Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Chhabra, Sandeep ^a,b   Dolezal, Olan ^b   Collins, Brett M ^c   Newman, Janet ^b   Simpson, Jamie S ^a   Macreadie, Ian G ^d   Fernley, Ross ^b   Peat, Thomas S ^b   Swarbrick, James D ^a  

^a MONASH UNIVERSITY   (Australia)

^b CSIRO   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYMETHYL 7,8 DIHYDROPTERIN; 6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE; 6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE INHIBITOR; 8 MERCAPTOGUANINE; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BACTERIAL ENZYME; ENZYME INHIBITOR; GUANINE DERIVATIVE; MAGNESIUM; PTERIN DERIVATIVE; UNCLASSIFIED DRUG; 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN; BACTERIAL PROTEIN; PHOSPHOTRANSFERASE;

ARTICLE; CATALYSIS; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ENZYME BINDING; ENZYME STABILITY; ENZYME STRUCTURE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR INTERACTION; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; SCREENING; STAPHYLOCOCCUS AUREUS; SURFACE PLASMON RESONANCE; THERMODYNAMICS; CHEMISTRY; ENZYMOLOGY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; DIPHOSPHOTRANSFERASES; MAGNETIC RESONANCE SPECTROSCOPY; PTERINS; STAPHYLOCOCCUS AUREUS;

EID: 84856023495     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029444     Document Type: Article

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