Probing structural features of Alzheimers amyloid-β pores in bilayers using site-specific amino acid substitutions

Biochemistry

Volumn 51, Issue 3, 2012, Pages 776-785

  Capone, Ricardo ^a   Jang, Hyunbum ^b   Kotler, Samuel A ^a   Kagan, Bruce L ^c   Nussinov, Ruth ^b,d   Lal, Ratnesh ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMERS DISEASE; AMINO ACID SUBSTITUTION; ATOMIC RESOLUTION; BI-LAYER; CELLULAR MEMBRANES; CHANNEL ACTIVITY; CHANNEL CONDUCTANCE; CHANNEL FORMATION; CHANNEL STRUCTURES; COMPUTATIONAL MODEL; DRUG DESIGN; EXPERIMENTAL EVIDENCE; ION FLUXES; MD SIMULATION; MOLECULAR DYNAMICS SIMULATIONS; MUTATION SITES; MUTATIONAL ANALYSIS; POINT MUTATIONS; POLYMORPHIC STATE; SITE-SPECIFIC; STRUCTURAL FEATURE; STRUCTURAL MODELS; WILD TYPES;

AMINO ACIDS; CELL MEMBRANES; GLYCOPROTEINS; IONS; MODEL STRUCTURES; MOLECULAR DYNAMICS; NEURODEGENERATIVE DISEASES; PEPTIDES;

LIPID BILAYERS;

AMYLOID BETA PROTEIN[1-42]; CYSTEINE;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CONDUCTANCE; LIPID BILAYER; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIMULATION; WILD TYPE;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PEPTIDES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DNA MUTATIONAL ANALYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHENYLALANINE; POINT MUTATION; PROLINE;

EID: 84856262919     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2017427     Document Type: Article

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