Mechanism of the conformational transitions in 6-hydroxymethyl-7,8- dihydropterin pyrophosphokinase as revealed by NMR spectroscopy

Biochemistry

Volumn 45, Issue 41, 2006, Pages 12573-12581

  Li, Guangyu ^a,c   Felczak, Krzysztof ^a,d   Shi, Genbin ^a,b   Yan, Honggao ^a  

^a Michigan State University   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; COMPLEXATION; CONFORMATIONS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CROSS PEAK INTENSITIES; DIMETHYL-6-HYDROXYPTERIN (DMHP); METHYLENEADENOSINE TRIPHOSPHATE (MGAMPPCP); PYROPHOSPHORYL TRANSFER;

PROTEINS;

6 HYDROXYMETHYL 7,8 DIHYDROPTERIN; 6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BETA,GAMMA METHYLENEADENOSINE TRIPHOSPHATE MAGNESIUM; FOLIC ACID; MAGNESIUM DERIVATIVE; PHOSPHOTRANSFERASE; PTERIN DERIVATIVE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME MECHANISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; DIPHOSPHOTRANSFERASES; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 33750050233     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061057m     Document Type: Article

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