2.0 Å X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue

FEBS Letters

Volumn 456, Issue 1, 1999, Pages 49-53

  Stammers, David K ^a   Achari, Aniruddha ^a   Somers, Donald O'N ^a   Bryant, Patrick K ^a   Rosemond, Jane ^a   Scott, David L ^a   Champness, John N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

7,8 Dihydro 6 hydroxymethylpterinpyrophosphokinase; Anti microbial; Drug target; Folate pathway; X ray crystallography

Indexed keywords

7,8 DIHYDRO 6 HYDROXYMETHYLPTERINPYROPHOSPHATASE; ADENOSINE TRIPHOSPHATE; PHOSPHOTRANSFERASE; PTERIN DERIVATIVE; UNCLASSIFIED DRUG; 2 AMINO 4 HYDROXY 6 HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; DIHYDROPTEROATE SYNTHASE;

ARTICLE; COMPLEX FORMATION; CRYSTAL; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE EXPRESSION; GENE TRANSFER; IN VITRO STUDY; PRIORITY JOURNAL; X RAY DIFFRACTION; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; ENZYMOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; PROTEIN FOLDING; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIHYDROPTEROATE SYNTHASE; DIPHOSPHOTRANSFERASES; ESCHERICHIA COLI; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PTERINS;

EID: 0032587194     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)00860-1     Document Type: Article

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