Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f] quinolin-9-ones: A new class of antimitotic agents devoid of aromatase activity

Journal of Medicinal Chemistry

Volumn 49, Issue 6, 2006, Pages 1910-1915

  Gasparotto, Venusia ^a   Castagliuolo, Ignazio ^a   Chiarelotto, Gianfranco ^a   Pezzi, Vincenzo ^b   Montanaro, Daniela ^b   Brun, Paola ^a   Palù, Giorgio ^a   Viola, Giampietro ^a   Ferlin, Maria Grazia ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CARBOXYMETHYL 4 METHOXY 4 PHENYL 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 (3' AMINO)PHENYL 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 (3' BROMOPHENYL) 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 (3' CYANOPHENYL) 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 (3' METHOXYPHENYL) 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 (3' METHYLPHENYL) 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 (3' NITROPHENYL) 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 (4' CYANOPHENYL) 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 PHENYL 3 (DIETHYLAMINOETHYL) 6,9 DIHYDROPYRROLO[3,2 F]QUINOLIN 9 ONE; 7 PHENYL 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; 7 THIENYL 6,9 DIHYDRO 3H PYRROLO[3,2 F]QUINOLIN 9 ONE; AROMATASE; QUINOLINE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; LIVER CELL CARCINOMA; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN;

ANIMALS; ANTIMITOTIC AGENTS; AROMATASE; BIOPOLYMERS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOSKELETON; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; MICE; MICROSCOPY, FLUORESCENCE; NEOPLASM TRANSPLANTATION; PYRROLES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, ISOGENEIC; TRITIUM; TUBULIN; WATER;

EID: 33645380372     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0510676     Document Type: Article

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