Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids

Journal of Cell Biology

Volumn 149, Issue 3, 2000, Pages 707-717

  Tvrdik, Petr ^a,c   Westerberg, Rolf ^a   Silve, Sandra ^b   Asadi, Abolfazl ^a   Jakobsson, Andreas ^a   Cannon, Barbara ^a   Loison, Gerard ^b   Jacobsson, Anders ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b SANOFI   (France)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Elongation; Gene expression; Lipids; Membrane; Myelin

Indexed keywords

MEMBRANE PROTEIN; SPHINGOLIPID; VERY LONG CHAIN FATTY ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; FATTY ACID SYNTHESIS; GENE EXPRESSION REGULATION; HYDROPHOBICITY; MALE; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; TISSUE SPECIFICITY;

ADIPOSE TISSUE, BROWN; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DOWN-REGULATION; FATTY ACIDS; GENETIC COMPLEMENTATION TEST; MEMBRANE PROTEINS; MICE; MICE, JIMPY; MICE, QUAKING; MICROSOMES; MOLECULAR SEQUENCE DATA; MUTATION; MYELIN SHEATH; RNA, MESSENGER; SEQUENCE ALIGNMENT; SPHINGOLIPIDS; YEASTS;

EID: 0034193457     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.149.3.707     Document Type: Article

References (43)

