Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 282, Issue 6 26-6, 2002, Pages

  Kulisz, Andre ^a   Chen, Ningfang ^a   Chandel, Navdeep S ^a   Shao, Zuohui ^a   Schumacker, Paul T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Hydrogen peroxide; Oxidant stress; Protein kinases; Respiration; Superoxide

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ACETYLCYSTEINE; ANTIMYCIN A1; ANTIOXIDANT; MITOGEN ACTIVATED PROTEIN KINASE; MYXOTHIAZOL; REACTIVE OXYGEN METABOLITE; ROTENONE; THENOYLTRIFLUOROACETONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GENETIC TRANSCRIPTION; HEART INFARCTION PREVENTION; HEART MUSCLE CELL; HYPOXIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0036080832     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00326.2001     Document Type: Article

References (35)

1. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
2. Effects of graded hypoxia on contraction of cultured chick embryo ventricular cells
3. The mitochondrial inner membrane anion channel is inhibited by DIDS
4. Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes
5. 2 sensor
6. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
7. Redox regulation of p53 during hypoxia
8. Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses
9. Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells
10. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
11. Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes
12. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
13. Ordered phosphorylation of p42mapk by MAP kinase kinase
14. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
17. Activation of protein kinase cascades by osmotic shock
18. 2
19. Reactive oxygen species and antioxidants in signal transduction and gene expression
20. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
21. The effect of inhibitors on the oxygen kinetics of cytochrome c oxidase
22. Role of p38 mitogen-activated protein kinases in preconditioning: A detrimental factor or a protective kinase?
23. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
24. Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: Analysis by peptide mapping
25. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
26. Oxidative stress and signal transduction
27. Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes
28. Oxidants as stimulators of signal transduction
29. Myxothiazol, a new inhibitor of the cytochrome b-c1 segment of the respiratory chain
30. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
31. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
32. Possible involvement of p38 MAP kinase in HSP70 expression induced by hypoxia in rat primary astrocytes
33. p38 mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II
34. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes
35. Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart