Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: A critical role of mitogen-activated protein kinase phosphatase 1

Endocrinology

Volumn 149, Issue 8, 2008, Pages 4086-4094

  Ichikawa, Tomonaga ^a,b   Zhang, Jifeng ^a   Chen, Kai ^a   Liu, Yusen ^c   Schopfer, Francisco J ^d   Baker, Paul R S ^d   Freeman, Bruce A ^d   Chen, Yuqing E ^a   Cui, Taixing ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; GLUTATHIONE; INOSINE; LINOLEIC ACID; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMALL INTERFERING RNA; STAT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINE; MACROPHAGE; MOUSE; NITRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ALKENES; ANIMALS; CELLS, CULTURED; DUAL SPECIFICITY PHOSPHATASE 1; INFLAMMATION; LINOLEIC ACIDS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; NITRO COMPOUNDS; OLEIC ACIDS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; SULFHYDRYL COMPOUNDS;

EID: 47949104210     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1639     Document Type: Article

References (43)

1. Rubbo H, Radi R, Trujillo M, Telleri R, Kalyanaraman B, Barnes S, Kirk M, Freeman BA 1994 Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem 269:26066-26075
2. Rubbo H, Parthasarathy S, Barnes S, Kirk M, Kalyanaraman B, Freeman BA 1995 Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. Arch Biochem Biophys 324:15-25
3. O'Donnell VB, Eiserich JP, Chumley PH, Jablonsky MJ, Krishna NR, Kirk M, Barnes S, Darley-Usmar VM, Freeman BA 1999 Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ion. Chem Res Toxicol 12:83-92
4. Lima ES, Di Mascio P, Rubbo H, Abdalla DS 2002 Characterization of linoleic acid nitration in human blood plasma by mass spectrometry. Biochemistry 41:10717-10722
5. Kalyanaraman B 2004 Nitrated lipids: a class of cell-signaling molecules. Proc Natl Acad Sci USA 101:11527-11528
6. Serhan CN, Oliw E 2001 Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways. J Clin Invest 107:1481-1489
7. Smith WL, Langenbach R 2001 Why there are two cyclooxygenase isozymes. J Clin Invest 107:1491-1495
8. Lim DG, Sweeney S, Bloodsworth A, White CR, Chumley PH, Krishna NR, Schopfer F, O'Donnell VB, Eiserich JP, Freeman BA 2002 Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity. Proc Natl Acad Sci USA 99:15941-15946
9. Coles B, Bloodsworth A, Eiserich JP, Coffey MJ, McLoughlin RM, Giddings JC, Lewis MJ, Haslam RJ, Freeman BA, O'Donnell VB 2002 Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP. J Biol Chem 277:5832-5840
10. Coles B, Bloodsworth A, Clark SR, Lewis MJ, Cross AR, Freeman BA, O'Donnell VB 2002 Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells. Circ Res 91:375-381
11. Baker PR, Lin Y, Schopfer FJ, Woodcock SR, Groeger AL, Batthyany C, Sweeney S, Long MH, Iles KE, Baker LM, Branchaud BP, Chen YE, Freeman BA 2005 Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands. J Biol Chem 280:42464-42475
12. Schopfer FJ, Lin Y, Baker PR, Cui T, Garcia-Barrio M, Zhang J, Chen K, Chen YE, Freeman BA 2005 Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor γ ligand. Proc Natl Acad Sci USA 102:2340-2345
13. Baker PR, Schopfer FJ, Sweeney S, Freeman BA 2004 Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. Proc Natl Acad Sci USA 101:11577-11582
14. Batthyany C, Schopfer FJ, Baker PR, Duran R, Baker LM, Huang Y, Cervenansky C, Branchaud BP, Freeman BA 2006 Reversible post-translational modification of proteins by nitrated fatty acids in vivo. J Biol Chem 281:20450-20463
15. Baker LM, Baker PR, Golin-Bisello F, Schopfer FJ, Fink M, Woodcock SR, Branchaud BP, Radi R, Freeman BA 2007 Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction. J Biol Chem 282:31085-31093
16. Cui T, Schopfer FJ, Zhang J, Chen K, Ichikawa T, Baker PR, Batthyany C, Chacko BK, Feng X, Patel RP, Agarwal A, Freeman BA, Chen YE 2006 Nitrated fatty acids: endogenous anti-inflammatory signaling mediators. J Biol Chem 281:35686-35698
17. Shepherd EG, Zhao Q, Welty SE, Hansen TN, Smith CV, Liu Y 2004 The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages. J Biol Chem 279:54023-54031
18. Villacorta L, Zhang J, Garcia-Barrio MT, Chen XL, Freeman BA, Chen YE, Cui T 2007 Nitro-linoleic acid inhibits vascular smooth muscle cell proliferation via the Keap1/Nrf2 signaling pathway. Am J Physiol Heart Circ Physiol 293:H770-H776
19. Park EJ, Park SY, Joe EH, Jou I 2003 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. J Biol Chem 278:14747-14752
20. Chen CW, Chang YH, Tsi CJ, Lin WW 2003 Inhibition of IFN-γ-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor γ agonist, 15-deoxy-Δ12,14- prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. J Immunol 171:979-988
21. Weber SM, Scarim AL, Corbett JA 2004 PPARγ is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic -cells. Am J Physiol Endocrinol Metab 286:E329-E336
22. Xie QW, Whisnant R, Nathan C 1993 Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J Exp Med 177:1779-1784
23. Eberhardt W, Kunz D, Hummel R, Pfeilschifter J 1996 Molecular cloning of the rat inducible nitric oxide synthase gene promoter. Biochem Biophys Res Commun 223:752-756
24. Llovera M, Pearson JD, Moreno C, Riveros-Moreno V 2001 Impaired response to interferon-γ in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric oxide. Br J Pharmacol 132:419-426
25. Ni CW, Hsieh HJ, Chao YJ, Wang DL 2004 Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow. Am J Physiol Cell Physiol 287:C771-C780
26. Villavicencio RT, Liu S, Kibbe MR, Williams DL, Ganster RW, Dyer KF, Tweardy DJ, Billiar TR, Pitt BR 2000 Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression. Shock 13:441-445
27. Schopfer FJ, Baker PR, Giles G, Chumley P, Batthyany C, Crawford J, Patel RP, Hogg N, Branchaud BP, Lancaster Jr JR, Freeman BA 2005 Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor. J Biol Chem 280:19289-19297
28. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F 2003 Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374:1-20
29. Wormald S, Hilton DJ 2004 Inhibitors of cytokine signal transduction. J Biol Chem 279:821-824
30. Venema RC, Venema VJ, Eaton DC, Marrero MB 1998 Angiotensin II-induced tyrosine phosphorylation of signal transducers and activators of transcription 1 is regulated by Janus-activated kinase 2 and Fyn kinases and mitogen-activated protein kinase phosphatase 1. J Biol Chem 273:30795-30800
31. Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME, Baliga RS, Meng X, Smith CV, Bauer JA, Chang CH, Liu Y 2006 MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med 203:131-140
32. Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA 2006 Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA 103:2274-2279
33. Zhou ZH, Chaturvedi P, Han YL, Aras S, Li YS, Kolattukudy PE, Ping D, Boss JM, Ransohoff RM 1998 IFN-γ induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: functional interaction between an IFN-γ-activated site and a GC-rich element. J Immunol 160:3908-3916
34. Pfitzner E, Kliem S, Baus D, Litterst CM 2004 The role of STATs in inflammation and inflammatory diseases. Curr Pharm Des 10:2839-2850
35. Kamezaki K, Shimoda K, Numata A, Matsuda T, Nakayama K, Harada M 2004 The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals. Int Immunol 16:1173-1179
36. McLoughlin RM, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, Ernst M, Topley N, Jones SA 2005 IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc Natl Acad Sci USA 102:9589-9594
37. O'Shea JJ, Pesu M, Borie DC, Changelian PS 2004 A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat Rev Drug Discov 3:555-564
38. Dong C, Davis RJ, Flavell RA 2002 MAP kinases in the immune response. Annu Rev Immunol 20:55-72
39. Brondello JM, Pouyssegur J, McKenzie FR 1999 Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286:2514-2517
40. Lin YW, Chuang SM, Yang JL 2003 ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway. J Biol Chem 278:21534-21541
41. Valledor AF, Xaus J, Comalada M, Soler C, Celada A 2000 Protein kinase C- is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J Immunol 164:29-37
42. Chen P, Li J, Barnes J, Kokkonen GC, Lee JC, Liu Y 2002 Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J Immunol 169:6408-6416
43. Hu JH, Chen T, Zhuang ZH, Kong L, Yu MC, Liu Y, Zang JW, Ge BX 2007 Feedback control of MKP-1 expression by p38. Cell Signal 19:393-400