1. Alani, E., L. Cao, and N. Kleckner. 1987. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics. 116:541-545.
2. Bernert, J.J., and H. Sprecher. 1979. Solubilization and partial purification of an enzyme involved in rat liver microsomal fatty acid chain elongation: beta-hydroxyacyl-CoA dehydrase. J. Biol. Chem. 254:11584-11590.
3. Bourre, J.M., J.M. Paturneau, O.L. Daudu, and N.A. Baumann. 1977. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). Eur. J. Biochem. 72:41-47.
4. Cinti, D.L., L. Cook, M.N. Nagi, and S.K. Suneja. 1992. The fatty acid chain elongation system of mammalian endoplasmic reticulum. Prog. Lipid. Res. 31:1-51.
5. Clarke, N.G., and R.M. Dawson. 1981. Alkaline O leads to N-transacylation. A new method for the quantitative deacylation of phospholipids. Biochem. J. 195:301-306.
6. David, D., S. Sundarababu, and J.E. Gerst. 1998. Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast. J. Cell Biol. 143:1167-1182.
7. Desfarges, L., P. Durrens, H. Juguelin, C. Cassagne, M. Bonneu, and M. Aigle. 1993. Yeast mutants affected in viability upon starvation have a modified phospholipid composition. Yeast. 9:267-277.
8. Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs of the VAX. Nucleic Acids Res. 12:387-395.
9. Dickson, R.C. 1998. Sphingolipid functions in Saccharomyces cerevisiae: comparison to mammals. Annu. Rev. Biochem. 67:27-48.
10. Durrens, P., E. Revardel, M. Bonneu, and M. Aigle. 1995. Evidence for a branched pathway in the polarized cell division of Saccharomyces cerevisiae. Curr. Genet. 27:213-216.
11. El-Sherbeini, M., and J.A. Clemas. 1995. Cloning and characterization of GNS1: a Saccharomyces cerevisiae gene involved in synthesis of 1,3-beta-glucan in vitro. J. Bacteriol. 177:3227-3234.
12. Engelman, D.M., T.A. Steitz, and A. Goldman. 1986. Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu. Rev. Biophys. Chem. 15:321-353.
13. Fox, B.G., J. Shanklin, J. Ai, T.M. Loehr, and L.J. Sanders. 1994. Resonance raman evidence for an Fe-O-Fe center in stearoyl-ACP desaturase. Primary sequence identity with other diiron-oxo proteins. Biochemistry. 33:12776-12786.
14. García-Arranz, M., A.M. Maldonado, M.J. Mazón, and F. Portillo. 1994. Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation. J. Biol. Chem. 269:18076-18082.
15. Gielz, D., A. St. Jean, R.A. Woods, and R.H. Schiestl. 1992. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20: 1425.
16. Hakomori, S., and Y. Igarashi. 1995. Functional role of glycosphingolipids in cell recognition and signaling. J. Biochem. (Tokyo). 118:1091-1103.
17. Hanada, K., M. Nishijima, M. Kiso, A. Hasegawa, S. Fujita, T. Ogawa, and Y. Akamatsu. 1992. Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids. J. Biol. Chem. 267:23527-23533.
18. Hannun, Y.A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science. 274:1855-1859.
19. Hanson, B.A., and R.L. Lester. 1980. The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa. J. Lipid Res. 21:309-315.
20. Hardy, R.J. 1998. Molecular defects in thc dysmyelinating mutant quaking. J. Neurosci. Res. 51:417-122.
21. Jackson, M.R., T. Nilsson, and P.A. Peterson. 1990. Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO (Eur. Mol. Biol. Organ.) J. 9:3153-3162.
22. Kuroshima, A., and T. Ohnn. 1990. Cold-induced and postnatal changes in brown adipose tissue ganglioside levels. Jpn. J. Physiol. 40:57-64.
23. Ladeveze, V., C. Marcireau, D. Delourme, and F. Karst. 1993. General resistance to sterol biosynthesis inhibitors in Saccharomyces cerevisiae. Lipids. 28:907-912.
24. Lester, R.L., G.B. Wells, G. Oxford, and R.C. Dickson. 1993. Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphingolipid structures. J. Biol. Chem. 268: 845-856.
25. Millar, A.A., and L. Kunst. 1997. Very-long-chain fatty acid biosynthesis is controlled through the expression and specificity of the condensing enzyme. Plant J. 12:121-131.
26. Millar, A.A., S. Clemens, S. Zachgo, E.M. Giblin, D.C. Taylor, and L. Kunst. 1999. CUT1, an arabidopsis gene required for cuticular wax biosynthesis and pollen fertility, encodes a very-long-chain fatty acid condensing enzyme. Plant Cell. 11:825-838.
27. Oh, C.S., D.A. Toke, S. Mandala, and C.E. Martin. 1997. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J. Biol. Chem. 272: 17376-17384.
28. Poulos, A. 1995. Very long chain fatty acids in higher animals: a review. Lipids. 30:1-14.
29. Revardel, E., M. Bonneau, P. Durrens, and M. Aigle. 1995. Characterization of a new gene family developing pleiotropic phenotypes upon mutation in Saccharomyces cerevisiae. Biochim. Biophys. Acta. 1263:261-265.
30. Shanklin, J., E. Whittle, and B.G. Fox. 1994. Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. Biochemistry. 33:12787-12794.
31. Silve, S., P. Leplatois, A. Josse, P.H. Dupuy, C. Lanau, M. Kaghad, C. Dhers, C. Picard, A. Rahier, M. Taton, et al. 1996. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:2719-2727.
32. Simons, K., and E. Ikonen. 1997. Functional rafts in cell membranes. Nature. 387:569-572.
33. Spiegel, S., and A.J. Merrill. 1996. Sphingolipid metabolism and cell growth regulation. FASEB J. 10:1388-1397.
34. Suneja, S.K., M.N. Nagi, L. Cook, and D.L. Cinti. 1991. Decreased long-chain fatty acyl CoA elongation activity in quaking and jimpy mouse brain: deficiency in one enzyme or multiple enzyme activities? J. Neurochem. 57:140-146.
35. Testi, R. 1996. Sphingomyelin breakdown and cell fate. Trends Biochim. Sci. 21:468-471.
36. Todd, J., B.D. Post, and J.G. Jaworski. 1999. KCS1 encodes a fatty acid elongase 3-ketoacyl-CoA synthase affecting wax biosynthesis in Arabidopsis thaliana. Plant J. 17:119-130.
37. Toke, D.A., and C.E. Martin. 1996. Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae. J. Biol. Chem. 271: 18413-18422.
38. Trayhurn, P., and D.G. Nicholls. 1986. Brown Adipose Tissue. Edward Arnold Ltd., London. 374 pp.
39. Tvrdik, P., A. Asadi, L.P. Kozak, J. Nedergaard, B. Cannon, and A. Jacohsson. 1997. Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue. J. Biol. Chem. 272: 31738-31746.
40. Vela, J.M., B. Gonzalez, and B. Castellano. 1998. Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse. Brain Res. Rev. 26:29-42.
41. Wells, G.B., and R.L. Lester. 1983. The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids. J. Biol. Chem. 258:10200-10203.
42. Wertz, P.W. 1992. Epidermal lipids. Semin. Dermatol. 11:106-113.
43. Zeidel, M.L. 1996. Low permeabilities of apical membranes of barrier epithelia: what makes watertight membranes watertight? Am. J. Physiol. F243-F245.