Asiatic acid inhibits liver fibrosis by blocking TGF-beta/smad signaling in vivo and in vitro

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Tang, Li xia ^a   He, Rui hua ^a   Yang, Guang ^a   Tan, Jia ju ^a   Zhou, Li ^b   Meng, Xiao ming ^c   Huang, Xiao Ru ^c   Lan, Hui Yao ^c  

^a THE FIRST PEOPLE S HOSPITAL OF FOSHAN   (China)

^b SICHUAN UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASIATIC ACID; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; PENTACYCLIC TRITERPENE; TRANSFORMING GROWTH FACTOR BETA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHEPATOFIBROTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ACTIVATION; CELL STIMULATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; EXTRACELLULAR MATRIX; GENE SILENCING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; LIVER PROTECTION; MALE; METABOLIC INHIBITION; MYOFIBROBLAST; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION; ANIMAL; CELL LINE; DRUG EFFECT; LIVER; LIVER CIRRHOSIS; LIVER FUNCTION TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TIME; WESTERN BLOTTING;

RATTUS;

ANIMALS; BLOTTING, WESTERN; CARBON TETRACHLORIDE; CELL LINE; COLLAGEN TYPE I; GENE KNOCKDOWN TECHNIQUES; HEPATIC STELLATE CELLS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; MALE; PENTACYCLIC TRITERPENES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD PROTEINS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84856753646     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031350     Document Type: Article

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