Electrophysiologic properties of channels induced by Aβ25-35 in planar lipid bilayers

Peptides

Volumn 23, Issue 7, 2002, Pages 1215-1228

  Lin, Meng Chin Allison ^a   Kagan, Bruce L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyloid; Bilayers; Membranes; Pores

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[25-35]; CHOLESTEROL; MEMBRANE LIPID; PEPTIDE FRAGMENT; SOLVENT; UNCLASSIFIED DRUG; AZOLECTIN; ION CHANNEL; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

ARTICLE; CHANNEL GATING; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; IONIC STRENGTH; LIPID BILAYER; LIPID COMPOSITION; MEMBRANE POTENTIAL; NONLINEAR SYSTEM; PEPTIDE ANALYSIS; PH; PRIORITY JOURNAL; PROTEIN FUNCTION; CHEMISTRY; ELECTRIC CONDUCTIVITY; HUMAN; OSMOLARITY; PHYSIOLOGY;

AMYLOID BETA-PROTEIN; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNELS; LIPID BILAYERS; MEMBRANE LIPIDS; OSMOLAR CONCENTRATION; PEPTIDE FRAGMENTS; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; SOLVENTS;

EID: 0035997224     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(02)00057-8     Document Type: Article

References (78)

1. How to set up a bilayer system
2. Monazomycin-induced single channels. I. Characterization of the elementary conductance events
3. Alzheimer disease amyloid β protein forms calcium channels in bilayer membranes: Blockade by tromethamine and aluminum
4. Giant multilevel cation channels formed by Alzheimer disease amyloid β protein[AβP-(1-40)] in bilayer membranes
5. 2+ interaction with Alzheimer amyloid β-amyloid calcium channels
6. β-Amyloid precursor protein mismetabolism and loss of calcium homeostasis in Alzheimer's disease
7. Amyloid β peptide induces necrosis rather than apoptosis
8. Hydrogen peroxide mediates amyloid protein toxicity
9. Statistical analysis of alamethicin channels in black lipid membranes
10. 2+ influx induced by β-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation
11. Congo red protects against toxicity of β-amyloid peptides on rat hippocampal neurons
12. Aerolysin of Aeromonas sobria: Evidence for formation of ion-permeable channels and comparison with alpha-toxin of Staphylococcus aureus
13. Impairment of hippocampal long-term potentiation by Alzheimer amyloid-Aβ peptides
14. Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by β-amyloid peptide
15. β-Amyloid neurotoxicity: A discussion of in vitro findings
16. Crystal structures explain functional properties of two E. coli porins
17. Sc causes nerve cell death and stimulates astrocyte proliferation: A paradox
18. Studies on peptide-containing the 25-35 sequence of amyloid β peptide
19. Neurotoxicity of a prion protein fragment
20. Apoptosis mediated neurotoxicity induced by chronic application of β-amyloid fragment 25-35
21. Amyloid β protein-induced irreversible current in rat cortical neurons
22. Flow cytometric analyses on cytotoxic action of amyloid β protein fragment 25-35 on brain neurons dissociated from the rats
23. Reduction in membrane proteins and lipids in basal ganglia of classic Alzheimer disease patients
24. Alzheimer's disease: The amyloid cascade
25. Apolipoprotein E and cholesterol affect neuronal calcium signaling: The possible relationship to β-amyloid neurotoxicity
26. Pore formation by beta-2-microglobulin: A mechanism for the pathogenesis of dialysis associated amyloidosis
27. Amyloid peptide channels: Blockade by zinc and inhibition by Congo red
28. Ion movements in gramicidin channels
29. Structure predictions of membrane proteins are not bad
30. Amyloid β protein fragment 25-35 causes activation of cytoplasmic calcium in neurons
31. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes
32. The use of lipid bilayer membranes to detect pore formation by toxins
33. 2+-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons
34. Voltage-dependent trans-bilayer orientation of melittin
35. β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage
36. Mode of action of the Staphylococcin like peptide Pep 5: Voltage-dependent depolarization of bacterial and artificial membranes
37. An in vivo model for the neurodegenerative effects of β-amyloid and protection by substance P
38. Channel formation by a neurotoxic beta amyloid peptide Aβ25-35
39. Channel forming activity of amyloidogenic peptides
40. Pore formation by neurotoxic fragment of the prion protein
41. Channel formation by a neurotoxic fragment of the prion protein
42. 25-35 peptide-mediated neurotoxicity in rat hippocampal cultures
43. Apoptosis is induced by β-amyloid in cultured central nervous system neurons
44. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
45. Amyloid fibril toxicity in Alzheimer's disease and diabetes
46. Toward the molecular structure of the mitochondrial channel, VDAC
47. Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol
48. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
49. Reconstitution of the native mitochondrial outer membrane in planar bilayers comparison with the outer membrane in a patch pipette and effect of aluminum compounds
50. Amylin induces ion channels in phospholipid membranes
51. Ion permeability properties of lipid bilayers containing amyloid beta-peptide and its fragments
52. Pore formation by the cytotoxic islet amyloid peptide amylin
53. Channel formation in planar lipid bilayers by a neurotoxic fragment of the β-amyloid peptide
54. The use of planar lipid bilayer membranes for rapid screening of membrane active compounds
55. Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties
56. Reconstitution of cell membrane structure in vitro and its transformation into an excitable system
57. Genetic and molecular advances in Alzheimer's disease
58. Sc)-induced toxicity in rat cortical cell cultures
59. Genetics and biology of Alzheimer amyloid precursor
60. Change in membrane permeability induced by amyloid β protein fragment 25-35 in brain neurons dissociated from rats
61. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
62. Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures
63. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity
64. Structure-activity analyses of β-amyloid peptides: Contributions of β25-35 region to aggregation and neurotoxicity
65. A new hypothesis for the mechanism of amyloid toxicity, based on the calcium channel activity of amyloid β protein (AβP) in phospholipid bilayer membranes
66. Calcium ionophore increases amyloid β peptide production by cultured cells
67. Voltage-dependent depolarization of bacterial membranes and artificial lipid bilayers by the peptide antibiotic nisin
68. Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease
69. Amyloid β peptides act directly on single neurons
70. Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease
71. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)
72. Reversible random coil-β sheet transition of Alzheimer β-amyloid fragment 25-35
73. Alzheimer β-amyloid peptide 25-35: Electrostatic interactions with phospholipid membranes
74. Secondary structure and assembly mechanism of an oligomeric channel protein
75. The physical nature of planar bilayer membranes
76. Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides
77. Mechanisms of neuronal degeneration in Alzheimer's disease
78. Prospective study of increased platelet membrane fluidity as a risk factor for Alzheimer's disease: Results at 5 years