Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia

Journal of Neuroscience Research

Volumn 87, Issue 11, 2009, Pages 2541-2550

  Krishnamurthy, Rajanikant G ^a,d   Senut, Marie Claude ^a   Zemke, Daniel ^a   Min, Jiangyong ^a   Frenkel, Mark B ^a   Greenberg, Eric J ^a   Yu, Seong Woon ^a,b   Ahn, Nick ^a,b   Goudreau, John ^a,b   Kassab, Mounzer ^a   Panickar, Kiran S ^c   Majid, Arshad ^a  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

^d NATIONAL INSTITUTE OF TECHNOLOGY CALICUT   (India)

Author keywords

Apoptosis; Blood brain barrier; Infarct volume; Mitochondria; Oxygen glucose deprivation

Indexed keywords

ASIATIC ACID; CYTOCHROME C; IMMUNOGLOBULIN G; GLUCOSE; NEUROPROTECTIVE AGENT; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL VIABILITY; CENTELLA ASIATICA; CONTROLLED STUDY; DRUG EFFICACY; IMMUNOHISTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SECRETION; TREATMENT RESPONSE; ANIMAL; BRAIN; C57BL MOUSE; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; CEREBRAL ARTERY DISEASE; DISEASE MODEL; DRUG EFFECT; HOSPITALIZATION; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; TIME; TREATMENT OUTCOME;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; CYTOCHROMES C; DISEASE MODELS, ANIMAL; GLUCOSE; IMMUNOGLOBULIN G; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME; TRITERPENES;

EID: 70349236027     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22071     Document Type: Article

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