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Volumn 3, Issue 9, 2011, Pages 889-895

Accelerated aging syndromes, are they relevant to normal human aging?

Author keywords

Aging; DNA damage; Hutchinson Gilford Progeria; Lef1; Telomeres; Werner syndrome; Wnt signaling

Indexed keywords

EXODEOXYRIBONUCLEASE; LAMIN A; RECQ HELICASE; WRN PROTEIN, HUMAN;

EID: 84856646656     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100383     Document Type: Article
Times cited : (56)

References (63)
  • 1
    • 0035989631 scopus 로고    scopus 로고
    • Historical claims and current interpretations of replicative aging
    • Wright WE, Shay JW. Historical claims and current interpretations of replicative aging. Nat Biotechnol. 2002; 20: 682-688.
    • (2002) Nat Biotechnol , vol.20 , pp. 682-688
    • Wright, W.E.1    Shay, J.W.2
  • 2
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010; 464: 520-528.
    • (2010) Nature , vol.464 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2
  • 3
    • 0030896923 scopus 로고    scopus 로고
    • Comparative aging and life histories in mammals
    • Austad SN. Comparative aging and life histories in mammals. Exp Gerontol. 1997; 32: 23-38.
    • (1997) Exp Gerontol , vol.32 , pp. 23-38
    • Austad, S.N.1
  • 4
    • 71149093724 scopus 로고    scopus 로고
    • How telomeres solve the end-protection problem
    • de Lange T. How telomeres solve the end-protection problem. Science. 2009; 326: 948-952.
    • (2009) Science , vol.326 , pp. 948-952
    • de Lange, T.1
  • 5
    • 67650079362 scopus 로고    scopus 로고
    • Syndromes of telomere shortening
    • Armanios M. Syndromes of telomere shortening. Annu Rev Genomics Hum Genet. 2009; 10: 45-61.
    • (2009) Annu Rev Genomics Hum Genet , vol.10 , pp. 45-61
    • Armanios, M.1
  • 10
    • 10344256183 scopus 로고    scopus 로고
    • Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
    • Crabbe L, Verdun RE, Haggblom CI, and Karlseder J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science. 2004; 306: 1951-1953.
    • (2004) Science , vol.306 , pp. 1951-1953
    • Crabbe, L.1    Verdun, R.E.2    Haggblom, C.I.3    Karlseder, J.4
  • 11
    • 2442531966 scopus 로고    scopus 로고
    • Junction of RecQ helicase biochemistry and human disease
    • Opresko PL, Cheng WH, and Bohr VA. Junction of RecQ helicase biochemistry and human disease. J Biol Chem. 2004; 279: 18099-18102.
    • (2004) J Biol Chem , vol.279 , pp. 18099-18102
    • Opresko, P.L.1    Cheng, W.H.2    Bohr, V.A.3
  • 14
    • 33750379023 scopus 로고    scopus 로고
    • The laminopathies: the functional architecture of the nucleus and its contribution to disease
    • Burke B, Stewart CL. The laminopathies: the functional architecture of the nucleus and its contribution to disease. Annu Rev Genomics Hum Genet. 2006; 7: 369-405.
    • (2006) Annu Rev Genomics Hum Genet , vol.7 , pp. 369-405
    • Burke, B.1    Stewart, C.L.2
  • 15
    • 55849129996 scopus 로고    scopus 로고
    • Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
    • Yang SH, Andres DA, Spielmann HP, Young SG, and Fong LG. Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. J Clin Invest. 2008; 118: 3291-3300.
    • (2008) J Clin Invest , vol.118 , pp. 3291-3300
    • Yang, S.H.1    Andres, D.A.2    Spielmann, H.P.3    Young, S.G.4    Fong, L.G.5
  • 16
    • 33845699084 scopus 로고    scopus 로고
    • DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
    • Liu Y, Rusinol A, Sinensky M, Wang Y, and Zou Y. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci. 2006; 119: 4644-4649.
    • (2006) J Cell Sci , vol.119 , pp. 4644-4649
    • Liu, Y.1    Rusinol, A.2    Sinensky, M.3    Wang, Y.4    Zou, Y.5
  • 18
    • 33144478270 scopus 로고    scopus 로고
    • Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody
    • McClintock D, Gordon LB, and Djabali K. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. Proc Natl Acad Sci U S A. 2006; 103: 2154-2159.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2154-2159
    • McClintock, D.1    Gordon, L.B.2    Djabali, K.3
  • 19
    • 17644373758 scopus 로고    scopus 로고
    • Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
    • Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med. 2005; 11: 440-445.
    • (2005) Nat Med , vol.11 , pp. 440-445
    • Scaffidi, P.1    Misteli, T.2
  • 22
    • 67349126486 scopus 로고    scopus 로고
    • Telomere length in Hutchinson-Gilford progeria syndrome
    • Decker ML, Chavez E, Vulto I, and Lansdorp PM. Telomere length in Hutchinson-Gilford progeria syndrome. Mech Ageing Dev. 2009; 130: 377-383.
    • (2009) Mech Ageing Dev , vol.130 , pp. 377-383
    • Decker, M.L.1    Chavez, E.2    Vulto, I.3    Lansdorp, P.M.4
  • 23
    • 59449095581 scopus 로고    scopus 로고
    • Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53
    • Kudlow BA, Stanfel MN, Burtner CR, Johnston ED, and Kennedy BK. Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. Mol Biol Cell. 2008; 19: 5238-5248.
    • (2008) Mol Biol Cell , vol.19 , pp. 5238-5248
    • Kudlow, B.A.1    Stanfel, M.N.2    Burtner, C.R.3    Johnston, E.D.4    Kennedy, B.K.5
  • 25
    • 69949144385 scopus 로고    scopus 로고
    • Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A
    • Musich PR, Zou Y. Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A. Aging (Albany NY). 2009; 1: 28-37.
