, 635-641.
    • (2008) Paediatr. Anaesth , vol.18 , pp. 635-641
    • Isik, B.1    Baygin, O.2    Bodur, H.3
  • 246
    • 34547788807 scopus 로고    scopus 로고
    • Melatonin is a useful alternative to sedation in children undergoing brainstem audiometry with an age dependent success rate-a field report of 250 investigations
    • Schmidt, C.M.; Knief, A.; Deuster, D.; Matulat, P.; Zehnhoff-Dinnesen, A.G. Melatonin is a useful alternative to sedation in children undergoing brainstem audiometry with an age dependent success rate-a field report of 250 investigations. Neuropediatrics, 2007, 38, 2-4.
    • (2007) Neuropediatrics , vol.38 , pp. 2-4
    • Schmidt, C.M.1    Knief, A.2    Deuster, D.3    Matulat, P.4    Zehnhoff-Dinnesen, A.G.5
  • 247
    • 33747362947 scopus 로고    scopus 로고
    • The effect of melatonin on sedation of children undergoing magnetic resonance imaging
    • Sury, M.R.; Fairweather, K. The effect of melatonin on sedation of children undergoing magnetic resonance imaging. Br. J. Anaesth. 2006, 97, 220-225.
    • (2006) Br. J. Anaesth , vol.97 , pp. 220-225
    • Sury, M.R.1    Fairweather, K.2
  • 248
    • 53449100558 scopus 로고    scopus 로고
    • Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia
    • Mowafi, H.A.; Ismail, S.A. Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia. Anesth. Analg., 2008, 107, 1422-6.
    • (2008) Anesth. Analg , vol.107 , pp. 1422-1426
    • Mowafi, H.A.1    Ismail, S.A.2
  • 249
    • 33845590402 scopus 로고    scopus 로고
    • The effects of melatonin premedication on propofol and thiopental induction dose-response curves: A prospective, randomized,double-blind study
    • Naguib, M.; Samarkandi, A.H.; Moniem, M.A.; Mansour, E.D.; Alshaer, A.A.; Al-Ayyaf, H.A.; Fadin, A.; Alharby, S.W. The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized,double-blind study. Anesth. Analg., 2006, 103, 1448-1452.
    • (2006) Anesth. Analg , vol.103 , pp. 1448-1452
    • Naguib, M.1    Samarkandi, A.H.2    Moniem, M.A.3    Mansour, E.D.4    Alshaer, A.A.5    Al-Ayyaf, H.A.6    Fadin, A.7    Alharby, S.W.8
  • 251
    • 62649131630 scopus 로고    scopus 로고
    • Melatonin premedication does not enhance induction of anaesthesia with sevoflurane as assessed by bispectral index monitoring
    • Evagelidis, P.; Paraskeva, A.; Petropoulos, G.; Staikou, C.; Fassou laki, A. Melatonin premedication does not enhance induction of anaesthesia with sevoflurane as assessed by bispectral index monitoring. Singapore Med. J., 2009, 50, 78-81.
    • (2009) Singapore Med. J , vol.50 , pp. 78-81
    • Evagelidis, P.1    Paraskeva, A.2    Petropoulos, G.3    Staikou, C.4    Fassoulaki, A.5
  • 252
    • 58049211820 scopus 로고    scopus 로고
    • Preoperative anxiolytic effect ofmelatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: A double-blind, randomized, placebo-controlled study
    • Caumo, W.; Levandovski, R.; Hidalgo, M.P. Preoperative anxiolytic effect ofmelatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. J. Pain. 2009, 10, 100-108.
    • (2009) J. Pain , vol.10 , pp. 100-108
    • Caumo, W.1    Levandovski, R.2    Hidalgo, M.P.3
  • 253
    • 0036146467 scopus 로고    scopus 로고
    • Melatonin for treatment and prevention of postoperative delirium
    • Hanania, M.; Kitain, E. Melatonin for treatment and prevention of postoperative delirium. Anesth. Analg., 2002, 94, 338-339.
    • (2002) Anesth. Analg , vol.94 , pp. 338-339
    • Hanania, M.1    Kitain, E.2
  • 254
    • 70349231177 scopus 로고    scopus 로고
    • Circadian sleep-wake rhythm disturbances in end-stage renal disease
    • Koch, B.C.; Nagtegaal, J.E.; Kerkhof, G.A.; Ter Wee, P.M. Circadian sleep-wake rhythm disturbances in end-stage renal disease. Nat. Rev. Nephrol., 2009, 5, 407-416.
    • (2009) Nat. Rev. Nephrol , vol.5 , pp. 407-416
    • Koch, B.C.1    Nagtegaal, J.E.2    Kerkhof, G.A.3    Ter Wee, P.M.4
  • 255
    • 58149114722 scopus 로고    scopus 로고
    • The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients:A randomized, placebo-controlled, cross-over study (EMSCAP study)
    • Koch, B.C.; Nagtegaal, J.E.; Hagen, E.C.; van der Westerlaken, M.M.; Boringa, J.B.; Kerkhof, G.A.; Ter Wee, P.M. The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients:a randomized, placebo-controlled, cross-over study (EMSCAP study). Br. J. Clin. Pharmacol., 2009, 67, 68-75.
    • (2009) Br. J. Clin. Pharmacol , vol.67 , pp. 68-75
    • Koch, B.C.1    Nagtegaal, J.E.2    Hagen, E.C.3    van der Westerlaken, M.M.4    Boringa, J.B.5    Kerkhof, G.A.6    Ter Wee, P.M.7
  • 256
    • 0035060503 scopus 로고    scopus 로고
    • Melatonin prevents oxidative stress resulting from iron and erythropoietin administration
    • Herrera, J.; Nava, M.; Romero, F.; Rodríguez-Iturbe, B. Melatonin prevents oxidative stress resulting from iron and erythropoietin administration. Am. J. Kidney Dis., 2001, 37, 750-757.
    • (2001) Am. J. Kidney Dis , vol.37 , pp. 750-757
    • Herrera, J.1    Nava, M.2    Romero, F.3    Rodríguez-Iturbe, B.4
  • 257
    • 29144442281 scopus 로고    scopus 로고
    • Melatonin corrects reticuloendothelial blockade and iron status in haemodialysed patients
    • Labonia, W.; Rubio, D.; Arias, C. Melatonin corrects reticuloendothelial blockade and iron status in haemodialysed patients. Nephrology, (Carlton), 2005, 10, 583-587.
    • (2005) Nephrology, (Carlton) , vol.10 , pp. 583-587
    • Labonia, W.1    Rubio, D.2    Arias, C.3


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