The NGFI-B family of transcription factors regulates expression of 3β-hydroxysteroid dehydrogenase type 2 in the human ovary

Molecular Human Reproduction

Volumn 11, Issue 2, 2005, Pages 79-85

  Havelock, Jon C ^a   Smith, Allison L ^a   Seely, Jeremiah B ^a   Dooley, Christina A ^a   Rodgers, Raymond J ^b   Rainey, William E ^a   Carr, Bruce R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Corpus luteum; HSD3B2; NGFI B; Nur77; Ovary; Progesterone

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ENZYME; FOLLITROPIN; FORSKOLIN; MESSENGER RNA; NERVE GROWTH FACTOR INDUCED CLONE B; NEURON DERIVED ORPHAN RECEPTOR 1; NUCLEAR RECEPTOR NUR77; NUCLEAR RECEPTOR RELATED FACTOR 1; PHORBOL ESTER; PROGESTERONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; STEROIDOGENIC FACTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NOR 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHOLESTEROL SIDE CHAIN CLEAVAGE; CORPUS LUTEUM; DNA RESPONSIVE ELEMENT; EXPRESSION VECTOR; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GRANULOSA CELL TUMOR; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; OVARY FOLLICLE; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 14744282485     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gah139     Document Type: Article

References (36)

1. Bassett MH, Suzuki T, Sasano H, De Vries CJ, Jimenez PT, Carr BR and Rainey WE (2004) The orphan nuclear receptor NGFIB regulates transcription of 3beta-hydroxysteroid dehydrogenase. Implications for the control of adrenal functional zonation. J Biol Chem 279,37622-37630.
2. Beckmann MW, Polacek D, Seung L and Schreiber JR (1991) Human ovarian granulosa cell culture: determination of blood cell contamination and evaluation of possible culture purification steps. Fertil Steril 56,881-887.
3. Breckwoldt M, Selvaraj N, Aharoni D, Barash A, Segal I, Insler V and Amsterdam A (1996) Expression of Ad4-BP/cytochrome P450 side chain cleavage enzyme and induction of cell death in long-term cultures of human granulosa cells. Mol Hum Reprod 2,391-400.
4. Chirgwin JM, Przybyla AE, MacDonald RJ and Rutter WJ (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 24,5294-5299.
5. Crawford PA, Sadovsky Y, Woodson K, Lee SL and Milbrandt J (1995) Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol Cell Biol 15, 4331-4336.
6. Davis IJ and Lau LF (1994) Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and NURR-1 in the adrenal glands. Mol Cell Biol 14,3469-3483.
7. Diao FY, Xu M, Hu Y, Li J, Xu Z, Lin M, Wang L, Zhou Y, Zhou Z, Liu J et al. (2004) The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray. J Mol Endocrinol 33,59-72.
8. Doody KJ, Lorence MC, Mason JI and Simpson ER (1990) Expression of messenger ribonucleic acid species encoding steroidogenic enzymes in human follicles and corpora lutea throughout the menstrual cycle. J Clin Endocrinol Metab 70,1041-1045.
9. Fernandez PM, Brunel F, Jimenez MA, Saez JM, Cereghini S and Zakin MM (2000) Nuclear receptors Nor1 and NGFI-B/Nur77 play similar, albeit distinct, roles in the hypothalamo-pituitary-adrenal axis. Endocrinology 141,2392-2400.
10. Giguere V (1999) Orphan nuclear receptors: from gene to function. Endocr Rev 20,689-725.
11. Hazel TG, Misra R, Davis IJ, Greenberg ME and Lau LF (1991) Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. Mol Cell Biol 11,3239-3246.
12. Jansen E, Laven JS, Dommerholt HB, Polman J, Van Rijt C, Van Den Hurk C, Westland J, Mosselman S and Fauser BC (2004) Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients. Mol Endocrinol 18,3050-3063.
13. Kim JW, Peng N, Rainey WE, Carr BR and Attia GR (2004) Liver receptor homolog-1 regulates the expression of steroidogenic acute regulatory protein in human granulosa cells. J Clin Endocrinol Metab 89,3042-3047.
14. Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F and Arzt E (2002) Activation and induction of NUR77/NURR-1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways. Mol Endocrinol 16,1638-1651.
15. 4 isomerase (3β-HSD) gene: adrenal and gonadal specificity. DNA Cell Biol 10,701-711.
16. Lalli E, Melner MH, Stocco DM and Sassone-Corsi P (1998) Dax-1 blocks steroid production at multiple levels. Endocrinology 10,4237-4243.
17. 4 isomerase promoter by the transcription factor steroidogenic factor-1/adrenal 4-binding protein and phorbol ester. J Biol Chem 272,7960-7967.
18. Martin LJ and Tremblay JJ (2004) The human HSD3B2 promoter is a novel target for the immediate early orphan nuclear receptor nur77 in steroidogenic cells. Endocrinology Epub ahead of print.
19. Maruyama K, Tsukada T, Bandoh S, Sasaki K, Ohkura N and Yamaguchi K (1997) Expression of the putative transcription factor NOR-1 in the nervous, the endocrine and the immune systems and the developing brain of the rat. Neuroendocrinology 1,2-8.
20. Maruyama K, Tsukada T, Ohkura N, Bandoh S, Hosono T and Yamaguchi K (1998) The NGFI-B subfamily of the nuclear receptor family. Int J Oncol 12,1237-1243.
21. Murphy EP and Conneely OM (1997) Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the NURR-1/nur77 subfamily of nuclear receptors. Mol Endocrinol 11,39-47.
22. Park J, Park H, Choi H, Lee K, Lee W and Chun S (2001) Gonadotropin regulation of NGFI-B messenger ribonucleic acid expression during ovarian follicle development in the rat. Endocrinology 142,3051-3059.
23. Park JI, Park HJ, Lee YI, Seo YM and Chun SY (2003) Regulation of NGFI-B expression during the ovulatory process. Mol Cell Endocrinol 202,25-29.
24. Peng N, Kim JW, Rainey WE, Carr BR and Attia GR (2003) The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II. J Clin Endocrinol Metab 88,6020-6028.
25. Philips A, Lesage S, Gingras R, Maira M, Gauthier Y, Hugo O and Drouin J (1997) Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells. Mol Cell Biol 17,5946-5951.
26. Rheaume E, Lachance Y, Zhao HF, Breton N, Dumont M, de Launoit Y, Trudel C, Luu-The V, Simard J and Labrie F (1991) Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/defta 5-delta 4-isomerase in human adrenals and gonads. Mol Endocrinol 5,1147-1157.
27. Ryan KJ and Petro Z (1966) Steroid biosynthesis by human ovarian granulosa and thecal cells. J Clin Endocrinol Metab 26,46-52.
28. Sasson R, Rimon E, Dantes A, Cohen T, Shinder V, Land-Bracha A and Amsterdam A (2004) Gonadotrophin-induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic genes, cytoskeletal genes and genes coding for apoptotic signalling and protein kinases. Mol Hum Reprod 10,299-311.
29. Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S and Sasanc, H (2003) Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/ steroidogenic factor-1 immunolocalization during the menstrual cycle. J Clin Endocrinol Metab 7,3415-3420.
30. Sirianni R, Seely JB, Attia G, Stocco DM, Carr BR, Pezzi V and Rainey WE (2002) Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes. J Endocrinol 174,RI3-RI7.
31. Song K, Park J, Lee M, Soh J, Lee K and Choi H (2001) LH induces orphan nuclear receptor Nur77 gene expression in testicular leydig cells. Endocrinology 142,5116-5123.
32. Stocco CO, Zhong L, Sugimoto Y, Ichikawa A, Lau LF and Gibori G (2000) Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. J Biol Chem 275,37202-37211.
33. 2α in ovarian cells. J Biol Chem 277,3293-3302.
34. Suzuki T, Sasano H, Tamura M, Aoki H, Fukaya T, Yajima A, Nagura H and Mason JI (1993) Temporal and spatial localization of steroidogenic enzymes in premenopausal human ovaries: in situ hybridization and immunohistochemical study. Mol Cell Endocrinol 97,135-143.
35. Wilson TE, Fahrner TJ, Johnston M and Milbrandt J (1991) Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 2252,1297-1300.
36. Wilson TE, Mouw AR, Weaver CA, Milbrandt J and Parker KL (1993) The orphan nuclear receptor NGFI-B regulates expression of the gene encoding 21-hydroxylase. Mol Cell Biol 13,861-868.