Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: Critical role of the p38 C-terminal domain in its negative regulation

Biochemical Journal

Volumn 352, Issue 1, 2000, Pages 155-163

  Hutter, D ^a   Chen, P ^a   Barnes, J ^a   Liu, Y ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Feedback control; MKP 1; Protein protein interaction; Signal transduction

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PHOSPHATASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ASPARAGINE; ASPARTIC ACID; BLOTTING, WESTERN; CATALYSIS; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HELA CELLS; HUMANS; IMMEDIATE-EARLY PROTEINS; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PLASMIDS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0034668924     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3520155     Document Type: Article

References (37)

1. Mitogen-activated protein kinase pathways
2. Protein kinase cascades activated by stress and inflammatory cytokines
3. Transcriptional regulation by MAP kinases
4. Regulation of transcription by MAP kinase cascades
5. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
6. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
7. MAP kinase-dependent pathways in cell cycle control
8. The p38 signal transduction pathway: Activation and function
9. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
10. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
11. PAC-1 : A mitogen-induced nuclear protein tyrosine phosphatase
12. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gone activation
13. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase
14. Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: Characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases
15. The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity
16. The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action
17. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
18. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
19. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
20. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
21. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc
22. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells
23. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
24. Oxidative stress and heat shock induce a human gone encoding a protein-tyrosine phosphatase
25. Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
26. Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm
27. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase
28. A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation
29. A conserved docking motif in MAP kinases common to substrates, activators and regulators
30. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5
31. Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phesphatase
32. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells
33. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
34. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
35. Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts
36. Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation
37. Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation