Structural studies of pterin-based inhibitors of dihydropteroate synthase

Journal of Medicinal Chemistry

Volumn 53, Issue 1, 2010, Pages 166-177

  Hevener, Kirk E ^a   Yun, Mi Kyung ^b   Qi, Jianjun ^a   Kerr, Iain D ^b   Babaoglu, Kerim ^b   Hurdle, Julian G ^a   Balakrishna, Kanya ^a   White, Stephen W ^a,b   Lee, Richard E ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DIHYDROPTEROATE SYNTHASE; DIHYDROPTEROATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS ANTHRACIS; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; FOLATE METABOLISM; IC 50; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIHYDROPTEROATE SYNTHASE; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PTERINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74849088241     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900861d     Document Type: Article

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