Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 4, 2008, Pages

  Calvert, Thomas J ^b   Chicoine, Louis G ^b   Liu, Yusen ^b   Nelin, Leif D ^a  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

Cell signaling; Lipopolysaccharide; Nitric oxide; Septic shock

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTOXIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; ENZYME DEFICIENCY; HYPOTENSION; KNOCKOUT MOUSE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD PRESSURE; BREATH TESTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DUAL SPECIFICITY PHOSPHATASE 1; ENZYME INHIBITORS; GUANIDINES; HYPOTENSION; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE II; SPERMINE; TIME FACTORS; UP-REGULATION;

EID: 41749093006     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01008.2007     Document Type: Article

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