Lactosylceramide stimulates ras-GTP loading, kinases (MEK, Raf), p44 mitogen-activated protein kinase, and c-fos expression in human aortic smooth muscle cells

Journal of Biological Chemistry

Volumn 271, Issue 18, 1996, Pages 10660-10666

  Bhunia, Anil Kumar ^a   Han, Hui ^a   Snowden, Ann ^a   Chatterjee, Subroto ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; GLUCOSYLCERAMIDE; GUANOSINE TRIPHOSPHATE; LACTOSYLCERAMIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; PHOSPHOAMINO ACID; PHOSPHOTRANSFERASE; THREONINE; TYROSINE; TYRPHOSTIN;

ANIMAL CELL; AORTA MEDIA; ARTICLE; ATHEROSCLEROSIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; ONCOGENE C FOS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; ANTIGENS, CD; AORTA; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENES, FOS; GUANOSINE TRIPHOSPHATE; HUMANS; LACTOSYLCERAMIDES; MAP KINASE KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RABBITS; RAS PROTEINS;

EID: 17544384366     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.18.10660     Document Type: Article

References (50)

1. Hakomori, S. (1990) J. Biol. Chem. 265, 18713-18716
2. Chatterjee, S. (1991) Biochem. Biophys. Res. Commun. 181, 554-561
3. Bremer, E., Schlessinger, J., and Hakomori, S. (1986) J. Biol. Chem. 261, 2434-2440
4. Sadahira, Y., Ruan, F., Hakomori, S. I., and Igarashi, Y. (1994) Proc. Natl. Acad. Sci. U. S. A. 89, 9686-9690
5. Obeid, L. M., Linardic, C. M., Karolak, L. A., and Hannun, Y. A. (1993) Science 259, 1769-1771
6. Nishida, E., and Gotoh, Y. (1992) Int. Rev. Cytol. 138, 211-238
7. Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radziejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., and Yancopoulos, G. D. (1991) Cell 65, 663-675
8. Davis, R. J. (1994) Trends Biochem. Sci. 19, 470-473
9. Cano, E., and Mahadevan, L. C. (1995) Trends Biochem. Sci. 20, 117-122
10. Rossomando, A. J., Sanghera, J. S., Marsden, L. A., Weber, M. J., Pelech, S. L., and Sturgill, T. W. (1992) J. Biol. Chem. 266, 20270-20275
11. Traverse, S., Gomez, N., Peterson, H., Marshall, C., and Cohen, P. (1992) Biochem. J. 288, 351-355
12. Seth, A., Alvarez, E., Gupta, S., and Davis, R. J. (1991) J. Biol. Chem. 266, 23521-23524
13. Seth, A., Gonzalez, F. A., Gupta, S., Raden, D. L., and Davis, R. J. (1992) J. Biol. Chem. 267, 24796-24804
14. Deug, T., and Karin, M. (1994) Nature 371, 171-175
15. Gille, H., Sharrocks, A. D., and Shaw, P. E. (1992) Nature 358, 414-417
16. Marais, R., Wynne, J., and Treisman, R. (1993) Cell 73, 381-393
17. Davis, R. J. (1993) J. Biol. Chem. 268, 14553-14556
18. Ahn, N. G., and Krebs, E. G. (1992) Current Opin. Cell Biol. 4, 992-999
19. Kyriakis, J. M., App, H., Zhang, X., Banerjee, P., Brautigan, D. Z., Rapp, U.R., and Avruch, J. (1992) Nature 358, 417-421
20. Blenis, J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5889-5892
21. Blummer, K. J., and Johnson, G. L. (1994) Trends. Biochem. Sci. 19, 236-240
22. Ross, R. (1971) J. Cell Biol. 50, 172-186
23. Laird, A. D., Taylor, S. J., Oberst, M., and Shalloway, D. (1995) J. Biol. Chem. 270, 26742-26745
24. Clark-Lewis, I., Sanghera, J. S., and Pelech, S. L. (1991) J. Biol. Chem. 266, 15180-15184
25. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 256-275
26. Chatterjee, S., and Ghosh, N. (1989) J. Biol. Chem. 264, 12554-12561
27. Sengupta, A., Liu, W. K., Yeung, Y. G., Yeung, D. C. Y., Frackelton, A. R., and Stanley E. R. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 8062-8066
28. Boyle, W. J., Geer, P. V. D., and Hunter, T. (1991) Methods Emymol. 201, 110-152
29. Downward, J., Graves, J. D., Warne, P. H., Rayter, S., and Cantrell, D. A. (1990) Nature 346, 719-723
30. Chomczynski, P., and Sacchi, N. (1987) Anal. Biochem. 162, 156-159
31. Weinstein, S. L., Sanghera, J. S., Lemke, K., DeFranco, A. L., and Pelech, S. L. (1992) J. Biol. Chem. 267, 14955-14962
32. Novogrodsky, A, Vanichkin, A., Patya, M., Gazit, A., Osherov, N., and Levitzki, A. (1994) Science 264, 1319-1322
33. Shayman, J. A., Deshmukh, G. D., Mahdiyoun, S., Thomas, T. P., Wu, D., Barcelon, F. S., and Radin, N. S. (1991) J. Biol. Chem. 266, 22968-22974
34. Ward Y., Gupta, S., Jensen, P., Wartmann, M., Davis, R. J., and Kelly, K. (1994) Nature 367, 651-654
35. Fialkov, L., Chan, C. K., Rotin, D., Grinstein, S., and Downey, G. P. (1994) J. Biol. Chem. 269, 31234-31242
36. Johnson, G. L., and Langer-Carter, C. A. (1994) Science 265, 1458-1461
37. Lander, H. M., Ogiste, J. S., Pearce, S. F. A., Levi, R., and Novogrodsky, A. (1995) J. Biol. Chem. 270, 7017-7020
38. Boguski, M. S., and Macormick, F. (1993) Nature 366, 643-654
39. Bokoch, G. M., and Der, C. J. (1993) FASEB J. 7, 750-759
40. Warne, P. H., Viciana, P. R., and Downward, J. (1993) Nature 364, 352-355
41. Vojtek, A. B., Hollenberg, S. M., and Cooper, J. A. (1993) Cell 74, 205-214
42. Kikuchi, A., and Williams L. T. (1994) J. Biol. Chem. 269, 20054-20059
43. Ghosh, S., Xie, W. Q., Quest, A. F. G., Mabrouk, G. M., Strum, J. C., and Bell, R. M. (1994). Biol. Chem. 269, 10000-10007
44. Lau, L. F., and Nathans, D. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 1182-1186
45. Curran, T., and Franza, B. R. J. (1988) Cell 55, 395-397
46. Angel, P., and Karin, M. (1991) Biochim. Biophys. Acta 1072, 129-137
47. Holt, J. T., Gopal, T. V., Moulton, A. D., and Nienhuis, A. W. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 4794-4798
48. Rao, G. N., Baas, A. S., Glasgow, W. C., Eling, T. E., Runge, M. S., and Alexander, R. W. (1994) J. Biol. Chem. 269, 32586-32591
49. Rao, G. N., Alexander, R. W., and Runge, M. S. (1995) J. Clin. Invest. 96, 842-847
50. Winston, B. W., Remigio, L. K., and Riches, D. W. H. (1995) J. Biol. Chem. 270, 27391-27394