Autoproteolytic cleavage and activation of human acid ceramidase

Journal of Biological Chemistry

Volumn 283, Issue 17, 2008, Pages 11253-11259

  Shtraizent, Nataly ^a,b   Eliyahu, Efrat ^a   Park, Jae Ho ^a   He, Xingxuan ^a   Shalgi, Ruth ^b   Schuchman, Edward H ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINATION; AMINES; AMINO ACIDS; HYDROGEN; HYDROGEN BONDS; HYDROLYSIS; NUCLEOPHILES; ORGANIC ACIDS; REACTION KINETICS;

ACID CERAMIDASE; ACIDIC PH; CERAMIDE; CLEAVAGE SITES; CONFORMATIONAL CHANGES; CYSTEINE PROTEASES; ENZYMATIC ACTIVITIES; FIRST ORDERS; HYDROLASE; METHANETHIOSULFONATE; NEUTRAL PH; PROTON ACCEPTORS; THIOETHER BONDS;

ANIMAL CELL CULTURE;

ACYLSPHINGOSINE DEACYLASE; ARGININE; ASPARTIC ACID; CERAMIDE; CYSTEINE; ISOLEUCINE; RECOMBINANT ENZYME; SULFIDE; THIOMESYLIC ACID METHYL ESTER; GALACTOSYLGALACTOSYLGLUCOSYLCERAMIDASE; RECOMBINANT PROTEIN;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; HYDROGEN BOND; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; ANIMAL; CHEMISTRY; CHO CELL; CRICETULUS; HAMSTER; HUMAN; METABOLISM; PROTEIN CONFORMATION;

ANIMALS; ARGININE; ASPARTIC ACID; CERAMIDE TRIHEXOSIDASE; CHO CELLS; CRICETINAE; CRICETULUS; CYSTEINE; ENZYME ACTIVATION; HUMANS; HYDROGEN BONDING; ISOLEUCINE; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 45549093120     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709166200     Document Type: Article

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