Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Pemble, Charles W ^a,c   Mehta, Perdeep K ^a   Mehra, Smriti ^a,d   Li, Zhenmei ^a   Nourse, Amanda ^a   Lee, Richard E ^a   White, Stephen W ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE; DIHYDROPTEROATE SYNTHASE; FOLIC ACID; PHOSPHOTRANSFERASE; PTERIN; UNCLASSIFIED DRUG; 2 AMINO 4 HYDROXY 6 HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE 7,8 DIHYDROPTEROATE SYNTHASE; 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE-7,8-DIHYDROPTEROATE SYNTHASE; BACTERIAL PROTEIN; ENZYME INHIBITOR; MULTIENZYME COMPLEX;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; FRANCISELLA TULARENSIS; NONHUMAN; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

EUKARYOTA; FRANCISELLA TULARENSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIHYDROPTEROATE SYNTHASE; DIPHOSPHOTRANSFERASES; ENZYME INHIBITORS; FRANCISELLA TULARENSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 78649792111     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014165     Document Type: Article

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