    • (2009) Aging (Albany NY) , vol.1 , pp. 28-37
    • Musich, P.R.1    Zou, Y.2
  • 27
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H, Smogorzewska A, and de Lange T. DNA damage foci at dysfunctional telomeres. Curr Biol. 2003; 13: 1549-1556.
    • (2003) Curr Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 28
    • 77955385716 scopus 로고    scopus 로고
    • Role of progerininduced telomere dysfunction in HGPS premature cellular senescence
    • Benson EK, Lee SW, and Aaronson SA. Role of progerininduced telomere dysfunction in HGPS premature cellular senescence. J Cell Sci. 2010; 123: 2605-2612.
    • (2010) J Cell Sci , vol.123 , pp. 2605-2612
    • Benson, E.K.1    Lee, S.W.2    Aaronson, S.A.3
  • 30
    • 57049132043 scopus 로고    scopus 로고
    • 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
    • Dimitrova N, Chen YC, Spector DL, and de Lange T. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature. 2008; 456: 524-528.
    • (2008) Nature , vol.456 , pp. 524-528
    • Dimitrova, N.1    Chen, Y.C.2    Spector, D.L.3    de Lange, T.4
  • 34
    • 0032573157 scopus 로고    scopus 로고
    • A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
    • Lebel M, Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A. 1998; 95: 13097-13102.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13097-13102
    • Lebel, M.1    Leder, P.2
  • 36
    • 0034669532 scopus 로고    scopus 로고
    • Wild-derived inbred mouse strains have short telomeres
    • Hemann MT, Greider CW. Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res. 2000; 28: 4474-4478.
    • (2000) Nucleic Acids Res , vol.28 , pp. 4474-4478
    • Hemann, M.T.1    Greider, C.W.2
  • 37
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse KR, Greider CW. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A. 1995; 92: 4818-4822.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 39
    • 0037673940 scopus 로고    scopus 로고
    • A progeroid syndrome in mice is caused by defects in A-type lamins
    • Mounkes LC, Kozlov S, Hernandez L, Sullivan T, and Stewart CL. A progeroid syndrome in mice is caused by defects in A-type lamins. Nature. 2003; 423: 298-301.
    • (2003) Nature , vol.423 , pp. 298-301
    • Mounkes, L.C.1    Kozlov, S.2    Hernandez, L.3    Sullivan, T.4    Stewart, C.L.5
  • 46
    • 0023646768 scopus 로고
    • Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B
    • Stewart C, Burke B. Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B. Cell. 1987; 51: 383-392.
    • (1987) Cell , vol.51 , pp. 383-392
    • Stewart, C.1    Burke, B.2
  • 47
    • 0024561417 scopus 로고
    • Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study
    • Rober RA, Weber K, and Osborn M. Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study. Development. 1989; 105: 365-378.
    • (1989) Development , vol.105 , pp. 365-378
    • Rober, R.A.1    Weber, K.2    Osborn, M.3
  • 49
    • 8344274464 scopus 로고    scopus 로고
    • Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis
    • Csoka AB, English SB, Simkevich CP, Ginzinger DG, Butte AJ, Schatten GP, Rothman FG, and Sedivy JM. Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell. 2004; 3: 235-243.
    • (2004) Aging Cell , vol.3 , pp. 235-243
    • Csoka, A.B.1    English, S.B.2    Simkevich, C.P.3    Ginzinger, D.G.4    Butte, A.J.5    Schatten, G.P.6    Rothman, F.G.7    Sedivy, J.M.8
  • 50
    • 43149124203 scopus 로고    scopus 로고
    • Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
    • Scaffidi P, Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol. 2008; 10: 452-459.
    • (2008) Nat Cell Biol , vol.10 , pp. 452-459
    • Scaffidi, P.1    Misteli, T.2
  • 54
    • 43149117884 scopus 로고    scopus 로고
    • Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease
    • Sagelius H, Rosengardten Y, Hanif M, Erdos MR, Rozell B, Collins FS, and Eriksson M. Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease. J Cell Sci. 2008; 121: 969-978.
    • (2008) J Cell Sci , vol.121 , pp. 969-978
    • Sagelius, H.1    Rosengardten, Y.2    Hanif, M.3    Erdos, M.R.4    Rozell, B.5    Collins, F.S.6    Eriksson, M.7
  • 55
    • 48049117058 scopus 로고    scopus 로고
    • Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin
    • Wang Y, Panteleyev AA, Owens DM, Djabali K, Stewart CL, and Worman HJ. Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin. Hum Mol Genet. 2008; 17: 2357-2369.
    • (2008) Hum Mol Genet , vol.17 , pp. 2357-2369
    • Wang, Y.1    Panteleyev, A.A.2    Owens, D.M.3    Djabali, K.4    Stewart, C.L.5    Worman, H.J.6
  • 59
    • 35648929883 scopus 로고    scopus 로고
    • Gone with the Wnts: betacatenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism
    • Manolagas SC, Almeida M. Gone with the Wnts: betacatenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol. 2007; 21: 2605-2614.
    • (2007) Mol Endocrinol , vol.21 , pp. 2605-2614
    • Manolagas, S.C.1    Almeida, M.2
  • 63
    • 67649188781 scopus 로고    scopus 로고
    • Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging
    • Rodriguez S, Coppede F, Sagelius H, and Eriksson M. Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging. Eur J Hum Genet. 2009; 17: 928-937.
    • (2009) Eur J Hum Genet , vol.17 , pp. 928-937
    • Rodriguez, S.1    Coppede, F.2    Sagelius, H.3    Eriksson, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.