Structure-related cytotoxicity and anti-hepatofibric effect of asiatic acid derivatives in rat hepatic stellate cell-line, HSC-T6

Archives of Pharmacal Research

Volumn 27, Issue 5, 2004, Pages 512-517

  Dong, Mi Sook ^a   Jung, Seung Hyun ^a   Kim, Hyun Jung ^a   Kim, Jeong Ran ^a   Zhao, Long Xuan ^b   Lee, Eung Seok ^b   Lee, Eun Joo ^c   Jung, Bum Yi ^c   Lee, Namkyu ^c   Cho, Yong Baik ^c   Wie, Jong Kwak ^c   Young, In Park ^a  

^a Korea University   (South Korea)

^b Yeungnam University   (South Korea)

^c SK Chemicals   (South Korea)

Author keywords

Anti hepatofibrotic effect; Asiatic acid derivatives; Cytotoxicity; Rat hepatic stellate cell

Indexed keywords

ASIATIC ACID; TRITERPENE;

ANIMAL; ARTICLE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; LIVER CELL; PHYSIOLOGY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CELL LINE, TRANSFORMED; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 15744378487     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02980124     Document Type: Article

References (9)

1. Liu J, Liu Y, Mao Q., and Klaassen, C. D., The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundamental Appl. Toxicol., 22, 34-40 (1994).
2. Mook-Jung, I., Shin, J. E., Yun, S. H., Huh, K., Koh, J. Y., Park, H. K., Jew, S. S., and Jung, M. W., Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. J. Neurosci. Res., 58, 417-425 (1999).
3. Maquart, F. X., Chastang, F., Simeon, A., Birembaut, P., Gillery, P., and Wegrowski, Y., Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur. J. Dermatol., 9, 289-296 (1999).
4. Shukla, A., Rasik, A. M., Jain, G. K., Shankar, R., Kulshrestha, D. K., and Dhawan, B. N., In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J. Ethnopharmacol., 65, 1-11 (1999).
5. Kwon, J., Lee, M., Cha K., Kim, J.-C., and Han J., Genotoxocity study if AS6, a triterpenoid derivative. J. Appl. Phamacol., 11, 190-195 (2003).
6. Han, J., Lee, M., Cha, S.-W., Im, D., Yang, B.-C., Lim, W.-H., Cha, K., Kim, J.-C., and Chun, M. K., Toxicity study of AS6, a triterpenoid derivative: 4-week repeated oral administration in rats. J. Appl. Phamacol., 11, 723-779 (2003).
7. Sampson, J. H., Raman, A., Karlsen, G., Navsaria, H., and Leigh, I. M., In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. Phytomedicine, 8, 230-235 (2001).
8. Qi, S., Xie, J., and Li, T., Effects of Asiaticoside on hypertrophic scars in a nude mice model. Zhonghua Shao Shang Za Zhi., 16, 53-56 (2000).
9. 2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. Cancer Lett., 186, 83-91 (2002).